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E. Chufán · SciRah

Researcher profile · Semantic Scholar

E. Chufán

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E. Chufán — researcher profile on SciRah

h-index: 19
Works: 61
Citations: 1,463

Most-cited papers

Synthetic models for heme-copper oxidases.
Eunsuk Kim, E. Chufán, K. Kamaraj, K. Karlin
2004Chemical Reviews323 citations
Semantic Scholar
Heme-copper/dioxygen adduct formation, properties, and reactivity.
E. Chufán, S. Puiu, K. Karlin
2007Accounts of Chemical Research123 citations
Semantic Scholar
Molecular Basis of the Polyspecificity of P-Glycoprotein (ABCB1): Recent Biochemical and Structural Studies
E. Chufán, Hong-May Sim, S. Ambudkar
2015Advances in Cancer Research121 citations Open access
Semantic Scholar
Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)
E. Chufán, K. Kapoor, Hong-May Sim, Satyakam Singh +3 more
2013PLoS ONE109 citations Open access
Semantic Scholar
Drug-Protein Hydrogen Bonds Govern the Inhibition of the ATP Hydrolysis of the Multidrug Transporter P-glycoprotein
E. Chufán, K. Kapoor, S. Ambudkar
2015Biochemical Pharmacology90 citations Open access
Semantic Scholar
Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)-Valine-Derived Thiazole Amino Acid
Satyakam Singh, N. R. Prasad, E. Chufán, Bhargav A. Patel +4 more
2014Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Heme-Copper/Dioxygen Complexes: Towards Understanding Ligand-Environmental Effects on Coordination Geometry, Electronic Structure and Reactivity
Zakaria Halime, Matthew T. Kieber-Emmons, Munzarin F. Qayyum, Biplab Mondal +8 more
2010Inorganic Chemistry61 citations Open access
Semantic Scholar
How Much Binding Affinity Can be Gained by Filling a Cavity?
Y. Kawasaki, E. Chufán, V. Lafont, K. Hidaka +3 more
2009Chemical Biology and Drug Design52 citations Open access
Semantic Scholar
Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2
Megumi Murakami, S. Ohnuma, Michihiro Fukuda, E. Chufán +9 more
2017Drug Metabolism And Disposition45 citations Open access
Semantic Scholar
PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells
Atish Patel, A. Tiwari, E. Chufán, K. Sodani +5 more
2013Cancer Chemotherapy and Pharmacology45 citations Open access
Semantic Scholar
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions
S. Shukla, Biebele Abel, E. Chufán, S. Ambudkar
2017Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein
Andaleeb Sajid, S. Lusvarghi, Megumi Murakami, E. Chufán +4 more
2020Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
Semantic Scholar
Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency
Shahrooz Vahedi, E. Chufán, S. Ambudkar
2017Biochemical Pharmacology35 citations Open access
Semantic Scholar
An iron-peroxo porphyrin complex: new synthesis and reactivity toward a Cu(II) complex giving a heme-peroxo-copper adduct.
E. Chufán, K. Karlin
2003Journal of the American Chemical Society31 citations
Semantic Scholar
Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP)
Danwen Yang, Rishil J. Kathawala, E. Chufán, Atish Patel +3 more
2013Future Oncology30 citations
Semantic Scholar
Reactivity studies on Fe(III)-(O2(2-))-Cu(II) compounds: influence of the ligand architecture and copper ligand denticity.
E. Chufán, Biplab Mondal, T. Gandhi, Eunsuk Kim +3 more
2007Inorganic Chemistry30 citations
Semantic Scholar
Infrared and Raman spectra of 5-amino-1,3,4-thiadiazole-2-sulfonamide (Hats). Experimental data and quantum chemistry calculations
G. Camí, E. Chufán, J. Pedregosa, E. Varetti
200128 citations
Semantic Scholar
Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp70*
K. Kapoor, Jaya Bhatnagar, E. Chufán, S. Ambudkar
