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Isao Kashima · SciRah

Researcher profile · Semantic Scholar

Isao Kashima

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Isao Kashima — researcher profile on SciRah

h-index: 12
Works: 15
Citations: 2,859

Most-cited papers

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
Isao Kashima, A. Yamashita, N. Izumi, N. Kataoka +5 more
2006Genes & Development653 citations Open access
Semantic Scholar
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
A. Yamashita, T. Ohnishi, Isao Kashima, Y. Taya +1 more
2001Genes & Development428 citations Open access
Semantic Scholar
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
T. Ohnishi, A. Yamashita, Isao Kashima, Thomas Schell +6 more
2003Molecules and Cells352 citations Open access
Semantic Scholar
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan.
E. Huntzinger, Isao Kashima, Maria Fauser, Jérôme Saulière +1 more
2008RNA: A publication of the RNA Society340 citations Open access
Semantic Scholar
Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA.
Tatsuhisa Tsuboi, Kazushige Kuroha, Kazuhei Kudo, Shiho Makino +3 more
2012Molecules and Cells260 citations Open access
Semantic Scholar
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
A. Yamashita, N. Izumi, Isao Kashima, T. Ohnishi +10 more
2009Genes & Development254 citations Open access
Semantic Scholar
mRNA quality control: An ancient machinery recognizes and degrades mRNAs with nonsense codons
I. Behm-Ansmant, Isao Kashima, J. Rehwinkel, Jérôme Saulière +2 more
2007FEBS Letters212 citations
Semantic Scholar
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts.
F. Usuki, A. Yamashita, Isao Kashima, I. Higuchi +2 more
2006Molecular Therapy100 citations Open access
Semantic Scholar
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.
Isao Kashima, S. Jonas, U. Jayachandran, G. Buchwald +3 more
2010Genes & Development93 citations Open access
Semantic Scholar
The role of SMG-1 in nonsense-mediated mRNA decay.
A. Yamashita, Isao Kashima, S. Ohno
2005Biochimica et Biophysica Acta91 citations
Semantic Scholar
Distant N- and C-terminal Domains Are Required for Intrinsic Kinase Activity of SMG-1, a Critical Component of Nonsense-mediated mRNA Decay*
Tomoko Morita, A. Yamashita, Isao Kashima, K. Ogata +2 more
2007Journal of Biological Chemistry46 citations Open access
Semantic Scholar
A functional involvement of ABCE1, eukaryotic ribosome recycling factor, in nonstop mRNA decay in Drosophila melanogaster cells.
Isao Kashima, Masaki Takahashi, Y. Hashimoto, Eri Sakota +2 more
2014Biochimie15 citations
Semantic Scholar
SMG 6 interacts with the exon junction complex via two conserved EJC-binding motifs ( EBMs ) required for nonsense-mediated mRNA decay
Isao Kashima, S. Jonas, U. Jayachandran, G. Buchwald +3 more
201011 citations
Semantic Scholar
Role of SMG-1-mediated Phosphorylation of Upf1 in NMD
A. Yamashita, Isao Kashima, S. Ohno
20133 citations
Semantic Scholar
Figure 3, [Hypothetical model showing the roles...].
A. Yamashita, Isao Kashima, S. Ohno
20130 citations
Semantic Scholar

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