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M. Scheffner · SciRah

Researcher profile · Semantic Scholar

M. Scheffner

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M. Scheffner — researcher profile on SciRah

h-index: 56
Works: 149
Citations: 22K

Most-cited papers

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.
Sovana Adhikary, Federica Marinoni, A. Hock, E. Hulleman +10 more
2005Cell419 citations Open access
Semantic Scholar
Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects.
M. Scheffner, Sharad Kumar
2014Biochimica et Biophysica Acta295 citations Open access
Semantic Scholar
The Chaperone-associated Ubiquitin Ligase CHIP Is Able to Target p53 for Proteasomal Degradation*
C. Esser, M. Scheffner, J. Höhfeld
2005Journal of Biological Chemistry273 citations Open access
Semantic Scholar
Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells
A. Honegger, D. Schilling, S. Bastian, Jasmin Sponagel +5 more
2015PLoS Pathogens248 citations Open access
Semantic Scholar
UBE1L2, a Novel E1 Enzyme Specific for Ubiquitin*♦
C. Pelzer, Ingrid Kassner, K. Matentzoglu, R. Singh +4 more
2007Journal of Biological Chemistry193 citations Open access
Semantic Scholar
Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc
Simone Kühnle, B. Mothes, K. Matentzoglu, M. Scheffner
2013Proceedings of the National Academy of Sciences of the United States of America135 citations Open access
Semantic Scholar
Synthesis of defined ubiquitin dimers.
S. Eger, M. Scheffner, A. Marx, Marina Rubini
2010Journal of the American Chemical Society112 citations Open access
Semantic Scholar
HECT E3s and human disease
M. Scheffner, O. Staub
2007BMC Biochemistry112 citations Open access
Semantic Scholar
E6AP promotes the degradation of the PML tumor suppressor
I. Louria-Hayon, O. Alsheich-Bartok, Y. Levav-Cohen, I. Silberman +8 more
2009Cell Death and Differentiation101 citations
Semantic Scholar
Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome
D. Zaaroor-Regev, P. de Bie, M. Scheffner, T. Noy +5 more
2010Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
Regulation of p27 Degradation and S-Phase Progression by Ro52 RING Finger Protein
A. Sabile, A. Meyer, C. Wirbelauer, D. Hess +3 more
2006Molecular and Cellular Biology93 citations Open access
Semantic Scholar
Mutation of HERC2 causes developmental delay with Angelman-like features
G. Harlalka, E. Baple, H. Cross, Simone Kühnle +11 more
2012Journal of Medical Genetics83 citations
Semantic Scholar
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.
Katrin Bagola, Maximilian von Delbrück, G. Dittmar, M. Scheffner +4 more
2013Molecules and Cells81 citations Open access
Semantic Scholar
Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2*
Simone Kühnle, U. Kogel, Sandra Glockzin, A. Marquardt +3 more
2011Journal of Biological Chemistry79 citations Open access
Semantic Scholar
Poly(ADP‐ribose)‐mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function
Jan M. F. Fischer, O. Popp, D. Gebhard, S. Veith +8 more
2014The FEBS Journal75 citations Open access
Semantic Scholar
Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
C. Sailer, Fabian Offensperger, A. Julier, Kai-Michael Kammer +4 more
2018Nature Communications70 citations Open access
Semantic Scholar
Regulation of Estrogen-Dependent Transcription by the LIM Cofactors CLIM and RLIM in Breast Cancer
S. Johnsen, C. Güngör, T. Prenzel, S. Riethdorf +10 more
2009Cancer Research69 citations Open access
Semantic Scholar
Hetero-oligomerization with MdmX Rescues the Ubiquitin/Nedd8 Ligase Activity of RING Finger Mutants of Mdm2*
R. Singh, S. Iyappan, M. Scheffner
2007Journal of Biological Chemistry66 citations Open access
Semantic Scholar
The Role of the Ubiquitin Ligase E6-AP in Human Papillomavirus E6-mediated Degradation of PDZ Domain-containing Proteins*
Petric Kuballa, K. Matentzoglu, M. Scheffner
2007Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination
Franziska Mortensen, Daniel Schneider, Tanja Barbic, Anna Sladewska-Marquardt +3 more
2015Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53
Arnd Hengstermann, M. D'silva, Petric Kuballa, K. Butz +2 more
2005Journal of Virology56 citations Open access
Semantic Scholar
Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation
Daniel Rösner, Tatjana Schneider, Daniel Schneider, M. Scheffner +1 more
2015Nature Protocols55 citations
Semantic Scholar
Roles of larval sea urchin spicule SM50 domains in organic matrix self-assembly and calcium carbonate mineralization.
Ashit Rao, Se-To Jong, John K. Berg, Stefan G. Kreft +2 more
2013Journal of Structural Biology53 citations Open access
Semantic Scholar
Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains.
Tatjana Schneider, Daniel Schneider, Daniel Rösner, Saurav Malhotra +4 more
2014Angewandte Chemie51 citations Open access
Semantic Scholar
Recognition and Cleavage of Related to Ubiquitin 1 (Rub1) and Rub1-Ubiquitin Chains by Components of the Ubiquitin-Proteasome System*
R. Singh, Sylvia Zerath, O. Kleifeld, M. Scheffner +2 more
