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M. Sheardown · SciRah

Researcher profile · Semantic Scholar

M. Sheardown

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M. Sheardown — researcher profile on SciRah

h-index: 32
Works: 105
Citations: 4,620

Most-cited papers

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
M. Sheardown, E. Nielsen, A. Hansen, P. Jacobsen +1 more
1990Science1,119 citations
Semantic Scholar
Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells
R. Porter, K. Benwell, H. Lamb, C. Malcolm +4 more
1999British Journal of Pharmacology382 citations Open access
Semantic Scholar
Regional Changes in Interstitial K+ and Ca2+ Levels following Cortical Compression Contusion Trauma in Rats
P. Nilsson, L. Hillered, Y. Olsson, M. Sheardown +1 more
1993Journal of Cerebral Blood Flow and Metabolism285 citations Open access
Semantic Scholar
Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.
H. Shannon, F. Bymaster, D. Calligaro, B. Greenwood +9 more
1994Journal of Pharmacology and Experimental Therapeutics195 citations
Semantic Scholar
AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h.
M. Sheardown, P. Suzdak, L. Nordholm
1993European Journal of Pharmacology190 citations
Semantic Scholar
Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.
H. Shannon, K. Rasmussen, F. Bymaster, J. Hart +6 more
2000Schizophrenia Research151 citations
Semantic Scholar
Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .
P. Sauerberg, P. Olesen, S. Nielsen, S. Treppendahl +6 more
1992Journal of Medicinal Chemistry148 citations Open access
Semantic Scholar
Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.
G. Castillo, J. Cummings, Wen-Hua Yang, M. Judge +4 more
1998Diabetes145 citations
Semantic Scholar
The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.
K. Stanhope, N. Mirza, M. Bickerdike, J. Bright +10 more
2001Journal of Pharmacology and Experimental Therapeutics120 citations
Semantic Scholar
Protection against ischemic hippocampal CAI damage in the rat with a new non‐NMDA antagonist, NBQX
N. H. Diemer, M. B. Jørgensen, F. Johansen, M. Sheardown +1 more
1992Acta Neurologica Scandinavica111 citations Open access
Semantic Scholar
Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease
F. Bymaster, C. Whitesitt, H. Shannon, N. Delapp +13 more
1997102 citations
Semantic Scholar
Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane .
F. Bymaster, H. Shannon, K. Rasmussen, N. Delapp +9 more
1998European Journal of Pharmacology91 citations
Semantic Scholar
Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.
H. Shannon, J. Hart, F. Bymaster, D. Calligaro +8 more
1999Journal of Pharmacology and Experimental Therapeutics74 citations
Semantic Scholar
The triggering of spreading depression in the chicken retina: a pharmacological study.
M. Sheardown
1993Brain Research67 citations
Semantic Scholar
Changes in Metabotropic Glutamate Receptor mRNA Levels Following Global Ischemia: Increase of a Putative Presynaptic Subtype (mGluR4) in Highly Vulnerable Rat Brain Areas
L. Iversen, E. Mulvihill, Betty A. Haldeman, Nils Henrik Diemer +3 more
1994Journal of Neurochemistry66 citations
Semantic Scholar
Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232).
F. Bymaster, D. Wong, C. Mitch, J. S. Ward +8 more
1994Journal of Pharmacology and Experimental Therapeutics62 citations
Semantic Scholar
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
F. Bymaster, Petra A. Carter, S. Peters, Wei Zhang +11 more
1998Brain Research61 citations
Semantic Scholar
Protection against post-ischemic behavioral pathology by the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil.
M. Judge, M. Sheardown, P. Jacobsen, T. Honoré
1991Neuroscience Letters56 citations
Semantic Scholar
Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice.
Harold Dadomo, V. Sanghez, Luisana Di Cristo, A. Lori +6 more
2011Progress in Neuro-psychopharmacology and Biological Psychiatry51 citations
Semantic Scholar
M1 receptor agonist activity is not a requirement for muscarinic antinociception.
M. Sheardown, H. Shannon, Michael D B Swedberg, P. Suzdak +5 more
1997Journal of Pharmacology and Experimental Therapeutics50 citations
Semantic Scholar
(S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice
C. Thomsen, H. Klitgaard, M. Sheardown, H. C. Jackson +4 more
1994Journal of Neurochemistry48 citations
Semantic Scholar
Amino acid receptor mediated excitatory synaptic transmission in the cat red nucleus.
J. Davies, A. J. Miller, M. Sheardown
1986Journal of Physiology43 citations Open access
Semantic Scholar
Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.
Thøger Rasmussen, P. Sauerberg, E. B. Nielsen, Michael D B Swedberg +10 more
2000European Journal of Pharmacology41 citations
Semantic Scholar
Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships.
P. Sauerberg, J. Kindtler, L. Nielsen, M. Sheardown +1 more
1991Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischemia.
F. Barone, W. Price, P. Jakobsen, M. Sheardown +1 more
1994Pharmacology, Biochemistry and Behavior38 citations
Semantic Scholar
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
