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A. Borodovsky · SciRah

Researcher profile · Semantic Scholar

A. Borodovsky

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A. Borodovsky — researcher profile on SciRah

h-index: 31
Works: 66
Citations: 10K

Most-cited papers

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape
J. Gilleron, W. Querbes, Anja Zeigerer, A. Borodovsky +16 more
2013Nature Biotechnology1,549 citations
Semantic Scholar
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
A. Akinc, A. Zumbuehl, Michael S. Goldberg, Elizaveta S. Leshchiner +28 more
2008Nature Biotechnology1,197 citations Open access
Semantic Scholar
Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery
Hyukjin Lee, A. Lytton-Jean, Yi Chen, Kevin T. Love +15 more
2012Nature Nanotechnology1,022 citations Open access
Semantic Scholar
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
D. Jensen, M. L. Proctor, S. Marquis, H. P. Gardner +15 more
1998Oncogene751 citations Open access
Semantic Scholar
Multiple associated proteins regulate proteasome structure and function.
D. Leggett, John Hanna, A. Borodovsky, Bernat Crosas +5 more
2002Molecules and Cells673 citations Open access
Semantic Scholar
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
A. Borodovsky, H. Ovaa, Nagamalleswari Kolli, T. Gan-Erdene +3 more
2002Chemistry and Biology536 citations Open access
Semantic Scholar
A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
A. Borodovsky, B. Kessler, Rocco Casagrande, H. Overkleeft +2 more
2001EMBO Journal509 citations Open access
Semantic Scholar
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
K. Fitzgerald, S. White, A. Borodovsky, B. Bettencourt +11 more
2016New England Journal of Medicine394 citations Open access
Semantic Scholar
Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure
H. Sager, Maarten Hulsmans, Kory J. Lavine, M. B. Moreira +14 more
2016Circulation Research373 citations Open access
Semantic Scholar
Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice
M. Majmudar, E. Keliher, T. Heidt, F. Leuschner +17 more
2013Circulation287 citations Open access
Semantic Scholar
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
C. Yin, Susanne Ackermann, Zhe Ma, Sarajo K. Mohanta +25 more
2019Nature Medicine274 citations Open access
Semantic Scholar
In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing
G. Courties, T. Heidt, Matthew Sebas, Yoshiko Iwamoto +15 more
2013Journal of the American College of Cardiology267 citations Open access
Semantic Scholar
TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
B. Pappu, A. Borodovsky, Timothy S. Zheng, Xue-Xian O. Yang +12 more
2008Journal of Experimental Medicine238 citations Open access
Semantic Scholar
Myocardial infarction activates CCR2+ hematopoietic stem and progenitor cells
Partha Dutta, H. Sager, K. Stengel, K. Naxerova +25 more
2015Cell Stem Cell217 citations Open access
Semantic Scholar
Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins
J. Hemelaar, A. Borodovsky, B. Kessler, D. Reverter +8 more
2004Molecular and Cellular Biology212 citations Open access
Semantic Scholar
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
H. Sager, Partha Dutta, J. Dahlman, Maarten Hulsmans +19 more
2016Science Translational Medicine195 citations Open access
Semantic Scholar
Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent N‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo
K. G. Rajeev, Jayaprakash K. Nair, M. Jayaraman, K. Charissé +13 more
2015ChemBioChem177 citations
Semantic Scholar
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1
Partha Dutta, F. Hoyer, Lubov S. Grigoryeva, H. Sager +15 more
2015Journal of Experimental Medicine175 citations Open access
Semantic Scholar
Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques
M. Majmudar, Jeongsoo Yoo, E. Keliher, J. Truelove +11 more
2013Circulation Research158 citations Open access
Semantic Scholar
Silencing of CCR2 in myocarditis.
F. Leuschner, G. Courties, Partha Dutta, L. Mortensen +18 more
2015European Heart Journal144 citations Open access
Semantic Scholar
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells
T. Novobrantseva, A. Borodovsky, J. Wong, B. Klebanov +27 more
2012Molecular Therapy: Nucleic Acids134 citations Open access
Semantic Scholar
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Evelyn W. Wang, B. Kessler, A. Borodovsky, B. Cravatt +3 more
2000Proceedings of the National Academy of Sciences of the United States of America125 citations Open access
Semantic Scholar
The classical pathway triggers pathogenic complement activation in membranous nephropathy
Larissa Seifert, G. Zahner, C. Meyer-Schwesinger, Naemi C. Hickstein +20 more
2023Nature Communications106 citations Open access
Semantic Scholar
TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.
T. Dohi, A. Borodovsky, Ping Wu, Jeffrey R Shearstone +8 more
2009Gastroenterology78 citations
Semantic Scholar
Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases.
J. Hemelaar, P. Galardy, A. Borodovsky, B. Kessler +2 more
