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P. Mäkinen · SciRah

Researcher profile · Semantic Scholar

P. Mäkinen

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P. Mäkinen — researcher profile on SciRah

h-index: 21
Works: 52
Citations: 1,408

Most-cited papers

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain
P. Mäkinen, J. Koponen, Anna-Mari Kärkkäinen, T. Malm +4 more
2006Journal of Gene Medicine144 citations
Semantic Scholar
Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors.
P. Mäkinen, Jari P. Lappalainen, Suvi E. Heinonen, P. Leppänen +5 more
2010Cardiovascular Research127 citations
Semantic Scholar
The absence of macrophage Nrf2 promotes early atherogenesis.
Anna-Kaisa Ruotsalainen, M. Inkala, Mervi E Partanen, Jari P. Lappalainen +11 more
2013Cardiovascular Research112 citations Open access
Semantic Scholar
Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion.
T. Kaartinen, A. Luostarinen, Pilvi Maliniemi, J. Keto +9 more
2017Cytotherapy102 citations Open access
Semantic Scholar
Aggravated Postinfarct Heart Failure in Type 2 Diabetes Is Associated with Impaired Mitophagy and Exaggerated Inflammasome Activation.
Thota Durga Devi, M. Babu, P. Mäkinen, M. Kaikkonen +8 more
2017American Journal of Pathology73 citations Open access
Semantic Scholar
Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study.
M. Babu, Thota Durga Devi, P. Mäkinen, M. Kaikkonen +6 more
2015Circulation Research72 citations Open access
Semantic Scholar
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
G. Mocci, Katyayani Sukhavasi, T. Örd, Sean Bankier +31 more
2024Circulation Research60 citations Open access
Semantic Scholar
The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models.
Suvi E. Heinonen, Annukka M. Kivelä, J. Huusko, M. Dijkstra +7 more
2013Cardiovascular Research58 citations Open access
Semantic Scholar
Macrophage selective photodynamic therapy by meta‐tetra(hydroxyphenyl)chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases
J. W. H. Wennink, Yanna Liu, P. Mäkinen, Francesca Setaro +11 more
2017European Journal of Pharmaceutical Sciences45 citations Open access
Semantic Scholar
Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells.
Annukka M. Kivelä, P. Mäkinen, Henna-Kaisa Jyrkkänen, Eero Mella-Aho +6 more
2010Atherosclerosis45 citations
Semantic Scholar
Nucleic Acid–Based Therapies for Atherosclerosis
P. Mäkinen, Anna-Kaisa Ruotsalainen, S. Ylä-Herttuala
2020Current Atherosclerosis Reports44 citations Open access
Semantic Scholar
The effect of subcellular localization on the efficiency of EGFR‐targeted VHH photosensitizer conjugates
S. V. van Lith, D. van den Brand, R. Wallbrecher, L. Wübbeke +7 more
2018European journal of pharmaceutics and biopharmaceutics34 citations Open access
Semantic Scholar
Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation.
Anna-Mari Kärkkäinen, Antti Kotimaa, J. Huusko, I. Kholová +8 more
2009Blood34 citations Open access
Semantic Scholar
Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI
Auni Lindgren, M. Anttila, Suvi Rautiainen, Otso Arponen +8 more
2017European Radiology33 citations Open access
Semantic Scholar
Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities
J. Mehtonen, S. Teppo, M. Lahnalampi, Aleksi Kokko +14 more
2020Genome Medicine30 citations Open access
Semantic Scholar
Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium.
Johanna E. Lähteenvuo, Olli-Pekka Hätinen, A. Kuivanen, J. Huusko +11 more
2020Molecular Therapy30 citations Open access
Semantic Scholar
Amphiphilic phthalocyanines in polymeric micelles: a supramolecular approach toward efficient third-generation photosensitizers.
