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T. Hornemann · SciRah

Researcher profile · Semantic Scholar

T. Hornemann

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T. Hornemann — researcher profile on SciRah

h-index: 49
Works: 165
Citations: 7,389

Most-cited papers

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol
R. Laaksonen, K. Ekroos, Marko Sysi-Aho, M. Hilvo +24 more
2016European Heart Journal633 citations Open access
Semantic Scholar
Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis
P. Mohassel, S. Donkervoort, M. A. Lone, M. Nalls +42 more
2021Nature Medicine140 citations Open access
Semantic Scholar
Structure-function relationships of HDL in diabetes and coronary heart disease.
M. Cardner, M. Yalçınkaya, S. Goetze, E. Luca +21 more
2019JCI Insight107 citations Open access
Semantic Scholar
Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy
S. Costantino, A. Akhmedov, G. Melina, S. Mohammed +15 more
2019European Heart Journal103 citations Open access
Semantic Scholar
Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1
V. Fridman, S. Suriyanarayanan, P. Novak, W. David +8 more
2019Neurology101 citations Open access
Semantic Scholar
1-Deoxysphingolipids.
M. A. Lone, T. Santos, I. Alecu, L. C. Silva +1 more
2019Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids98 citations
Semantic Scholar
Genotype, phenotype and disease severity reflected by serum LysoGb3 levels in patients with Fabry disease.
A. Nowak, T. Mechtler, T. Hornemann, J. Gawinecka +3 more
2017Molecular Genetics and Metabolism98 citations Open access
Semantic Scholar
A global lipid map defines a network essential for Zika virus replication
H. Leier, Jules B. Weinstein, J. Kyle, Joon-Yong Lee +11 more
2020Nature Communications93 citations Open access
Semantic Scholar
DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans
G. Karsai, Florian Kraft, N. Haag, G. Korenke +13 more
2019Journal of Clinical Investigation92 citations Open access
Semantic Scholar
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
F. Storti, Katrin Klee, V. Todorova, Regula Steiner +18 more
2019eLife90 citations Open access
Semantic Scholar
Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction[S]
I. Alecu, Andrea Tedeschi, Natascha Behler, Klaus Wunderling +13 more
2016Journal of Lipid Research86 citations Open access
Semantic Scholar
Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARγ signature.
S. Oppi, Stefanie Nusser-Stein, P. Błyszczuk, Xu Wang +16 more
2019European Heart Journal85 citations Open access
Semantic Scholar
HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship.
H. Bode, F. Bourquin, S. Suriyanarayanan, Yu Wei +4 more
2016Human Molecular Genetics82 citations Open access
Semantic Scholar
FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome
G. Karsai, M. A. Lone, Z. Kutalik, J. Brenna +4 more
2019Journal of Biological Chemistry80 citations Open access
Semantic Scholar
Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases
M. A. Lone, Andreas J. Hülsmeier, Essa M. Saied, G. Karsai +3 more
2020Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
Frequent genes in rare diseases: panel‐based next generation sequencing to disclose causal mutations in hereditary neuropathies
M. Dohrn, N. Glöckle, L. Mulahasanovic, Corina Heller +29 more
2017Journal of Neurochemistry70 citations Open access
Semantic Scholar
Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy
D. Atkinson, Jelena Nikodinovic Glumac, B. Asselbergh, Biljana Ermanoska +10 more
2017Neurology63 citations Open access
Semantic Scholar
Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga
C. Ziv, S. Malitsky, A. Othman, S. Ben-Dor +5 more
2016Proceedings of the National Academy of Sciences of the United States of America63 citations Open access
Semantic Scholar
Elevation of plasma 1‐deoxy‐sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?
M. Dohrn, A. Othman, S. Hirshman, H. Bode +7 more
2015European Journal of Neurology63 citations
Semantic Scholar
Decreased phosphatidylcholine plasmalogens--A putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction.
I. Sutter, R. Klingenberg, A. Othman, L. Rohrer +9 more
2016Atherosclerosis61 citations Open access
Semantic Scholar
Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway[S]
I. Alecu, A. Othman, Anke Penno, Essa M. Saied +3 more
2016Journal of Lipid Research58 citations Open access
Semantic Scholar
Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars
S. Parry, F. Rosqvist, F. Mózes, T. Cornfield +6 more
2020Diabetes Care51 citations Open access
Semantic Scholar
Elucidating the chemical structure of native 1-deoxysphingosine[S]
Regula Steiner, Essa M. Saied, A. Othman, Christoph Arenz +5 more
2016Journal of Lipid Research51 citations Open access
Semantic Scholar
NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma.
Ulrike A. Köhler, Friederike Böhm, F. Rolfs, Michèle Egger +4 more
2016Journal of Hepatology50 citations Open access
Semantic Scholar
SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins
M. A. Lone, Mari J. Aaltonen, Aliza Zidell, Helio F. Pedro +6 more
2022Journal of Clinical Investigation49 citations Open access