2013Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Geometric and electronic structure of the heme-peroxo-copper complex [(F8TPP)FeIII-(O22-)-CuII(TMPA)](ClO4).
D. D. del Río, R. Sarangi, E. Chufán, K. Karlin +3 more
2005Journal of the American Chemical Society21 citations
Semantic Scholar
Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)
Andaleeb Sajid, S. Lusvarghi, E. Chufán, S. Ambudkar
2018PLoS ONE19 citations Open access
Semantic Scholar
Spectroscopic behavior of metal–drug complexes. Infrared spectra of Cu(II) dimer complexes with acetazolamide (H2acm) and an analogue sulfonamide (B-H2ats)
E. Chufán, J. Pedregosa, S. Ferrer, J. Borrás
199919 citations
Semantic Scholar
Further Insights into the Spectroscopic Properties, Electronic Structure, and Kinetics of Formation of the Heme−Peroxo−Copper Complex [(F8TPP)FeIII−(O22-)−CuII(TMPA)]+
R. Ghiladi, E. Chufán, D. D. del Río, E. Solomon +10 more
200718 citations
Semantic Scholar
Human-Mouse Chimeras With Normal Expression and Function Reveal That Major Domain Swapping is Tolerated by P-glycoprotein (ABCB1)
Kristen M. Pluchino, M. Hall, Janna K. Moen, E. Chufán +7 more
2016Biochemistry17 citations Open access
Semantic Scholar
Inhibition of Multidrug Resistance-Linked P-Glycoprotein (ABCB1) Function by 5′-Fluorosulfonylbenzoyl 5′-Adenosine: Evidence for an ATP Analog That Interacts With Both Drug-Substrate- and Nucleotide-Binding Sites
S. Ohnuma, E. Chufán, K. Nandigama, L. M. Miller Jenkins +4 more
2011Biochemistry16 citations Open access
Semantic Scholar
Generation and characterization of [(P)M-(X)-Co(TMPA)]n+ assemblies; P = Porphyrinate, M = FeIII and CoIII, X = O2-, OH-, O2(2-), and TMPA = tris(2-pyridylmethyl)amine.
E. Chufán, C. Verani, S. Puiu, E. Rentschler +4 more
2007Inorganic Chemistry16 citations
Semantic Scholar
SEVERAL COORDINATION MODES OF 5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE (HATS) WITH Cu(II), Ni(II) AND Zn(II): MIMETIC TERNARY COMPLEXES OF CARBONIC ANHYDRASE-INHIBITOR
E. Chufán, S. García-Granda, M. Díaz, J. Borrás +1 more
200116 citations
Semantic Scholar
Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna®) with the human ABC drug transporter P-glycoprotein
S. Shukla, E. Chufán, Satyakam Singh, A. P. Skoumbourdis +6 more
2014Leukemia12 citations Open access
Semantic Scholar
Conserved Walker A Cysteines 431 and 1074 in Human P-glycoprotein Are Accessible to Thiol-Specific Agents in the Apo and ADP-Vanadate Trapped Conformations
Hong-May Sim, Jaya Bhatnagar, E. Chufán, K. Kapoor +1 more
2013Biochemistry10 citations Open access
Semantic Scholar
Synthetic Models for Heme—Copper Oxidases
Eunsuk Kim, E. Chufán, K. Kamaraj, K. Karlin
20045 citations
Semantic Scholar
Bis(diethylenetriamine-κ3N)nickel(II) 5-amino-1,3,4-thiadiazole-2-sulfonamidate chloride monohydrate
M. Liu-González, F. Sanz-Ruiz, E. Chufán, J. Pedregosa +1 more
20013 citations
Semantic Scholar
Mapping Conformational Changes Associated with the Catalytic Cycle of Human P-Glycoprotein (ABCB1)
Jaya Bhatnagar, Hong-May Sim, Elka R Georgieva, K. Kapoor +6 more
20122 citations Open access
Semantic Scholar
Abstract 3242: Synthetic analogs of curcumin as modulators of multidrug resistance-linked ABC transporters
Megumi Obara, S. Ohnuma, E. Chufán, M. Ishida +8 more
20171 citations
Semantic Scholar
Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ABC transporter ABCG2
Megumi Murakami, S. Ohnuma, Michihiro Fukuda, E. Chufán +9 more
20171 citations
Semantic Scholar
Chemical Flexibility of P-Glycoprotein for Interaction with Substrates and Modulators
E. Chufán, K. Kapoor, Hong-May Sim, S. Durrell +1 more
20131 citations Open access
Semantic Scholar
Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM)
E. Chufán, S. Prigge, Xavier Siebert, B. Eipper +2 more
