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H. Tomioka · SciRah

Researcher profile · Semantic Scholar

H. Tomioka

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H. Tomioka — researcher profile on SciRah

h-index: 28
Works: 174
Citations: 2,424

Most-cited papers

Current status of some antituberculosis drugs and the development of new antituberculous agents with special reference to their in vitro and in vivo antimicrobial activities.
H. Tomioka
2006Current pharmaceutical design105 citations
Semantic Scholar
Type II alveolar cells play roles in macrophage-mediated host innate resistance to pulmonary mycobacterial infections by producing proinflammatory cytokines.
Katsumasa Sato, H. Tomioka, Toshiaki Shimizu, T. Gonda +2 more
2002Journal of Infectious Diseases101 citations
Semantic Scholar
[Development of antituberculous drugs: current status and future prospects].
H. Tomioka, K. Namba
2006Kekkaku (Tuberculosis)89 citations
Semantic Scholar
Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages
H. Tomioka, Yutaka Tatano, W. Maw, C. Sano +2 more
2012Clinical and Developmental Immunology65 citations Open access
Semantic Scholar
Unique Macrophages Different from M1/M2 Macrophages Inhibit T Cell Mitogenesis while Upregulating Th17 Polarization
Yutaka Tatano, Toshiaki Shimizu, H. Tomioka
2014Scientific Reports64 citations Open access
Semantic Scholar
Comparative In Vitro Antimicrobial Activities of the Newly Synthesized Quinolone HSR-903, Sitafloxacin (DU-6859a), Gatifloxacin (AM-1155), and Levofloxacin againstMycobacterium tuberculosis and Mycobacterium avium Complex
H. Tomioka, Katsumasa Sato, T. Akaki, H. Kajitani +2 more
1999Antimicrobial Agents and Chemotherapy60 citations Open access
Semantic Scholar
Distribution and characterization of β-lactamases of mycobacteria and related organisms
H. Kwon, H. Tomioka, H. Saito
199558 citations
Semantic Scholar
Effector molecules In expression of the antimicrobial activity of macrophages against Mycobacterium avium complex: roles of reactive nitrogen intermediates, reactive oxygen intermediates, and free fatty acids
T. Akaki, Katsumasa Sato, Toshiaki Shimizu, C. Sano +3 more
1997Journal of Leukocyte Biology57 citations Open access
Semantic Scholar
Comparative Antimicrobial Activities of the Newly Synthesized Quinolone WQ-3034, Levofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis andMycobacterium avium Complex
H. Tomioka, Katsumasa Sato, H. Kajitani, T. Akaki +1 more
2000Antimicrobial Agents and Chemotherapy56 citations Open access
Semantic Scholar
Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolones.
S. Cai, Katsumasa Sato, Toshiaki Shimizu, S. Yamabe +3 more
2006Journal of Antimicrobial Chemotherapy52 citations Open access
Semantic Scholar
Adjunctive immunotherapy of mycobacterial infections.
H. Tomioka
2004Current pharmaceutical design50 citations
Semantic Scholar
The role of tumor necrosis factor, interferon‐γ, Transforming growth factor‐β, and nitric oxide in the expression of immunosuppressive functions of splenic macrophages induced by Mycobacterium avium complex infection
H. Tomioka, Katsumasa Sato, Win Win Maw, H. Saito
199544 citations
Semantic Scholar
Prospects for development of new antimycobacterial drugs
H. Tomioka
2000Journal of Infection and Chemotherapy40 citations
Semantic Scholar
Comparative in vitro and in vivo antimicrobial activities of sitafloxacin, gatifloxacin and moxifloxacin against Mycobacterium avium.
C. Sano, Yutaka Tatano, Toshiaki Shimizu, S. Yamabe +2 more
2011International Journal of Antimicrobial Agents37 citations
Semantic Scholar
Recent advances in antituberculous drug development and novel drug targets
H. Tomioka, Yutaka Tatano, K. Yasumoto, Toshiaki Shimizu
2008Expert Review of Respiratory Medicine37 citations
Semantic Scholar
Effects of secretory leukocyte protease inhibitor on the tumor necrosis factor-alpha production and NF-kappaB activation of lipopolysaccharide-stimulated macrophages.
C. Sano, Toshiaki Shimizu, H. Tomioka
2003Cytokine34 citations
Semantic Scholar
ATP Exhibits Antimicrobial Action by Inhibiting Bacterial Utilization of Ferric Ions
Yutaka Tatano, Y. Kanehiro, C. Sano, Toshiaki Shimizu +1 more
2015Scientific Reports30 citations Open access
Semantic Scholar
Antimicrobial activities of clarithromycin, gatifloxacin and sitafloxacin, in combination with various antimycobacterial drugs against extracellular and intramacrophage Mycobacterium avium complex.
H. Tomioka, C. Sano, Katsumasa Sato, Toshiaki Shimizu
2002International Journal of Antimicrobial Agents30 citations
Semantic Scholar
In vitro antimycobacterial activity of a new quinolone, levofloxacin (DR-3355).
