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D. Hoke · SciRah

Researcher profile · Semantic Scholar

D. Hoke

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D. Hoke — researcher profile on SciRah

h-index: 24
Works: 52
Citations: 1,756

Most-cited papers

Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity*
A. White, Tai Du, Katrina M. Laughton, I. Volitakis +11 more
2006Journal of Biological Chemistry290 citations Open access
Semantic Scholar
Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation.
Jun-Yong Chan, Hua-Cheng Zhang, Yada Nolvachai, Yao-Xin Hu +7 more
2018Angewandte Chemie170 citations Open access
Semantic Scholar
LipL32 Is an Extracellular Matrix-Interacting Protein of Leptospira spp. and Pseudoalteromonas tunicata
D. Hoke, S. Egan, P. Cullen, B. Adler
2008Infection and Immunity143 citations Open access
Semantic Scholar
Major Surface Protein LipL32 Is Not Required for Either Acute or Chronic Infection with Leptospira interrogans
Gerald L. Murray, Amporn Srikram, D. Hoke, E. Wunder +6 more
2008Infection and Immunity124 citations Open access
Semantic Scholar
Cross-protective immunity against leptospirosis elicited by a live, attenuated lipopolysaccharide mutant.
Amporn Srikram, Kun-Kun Zhang, Thanatchaporn Bartpho, M. Lo +4 more
2011Journal of Infectious Diseases70 citations Open access
Semantic Scholar
Selective modulation of the expression of L-selectin ligands by an immune response.
D. Hoke, R. Mebius, N. Dybdal, D. Dowbenko +4 more
1995Current Biology68 citations Open access
Semantic Scholar
Tibial shaft stress fractures resulting from placement of navigation tracker pins.
D. Hoke, S. Jafari, F. Orozco, A. Ong
2011Journal of Arthroplasty66 citations
Semantic Scholar
Crystal structure of LipL32, the most abundant surface protein of pathogenic Leptospira spp.
J. Vivian, T. Beddoe, A. McAlister, M. Wilce +9 more
2009Journal of Molecular Biology59 citations
Semantic Scholar
Reactive centre loop dynamics and serpin specificity
Emilia M. Marijanovic, James Fodor, B. Riley, B. Porebski +5 more
2018Scientific Reports49 citations Open access
Semantic Scholar
Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity
Sarah N. Le, B. Porebski, J. McCoey, James Fodor +8 more
2015PLoS ONE48 citations Open access
Semantic Scholar
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
G. Evin, L. Canterford, D. Hoke, Robyn A. Sharples +2 more
2005Biochemistry48 citations
Semantic Scholar
In vitro gamma‐secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
D. Hoke, Jiangli Tan, Nancy T. Ilaya, J. Culvenor +4 more
2005The FEBS Journal46 citations Open access
Semantic Scholar
Thyroid Peroxidase as an Autoantigen in Hashimoto’s Disease: Structure, Function, and Antigenicity
Daniel E. Williams, Sarah N. Le, M. Godlewska, D. Hoke +1 more
2018Hormone and Metabolic Research45 citations
Semantic Scholar
Screening of 71 P. multocida Proteins for Protective Efficacy in a Fowl Cholera Infection Model and Characterization of the Protective Antigen PlpE
T. Hatfaludi, K. Al-Hasani, Lan Gong, J. Boyce +6 more
2012PLoS ONE42 citations Open access
Semantic Scholar
Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis
Itamar Kass, D. Hoke, Maurício G. S. Costa, Cyril F. Reboul +16 more
2014Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
Semantic Scholar
Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain
B. Porebski, Adrian A. Nickson, D. Hoke, M. Hunter +4 more
2015Protein engineering, design & selection : PEDS38 citations Open access
Semantic Scholar
Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
B. Riley, O. Ilyichova, Maurício G. S. Costa, B. Porebski +6 more
2016Scientific Reports35 citations Open access
Semantic Scholar
Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate
Michael Ho, D. Hoke, Jia-Chua Yee, Qiao-Xin Li +4 more
2010International Journal of Alzheimer's Disease32 citations Open access
Semantic Scholar
Leptospiral LruA Is Required for Virulence and Modulates an Interaction with Mammalian Apolipoprotein AI
Kun-Kun Zhang, Gerald L. Murray, T. Seemann, Amporn Srikram +4 more
2013Infection and Immunity31 citations Open access
Semantic Scholar
An Analysis of the Cross-Reactivity of Autoantibodies to GAD65 and GAD67 in Diabetes
B. Jayakrishnan, D. Hoke, C. Langendorf, A. Buckle +1 more
2011PLoS ONE31 citations Open access
Semantic Scholar
Heparin/Heparan Sulfate (HP/HS) Interacting Protein (HIP) Supports Cell Attachment and Selective, High Affinity Binding of HP/HS*
Shou-Chun Liu, D. Hoke, J. Julian, D. Carson
1997Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
J. Culvenor, Nancy T. Ilaya, Michael T. Ryan, L. Canterford +5 more
2004European Journal of Biochemistry26 citations
Semantic Scholar
Smoothing a rugged protein folding landscape by sequence-based redesign
B. Porebski, S. Keleher, J. Hollins, Adrian A. Nickson +14 more
2016Scientific Reports25 citations Open access
Semantic Scholar
Circumventing the stability-function trade-off in an engineered FN3 domain
B. Porebski, P. Conroy, N. Drinkwater, P. Schofield +6 more
2016Protein engineering, design & selection : PEDS24 citations Open access
Semantic Scholar
