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K. Thielemans · SciRah

Researcher profile · Semantic Scholar

K. Thielemans

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K. Thielemans — researcher profile on SciRah

h-index: 73
Works: 333
Citations: 19K

Most-cited papers

Lung-resident eosinophils represent a distinct regulatory eosinophil subset.
Claire Mesnil, Stéfanie Raulier, G. Paulissen, Xue-lu Xiao +16 more
2016Journal of Clinical Investigation479 citations Open access
Semantic Scholar
Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas.
Guoying Zhou, D. Sprengers, P. Boor, M. Doukas +12 more
2017Gastroenterology382 citations
Semantic Scholar
Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma.
S. Wilgenhof, J. Corthals, C. Heirman, N. van Baren +4 more
2016Journal of Clinical Oncology267 citations
Semantic Scholar
Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend
H. Locy, S. de Mey, W. de Mey, M. de Ridder +2 more
2018Frontiers in Immunology224 citations Open access
Semantic Scholar
A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients.
S. Wilgenhof, A. V. Van Nuffel, D. Benteyn, J. Corthals +6 more
2013Annals of Oncology199 citations Open access
Semantic Scholar
mRNA-based dendritic cell vaccines
D. Benteyn, C. Heirman, A. Bonehill, K. Thielemans +1 more
2015Expert Review of Vaccines153 citations
Semantic Scholar
Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity.
Gregory Noël, Mireille Langouo Fontsa, S. Garaud, Pushpamali De Silva +15 more
2021Journal of Clinical Investigation152 citations Open access
Semantic Scholar
TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma
B. De Keersmaecker, S. Claerhout, J. Carrasco, I. Bar +4 more
2020Journal for ImmunoTherapy of Cancer133 citations Open access
Semantic Scholar
Challenges in neoantigen-directed therapeutics.
Lien Lybaert, Steve Lefever, B. Fant, E. Smits +9 more
2022Cancer Cell128 citations Open access
Semantic Scholar
Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety.
Kevin Van der Jeught, S. De Koker, Lukasz Bialkowski, C. Heirman +18 more
2018ACS Nano124 citations Open access
Semantic Scholar
The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy.
H. Dewitte, S. Van Lint, C. Heirman, K. Thielemans +3 more
2014Journal of Controlled Release117 citations Open access
Semantic Scholar
Trial watch: Dendritic cell (DC)-based immunotherapy for cancer
R. S. Laureano, J. Sprooten, Isaure Vanmeerbeerk, D. Borràs +21 more
2022Oncoimmunology110 citations Open access
Semantic Scholar
Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells
S. Van Lint, D. Renmans, K. Broos, L. Goethals +10 more
2015Cancer immunology research109 citations Open access
Semantic Scholar
Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon
K. Broos, Kevin Van der Jeught, J. Puttemans, C. Goyvaerts +6 more
2016Molecular Therapy: Nucleic Acids108 citations Open access
Semantic Scholar
Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula
S. Van Lint, S. Wilgenhof, C. Heirman, J. Corthals +4 more
2014Cancer Immunology and Immunotherapy88 citations
Semantic Scholar
The ReNAissanCe of mRNA-based cancer therapy
S. Van Lint, D. Renmans, K. Broos, H. Dewitte +4 more
2015Expert Review of Vaccines80 citations
Semantic Scholar
Neo-Antigen mRNA Vaccines
Arthur Esprit, W. de Mey, Rajendra Bahadur Shahi, K. Thielemans +2 more
2020Vaccines79 citations Open access
Semantic Scholar
Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity
Kevin Van der Jeught, P. Joe, Lukasz Bialkowski, C. Heirman +5 more
2014OncoTarget76 citations Open access
Semantic Scholar
Phase I clinical trial of an intranodally administered mRNA-based therapeutic vaccine against HIV-1 infection
L. Leal, A. Guardo, S. Morón-López, M. Salgado +16 more
2018AIDS (London)75 citations Open access
Semantic Scholar
Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs.
S. Du Four, Sarah K. Maenhout, S. Niclou, K. Thielemans +2 more
2016American Journal of Cancer Research75 citations
Semantic Scholar
A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases
Y. Jansen, V. Kruse, J. Corthals, K. Schats +7 more
2020Cancer Immunology and Immunotherapy72 citations Open access
Semantic Scholar
Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours
Lukasz Bialkowski, Alexia van Weijnen, Kevin Van der Jeught, D. Renmans +6 more
2016Scientific Reports72 citations Open access
Semantic Scholar
Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells
K. De Veirman, J. V. Van Ginderachter, Susanne Lub, Nathan De Beule +9 more
2015OncoTarget72 citations Open access
Semantic Scholar
Location, location, location: functional and phenotypic heterogeneity between tumor-infiltrating and non-infiltrating myeloid-derived suppressor cells
Sarah K. Maenhout, K. Thielemans, J. Aerts
2014Oncoimmunology72 citations Open access
Semantic Scholar
Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model
S. Du Four, Sarah K. Maenhout, Kari De Pierre, D. Renmans +4 more
2015Oncoimmunology71 citations Open access
Semantic Scholar
Long-term clinical outcome of melanoma patients treated with messenger RNA-electroporated dendritic cell therapy following complete resection of metastases
S. Wilgenhof, J. Corthals, A. V. Van Nuffel, D. Benteyn +4 more
2015Cancer Immunology and Immunotherapy70 citations
Semantic Scholar