Semantic Scholar
Mammalian sphingoid bases: Biophysical, physiological and pathological properties.
A. C. Carreira, T. Santos, M. A. Lone, E. Zupančič +4 more
2019Progress in lipid research42 citations Open access
Semantic Scholar
Effect of vitamin D3 on self-perceived fatigue
A. Nowak, L. Boesch, E. Andres, E. Battegay +5 more
2016Medicine41 citations Open access
Semantic Scholar
1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling.
Tanja Güntert, Pascal Hänggi, A. Othman, S. Suriyanarayanan +4 more
2016Neuropharmacology40 citations Open access
Semantic Scholar
Discovery and mechanism of action of small molecule inhibitors of ceramidases
R. D. Healey, Essa M. Saied, Xiaojing Cong, G. Karsai +15 more
2021bioRxiv39 citations Open access
Semantic Scholar
Mini Review: Lipids in peripheral nerve disorders.
T. Hornemann
2020Neuroscience Letters38 citations Open access
Semantic Scholar
Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect*
P. Forny, A. Schumann, Merima Mustedanagic, D. Mathis +15 more
2016Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Genetic pain loss disorders
A. Lischka, P. Laššuthová, A. Çakar, C. Record +18 more
2022Nature Reviews Disease Primers36 citations
Semantic Scholar
An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions
A. Clark, U. Kugathasan, G. Baskozos, D. Priestman +13 more
2021Cell Reports Medicine35 citations Open access
Semantic Scholar
The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice
N. Debeuf, A. Zhakupova, Regula Steiner, S. van Gassen +10 more
2019Journal of Allergy and Clinical Immunology35 citations Open access
Semantic Scholar
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis
K. Griess, Michael Rieck, N. Müller, G. Karsai +33 more
2022Nature Cell Biology34 citations Open access
Semantic Scholar
Clinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C
M. Auranen, J. Toppila, S. Suriyanarayanan, M. A. Lone +4 more
2017Cold Spring Harbor molecular case studies33 citations Open access
Semantic Scholar
Novel HSAN1 Mutation in Serine Palmitoyltransferase Resides at a Putative Phosphorylation Site That Is Involved in Regulating Substrate Specificity
D. Ernst, Sinéad M. Murphy, Karthik Sathiyanadan, Yu Wei +9 more
2015Neuromolecular medicine32 citations Open access
Semantic Scholar
Development of MRC Centre MRI calf muscle fat fraction protocol as a sensitive outcome measure in Hereditary Sensory Neuropathy Type 1
U. Kugathasan, M. Evans, J. Morrow, C. Sinclair +15 more
2019Journal of Neurology Neurosurgery & Psychiatry30 citations Open access
Semantic Scholar
Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids.
B. Poad, Alan T. Maccarone, Hai-Bo Yu, T. Mitchell +6 more
2018Analytical Chemistry30 citations
Semantic Scholar
ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase
A. Zhakupova, N. Debeuf, M. Krols, Wendy Toussaint +9 more
2016The FASEB Journal30 citations
Semantic Scholar
Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition
Markus Masek, C. Etard, C. Hofmann, Andreas J. Hülsmeier +7 more
2022Nature Communications29 citations Open access
Semantic Scholar
Farnesoid X receptor activation induces the degradation of hepatotoxic 1‐deoxysphingolipids in non‐alcoholic fatty liver disease
Zhi-Bo Gai, Ting Gui, I. Alecu, M. A. Lone +6 more
2019Liver international (Print)28 citations
Semantic Scholar
Defects in high density lipoprotein metabolism and hepatic steatosis in mice with liver-specific ablation of hepatocyte nuclear factor 4α.
E. Thymiakou, A. Othman, T. Hornemann, D. Kardassis
2020Metabolism: Clinical and Experimental25 citations
Semantic Scholar
CERT1 mutations perturb human development by disrupting sphingolipid homeostasis
Charlotte Gehin, M. A. Lone, Winston Lee, Laura Capolupo +81 more
2023Journal of Clinical Investigation24 citations Open access
Semantic Scholar
The pathophysiological role of dihydroceramide desaturase in the nervous system.
Fei-Yang Tzou, T. Hornemann, Jui-Yu Yeh, Shu-Yi Huang
2023Progress in lipid research24 citations Open access
Semantic Scholar
Common and Differential Traits of the Membrane Lipidome of Colon Cancer Cell Lines and Their Secreted Vesicles: Impact on Studies Using Cell Lines
Joan Bestard-Escalas, Albert Maimó-Barceló, D. López, R. Reigada +5 more
2020Cancers24 citations Open access
Semantic Scholar
Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies
A. Lischka, K. Eggermann, C. Record, M. Dohrn +78 more
2023Brain : a journal of neurology23 citations Open access
Semantic Scholar
Altered CSF Albumin Quotient Links Peripheral Inflammation and Brain Damage in MS
Marco Puthenparampil, Paula Tomas-Ojer, T. Hornemann, A. Lutterotti +7 more
2021Neurology: Neuroimmunology & Neuroinflammation23 citations Open access
Semantic Scholar
Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice
Rong Chen, T. Hornemann, S. Štefanić, E. Schraner +7 more
2020Diabetologia23 citations Open access
Semantic Scholar
ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma.
O. Eichhoff, C. Stoffel, Jan Käsler, Luzia Briker +28 more
2023Cancer Research22 citations Open access
Semantic Scholar

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