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K. Chadee · SciRah

Researcher profile · Semantic Scholar

K. Chadee

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K. Chadee — researcher profile on SciRah

h-index: 55
Works: 234
Citations: 9,780

Most-cited papers

Roles and regulation of the mucus barrier in the gut
Steve Cornick, A. Tawiah, K. Chadee
2015Tissue Barriers474 citations Open access
Semantic Scholar
NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations
L. Mortimer, F. Moreau, J. MacDonald, K. Chadee
2016Nature Immunology252 citations
Semantic Scholar
Unfermented β-fructan fibers fuel inflammation in select inflammatory bowel disease patients.
H. Armstrong, M. Bording-Jorgensen, D. Santer, Zheng-Xiao Zhang +29 more
2022Gastroenterology158 citations Open access
Semantic Scholar
VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
Steve Cornick, Manish Kumar, F. Moreau, H. Gaisano +1 more
2019Nature Communications97 citations Open access
Semantic Scholar
High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.
A. Tawiah, Steve Cornick, F. Moreau, H. Gorman +3 more
2018American Journal of Pathology92 citations Open access
Semantic Scholar
Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2
E. Cobo, Vanessa Kissoon‐Singh, F. Moreau, K. Chadee
2015Mucosal Immunology91 citations Open access
Semantic Scholar
The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction
L. Mortimer, F. Moreau, Steve Cornick, K. Chadee
2015PLoS Pathogens78 citations Open access
Semantic Scholar
Immune Evasion Mechanisms of Entamoeba histolytica: Progression to Disease
Sharmin Begum, Jeanie Quach, K. Chadee
2015Frontiers in Microbiology74 citations Open access
Semantic Scholar
The Probiotic Mixture VSL#3 Accelerates Gastric Ulcer Healing by Stimulating Vascular Endothelial Growth Factor
P. Dharmani, C. De Simone, K. Chadee
2013PLoS ONE74 citations Open access
Semantic Scholar
The future for vaccine development against Entamoeba histolytica
Jeanie Quach, J. St-Pierre, K. Chadee
2014Human Vaccines & Immunotherapeutics71 citations Open access
Semantic Scholar
Cysteine Protease-Dependent Mucous Disruptions and Differential Mucin Gene Expression in Giardia duodenalis Infection.
Christina B. Amat, Jean-Paul Motta, E. Fekete, F. Moreau +2 more
2017American Journal of Pathology68 citations Open access
Semantic Scholar
MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis
E. Cobo, Vanessa Kissoon‐Singh, F. Moreau, R. Holani +1 more
2017Infection and Immunity68 citations Open access
Semantic Scholar
Inflammation , Immunity , Fibrosis , and Infection Probiotic mixture VSL # 3 reduces colonic inflammation and improves intestinal barrier function in Muc 2 mucin-deficient mice
Manish Kumar, Vanessa Kissoon‐Singh, A. L. Coria, F. Moreau +1 more
201660 citations
Semantic Scholar
Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury
A. Leon-Coria, Manish Kumar, M. Workentine, F. Moreau +2 more
2020Cellular and Molecular Gastroenterology and Hepatology59 citations Open access
Semantic Scholar
Entamoeba histolytica: Host parasite interactions at the colonic epithelium
Steve Cornick, K. Chadee
2017Tissue Barriers58 citations Open access
Semantic Scholar
Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
Manish Kumar, Aralia Leon Coria, Steve Cornick, B. Petri +5 more
2020Nature Communications57 citations Open access
Semantic Scholar
Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin
Steve Cornick, F. Moreau, K. Chadee
2016PLoS Pathogens52 citations Open access
Semantic Scholar
Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica
A. Leon-Coria, Manish Kumar, F. Moreau, K. Chadee
2018PLoS Pathogens41 citations Open access
Semantic Scholar
Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice.
Manish Kumar, Vanessa Kissoon‐Singh, A. L. Coria, F. Moreau +1 more