Hajime Saito, Katsumasa Sato, H. Tomioka, S. Dekio
1995Tubercle and Lung Disease29 citations
Semantic Scholar
Identification of Novel Mycobacterial Inhibitors Against Mycobacterial Protein Kinase G
Y. Kanehiro, H. Tomioka, J. Pieters, Yutaka Tatano +3 more
2018Frontiers in Microbiology25 citations Open access
Semantic Scholar
Comparative antimicrobial activities of gatifloxacin, sitafloxacin and levofloxacin against Mycobacterium tuberculosis replicating within Mono Mac 6 human macrophage and A-549 type II alveolar cell lines.
Katsumasa Sato, H. Tomioka, C. Sano, Toshiaki Shimizu +4 more
2003Journal of Antimicrobial Chemotherapy23 citations Open access
Semantic Scholar
Development of new antituberculous drugs based on bacterial virulence factors interfering with host cytokine networks
H. Tomioka, Yutaka Tatano, C. Sano, Toshiaki Shimizu
2011Journal of Infection and Chemotherapy22 citations
Semantic Scholar
The role of B7 molecules in the cell contact‐mediated suppression of T cell mitogenesis by immunosuppressive macrophages induced with mycobacterial infection
T. Shimizu, C. Sano, H. Tomioka
2004Clinical and Experimental Immunology22 citations Open access
Semantic Scholar
Further study on the roles of the effector molecules of immunosuppressive macrophages induced by mycobacterial infection in expression of their suppressor function against mitogen‐stimulated T cell proliferation
W. Maw, Toshiaki Shimizu, K. Sato, H. Tomioka
1997Clinical and Experimental Immunology22 citations Open access
Semantic Scholar
Present status and future prospects of chemotherapeutics for intractable infections due to Mycobacterium avium complex.
H. Tomioka
2004Current Drug Discovery Technologies20 citations
Semantic Scholar
Effects of the Chinese Traditional Medicine Mao-Bushi-Saishin-To on Therapeutic Efficacy of a New Benzoxazinorifamycin, KRM-1648, against Mycobacterium avium Infection in Mice
Toshiaki Shimizu, H. Tomioka, Katsumasa Sato, C. Sano +6 more
1999Antimicrobial Agents and Chemotherapy20 citations Open access
Semantic Scholar
Usefulness of Chinese Herbal Medicines as Host-Directed Therapeutics against Mycobacterial Infections: A Review.
H. Tomioka
2017The American Journal of Chinese Medicine18 citations
Semantic Scholar
Roles of tumour necrosis factor‐alpha (TNF‐α), transforming growth factor‐beta (TGF‐β), and IL‐10 in the modulation of intercellular adhesion molecule‐1 (ICAM‐1) expression by macrophages during mycobacterial infection
H. Tomioka, Toshiaki Shimizu, W. Maw, K. Ogasawara
2000Clinical and Experimental Immunology18 citations Open access
Semantic Scholar
Editorial: Current status and perspective on drug targets in tubercle bacilli and drug design of antituberculous agents based on structure-activity relationship.
H. Tomioka
2014Current pharmaceutical design17 citations
Semantic Scholar
Combined Effects of ATP on the Therapeutic Efficacy of Antimicrobial Drug Regimens against Mycobacterium avium Complex Infection in Mice and Roles of Cytosolic Phospholipase A2-Dependent Mechanisms in the ATP-Mediated Potentiation of Antimycobacterial Host Resistance1
H. Tomioka, C. Sano, Katsumasa Sato, K. Ogasawara +4 more
2005Journal of Immunology17 citations Open access
Semantic Scholar
The role of tumour necrosis factor‐α in combination with interferon‐γ or interleukin‐1 in the induction of immunosuppressive macrophages because of Mycobacterium avium complex infection
H. Tomioka, W. W. Maw, K. Sato, H. Saito
199614 citations Open access
Semantic Scholar
Effects of picolinic acid on the antimicrobial functions of host macrophages against Mycobacterium avium complex.
H. Tomioka, Toshiaki Shimizu, Yutaka Tatano
2007International Journal of Antimicrobial Agents13 citations
Semantic Scholar
Intramacrophage Passage of Mycobacterium tuberculosis and M. avium Complex Alters the Drug Susceptibilities of the Organisms as Determined by Intracellular Susceptibility Testing Using Macrophages and Type II Alveolar Epithelial Cells
H. Tomioka, Katsumasa Sato, C. Sano, K. Sano +1 more
2002Antimicrobial Agents and Chemotherapy13 citations Open access
Semantic Scholar
[Prospects for development of new antituberculous drugs].
H. Tomioka
2002Kekkaku : [Tuberculosis]13 citations
Semantic Scholar
Interaction of Antimycobacterial Drugs with the Anti-Mycobacterium avium Complex Effects of Antimicrobial Effectors, Reactive Oxygen Intermediates, Reactive Nitrogen Intermediates, and Free Fatty Acids Produced by Macrophages
K. Sano, H. Tomioka, Katsumasa Sato, C. Sano +3 more
