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Alex C. Y. Chang · SciRah

Researcher profile · Semantic Scholar

Alex C. Y. Chang

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Alex C. Y. Chang — researcher profile on SciRah

h-index: 17
Works: 33
Citations: 1,943

Most-cited papers

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Recapitulate the Predilection of Breast Cancer Patients to Doxorubicin–Induced Cardiotoxicity
P. Burridge, Yong-Fu-Ga Li, E. Matsa, Hao-Di Wu +13 more
2016Nature Medicine673 citations Open access
Semantic Scholar
Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase.
Alex C. Y. Chang, Yang-Xin Fu, Victoria C Garside, Kyle Niessen +9 more
2011Developmental Cell161 citations Open access
Semantic Scholar
Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development
Victoria C Garside, Alex C. Y. Chang, A. Karsan, P. Hoodless
2012Cellular and Molecular Life Sciences157 citations Open access
Semantic Scholar
Humanizing the mdx mouse model of DMD: the long and the short of it
Nora Yucel, Alex C. Y. Chang, J. Day, N. Rosenthal +1 more
2018npj Regenerative Medicine137 citations Open access
Semantic Scholar
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.
Hao-Di Wu, Huaxiao Yang, J. Rhee, Joe Z. Zhang +9 more
2019European Heart Journal122 citations Open access
Semantic Scholar
A human iPSC double reporter system enables purification of cardiac lineage subpopulations with distinct function and drug response profiles
Joe Z. Zhang, Vittavat Termglinchan, Ning-Yi Shao, Ilanit Itzhaki +13 more
2019Cell Stem Cell114 citations Open access
Semantic Scholar
Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells*
Yang-Xin Fu, Alex C. Y. Chang, L. Chang, Kyle Niessen +3 more
2009Journal of Biological Chemistry111 citations Open access
Semantic Scholar
Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
Alex C. Y. Chang, S. Ong, Edward L LaGory, P. Kraft +3 more
2016Proceedings of the National Academy of Sciences of the United States of America81 citations Open access
Semantic Scholar
Telomere shortening is a hallmark of genetic cardiomyopathies
Alex C. Y. Chang, A. Chang, A. Kirillova, Koki Sasagawa +14 more
2018Proceedings of the National Academy of Sciences of the United States of America71 citations Open access
Semantic Scholar
RUNX3 Maintains the Mesenchymal Phenotype after Termination of the Notch Signal*
Yang-Xin Fu, Alex C. Y. Chang, Michèle Fournier, L. Chang +2 more
2011Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Apelin and APJ orchestrate complex tissue-specific control of cardiomyocyte hypertrophy and contractility in the hypertrophy-heart failure transition.
V. Parikh, Jing Liu, Ching Shang, C. Woods +11 more
2018American Journal of Physiology. Heart and Circulatory Physiology39 citations Open access
Semantic Scholar
A Notch‐dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion
Alex C. Y. Chang, Victoria C. Garside, Michèle Fournier, Justin Smrz +10 more
2014Developmental Dynamics35 citations Open access
Semantic Scholar
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
P. Cordero, V. Parikh, Elizabeth T. Chin, A. Erbilgin +31 more
2019Nature Communications32 citations Open access
Semantic Scholar
Pharmacological Silencing of miR-152 Prevents Pressure Overload-Induced Heart Failure
T. LaRocca, T. Seeger, Maricela Prado, I. Perea-Gil +7 more
2020Circulation: Heart Failure26 citations Open access
Semantic Scholar
Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells.
A. Elsehemy, Alex C. Y. Chang, A. Azad, N. Gupta +4 more
2013Cellular Signalling23 citations
Semantic Scholar
Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal.
P. Vrljicak, Alex C. Y. Chang, O. Morozova, Elizabeth D. Wederell +4 more