Francesca Setaro, J. W. H. Wennink, P. Mäkinen, L. Holappa +5 more
2019Journal of materials chemistry. B30 citations Open access
Semantic Scholar
Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion.
T. Kaartinen, A. Luostarinen, Pilvi Maliniemi, J. Keto +9 more
2017Cytotherapy29 citations
Semantic Scholar
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
A. Deen, S. Adinolfi, Jouni Härkönen, Tommi Patinen +15 more
2023bioRxiv25 citations Open access
Semantic Scholar
Novel RNAi-Based Therapies for Atherosclerosis
Anna-Kaisa Ruotsalainen, P. Mäkinen, S. Ylä-Herttuala
2021Current Atherosclerosis Reports24 citations Open access
Semantic Scholar
HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
U. T. Arasu, A. Deen, S. Pasonen-Seppänen, S. Heikkinen +9 more
2019Cellular and Molecular Life Sciences24 citations Open access
Semantic Scholar
Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities
J. Mehtonen, S. Teppo, M. Lahnalampi, Aleksi Kokko +14 more
2020Genome Medicine18 citations Open access
Semantic Scholar
O R I G I N a L I N V E S T I G a T I O N Open Access Left Ventricular Dysfunction with Reduced Functional Cardiac Reserve in Diabetic and Non-diabetic Ldl-receptor Deficient Apolipoprotein B100-only Mice
Suvi E. Heinonen, M. Merentie, M. Hedman, P. Mäkinen +5 more
18 citations
Semantic Scholar
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models.
Rebekka Wittrahm, M. Takalo, T. Kuulasmaa, P. Mäkinen +26 more
2023Neurobiology of Disease17 citations Open access
Semantic Scholar
Alzheimer's disease‐induced phagocytic microglia express a specific profile of coding and non‐coding RNAs
Flavia Scoyni, Luca Giudice, M. Väänänen, N. Downes +14 more
2023Alzheimer's & Dementia17 citations Open access
Semantic Scholar
SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer
Noora Leppänen, H. Kaljunen, Eerika Takala, R. Kaarijärvi +5 more
2024Nucleic Acids Research16 citations Open access
Semantic Scholar
Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice
M. Merentie, R. Rissanen, L. Lottonen-Raikaslehto, J. Huusko +5 more
2018PLoS ONE16 citations Open access
Semantic Scholar
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models
T. Freitag, R. Fagerlund, Nihay Laham Karam, Veli-Matti Leppänen +23 more
2023Vaccine15 citations Open access
Semantic Scholar
Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis
P. Mäkinen, S. Ylä-Herttuala
2013Current Opinion in Lipidology15 citations
Semantic Scholar
Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules
H. Belt, J. Koponen, T. Kekarainen, K. Puttonen +7 more
2018Frontiers in Cardiovascular Medicine14 citations Open access
Semantic Scholar
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
H. Martiskainen, R. Willman, P. Harju, S. Heikkinen +353 more
2025Molecular Neurodegeneration13 citations Open access
Semantic Scholar
Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia
P. Laitinen, M. Väänänen, Ida-Liisa Kolari, P. Mäkinen +9 more
2022PLoS ONE12 citations Open access
Semantic Scholar
DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
R. Kaarijärvi, H. Kaljunen, L. Nappi, L. Fazli +13 more
2024Communications Biology11 citations Open access
Semantic Scholar
In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued
S. V. van Lith, Ilse Roodink, J. Verhoeff, P. Mäkinen +8 more
2016OncoTarget11 citations Open access
Semantic Scholar
Insights into Prime Editing Technology: A Deep Dive into Fundamentals, Potentials, and Challenges
Seyed Younes Hosseini, Rahul Mallick, P. Mäkinen, S. Ylä-Herttuala
2024Human Gene Therapy9 citations Open access
Semantic Scholar
ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice
M. Babu, Durga Devi, P. Mäkinen, T. Örd +3 more
