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V. Leytin · SciRah

Researcher profile · Semantic Scholar

V. Leytin

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V. Leytin — researcher profile on SciRah

h-index: 24
Works: 76
Citations: 2,381

Most-cited papers

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
June Li, D. E. van der Wal, Guang-Heng Zhu, Miao Xu +16 more
2015Nature Communications366 citations Open access
Semantic Scholar
Apoptosis in the anucleate platelet.
V. Leytin
2012Blood reviews198 citations
Semantic Scholar
Thrombin‐triggered platelet apoptosis
V. Leytin, D. Allen, S. Mykhaylov, E. Lyubimov +1 more
2006Journal of Thrombosis and Haemostasis172 citations Open access
Semantic Scholar
Pathologic high shear stress induces apoptosis events in human platelets.
V. Leytin, D. Allen, S. Mykhaylov, L. Mis +3 more
2004Biochemical and Biophysical Research Communications - BBRC136 citations
Semantic Scholar
Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation
A. Reheman, P. Gross, H. Yang, P. Chen +4 more
2005Journal of Thrombosis and Haemostasis127 citations Open access
Semantic Scholar
Platelet apoptosis in stored platelet concentrates and other models.
V. Leytin, J. Freedman
2003Transfusion and Apheresis Science122 citations
Semantic Scholar
Markers of platelet apoptosis: methodology and applications
A. Gyulkhandanyan, A. Mutlu, J. Freedman, V. Leytin
2012Journal of Thrombosis and Thrombolysis101 citations
Semantic Scholar
Human peritoneal fibroblasts are a potent source of neutrophil-targeting cytokines: a key role of IL-1β stimulation
V. Leytin, D. Allen, A. Mutlu, A. Gyulkhandanyan +2 more
2009Laboratory Investigation97 citations Open access
Semantic Scholar
Role of platelet surface glycoprotein Ibα and P‐selectin in the clearance of transfused platelet concentrates
V. Leytin, D. Allen, A. Gwozdz, B. Garvey +1 more
2004Transfusion86 citations
Semantic Scholar
Intravenous immunoglobulin inhibits anti‐glycoprotein IIb‐induced platelet apoptosis in a murine model of immune thrombocytopenia
V. Leytin, S. Mykhaylov, A. F. Starkey, D. Allen +5 more
2006British Journal of Haematology83 citations Open access
Semantic Scholar
Platelet activation and apoptosis are different phenomena: evidence from the sequential dynamics and the magnitude of responses during platelet storage
V. Leytin, D. Allen, A. Mutlu, S. Mykhaylov +2 more
2008British Journal of Haematology65 citations
Semantic Scholar
Higher thrombin concentrations are required to induce platelet apoptosis than to induce platelet activation
V. Leytin, D. Allen, E. Lyubimov, J. Freedman
2007British Journal of Haematology61 citations
Semantic Scholar
Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations.
V. Leytin, M. Mody, J. Semple, B. Garvey +1 more
2000Biochemical and Biophysical Research Communications - BBRC58 citations
Semantic Scholar
Selective triggering of platelet apoptosis, platelet activation or both
A. Gyulkhandanyan, A. Mutlu, J. Freedman, V. Leytin
2013British Journal of Haematology44 citations
Semantic Scholar
Human plasma fibronectin promotes the adhesion and spreading of platelets on surfaces coated with fibrillar collagen
V. Koteliansky, V. Leytin, D. Sviridov, V. S. Repin +1 more
1981FEBS Letters44 citations Open access
Semantic Scholar
Activation of caspases‐9, ‐3 and ‐8 in human platelets triggered by BH3‐only mimetic ABT‐737 and calcium ionophore A23187: caspase‐8 is activated via bypass of the death receptors
A. Mutlu, A. Gyulkhandanyan, J. Freedman, V. Leytin
2012British Journal of Haematology41 citations
Semantic Scholar
Quantification of platelet activation status by analyzing P-selectin expression.
V. Leytin, M. Mody, J. Semple, B. Garvey +1 more
2000Biochemical and Biophysical Research Communications - BBRC40 citations
Semantic Scholar