2017American Journal of Physiology - Gastrointestinal and Liver Physiology41 citations Open access
Semantic Scholar
The delicate balance between Entamoeba histolytica, mucus and microbiota
A. Leon-Coria, Manish Kumar, K. Chadee
2020Gut microbes40 citations Open access
Semantic Scholar
Invasive amoebiasis: a review of Entamoeba infections highlighted with case reports.
C. Skappak, Sarah V Akierman, S. Belga, K. Novak +4 more
2014Canadian Journal of Gastroenterology and Hepatology40 citations Open access
Semantic Scholar
Entamoeba histolytica-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense
Steve Cornick, F. Moreau, H. Gaisano, K. Chadee
2017mBio34 citations Open access
Semantic Scholar
IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing
H. Gorman, F. Moreau, A. Dufour, K. Chadee
2023Frontiers in Immunology28 citations Open access
Semantic Scholar
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress.
S. Tiwari, Sharmin Begum, F. Moreau, H. Gorman +1 more
2021American Journal of Physiology - Gastrointestinal and Liver Physiology27 citations
Semantic Scholar
The macrophage cytoskeleton acts as a contact sensor upon interaction with Entamoeba histolytica to trigger IL-1β secretion
J. St-Pierre, F. Moreau, Steve Cornick, Jeanie Quach +4 more
2017PLoS Pathogens27 citations Open access
Semantic Scholar
Lymphocytic Colitis Is Associated with Increased Pro-Inflammatory Cytokine Profile and Up Regulation of Prostaglandin Receptor EP4
I. Dey, P. Beck, K. Chadee
2013PLoS ONE25 citations Open access
Semantic Scholar
Entamoeba histolytica Interaction with Enteropathogenic Escherichia coli Increases Parasite Virulence and Inflammation in Amebiasis
Luz A Fernández-López, K. Gil-Becerril, Silvia Galindo-Gómez, T. Estrada-Garcia +5 more
2019Infection and Immunity24 citations Open access
Semantic Scholar
Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D
Jeanie Quach, F. Moreau, Christina F Sandall, K. Chadee
2018Mucosal Immunology24 citations Open access
Semantic Scholar
High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors.
A. Tawiah, F. Moreau, Manish Kumar, S. Tiwari +2 more
2018American Journal of Pathology21 citations Open access
Semantic Scholar
The NF-κB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites
Attinder Chadha, K. Chadee
2021Frontiers in Cellular and Infection Microbiology18 citations Open access
Semantic Scholar
Entamoeba histolytica Cyclooxygenase-Like Protein Regulates Cysteine Protease Expression and Virulence
P. Shahi, F. Moreau, K. Chadee
2019Frontiers in Cellular and Infection Microbiology16 citations Open access
Semantic Scholar
Entamoeba histolytica Contains an Occludin-Like Protein That Can Alter Colonic Epithelial Barrier Function
M. Goplen, M. Lejeune, Steve Cornick, F. Moreau +1 more
2013PLoS ONE15 citations Open access
Semantic Scholar
The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion
Shanshan Wang, F. Moreau, K. Chadee
2022PLoS Pathogens14 citations Open access
Semantic Scholar
Giardia duodenalis cysteine proteases cleave proteinase-activated receptor-2 to regulate intestinal goblet cell mucin gene expression.
E. Fekete, T. Allain, Christina B. Amat, K. Mihara +4 more
2022International Journal of Parasitology12 citations Open access
Semantic Scholar
Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites
Shan Wang, F. Moreau, K. Chadee
2022Frontiers in Immunology12 citations Open access
Semantic Scholar
Functional Characterization of an Interferon Gamma Receptor-Like Protein on Entamoeba histolytica
Julieta Pulido-Ortega, P. Talamás-Rohana, M. Muñoz-Ortega, L. R. Aldaba-Muruato +7 more
2019Infection and Immunity12 citations Open access
Semantic Scholar
Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency
E. Cobo, R. Holani, F. Moreau, Kiminori Nakamura +5 more