2004Journal of Proteome Research75 citations
Semantic Scholar
Small‐Molecule Inhibitors and Probes for Ubiquitin‐ and Ubiquitin‐Like‐Specific Proteases
A. Borodovsky, H. Ovaa, Wim J. N. Meester, Emily S. Venanzi +5 more
2005ChemBioChem73 citations
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
P. Badri, Xuemin Jiang, A. Borodovsky, N. Najafian +5 more
2020Clinical Pharmacokinetics67 citations Open access
Semantic Scholar
Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis
L. Kusner, Kristina Yucius, Manjistha Sengupta, A. Sprague +8 more
2019Molecular Therapy: Methods & Clinical Development49 citations Open access
Semantic Scholar
Delivering silence: advancements in developing siRNA therapeutics.
T. Novobrantseva, A. Akinc, A. Borodovsky, A. D. de Fougerolles
2008Current opinion in drug discovery & development48 citations
Semantic Scholar
An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema
Jing-Xuan Liu, June Qin, A. Borodovsky, T. Racie +7 more
2018RNA: A publication of the RNA Society40 citations Open access
Semantic Scholar
The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP).
Y. Vugmeyster, A. Borodovsky, M. Maurice, René Maehr +2 more
2002Molecular Immunology33 citations
Semantic Scholar
Pathways Accessory to Proteasomal Proteolysis Are Less Efficient in Major Histocompatibility Complex Class I Antigen Production*
B. Kessler, X. Hong, J. Petrović, A. Borodovsky +5 more
2003Journal of Biological Chemistry29 citations Open access
Semantic Scholar
A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Preliminary Phase 1/2 Study Results in Patients with PNH
A. Hill, A. Valls, M. Griffin, T. Munir +8 more
201625 citations
Semantic Scholar
A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Interim Phase 1 Study Results
A. Hill, J. Taubel, J. Bush, A. Borodovsky +7 more
201519 citations
Semantic Scholar
Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates
K. Devalaraja-Narashimha, Cong Huang, Marc Cao, Ya-Ping Chen +4 more
2022PLoS ONE18 citations Open access
Semantic Scholar
Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function.
Jing-Xuan Liu, B. Cooley, A. Akinc, J. Butler +1 more
2020Thrombosis Research18 citations Open access
Semantic Scholar
Results of a phase 1/2 study of cemdisiran in healthy subjects and patients with paroxysmal nocturnal hemoglobinuria
A. Gaya, T. Munir, Á. Urbano-Ispizua, M. Griffin +7 more
2023eJHaem17 citations Open access
Semantic Scholar
Targeting of Liver Mannan-Binding Lectin–Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis
N. Banda, D. Desai, R. Scheinman, Rasmus Pihl +8 more
2018ImmunoHorizons17 citations Open access
Semantic Scholar
Development Of RNAi Therapeutics Targeting The Complement Pathway
A. Borodovsky, Kristina Yucius, A. Sprague, J. Butler +9 more
201316 citations
Semantic Scholar
Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D
V. Holers, A. Borodovsky, R. Scheinman, Nhu Ho +9 more
2020Frontiers in Immunology14 citations Open access
Semantic Scholar
Author Correction: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
C. Yin, Susanne Ackermann, Zhe Ma, Sarajo K. Mohanta +25 more
2018Nature Medicine14 citations Open access
Semantic Scholar
Aln-CC5, an Investigational RNAi Therapeutic Targeting C5 for Complement Inhibition
A. Borodovsky, Kristina Yucius, A. Sprague, N. Banda +11 more
201414 citations
Semantic Scholar
Monocyte-Directed RNAi Targeting CCR 2 Improves Infarct Healing in Atherosclerosis-Prone Mice
M. Majmudar, E. Keliher, T. Heidt, F. Leuschner +17 more
12 citations
Semantic Scholar
A bioassay for neuromuscular junction-restricted complement activation by myasthenia gravis acetylcholine receptor antibodies.
J. Plomp, M. Huijbers, J. Verschuuren, A. Borodovsky
2022Journal of Neuroscience Methods11 citations Open access
Semantic Scholar
Silencing of CCR 2 in myocarditis
F. Leuschner, G. Courties, Partha Dutta, L. Mortensen +18 more
201511 citations
Semantic Scholar
Applications for Chemical Probes of Proteolytic Activity
M. Bogyo, A. Baruch, D. Jeffery, D. Greenbaum +3 more
2004Current Protocols in Protein Science8 citations
Semantic Scholar
Abstract 7: A Subcutaneous, Potent and Durable RNAi Platform Targeting Metabolic Diseases, Genes PCSK9, ApoC3 and ANGPLT3
K. Fitzgerald, A. Borodovsky, W. Querbes, J. Sutherland +12 more
20147 citations
Semantic Scholar
Abstract 11936: Development of Monthly to Quarterly Subcutaneous Administration of RNAi Therapeutics Targeting the Metabolic Diseases Genes PCSK9, ApoC3 and ANGPTL3
A. Borodovsky, W. Querbes, J. Sutherland, R. Hutabarat +12 more
20144 citations
Semantic Scholar
Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models
D. Desai, A. Borodovsky, Wendell P. Davis, R. Degaonkar +8 more
2018Blood2 citations
Semantic Scholar
siRNA-mediated targeting of hepatocyte mannan-binding lectin-associated serine protease-3 for the treatment of murine collagen-antibody-inducsed arthritis (CAIA), a model for human rheumatoid arthritis
N. Banda, D. Desai, Adam Casterano, R. Scheinman +7 more
20171 citations
Semantic Scholar

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