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V. Combaret · SciRah

Researcher profile · Semantic Scholar

V. Combaret

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V. Combaret — researcher profile on SciRah

h-index: 47
Works: 167
Citations: 8,497

Most-cited papers

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
I. Janoueix-Lerosey, D. Lequin, L. Brugières, A. Ribeiro +12 more
2008Nature917 citations
Semantic Scholar
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
T. F. Eleveld, D. Oldridge, V. Bernard, J. Koster +42 more
2015Nature Genetics526 citations Open access
Semantic Scholar
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries
V. Boeva, Caroline Louis-Brennetot, A. Peltier, S. Durand +25 more
2017Nature Genetics452 citations Open access
Semantic Scholar
Overall genomic pattern is a predictor of outcome in neuroblastoma.
I. Janoueix-Lerosey, G. Schleiermacher, E. Michels, V. Mosseri +16 more
2009Journal of Clinical Oncology340 citations Open access
Semantic Scholar
Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells.
S. Valsesia-Wittmann, M. Magdeleine, S. Dupasquier, É. Garin +5 more
2004Cancer Cell263 citations Open access
Semantic Scholar
Emergence of new ALK mutations at relapse of neuroblastoma.
G. Schleiermacher, Niloufar Javanmardi, V. Bernard, Q. Leroy +19 more
2014Journal of Clinical Oncology212 citations
Semantic Scholar
Outcome Prediction of Children with Neuroblastoma using a Multigene Expression Signature, a Retrospective SIOPEN/COG/GPOH Study
J. Vermeulen, K. De Preter, A. Naranjo, L. Vercruysse +32 more
2009The Lancet Oncology191 citations Open access
Semantic Scholar
Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma.
J. Vandesompele, M. Baudis, K. De Preter, N. Van Roy +16 more
2005Journal of Clinical Oncology180 citations Open access
Semantic Scholar
Accumulation of segmental alterations determines progression in neuroblastoma.
G. Schleiermacher, I. Janoueix-Lerosey, A. Ribeiro, J. Klijanienko +13 more
2010Journal of Clinical Oncology166 citations Open access
Semantic Scholar
A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability
A. Morel, Christophe Ginestier, Roxane M. Pommier, O. Cabaud +29 more
2017Nature Medicine156 citations
Semantic Scholar
Netrin-1 acts as a survival factor for aggressive neuroblastoma
C. Delloye-Bourgeois, Julien Fitamant, A. Paradisi, D. Cappellen +11 more
2009Journal of Experimental Medicine138 citations Open access
Semantic Scholar
Quality assessment of genetic markers used for therapy stratification.
I. Ambros, J. Bénard, M. Boavida, N. Bown +29 more
2003Journal of Clinical Oncology133 citations
Semantic Scholar
Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma
Mathieu Chicard, Léo Colmet-Daage, Nathalie Clément, Adrien Danzon +16 more
2017Clinical Cancer Research125 citations Open access
Semantic Scholar
Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells
Christina Schönherr, K. Ruuth, Sattu Kamaraj, Cai-Ling Wang +7 more
2012Oncogene124 citations Open access
Semantic Scholar
Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma
Mathieu Chicard, S. Boyault, Leo Colmet Daage, W. Richer +26 more
2016Clinical Cancer Research106 citations Open access
Semantic Scholar
Expression of miR-487b and miR-410 encoded by 14q32.31 locus is a prognostic marker in neuroblastoma
Charles-Henry Gattolliat, L. Thomas, S. Ciafrè, G. Meurice +10 more
2011British Journal of Cancer105 citations Open access
Semantic Scholar
Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)
G. Schleiermacher, J. Michon, A. Ribeiro, G. Pierron +31 more
2011British Journal of Cancer97 citations Open access
Semantic Scholar
Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients
P. Depuydt, V. Boeva, T. Hocking, Robrecht Cannoodt +31 more
2018Journal of the National Cancer Institute88 citations Open access
Semantic Scholar
ArrayCGH‐based classification of neuroblastoma into genomic subgroups
E. Michels, J. Vandesompele, K. De Preter, J. Hoebeeck +14 more
2007Genes, Chromosomes and Cancer84 citations
Semantic Scholar
Detection of tumor ALK status in neuroblastoma patients using peripheral blood
V. Combaret, Isabelle Iacono, Angela Bellini, Stéphanie Bréjon +7 more
2015Cancer Medicine79 citations Open access
Semantic Scholar
Microenvironment-Driven Shift of Cohesion/Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma.
C. Delloye-Bourgeois, L. Bertin, Karine Thoinet, L. Jarrosson +9 more
2017Cancer Cell74 citations Open access
Semantic Scholar
Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis
Angela Bellini, V. Bernard, Q. Leroy, T. Rio Frio +17 more
2015Clinical Cancer Research74 citations
Semantic Scholar
Aberrant methylation of candidate tumor suppressor genes in neuroblastoma.
J. Hoebeeck, E. Michels, F. Pattyn, V. Combaret +7 more
2009Cancer Letters74 citations
Semantic Scholar
Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis.
Jimena Bouzas-Rodríguez, J. R. Cabrera, C. Delloye-Bourgeois, G. Ichim +7 more
2010Journal of Clinical Investigation73 citations Open access
Semantic Scholar
International Interlaboratory Digital PCR Study Demonstrating High Reproducibility for the Measurement of a Rare Sequence Variant.
A. Whale, Alison S. Devonshire, G. Karlin-Neumann, John F. Regan +30 more