Glycosaminoglycan Sulphation Affects the Seeded Misfolding of a Mutant Prion Protein
V. Lawson, Brooke Lumicisi, Jeremy M. Welton, D. Machalek +7 more
2010PLoS ONE24 citations Open access
Semantic Scholar
Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease
Daniel E. Williams, Sarah N. Le, D. Hoke, Peter G. Chandler +4 more
2019bioRxiv19 citations Open access
Semantic Scholar
Murine HIP/L29 Is a Heparin-binding Protein with a Restricted Pattern of Expression in Adult Tissues*
D. Hoke, E. Regisford, Joanne J. Julian, Asna Amin +2 more
1998Journal of Biological Chemistry18 citations Open access
Semantic Scholar
KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors
B. Riley, O. Ilyichova, S. D. de Veer, J. Swedberg +4 more
2019bioRxiv16 citations Open access
Semantic Scholar
Free to Choose but Liable for the Consequences: Should Non-Vaccinators Be Penalized for the Harm They Do?
A. Caplan, D. Hoke, Nicholas J. Diamond, Viktoriya Karshenboyem
2012Journal of Law, Medicine & Ethics15 citations
Semantic Scholar
Genetic variation affecting DNA methylation and the human imprinting disorder, Beckwith-Wiedemann syndrome
Vinod Dagar, W. Hutchison, Andrea M. Muscat, Anita P. Krishnan +30 more
2018Clinical Epigenetics13 citations Open access
Semantic Scholar
Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif
Xing-Chen Chen, B. Riley, S. D. de Veer, D. Hoke +7 more
2019PLoS ONE12 citations Open access
Semantic Scholar
An ortholog of the Leptospira interrogans lipoprotein LipL32 aids in the colonization of Pseudoalteromonas tunicata to host surfaces
Melissa R. Gardiner, D. Hoke, S. Egan
2014Frontiers in Microbiology11 citations Open access
Semantic Scholar
Multiple domains contribute to heparin/heparan sulfate binding by human HIP/L29.
D. Hoke, S. Labrenz, M. Höök, Daniel D. Carson
2000Biochemistry11 citations
Semantic Scholar
Mutational and biophysical robustness in a prestabilized monobody
Peter G. Chandler, L. Tan, B. Porebski, James S. Green +8 more
2021Journal of Biological Chemistry10 citations Open access
Semantic Scholar
The major surface Vsp proteins of Brachyspira hyodysenteriae form antigenic protein complexes.
Timothy D Witchell, D. Hoke, D. Bulach, S. Coutts +3 more
2011Veterinary Microbiology10 citations
Semantic Scholar
Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody
S. Ständer, Cyril F. Reboul, Sarah N. Le, Daniel E. Williams +15 more
2025Nature Communications9 citations Open access
Semantic Scholar
Membrane proteins of Pseudoalteromonas tunicata during the transition from planktonic to extracellular matrix-adherent state.
D. Hoke, Kun-Kun Zhang, S. Egan, T. Hatfaludi +2 more
2011Environmental Microbiology Reports6 citations
Semantic Scholar
Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11
S. Ständer, Cyril F. Reboul, Sarah N. Le, Daniel E. Williams +15 more
2024bioRxiv1 citations Open access
Semantic Scholar
Mutational and biophysical robustness in a pre-stabilized monobody
Peter G. Chandler, L. Tan, B. Porebski, James S. Green +8 more
2020bioRxiv1 citations Open access
Semantic Scholar
Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.
B. Riley, D. Hoke, S. McGowan, A. Buckle
2019Acta Crystallographica Section F Structural Biology Communications1 citations Open access
Semantic Scholar
Cyclic Peptide Serine Protease Inhibitors Based on the Natural Product SFTI‐1
B. Riley, O. Ilyichova, J. Harris, D. Hoke +1 more
20181 citations
Semantic Scholar
Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen
Srilakshmi Srinivasan, B. Hayes, M. G. S. Costa, B. Riley +8 more
2025BMC Biology0 citations Open access
Semantic Scholar
Direct and Allosteric Mechanisms of KLK4 Inhibition Revealed by Structural and Dynamical Characterization
B. Riley, O. Ilyichova, B. Porebski, J. Swedberg +5 more
20170 citations
Semantic Scholar
Eppur si Muove (and Yet it Does Move): A Perspective on the Past, Present and Future of Atomistic Simulations in Structural Biology
D. Hoke, Itamar Kass, A. Mark, Molecular Biosciences
20140 citations
Semantic Scholar
Combining theoretical and experimental approaches to enhance our understanding of biological macromolecules
D. Hoke, Itamar Kass
20140 citations
Semantic Scholar
The Marine Bacterium Pseudoalteromonas Tunicata Alters its Proteome Upon Adhesion to Extracellular Matrix
D. Hoke, Kun-Kun Zhang, S. Egan, B. Adler
20080 citations
Semantic Scholar
Leptospira Interrogans Selectively Binds Guinea Pig Serum Proteins in Vitro
K. Zhang, D. Hoke, K. Patarakul, I. Smith +1 more
20080 citations
Semantic Scholar
P4‐206: Identification of gamma‐secretase activities with distinct pharmacological properties
G. Evin, Michael Ho, Nancy T. Ilaya, D. Hoke +4 more
20080 citations Open access
Semantic Scholar
P3-401 CHARACTERIZATION OF GAMMA-SECRETASE USING A RECOMBINANT APP C99 SUBSTRATE AND COMPARTIVE ANALYSIS OF GAMMA- ACTIVITY IN MOUSE TISSUES
Michael Ho, Nancy T. Ilaya, D. Hoke, Anthony R. White +14 more
20060 citations
Semantic Scholar
Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases
A. White, Tai Du, Katrina M. Laughton, I. Volitakis +10 more
20060 citations
Semantic Scholar

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