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C. Seedhouse · SciRah

Researcher profile · Semantic Scholar

C. Seedhouse

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C. Seedhouse — researcher profile on SciRah

h-index: 27
Works: 109
Citations: 2,109

Most-cited papers

Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia
C. Seedhouse, R. Faulkner, Nadia Ashraf, E. Dasgupta +1 more
2004Clinical Cancer Research160 citations Open access
Semantic Scholar
Vascular Endothelial Growth Factor Induction by Prostaglandin E2 in Human Airway Smooth Muscle Cells Is Mediated by E Prostanoid EP2/EP4 Receptors and SP-1 Transcription Factor Binding Sites*
D. Bradbury, D. Clarke, C. Seedhouse, L. Corbett +2 more
2005Journal of Biological Chemistry96 citations Open access
Semantic Scholar
Synthetic lethal targeting of DNA double strand break repair deficient cells by human apurinic/apyrimidinic endonuclease (APE1) inhibitors
R. Sultana, D. R. McNeill, R. Abbotts, Mohammed Z. Mohammed +8 more
2012International Journal of Cancer95 citations Open access
Semantic Scholar
Targeting XRCC1 deficiency in breast cancer for personalized therapy.
R. Sultana, T. Abdel-Fatah, R. Abbotts, Claire Hawkes +7 more
2013Cancer Research91 citations Open access
Semantic Scholar
Advances in the understanding of susceptibility to treatment‐related acute myeloid leukaemia
C. Seedhouse, N. Russell
2007British Journal of Haematology88 citations Open access
Semantic Scholar
Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells
R. Sultana, T. Abdel-Fatah, Christina Perry, P. Moseley +5 more
2013PLoS ONE83 citations Open access
Semantic Scholar
Targeting BRCA1‐BER deficient breast cancer by ATM or DNA‐PKcs blockade either alone or in combination with cisplatin for personalized therapy
N. Albarakati, T. Abdel-Fatah, Rachel E. Doherty, R. Russell +13 more
2015Molecular Oncology78 citations Open access
Semantic Scholar
Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer.
M. Shafiee, C. Seedhouse, N. Mongan, C. Chapman +3 more
2016Molecular and Cellular Endocrinology74 citations Open access
Semantic Scholar
Preventing endometrial cancer risk in polycystic ovarian syndrome (PCOS) women: could metformin help?
M. Shafiee, G. Khan, R. Ariffin, J. Abu +6 more
2014Gynecologic Oncology70 citations
Semantic Scholar
Clinicopathological and functional significance of XRCC1 expression in ovarian cancer
T. Abdel-Fatah, R. Sultana, R. Abbotts, Claire Hawkes +3 more
2013International Journal of Cancer66 citations
Semantic Scholar
Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy
R. Abbotts, Rosalyn Jewell, J. Nsengimana, D. Maloney +12 more
2014OncoTarget52 citations Open access
Semantic Scholar
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia.
M. Jawad, C. Seedhouse, N. Russell, M. Plumb
2006Blood51 citations Open access
Semantic Scholar
Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia
M. Jawad, C. Seedhouse, U. Mony, M. Grundy +2 more
2010Leukemia46 citations Open access
Semantic Scholar
Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment
U. Mony, M. Jawad, C. Seedhouse, N. Russell +1 more
2008Leukemia46 citations Open access
Semantic Scholar
Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t‐AML/MDS
L. Fern, M. Pallis, G. Carter, C. Seedhouse +2 more
2004British Journal of Haematology41 citations Open access
Semantic Scholar
The FLT3 Internal Tandem Duplication Mutation Is a Secondary Target of the Aurora B Kinase Inhibitor AZD1152-HQPA in Acute Myelogenous Leukemia Cells
M. Grundy, C. Seedhouse, Shilli Shang, J. Richardson +2 more
2010Molecular Cancer Therapeutics38 citations Open access
Semantic Scholar
Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials
C. Seedhouse, M. Grundy, P. C. White, Yun Li +7 more
2007Clinical Cancer Research38 citations Open access
Semantic Scholar
Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention.
R. Ali, A. Al-Kawaz, M. Toss, A. Green +7 more
2018Cancer Research33 citations Open access
Semantic Scholar
The Ataxia Telangiectasia Mutated Kinase pathway Regulates IL-23 Expression by Human Dendritic Cells
Qun-Wei Wang, H. Franks, Stephanie J. Foan, Mohamed El Refaee +8 more
2013Journal of Immunology30 citations Open access
Semantic Scholar
Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells
M. Grundy, Sahana S Balakrishnan, M. Fox, C. Seedhouse +1 more
2018OncoTarget29 citations Open access
Semantic Scholar
Sterol regulatory element binding protein‐1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
M. Shafiee, N. Mongan, C. Seedhouse, C. Chapman +3 more
2017Acta Obstetricia et Gynecologica Scandinavica27 citations Open access
Semantic Scholar
The multi‐kinase inhibitor TG02 overcomes signalling activation by survival factors to deplete MCL1 and XIAP and induce cell death in primary acute myeloid leukaemia cells
M. Pallis, A. Abdul-Aziz, F. Burrows, C. Seedhouse +2 more
2012British Journal of Haematology27 citations Open access
Semantic Scholar
P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors.
Laura Connelly-Smith, Joanne Pattinson, M. Grundy, S. Shang +3 more
2007Experimental Hematology25 citations Open access
Semantic Scholar
Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells
M. Pallis, F. Burrows, J. Ryan, M. Grundy +5 more
2016OncoTarget22 citations Open access