Study of low density lipoprotein interaction with platelets by flow cytofluorimetry
A. Mazurov, S. N. Preobrazhensky, V. Leytin, V. S. Repin +1 more
1982FEBS Letters39 citations
Semantic Scholar
Endothelial cell culture on fibrillar collagen: model to study platelet adhesion and liposome targeting to intercellular collagen matrix.
E. Chazov, A. Alexeev, A. S. Antonov, V. Koteliansky +6 more
1981Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
Semantic Scholar
CD154 (CD40 ligand)‐deficient mice exhibit prolonged bleeding time and decreased shear‐induced platelet aggregates
A. R. Crow, V. Leytin, A. F. Starkey, M. L. Rand +1 more
2003Journal of Thrombosis and Haemostasis36 citations Open access
Semantic Scholar
Mitochondrial Inner Membrane Depolarization as a Marker of Platelet Apoptosis
A. Gyulkhandanyan, D. Allen, S. Mykhaylov, E. Lyubimov +3 more
2017Clinical and applied thrombosis/hemostasis27 citations Open access
Semantic Scholar
Hemolink™, an o‐raffinose cross‐linked haemoglobin‐based oxygen carrier, does not affect activation and function of human platelets in whole blood in vitro
V. Leytin, D. Mazer, M. Mody, B. Garvey +1 more
2003British Journal of Haematology25 citations Open access
Semantic Scholar
Mitochondrial permeability transition pore (MPTP)‐dependent and ‐independent pathways of mitochondrial membrane depolarization, cell shrinkage and microparticle formation during platelet apoptosis
A. Gyulkhandanyan, A. Mutlu, J. Freedman, V. Leytin
2015British Journal of Haematology24 citations Open access
Semantic Scholar
Interaction of stable prostaglandin endoperoxide analogs U46619 and U44069 with human platelet membranes: coupling of receptors with high-affinity GTPase and adenylate cyclase.
P. Avdonin, I. V. Svitina-Ulitina, V. Leytin, V. Tkachuk
1985Thrombosis Research24 citations
Semantic Scholar
Concurrent and separate inside‐out transition of platelet apoptosis and activation markers to the platelet surface
A. Mutlu, A. Gyulkhandanyan, J. Freedman, V. Leytin
2013British Journal of Haematology23 citations
Semantic Scholar
BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet shrinkage and microparticle formation.
A. Gyulkhandanyan, A. Mutlu, D. Allen, J. Freedman +1 more
2014Thrombosis Research21 citations
Semantic Scholar
Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil
A. Mazurov, M. Men'shikov, V. Leytin, V. Tkachuk +1 more
1984FEBS Letters20 citations Open access
Semantic Scholar
A rabbit model for monitoring in vivo viability of human platelet concentrates using flow cytometry
V. Leytin, D. Allen, M. Mody, Margaret L. Rand +3 more
2002Transfusion19 citations
Semantic Scholar
Endothelial cell cultures of fibrillar collagen: partial reconstitution of the vessel wall and platelet adhesion.
V. Leytin, E. V. Ljubimova, D. Sviridov, O. Zakharova +2 more
1980Thrombosis Research19 citations
Semantic Scholar
Sepsis- and endotoxemia-generated cytokines do not trigger activation of human platelets
V. Leytin, S. Shakoor, M. Mody, D. Allen +2 more
2002Critical Care Medicine18 citations
Semantic Scholar
Flow cytometric analysis of the platelet surface area and surface density of glycoprotein IIb-IIIa of unactivated human platelets of various sizes.
V. Leytin, H. Shapiro, I. Novikov, J. Radnay
1996Biochemical and Biophysical Research Communications - BBRC18 citations
Semantic Scholar
Step-by-step analysis of adhesion of human platelets to a collagen-coated surface defect in initial attachment and spreading of platelets in von Willebrand's disease.
V. Leytin, N. A. Gorbunova, F. Misselwitz, I. Novikov +5 more
1984Thrombosis Research18 citations
Semantic Scholar
Time-response changes in the thrombogenicity of platelets spread on a collagen-coated surface.
V. Leytin, E. V. Ljubimova, D. Sviridov, V. S. Repin +1 more
1980Thrombosis Research18 citations
Semantic Scholar