2022Arteriosclerosis, Thrombosis and Vascular Biology9 citations Open access
Semantic Scholar
Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N1-acetyltransferase
S. Pirnes-Karhu, P. Mäntymaa, R. Sironen, P. Mäkinen +7 more
2013Amino Acids7 citations
Semantic Scholar
and increased susceptibility to tumor formation blood capillary density, improved postischemic muscle regeneration, Vascular endothelial growth factor-D transgenic mice show enhanced
P. Turunen, S. Ylä-Herttuala, M. Dijkstra, Hanna Purhonen +6 more
20097 citations
Semantic Scholar
Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques
Subhadeep Banerjee, Jayeeta Sengupta, A. Aljarilla, Francesca Setaro +11 more
2019Precision Nanomedicine5 citations Open access
Semantic Scholar
Navigating the prime editing strategy to treat cardiovascular genetic disorders in transforming heart health
Seyed Younes Hosseini, Rahul Mallick, P. Mäkinen, S. Ylä-Herttuala
2024Expert Review of Cardiovascular Therapy3 citations Open access
Semantic Scholar
Citrate-Saline-Formulated mRNA Delivery into the Heart Muscle with an Electromechanical Mapping and Injection Catheter Does Not Lead to Therapeutic Effects in a Porcine Chronic Myocardial Ischemia Model
N. Järveläinen, P. Halonen, J. Nurro, Olli-Pekka Hätinen +5 more
2021Human Gene Therapy3 citations Open access
Semantic Scholar
Endothelialization of coronary stents after intra-luminal adenoviral VEGF-A gene transfer in a preclinical porcine restenosis model - Studies with optical coherence tomography, angioscopy, multiphoton and scanning electron microscopy.
J. Hytönen, J. Pajula, P. Halonen, J. Taavitsainen +8 more
2024Journal of Molecular and Cellular Cardiology2 citations Open access
Semantic Scholar
Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse.
S. Kemppainen, M. Aramburu-Núñez, H. Koivisto, A. Posado-Fernández +34 more
2025Experimental Neurology1 citations Open access
Semantic Scholar
Patient specific regulation of metabolism and cell death pathways in m.3243A>G mutated iPS-cells
Sanna Ryytty, K. Nurminen, Teemu Tiukuvaara, P. Mäkinen +2 more
2026Scientific Reports0 citations Open access
Semantic Scholar
Heightened sensitivity to adverse effects of metformin in mtDNA mutant patient cells.
Sanna Ryytty, K. Nurminen, P. Mäkinen, Anu Suomalainen +1 more
2025Life Science0 citations Open access
Semantic Scholar
Protective Alzheimer ’ s disease-associated APP A673T variant predominantly decreases sAPP β levels in cerebrospinal fluid and 2D/3D cell culture models
P. Mäkinen
20230 citations
Semantic Scholar
Pro-Resolving Lipoxin A4 Rescues Impaired Post-Ischemic Angiogenesis and Perfusion Recovery in Hyperlipidemic and Diabetic Mice
Durga Devi, Mohan Babu Budikote Venkatappa, P. Mäkinen, T. Örd +4 more
2022Social Science Research Network0 citations Open access
Semantic Scholar
Impact of starting material and expansion conditions on cell yield and composition of CAR T cell products
T. Kaartinen, A. Luostarinen, H. Belt, J. Koponen +6 more
20160 citations
Semantic Scholar
Abstract 203: Silencing of Macrophage Scavenger Receptor SR-A or CD36 Modulates Transcription Factor NF-κB Activity by Distinct Mechanisms
P. Mäkinen, Jari P. Lappalainen, Annukka M. Kivelä, A. Levonen +1 more
2012Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar
VEGF-D Transgenic Mice Show Enhanced Blood Capillary Density, Improved Post-Ischemic Muscle Regeneration and Increased Susceptibility to Tumor Formation Phenotypic Characterization of Transgenic Mice Generated by Lentiviral Techniques
M. Dijkstra, Hanna Purhonen, Eveliina Hämäläinen, P. Mäkinen +8 more
20080 citations
Semantic Scholar

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