M. Sheardown, Jørgen Drejer, L. H. Jensen, C. E. Stidsen +1 more
1989European Journal of Pharmacology36 citations
Semantic Scholar
Unchanged balance between levels of mRNA encoding AMPA glutamate receptor subtypes following global cerebral ischemia in the rat.
L. Frank, Nils Henrik Diemer, F. Kaiser, M. Sheardown +2 more
1995Acta Neurologica Scandinavica32 citations
Semantic Scholar
A new and specific non-NMDA receptor antagonist, FG 9065, blocks L-AP4-evoked depolarization in rat cerebral cortex.
M. Sheardown
1988European Journal of Pharmacology32 citations
Semantic Scholar
Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.
P. Sauerberg, Lone Jeppesen, P. Olesen, Thøger Rasmussen +11 more
1998Journal of Medicinal Chemistry31 citations
Semantic Scholar
Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic.
Michael D B Swedberg, M. Sheardown, P. Sauerberg, P. Olesen +8 more
1997Journal of Pharmacology and Experimental Therapeutics30 citations
Semantic Scholar
Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex.
M. Sheardown
1992NeuroReport30 citations
Semantic Scholar
Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.
N. DeLapp, Su Wu, Rama M. Belagaje, E. Johnstone +12 more
1998Biochemical and Biophysical Research Communications - BBRC29 citations
Semantic Scholar
Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.
J. Drejer, M. Sheardown, E. Nielsen, Tage Honore
1989Neuroscience Letters28 citations
Semantic Scholar
1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.
J. S. Ward, L. Merritt, D. Calligaro, F. Bymaster +9 more
1998Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity.
H. Shannon, M. Sheardown, F. Bymaster, D. Calligaro +11 more
1997Journal of Pharmacology and Experimental Therapeutics26 citations
Semantic Scholar
Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles.
J. S. Ward, L. Merritt, D. Calligaro, F. Bymaster +9 more
1995Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats.
Anders Fink-Jensen, P. Kristensen, Harlan E. Shannon, D. Calligaro +9 more
1998NeuroReport24 citations
Semantic Scholar
Selective potentiating effect of β-p-chlorophenylglutamate on responses induced by certain sulphur-containing excitatory amino acids and quisqualate
J. Davies, A. Francis, D. Oakes, M. Sheardown +1 more
198521 citations
Semantic Scholar
In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist.
H. Shannon, D. Womer, F. Bymaster, D. Calligaro +10 more
1997Life Science20 citations
Semantic Scholar
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.
C. Mitch, T. Brown, F. Bymaster, D. Calligaro +14 more
1997Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Muscarinic M1receptor agonists and M2 receptor antagonists as therapeutic targets in Alzheimer’s disease
M. Sheardown
200217 citations
Semantic Scholar
Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.
P. Sauerberg, P. Olesen, M. Sheardown, P. Suzdak +6 more
1995Life Science16 citations
Semantic Scholar
1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.
Lone Jeppesen, P. Olesen, Lena Hansen, M. Sheardown +13 more
1999Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
3-(3-Alkylthio- 1,2,5-thiadiazol-4-yl)- 1 -azabicycles. Structure-activity relationships for antinociception mediated by central muscarinic receptors
P. Olesen, P. Sauerberg, S. Treppendahl, O. Larsson +7 more
199615 citations
Semantic Scholar
The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties
L. J. Knutsen, J. Lau, M. Sheardown, C. Thomsen
199315 citations
Semantic Scholar
The pharmacology of AMPA receptors and their antagonists.
M. Sheardown
1993Stroke15 citations
Semantic Scholar
Effect of the Non‐NMDA Receptor Antagonist, 2,3‐Dihydro‐6‐Nitro‐7‐Sulfamoylbenzo(f)quinoxaline, on Local Cerebral Glucose Uptake in the Limbic Forebrain
P. Suzdak, M. Sheardown
1993Journal of Neurochemistry14 citations
Semantic Scholar
Anticonvulsant Actions of Novel and Reference Adenosine Agonists
L. J. Knutsen, J. Lau, M. Sheardown, K. Eskesen +4 more
199512 citations
Semantic Scholar
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
P. Suzdak, M. Sheardown, Tage Honore
1993European Journal of Pharmacology11 citations
Semantic Scholar
Novel Functional M1 Selective Muscarinic Agonists. Synthesis and Structure→Activity Relationships of 3‐(1,2,5‐Thiadiazolyl)‐1,2,5,6‐tetrahydro‐1‐methylpyridines.
P. Sauerberg, P. Olesen, S. Nielsen, S. Treppendahl +8 more
199211 citations
Semantic Scholar

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J. S. Ward×22
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F. Bymaster×20
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H. Shannon×19
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D. Calligaro — researcher profile on SciRah

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C. Mitch — researcher profile on SciRah

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Michael D B Swedberg×17

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Michael D B Swedberg — researcher profile on SciRah

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Lone Jeppesen×9

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