2010Physiological Genomics18 citations Open access
Semantic Scholar
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates
Foster Birnbaum, A. Eguchi, G. Pardon, Alex C. Y. Chang +1 more
2022npj Regenerative Medicine17 citations Open access
Semantic Scholar
Secretion of miRNA-326-3p by senescent adipose exacerbates myocardial metabolism in diabetic mice
Hao Lin, Xiaonan Chen, Jia-Yu Pan, Jia-Han Ke +5 more
2022Journal of Translational Medicine17 citations Open access
Semantic Scholar
Short Telomeres — A Hallmark of Heritable Cardiomyopathies
Alex C. Y. Chang, H. Blau
2018Differentiation; research in biological diversity14 citations Open access
Semantic Scholar
Twist1 Transcriptional Targets in the Developing Atrio-Ventricular Canal of the Mouse
P. Vrljicak, Rebecca Cullum, Eric Xu, Alex C. Y. Chang +6 more
2012PLoS ONE14 citations Open access
Semantic Scholar
Notch-Dependent Regulation of the Ischemic Vasodilatory Response—Brief Report
Alex C. Y. Chang, A. Patenaude, K. Lu, M. Fuller +8 more
2013Arteriosclerosis, Thrombosis and Vascular Biology12 citations
Semantic Scholar
An in vitro Model for Identifying Cardiac Side-Effects of Anesthetics
Alex C. Y. Chang, A. Chang, Luka Nicin, Gerhard Weber +4 more
2020Anesthesia and Analgesia9 citations Open access
Semantic Scholar
Targeting of CAT and VCAM1 as Novel Therapeutic Targets for DMD Cardiomyopathy
Bin Li, Weiyao Xiong, Wen-Miin Liang, Jian-Shiun Chiou +2 more
2021Frontiers in Cell and Developmental Biology7 citations Open access
Semantic Scholar
Leukocyte Telomere Length Shortening Implies Plaque Instability and Major Adverse Cardiovascular Events in Patients With Angiographically Intermediate Lesions
Alian Zhang, L. Fan, Xiao-Lu Bao, Zuo-Jun Xu +7 more
2022Frontiers in Cardiovascular Medicine3 citations Open access
Semantic Scholar
Insights into single hiPSC-derived cardiomyocyte phenotypes and maturation using ConTraX, an efficient pipeline for tracking contractile dynamics
G. Pardon, Henry Lewis, A. V. Vander Roest, Erica A. Castillo +9 more
2021bioRxiv3 citations Open access
Semantic Scholar
Abstract 243: Modeling of Diastolic Dysfunction in Induced Pluripotent Stem Cell-derived Cardiomyocytes From Hypertrophic Cardiomyopathy Patients
Hao-Di Wu, Huaxiao Yang, J. Rhee, Joe Z. Zhang +7 more
2018Circulation Research1 citations
Semantic Scholar
Investigation of Notch and nitric oxide signaling in the cardiovascular system
Alex C. Y. Chang
20121 citations
Semantic Scholar
Author Correction: Humanizing the mdx mouse model of DMD: the long and the short of it
Nora Yucel, Alex C. Y. Chang, J. Day, Nadia Rosenthal +1 more
2020npj Regenerative Medicine0 citations Open access
Semantic Scholar
Abstract 477: Role of Telomere Dysfunction in Duchenne Muscular Dystrophy Cardiomyopathy
A. Eguchi, Alex C. Y. Chang, G. Pardon, B. Pruitt +2 more
2019Circulation Research0 citations
Semantic Scholar
Abstract 211: Substrate Elasticity Impacts Duchenne Muscular Dystrophy Cardiomyopathy Progression
G. Pardon, Alex C. Y. Chang, B. Pruitt, H. Blau
2019Circulation Research0 citations
Semantic Scholar
Abstract 217: TBX5 Clover2 /NKX2-5 TagRFP hiPSCs for Simultaneously Isolating Lineage-Specific Cardiovascular Cells
Joe Z. Zhang, Vittavat Termglinchan, Ilanit Itzhaki, Vicky Y. Wang +10 more
2018Circulation Research0 citations
Semantic Scholar
Abstract 44: Telomere and Mitochondrial Dysfunction in Duchenne Muscular Dystrophy
Alex C. Y. Chang, S. Ong, Joseph C. Wu, H. Blau
20150 citations
Semantic Scholar
RUNX3 MAINTAINS THE MESENCHYMAL PHENOTYPE AFTER TERMINATION OF THE NOTCH SIGNAL
Yang-Xin Fu, Alex C. Y. Chang, Michèle Fournier, L. Chang +3 more
20110 citations
Semantic Scholar

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