A mathematical model of the kinetics of platelets and plasma hemostasis system interaction.
M. Khanin, V. Leytin, A. Popov
1991Thrombosis Research15 citations
Semantic Scholar
Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors
V. Leytin, A. Gyulkhandanyan, J. Freedman
2019Clinical and applied thrombosis/hemostasis11 citations Open access
Semantic Scholar
Effect of metabolic inhibitors on platelet attachment, spreading and aggregation on collagen-coated surfaces.
F. Misselwitz, V. Leytin, V. S. Repin
1987Thrombosis Research10 citations
Semantic Scholar
Ribonucleoprotein complexes containing messenger ribonucleic acid from rat liver polyribosomes: analysis of conditions of their appearance after diaminoethane tetra-acetic acid treatment of polyribosomes.
V. Leytin, O. Podobed, M. Lerman
1970Journal of Molecular Biology10 citations
Semantic Scholar
The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187
V. Leytin, A. Mutlu, S. Mykhaylov, D. Allen +2 more
2009Haematologica9 citations Open access
Semantic Scholar
The role of platelet prostanoids and dense granule compounds in initial attachment, spreading and aggregation of platelets on collagen substrates.
V. Leytin, F. Misseiwitz, E. Lyubimova, S. P. Domogatsky
1989Thrombosis Research9 citations
Semantic Scholar
Arachidonic acid and stable analogue of prostaglandin endoperoxides (U46619) induce platelet spreading and thrombi-like aggregate formation on a collagen substrate. Effect of fluid dynamics.
A. Mazurov, V. Leytin, V. S. Repin, V. Smirnov +1 more
1983Thrombosis Research9 citations
Semantic Scholar
Role of mitochondrial membrane permeabilization and depolarization in platelet apoptosis
V. Leytin, A. Gyulkhandanyan, J. Freedman
2018British Journal of Haematology8 citations Open access
Semantic Scholar
Stored platelet concentrates produced by the platelet‐rich plasma method are more resistant to apoptosis but more sensitive to activation than are platelets prepared by the buffy‐coat and apheresis methods
V. Leytin, D. Allen, A. Mutlu, S. Mykhaylov +2 more
2009Transfusion8 citations
Semantic Scholar
Platelet Spreading and Thrombi-Formation in Vitro
V. Leytin, S. P. Domogatsky, V. Koteliansky, A. Mazurov +5 more
19847 citations
Semantic Scholar
A Model for Studying Platelet Interaction with Cellular and Macromolecular Constituents of the Vessel Wall In Vitro
V. Leytin, D. Sviridov
19827 citations
Semantic Scholar
Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia
June Li, D. E. van der Wal, Guang-Heng Zhu, Miao Xu +15 more
20146 citations
Semantic Scholar
Ca2+ binding and charge movements in membranes of platelets and sarcoplasmic reticulum
D. Levitsky, V. Loginov, A. Lebedev, T. Levchenko +1 more
1984FEBS Letters6 citations
Semantic Scholar
Platelet prostanoids in interaction of platelets with collagen substrates. I. Activation of platelets by surfaces coated with different types of human collagen.
V. Leytin, F. Misselwitz, S. P. Domogatsky, S. Jahn +2 more
1984Biomedica biochimica acta5 citations
Semantic Scholar
Effects of prostacyclin analogue (carbacyclin) on the interaction of platelets with different collagen substrates. Inhibition of cAMP increase by collagens type I, III, and IV.
A. Mazurov, F. Misselwitz, U. Hoffman, V. Leytin +1 more
1988Prostaglandins4 citations
Semantic Scholar
How to Avoid False-Negative and False-Positive Diagnoses of Platelet Apoptosis: Illustrative Experimental and Clinically Relevant Cases
V. Leytin, A. Gyulkhandanyan, J. Freedman
2018Clinical and applied thrombosis/hemostasis3 citations Open access
Semantic Scholar
Extending storage of human platelets from 5 to 7 or 8 days does not significantly reduce their in vivo recovery and survival in a rabbit model
V. Leytin, D. Allen, B. Garvey, J. Freedman
2003Transfusion3 citations
Semantic Scholar

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