2018Infection and Immunity12 citations Open access
Semantic Scholar
Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis
Sharmin Begum, F. Moreau, A. Dufour, K. Chadee
2021Mucosal Immunology10 citations Open access
Semantic Scholar
Entamoeba histolytica.
Sharmin Begum, H. Gorman, Attinder Chadha, K. Chadee
2021Trends in Parasitology10 citations
Semantic Scholar
Entamoeba histolytica stimulates the alarmin molecule HMGB1 from macrophages to amplify innate host defenses
Sharmin Begum, F. Moreau, Aralia Leon Coria, K. Chadee
2019Mucosal Immunology10 citations Open access
Semantic Scholar
Loss of EP2 Receptor Subtype in Colonic Cells Compromise Epithelial Barrier Integrity by Altering Claudin-4
M. Lejeune, F. Moreau, K. Chadee
2014PLoS ONE10 citations Open access
Semantic Scholar
Role of inflammasomes in innate host defense against Entamoeba histolytica
Sharmin Begum, H. Gorman, Attinder Chadha, K. Chadee
2020Journal of Leukocyte Biology8 citations
Semantic Scholar
Giardia duodenalis Depletes Goblet Cell Mucins and Degrades MUC2, Facilitating Bacterial Translocation
Christina B. Amat, Jean-Paul Motta, Amol Bhargava, K. Chadee +1 more
20157 citations
Semantic Scholar
Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages
Attinder Chadha, F. Moreau, Shanshan Wang, A. Dufour +1 more
2021PLoS Pathogens6 citations Open access
Semantic Scholar
VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica
Steve Cornick, F. Moreau, H. Gaisano, K. Chadee
2017Microbial Cell5 citations Open access
Semantic Scholar
Giardia duodenalis Directly Depletes Mucins in Intestinal Goblet Cells
Christina B. Amat, Jean-Paul Motta, K. Chadee, A. Buret
2016The FASEB Journal5 citations
Semantic Scholar
Entamoeba Histolytica: Biology and Host Immunity
H. Gorman, K. Chadee
2019Reference Module in Life Sciences4 citations
Semantic Scholar
How the Discovery of TNF-α Has Advanced Gastrointestinal Diseases and Treatment Regimes
J. St-Pierre, K. Chadee
2014Digestive Diseases and Sciences4 citations Open access
Semantic Scholar
Human Mucin-2–Producing Colonic Goblet-Like Cells Secrete the Chemokine CXCL8 by Activating Multiple Proinflammatory Pathways in Response to Entamoeba histolytica
A. Kim, H. Gorman, F. Moreau, M. McManus +2 more
2025American Journal of Pathology3 citations
Semantic Scholar
Immunity to Intestinal Protozoa: Entamoeba, Cryptosporidium, and Giardia
Jeanie Quach, K. Chadee, J. Mead, S. Singer
20163 citations
Semantic Scholar

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F. Moreau×33
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F. Moreau — researcher profile on SciRah
Steve Cornick×11
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Steve Cornick — researcher profile on SciRah
H. Gorman×9
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H. Gorman — researcher profile on SciRah
Manish Kumar×9
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Manish Kumar — researcher profile on SciRah

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Sharmin Begum — researcher profile on SciRah

Jeanie Quach×5

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Jeanie Quach — researcher profile on SciRah

A. Leon-Coria×5

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A. Leon-Coria — researcher profile on SciRah

Vanessa Kissoon‐Singh×4

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Vanessa Kissoon‐Singh — researcher profile on SciRah

Christina B. Amat×4

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Christina B. Amat — researcher profile on SciRah

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A. Buret — researcher profile on SciRah

Attinder Chadha×4

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Attinder Chadha — researcher profile on SciRah

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A. Tawiah — researcher profile on SciRah