Semantic Scholar
P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA
M. Grundy, C. Seedhouse, N. Russell, M. Pallis
2011BMC Cancer21 citations Open access
Semantic Scholar
Impaired S-Phase Arrest in Acute Myeloid Leukemia Cells with a FLT3 Internal Tandem Duplication Treated with Clofarabine
C. Seedhouse, M. Grundy, S. Shang, J. Ronan +3 more
2009Clinical Cancer Research21 citations Open access
Semantic Scholar
Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
M. Pallis, F. Burrows, Abigail Whittall, N. Boddy +2 more
2013BMC Pharmacology and Toxicology19 citations Open access
Semantic Scholar
Saliva for COVID-19 Testing: Simple but Useless or an Undervalued Resource?
S. Pijuan-Galitó, F. Tarantini, Hannah Tomlin, H. Jenkins +29 more
2021Frontiers in Virology16 citations Open access
Semantic Scholar
Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling
M. Grundy, C. Seedhouse, Thomas Jones, Liban Elmi +4 more
2018PLoS ONE16 citations Open access
Semantic Scholar
Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia
M. Jawad, Yu Ning, C. Seedhouse, Karun Tandon +2 more
2012BMC Cancer14 citations Open access
Semantic Scholar
FLT3‐ITD expression levels and their effect on STAT5 in AML with and without NPM mutations
C. Seedhouse, M. Pallis, M. Grundy, S. Shang +1 more
2009British Journal of Haematology14 citations
Semantic Scholar
Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux
Rachael Nicholson, A. C. Menezes, Aleksandra Azevedo, A. Leckenby +6 more
2022Frontiers in Oncology13 citations Open access
Semantic Scholar
The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun
Hayaa M. Alhuthali, T. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam +1 more
2020BMC Cancer13 citations Open access
Semantic Scholar
Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma
H. Almasmoum, B. Airhihen, C. Seedhouse, G. Winkler
2020Leukemia and Lymphoma11 citations Open access
Semantic Scholar
Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML
J. R. James, Johnathan Curd, J. C. Ashworth, M. Abuhantash +6 more
2023International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome – a proof-of-concept study
M. Shafiee, D. A. Malik, R. M. Yunos, William Atiomo +6 more
2015Gynecological Endocrinology10 citations
Semantic Scholar
Increased FLYWCH1 Expression is Negatively Correlated with Wnt/β-catenin Target Gene Expression in Acute Myeloid Leukemia Cells
Amany Almars, P. S. Chondrou, E. Onyido, S. Almozyan +3 more
2019International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1.
C. Seedhouse, K. Mills, S. Ahluwalia, M. Grundy +4 more
2014Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis9 citations Open access
Semantic Scholar
Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples
Jamie L. Thompson, Angela Downie Ruiz Velasco, A. Cardall, R. Tarbox +13 more
2021Journal of Medical Microbiology8 citations Open access
Semantic Scholar
A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells
M. Al-Asadi, G. Brindle, M. Castellanos, S. May +4 more
2017OncoTarget8 citations Open access
Semantic Scholar
Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva
Harry H. Jenkins, Ana A. Tellechea Lopez, F. S. Tarantini, Hannah Tomlin +21 more
2022Scientific Reports7 citations Open access
Semantic Scholar
Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia
G. Bailey, L. Doolan, A. Baskar, L. Smith +1 more
2020Scientific Reports7 citations Open access
Semantic Scholar
How to drug a leukemic stem cell: deciphering heterogeneity for better specificity
Alice Worker, Nicholas Jinks, Peter Woodmancy, C. Seedhouse +1 more
2025Blood neoplasia6 citations Open access
Semantic Scholar
Direct RT-qPCR Assay for the Detection of SARS-CoV-2 in Saliva Samples
F. Tarantini, Siyu Wu, Harry H. Jenkins, Ana Tellechea Lopez +16 more
2022Methods and Protocols6 citations Open access
Semantic Scholar
DNA damage corrects the aberrant cytoplasmic localisation of nucleophosmin in NPM1 mutated acute myeloid leukaemia
G. Bailey, H. Qutob, A. Akhtar, N. Russell +1 more
2019British Journal of Haematology6 citations Open access
Semantic Scholar
Comparative effects of viral transport medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples
J. L. Thompson, A. Velasco, A. Cardall, Rebecca P. Tarbox +13 more
2020medRxiv4 citations Open access
Semantic Scholar
Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737
N. Yu, C. Seedhouse, N. Russell, M. Pallis
2018Leukemia and Lymphoma4 citations Open access
Semantic Scholar
275 Targeting XRCC1 (X-ray Repair Cross-complementing Gene 1), a Key DNA Base Excision Repair Protein for Personalized Therapy in Breast and Ovarian Cancer
R. Sultana, T. Abdel-Fatah, N. Albarakati, R. Abbotts +6 more
20124 citations
Semantic Scholar
A polymorphism in the 3'UTR region of ABCB1 is associated with increased allele activity with corresponding increases in P-glycoprotein expression and function [Abstract]
Nada Bajuaifer, M. Grundy, R. Hills, N. Russell +2 more
20104 citations
Semantic Scholar
Low dose rapamycin does not modulate p-glycoprotein function in acute myeloid leukaemia.
S. Shang, C. Seedhouse, N. Russell, M. Pallis
2008Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis4 citations Open access
Semantic Scholar

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