2012Molecular & Cellular Proteomics48 citations Open access
Semantic Scholar
Generation of a Mono‐ubiquitinated PCNA Mimic by Click Chemistry
S. Eger, Benoît Castrec, U. Hübscher, M. Scheffner +2 more
2011ChemBioChem44 citations Open access
Semantic Scholar
Identification of Proteins Interacting with Ubiquitin Chains.
Xiaohui Zhao, Joachim Lutz, Eva Höllmüller, M. Scheffner +2 more
2017Angewandte Chemie41 citations Open access
Semantic Scholar
Ubiquitin ligase E6-AP and its role in human disease.
K. Matentzoglu, M. Scheffner
2008Biochemical Society Transactions41 citations
Semantic Scholar
A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein
S. Dymalla, M. Scheffner, Elvira Weber, P. Sehr +3 more
2009Journal of molecular medicine40 citations
Semantic Scholar
Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses.
Stephanie Töpffer, A. Müller-Schiffmann, K. Matentzoglu, M. Scheffner +1 more
2007Journal of General Virology36 citations Open access
Semantic Scholar
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere
J. Bogomolovas, J. Fleming, B. Franke, B. Manso +10 more
2021EMBO Reports35 citations Open access
Semantic Scholar
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.
D. Heideman, R. Steenbergen, J. van der Torre, M. Scheffner +5 more
2005Molecular Therapy35 citations Open access
Semantic Scholar
Structural and functional consequences of NEDD8 phosphorylation
Katrin Stuber, Tobias D. Schneider, J. Werner, M. Kovermann +2 more
2021Nature Communications32 citations Open access
Semantic Scholar
Stabilization of Mineral Precursors by Intrinsically Disordered Proteins
Ashit Rao, M. Drechsler, S. Schiller, M. Scheffner +2 more
2018Advanced Functional Materials32 citations Open access
Semantic Scholar
Effects of the antifungal agent ciclopirox in HPV‐positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis
J. Braun, Anja L Herrmann, J. I. Blase, Kristin Frensemeier +5 more
2020International Journal of Cancer31 citations Open access
Semantic Scholar
Turning the RING Domain Protein MdmX into an Active Ubiquitin-Protein Ligase*
S. Iyappan, Hans-Peter Wollscheid, A. Rojas-Fernandez, A. Marquardt +3 more
2010Journal of Biological Chemistry31 citations Open access
Semantic Scholar
MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression.
Celeste Giansanti, Valentina Manzini, Antje Dickmanns, A. Dickmanns +7 more
2022Cell Reports30 citations Open access
Semantic Scholar
c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity.
Ai-Leen Chan, T. Grossman, Valentina Zuckerman, Dafne Campigli Di Giammartino +8 more
2013Biochemistry30 citations
Semantic Scholar
Site-specific ubiquitylation acts as a regulator of linker histone H1
Eva Höllmüller, Simon Geigges, M. L. Niedermeier, Kai-Michael Kammer +5 more
2021Nature Communications28 citations Open access
Semantic Scholar
Towards a molecular basis of ubiquitin signaling: A dual-scale simulation study of ubiquitin dimers
Andrej Berg, O. Kukharenko, M. Scheffner, C. Peter
2018PLoS Comput. Biol.28 citations Open access
Semantic Scholar
The Length of a Ubiquitin Chain: A General Factor for Selective Recognition by Ubiquitin‐Binding Proteins
Joachim Lutz, Eva Höllmüller, M. Scheffner, A. Marx +1 more
2020Angewandte Chemie27 citations Open access
Semantic Scholar
On Biomineralization: Enzymes Switch on Mesocrystal Assembly
Ashit Rao, T. Roncal-Herrero, Elina Schmid, M. Drechsler +4 more
2019ACS Central Science26 citations Open access
Semantic Scholar
Fluorogenic ATP analogues for online monitoring of ATP consumption: observing ubiquitin activation in real time.
S. Hacker, Dana Pagliarini, T. Tischer, N. Hardt +5 more
2013Angewandte Chemie25 citations Open access
Semantic Scholar
Ubiquitin Family Modifiers and the Proteasome
R. J. Dohmen, M. Scheffner
2012Methods in Molecular Biology25 citations
Semantic Scholar
Chemoproteomic discovery of a human RNA ligase
Yizhi Yuan, Florian M. Stumpf, Lisa A. Schlor, Olivia P. Schmidt +8 more
2023Nature Communications24 citations Open access
Semantic Scholar
Improving bioorthogonal protein ubiquitylation by click reaction.
Daniel Schneider, Tatjana Schneider, Daniel Rösner, M. Scheffner +1 more
2013Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
Fingerprinting differential active site constraints of ATPases
S. Hacker, N. Hardt, Alexander Buntru, Dana Pagliarini +5 more
201322 citations
Semantic Scholar
Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks.
J. Jung, Hans-Peter Wollscheid, A. Marquardt, M. Manea +2 more
2009Bioconjugate chemistry22 citations
Semantic Scholar
Selective monitoring of the enzymatic activity of the tumor suppressor Fhit.
S. Hacker, Franziska Mortensen, M. Scheffner, A. Marx
2014Angewandte Chemie19 citations Open access
Semantic Scholar
Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
Lena Krüger, Christoph J Albrecht, Hannah K Schammann, Florian M. Stumpf +7 more
2021Nature Communications18 citations Open access
Semantic Scholar

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