2017Analytical Chemistry67 citations Open access
Semantic Scholar
Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1)
Angela Bellini, Ulrike Poetschger, V. Bernard, E. Lapouble +41 more
2021Journal of Clinical Oncology64 citations Open access
Semantic Scholar
The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking
P. Mazot, A. Cazes, M. Boutterin, A. Figueiredo +7 more
2011Oncogene62 citations
Semantic Scholar
Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma.
A. Cazes, Caroline Louis-Brennetot, P. Mazot, F. Dingli +14 more
2013Cancer Research60 citations Open access
Semantic Scholar
High‐dose chemotherapy followed by locoregional irradiation improves the outcome of patients with international neuroblastoma staging system Stage II and III neuroblastoma with MYCN amplification
A. Laprie, J. Michon, O. Hartmann, C. Munzer +15 more
2004Cancer57 citations
Semantic Scholar
The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation
M. Lambert, Sophie Terrone, Guillaume Giraud, Clara Benoit-Pilven +5 more
2018Nucleic Acids Research55 citations Open access
Semantic Scholar
Methylation of tumor‐suppressor genes in neuroblastoma: The RASSF1A gene is almost always methylated in primary tumors
M. Michalowski, F. de Fraipont, D. Plantaz, S. Michelland +2 more
2008Pediatric Blood & Cancer55 citations
Semantic Scholar
Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma.
G. Schleiermacher, I. Janoueix-Lerosey, V. Combaret, J. Derré +3 more
2003Cancer Genetics and Cytogenetics53 citations
Semantic Scholar
Breakpoint Features of Genomic Rearrangements in Neuroblastoma with Unbalanced Translocations and Chromothripsis
V. Boeva, Stéphanie Jouannet, Romain Daveau, V. Combaret +13 more
2013PLoS ONE49 citations Open access
Semantic Scholar
A Multilocus Technique for Risk Evaluation of Patients with Neuroblastoma
I. Ambros, B. Brunner, G. Aigner, C. Bedwell +30 more
2011Clinical Cancer Research47 citations Open access
Semantic Scholar
Genome-wide analysis of gene expression in neuroblastomas detected by mass screening.
A. Krause, V. Combaret, Isabelle Iacono, Bruno Lacroix +6 more
2005Cancer Letters46 citations
Semantic Scholar
Activated ALK signals through the ERK–ETV5–RET pathway to drive neuroblastoma oncogenesis
Lucille Lopez-Delisle, C. Pierre-Eugene, Caroline Louis-Brennetot, D. Surdez +8 more
2018Oncogene45 citations Open access
Semantic Scholar
Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification
R. Defferrari, K. Mazzocco, I. Ambros, P. Ambros +26 more
2014British Journal of Cancer45 citations Open access
Semantic Scholar
Focal DNA Copy Number Changes in Neuroblastoma Target MYCN Regulated Genes
C. Kumps, A. Fieuw, P. Mestdagh, B. Menten +17 more
2013PLoS ONE43 citations Open access
Semantic Scholar
ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome
F. Bourdeaut, S. Ferrand, L. Brugières, Marjorie Hilbert +16 more
2011European Journal of Human Genetics42 citations Open access
Semantic Scholar
Lack of Antitumor Activity of Recombinant Endostatin in a Human Neuroblastoma Xenograft Model
E. Jouanneau, L. Alberti, M. Nejjari, I. Treilleux +6 more
2004Journal of Neuro-Oncology42 citations
Semantic Scholar
Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicity
V. Combaret, S. Boyault, Isabelle Iacono, Stéphanie Bréjon +2 more
2008Molecular Cancer41 citations Open access
Semantic Scholar
Variety and complexity of chromosome 17 translocations in neuroblastoma
G. Schleiermacher, V. Raynal, I. Janoueix-Lerosey, V. Combaret +2 more
2004Genes, Chromosomes and Cancer41 citations
Semantic Scholar
Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study
Ana P. Berbegall, D. Bogen, U. Pötschger, K. Beiske +20 more
2018British Journal of Cancer40 citations Open access
Semantic Scholar
Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA
V. Combaret, Stéphanie Bréjon, Isabelle Iacono, G. Schleiermacher +5 more
2011Pediatric Blood & Cancer39 citations
Semantic Scholar
Protein chip array profiling analysis of sera from neuroblastoma patients.
V. Combaret, C. Bergeron, Stéphanie Bréjon, Isabelle Iacono +3 more
2005Cancer Letters39 citations
Semantic Scholar
Bromohydrin Pyrophosphate-stimulated Vγ9δ2 T Cells Expanded Ex Vivo From Patients With Poor-Prognosis Neuroblastoma Lyse Autologous Primary Tumor Cells
J. Chargui, V. Combaret, Virginie Scaglione, Isabelle Iacono +7 more
2010Journal of immunotherapy36 citations
Semantic Scholar
The neuroblastoma ALK(I1250T) mutation is a kinase- dead RTK in vitro and in vivo
Christina Schönherr, K. Ruuth, Therese Eriksson, Y. Yamazaki +6 more
201133 citations
Semantic Scholar
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
A. Decock, M. Ongenaert, Robrecht Cannoodt, Kimberly Verniers +20 more
2015OncoTarget31 citations Open access
Semantic Scholar
Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
Fjoralba Zeka, A. Decock, Alan Van Goethem, K. Vanderheyden +27 more
2018bioRxiv30 citations Open access
Semantic Scholar
Circulating MYCN DNA predicts MYCN-amplification in neuroblastoma.
V. Combaret, C. Bergeron, R. Noguera, Isabelle Iacono +1 more
2005Journal of Clinical Oncology30 citations Open access
Semantic Scholar

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