Enhanced suppressive capacity of tumor‐infiltrating myeloid‐derived suppressor cells compared with their peripheral counterparts
Sarah K. Maenhout, S. Van Lint, Perpetua U. Emeagi, K. Thielemans +1 more
2014International Journal of Cancer67 citations Open access
Semantic Scholar
Targeting the tumor microenvironment to enhance antitumor immune responses
Kevin Van der Jeught, Lukasz Bialkowski, L. Daszkiewicz, K. Broos +6 more
2014OncoTarget66 citations Open access
Semantic Scholar
A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor–Infiltrating Lymphocytes
N. Demotte, René Bigirimana, Grégoire Wieërs, V. Stroobant +7 more
2014Clinical Cancer Research58 citations Open access
Semantic Scholar
Modulation of Regulatory T Cell Function by Monocyte-Derived Dendritic Cells Matured through Electroporation with mRNA Encoding CD40 Ligand, Constitutively Active TLR4, and CD70
J. Pen, B. De Keersmaecker, Sarah K. Maenhout, A. V. Van Nuffel +7 more
2013Journal of Immunology53 citations Open access
Semantic Scholar
mRNA
S. Van Lint, C. Heirman, K. Thielemans, K. Breckpot
2013Human Vaccines & Immunotherapeutics52 citations Open access
Semantic Scholar
iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy
W. de Jong, J. Aerts, S. Allard, C. Brander +10 more
2019Trials48 citations Open access
Semantic Scholar
Long-Peptide Cross-Presentation by Human Dendritic Cells Occurs in Vacuoles by Peptide Exchange on Nascent MHC Class I Molecules
Wenbin Ma, Yi Zhang, Nathalie Vigneron, V. Stroobant +3 more
2016Journal of Immunology46 citations Open access
Semantic Scholar
Current status and perspectives of immune-based therapies for hepatocellular carcinoma.
M. Aerts, D. Benteyn, H. van Vlierberghe, K. Thielemans +1 more
2016World Journal of Gastroenterology43 citations Open access
Semantic Scholar
Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell numbers and T cell exhaustion
S. Du Four, Sarah K. Maenhout, D. Benteyn, B. De Keersmaecker +4 more
2016Cancer Immunology and Immunotherapy42 citations
Semantic Scholar
Thymus‐derived regulatory T cells restrain pro‐inflammatory Th1 responses by downregulating CD70 on dendritic cells
Maxime Dhainaut, Caroline Coquerelle, Sophie Uzureau, Julie Denoeud +9 more
2015EMBO Journal39 citations Open access
Semantic Scholar
Preclinical evaluation of an mRNA HIV vaccine combining rationally selected antigenic sequences and adjuvant signals (HTI-TriMix)
A. Guardo, P. Joe, L. Miralles, M. Bargalló +8 more
2016AIDS (London)38 citations
Semantic Scholar
Immune checkpoint blockade combined with IL‐6 and TGF‐β inhibition improves the therapeutic outcome of mRNA‐based immunotherapy
Lukasz Bialkowski, Kevin Van der Jeught, Sanne Bevers, Patrick Tjok Joe +4 more
2018International Journal of Cancer36 citations
Semantic Scholar
Single-Domain Antibody Nuclear Imaging Allows Noninvasive Quantification of LAG-3 Expression by Tumor-Infiltrating Leukocytes and Predicts Response of Immune Checkpoint Blockade
Q. Lecocq, R. M. Awad, Y. De Vlaeminck, W. de Mey +7 more
2021Journal of Nuclear Medicine35 citations Open access
Semantic Scholar
Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients
T. Seremet, A. Koch, Y. Jansen, M. Schreuer +11 more
2016Journal of Translational Medicine35 citations Open access
Semantic Scholar
Immunomodulatory drugs improve the immune environment for dendritic cell-based immunotherapy in multiple myeloma patients after autologous stem cell transplantation
B. De Keersmaecker, K. Fostier, J. Corthals, S. Wilgenhof +4 more
2014Cancer Immunology and Immunotherapy34 citations
Semantic Scholar
Impact of lenalidomide maintenance on the immune environment of multiple myeloma patients with low tumor burden after autologous stem cell transplantation
K. Fostier, J. Caers, N. Meuleman, K. Broos +4 more
2018OncoTarget30 citations Open access
Semantic Scholar
Therapeutic Vaccine in Chronically HIV-1-Infected Patients: A Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial with HTI-TriMix
W. de Jong, L. Leal, J. Buyze, P. Pannus +16 more
2019Vaccines29 citations Open access
Semantic Scholar
Neoantigen-directed therapeutics in the clinic: where are we?
Lien Lybaert, K. Thielemans, Steven A. Feldman, S. van der Burg +2 more
2023Trends in Cancer28 citations Open access
Semantic Scholar
Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring
H. Locy, S. Verhulst, Wilfried Cools, W. Waelput +8 more
2022Frontiers in Immunology28 citations Open access
Semantic Scholar
Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation
Willem Staels, Yannick Verdonck, Y. Heremans, G. Leuckx +8 more
2018Diabetologia28 citations Open access
Semantic Scholar
Immunogenicity of targeted lentivectors
C. Goyvaerts, Decker Kurt, S. Van Lint, C. Heirman +5 more
2014OncoTarget25 citations Open access
Semantic Scholar
AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells
Sarah K. Maenhout, S. Du Four, J. Corthals, B. Neyns +2 more
2014OncoTarget25 citations Open access
Semantic Scholar
Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice
P. Joe, Ioanna Christopoulou, L. Van Hoecke, B. Schepens +5 more
2019Journal of Translational Medicine24 citations Open access
Semantic Scholar
Single‐domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages
Y. De Vlaeminck, Q. Lecocq, P. Giron, C. Heirman +9 more
2019Journal of Controlled Release23 citations Open access
Semantic Scholar

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