2004Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Therapeutic Effects of Benzoxazinorifamycin KRM-1648 Administered Alone or in Combination with a Half-Sized Secretory Leukocyte Protease Inhibitor or the Nonsteroidal Anti-Inflammatory Drug Diclofenac Sodium against Mycobacterium avium Complex Infection in Mice
C. Sano, Toshiaki Shimizu, Katsumasa Sato, H. Kawauchi +2 more
1999Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
The modulating effects of proinflammatory cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), and immunoregulating cytokines IL-10 and transforming growth factor-beta (TGF-beta), on anti-microbial activity of murine peritoneal macrophages against Mycobacterium avium-
C. Sano, K. Sato, T. Shimizu, H. Kajitani +2 more
1999Clinical and Experimental Immunology12 citations
Semantic Scholar
Correlation between variable-number tandem-repeat-based genotypes and drug susceptibility in Mycobacterium avium isolates
Yutaka Tatano, C. Sano, K. Yasumoto, Toshiaki Shimizu +6 more
2011European Journal of Clinical Microbiology and Infectious Diseases11 citations
Semantic Scholar
Phospholipids and reactive nitrogen intermediates collaborate in expression of the T cell mitogenesis‐inhibitory activity of immunosuppressive macrophages induced in mycobacterial infection
H. Tomioka, T. Kishimoto, W. W. Maw
1996Clinical and Experimental Immunology11 citations Open access
Semantic Scholar
New approaches to tuberculosis--novel drugs based on drug targets related to toll-like receptors in macrophages.
H. Tomioka
2013Current pharmaceutical design10 citations
Semantic Scholar
Development of new antituberculous agents based on new drug targets and structure–activity relationship
H. Tomioka
2008Expert Opinion on Drug Discovery10 citations
Semantic Scholar
Comparative study for the virulence of Mycobacterium avium isolates from patients with nodular-bronchiectasis- and cavitary-type diseases
Yutaka Tatano, K. Yasumoto, Toshiaki Shimizu, C. Sano +4 more
2010European Journal of Clinical Microbiology and Infectious Diseases9 citations
Semantic Scholar
Activity of Picolinic Acid in Combination with the Antiprotozoal Drug Quinacrine against Mycobacterium avium Complex
Toshiaki Shimizu, H. Tomioka
2006Antimicrobial Agents and Chemotherapy9 citations Open access
Semantic Scholar
Prospects for development of new antimycobacterial drugs, with special reference to a new benzoxazinorifamycin, KRM-1648.
H. Tomioka
2000Archivum Immunologiae et Therapiae Experimentalis9 citations
Semantic Scholar
Host-Directed Therapeutics against Mycobacterial Infections.
H. Tomioka, C. Sano, Yutaka Tatano
2017Current pharmaceutical design8 citations
Semantic Scholar
Clinical and Basic Studies on Therapeutic Efficacy of Herbal Medicines against Mycobacterial Infections
H. Tomioka, Yutaka Tatano, Toshiaki Shimizu, C. Sano
2019Medicines7 citations Open access
Semantic Scholar
Comparative roles of macrophages and NK cells in the host innate resistance of mice to Mycobacterium fortuitum infection.
H. Tomioka, Toshiaki Shimizu, Katsumasa Sato, C. Sano +3 more
2004Journal of Infection7 citations
Semantic Scholar
Aldose reductase participates in the downregulation of T cell functions due to suppressor macrophages
Toshiaki Shimizu, Yutaka Tatano, H. Tomioka
2016Scientific Reports6 citations Open access
Semantic Scholar
Development of New Antituberculous Drugs: Strategies for New Drug Targets and Drug Delivery
H. Tomioka
20056 citations
Semantic Scholar
Roles of reactive nitrogen intermediates and transforming growth factor-beta produced by immunosuppressive macrophages in the expression of suppressor activity against T cell proliferation induced by TCR stimulation.
Toshiaki Shimizu, S. Cai, H. Tomioka
2005Cytokine6 citations
Semantic Scholar

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Toshiaki Shimizu — researcher profile on SciRah
C. Sano×22
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C. Sano — researcher profile on SciRah
Katsumasa Sato×16
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Katsumasa Sato — researcher profile on SciRah
Yutaka Tatano×13
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T. Akaki — researcher profile on SciRah

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Toshiaki Shimizu — researcher profile on SciRah

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K. Sato — researcher profile on SciRah

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H. Kajitani — researcher profile on SciRah

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H. Saito — researcher profile on SciRah

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K. Sano — researcher profile on SciRah

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W. Maw — researcher profile on SciRah