20101 citations
Semantic Scholar
Heme—Copper/Dioxygen Adduct Formation, Properties, and Reactivity
E. Chufán, S. Puiu, K. Karlin
20071 citations
Semantic Scholar
Abstract 1270: Human P-glycoprotein-mediated drug transport: Two aromatic residues in the drug-binding pocket are critical for function
Megumi Murakami, E. Chufán, S. Lusvarghi, S. Ambudkar
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 5217: Mechanism of polyspecificity of P-glycoprotein: Substitution of fifteen residues in the drug-binding pocket with tyrosine reveals a negative correlation between substrate size and transport
Shahrooz Vahedi, E. Chufán, S. Ambudkar
20170 citations
Semantic Scholar
Identification of Structural Motifs in P-Glycoprotein Responsible for the Drug-Mediated Inhibition of ATP Hydrolysis
E. Chufán, K. Kapoor, S. Ambudkar
20150 citations Open access
Semantic Scholar
Abstract 4422: TTT-28, a newly synthesized thiazole-valine peptide, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1 transporter
Yi-Jun Wang, Nagaraju Anreddy, Bhargav A. Patel, E. Chufán +7 more
20150 citations
Semantic Scholar
Abstract LB-224: Identification of a binding site for the tyrosine kinase inhibitor Nilotinib on the human ABC drug transporter, P-glycoprotein as determined by 3D-QSAR, molecular docking and mutational mapping
S. Shukla, E. Chufán, Satyakam Singh, A. P. Skoumbourdis +6 more
20140 citations
Semantic Scholar
Abstract 980: PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells.
Atish Patel, A. Tiwari, E. Chufán, Satyakam Singh +6 more
2013Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 898: Probing accessibility and conformational changes in ATP-binding sites during the catalytic cycle of human P-glycoprotein (ABCB1).
Hong-May Sim, Jaya Bhatnagar, S. Green, Adamar F. Gonzalez +2 more
20130 citations
Semantic Scholar
Abstract 897: Role of intracellular loops 1 and 3 in folding and cell surface expression of human P-glycoprotein (ABCB1).
K. Kapoor, Jaya Bhatnagar, E. Chufán, S. Ambudkar
20130 citations
Semantic Scholar
Abstract LB-222: Chemical and structural flexibility contribute to the broad substrate and modulator specificity of multidrug resistance-linked P-glycoprotein (ABCB1).
S. Ambudkar, E. Chufán, K. Kapoor, S. Durell +1 more
20130 citations
Semantic Scholar
Structural and mechanistic studies of peptidylglycine alpha‐amidating monooxygenase
L. Amzel, E. Chufán, K. Rudzka, B. Eipper +1 more
20110 citations
Semantic Scholar
OXIDIZED (CU2+) PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM) WITH BOUND SUBSTRATE
E. Chufán, B. Eipper, R. Mains, L. Amzel
20110 citations
Semantic Scholar
Peptidyl‐α‐Hydroxyglycine α‐Amidating Lyase (PAL)
E. Chufán, B. Eipper, R. Mains, M. Amzel
20100 citations
Semantic Scholar
Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide obtained by co-crystallization
E. Chufán, B. Eipper, R. Mains, L. Amzel
20100 citations
Semantic Scholar
Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006
E. Chufán, V. Lafont, E. Freire, L. Amzel
20100 citations
Semantic Scholar

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S. Ambudkar×29
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S. Ambudkar — researcher profile on SciRah
K. Kapoor×11
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K. Kapoor — researcher profile on SciRah
K. Karlin×10
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K. Karlin — researcher profile on SciRah
Hong-May Sim×7
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×7

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Satyakam Singh — researcher profile on SciRah

T. T. Talele×6

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Zhe-Sheng Chen×5

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