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L. Marton · SciRah

Researcher profile · Semantic Scholar

L. Marton

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L. Marton — researcher profile on SciRah

h-index: 33
Works: 153
Citations: 5,729

Most-cited papers

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
R. A. Casero, L. Marton
2007Nature reviews. Drug discovery744 citations
Semantic Scholar
Polyamines as targets for therapeutic intervention.
L. Marton, A. Pegg
1995Annual Review of Pharmacology and Toxicology682 citations
Semantic Scholar
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
T. Schenk, W. Chen, Stefanie Göllner, L. Howell +16 more
2012Nature Medicine631 citations Open access
Semantic Scholar
Subtype and pathway specific responses to anticancer compounds in breast cancer
L. Heiser, A. Sadanandam, Wen-Lin Kuo, S. Benz +39 more
2011Proceedings of the National Academy of Sciences of the United States of America482 citations Open access
Semantic Scholar
Novel oligoamine analogues inhibit lysine-specific demethylase 1 (LSD1) and induce re-expression of epigenetically silenced genes
Yi Huang, T. M. Stewart, Yu Wu, S. Baylin +5 more
2009Clinical Cancer Research196 citations Open access
Semantic Scholar
Polyamine analogues modulate gene expression by inhibiting Lysine-Specific Demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells
Qingsong Zhu, Yi Huang, L. Marton, P. Woster +2 more
2011Amino Acids93 citations Open access
Semantic Scholar
The Polyamine Binding Site in Inward Rectifier K+ Channels
H. Kurata, L. Marton, C. Nichols
2006The Journal of General Physiology88 citations Open access
Semantic Scholar
Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy
Ying Xie, Tracy Murray-Stewart, Ya-Zhe Wang, Fei Yu +4 more
2016Journal of Controlled Release86 citations Open access
Semantic Scholar
A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.
Yi Huang, E. Hager, D. Phillips, Valerie R. Dunn +8 more
2003Clinical Cancer Research77 citations
Semantic Scholar
Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection
C. Bacchi, L. Weiss, S. Lane, B. Frydman +8 more
2002Antimicrobial Agents and Chemotherapy61 citations Open access
Semantic Scholar
Polyamine analogues targeting epigenetic gene regulation
Yi Huang, L. Marton, P. Woster, R. A. Casero
2009Essays in Biochemistry59 citations Open access
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Antizyme induction by polyamine analogues as a factor of cell growth inhibition.
John L. A. Mitchell, Aviva Leyser, Michelle S Holtorff, Jill S Bates +4 more
2002Biochemical Journal59 citations Open access
Semantic Scholar
Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells
W. Devereux, Yanlin Wang, T. M. Stewart, A. Hacker +8 more
2003Cancer Chemotherapy and Pharmacology56 citations
Semantic Scholar
Long-chain polyamines (oligoamines) exhibit strong cytotoxicities against human prostate cancer cells.
Aldonia L. Valasinas, V. K. Reddy, A. Blokhin, H. Basu +4 more
2003Bioorganic & Medicinal Chemistry43 citations
Semantic Scholar
In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells
A. Hacker, L. Marton, Michelle Sobolewski, R. A. Casero
2008Cancer Chemotherapy and Pharmacology39 citations Open access
Semantic Scholar
A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice
B. Frydman, C. Porter, Y. Maxuitenko, A. Sarkar +6 more
2003Cancer Chemotherapy and Pharmacology39 citations
Semantic Scholar
Polyamine Analogues Down-regulate Estrogen Receptor α Expression in Human Breast Cancer Cells*
Yi Huang, J. Keen, Allison Pledgie, L. Marton +7 more
2006Journal of Biological Chemistry38 citations Open access
Semantic Scholar
A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047
Wen-Lin Kuo, D. Das, S. Ziyad, Sanchita Bhattacharya +13 more
2009BMC Medicine37 citations Open access
Semantic Scholar
Leishmania donovani Polyamine Biosynthetic Enzyme Overproducers as Tools To Investigate the Mode of Action of Cytotoxic Polyamine Analogs
Sigrid C. Roberts, Yuqui Jiang, Judith E. Gasteier, B. Frydman +3 more
2007Antimicrobial Agents and Chemotherapy37 citations Open access
Semantic Scholar
Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells.
Yi Huang, J. Keen, E. Hager, Renee Smith +7 more
2004Molecular Cancer Research37 citations
Semantic Scholar
Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells.
B. Frydman, S. Bhattacharya, A. Sarkar, K. Drandarov +8 more
2004Journal of Medicinal Chemistry34 citations
Semantic Scholar
A new model for disruption of the ornithine decarboxylase gene, SPE1, in Saccharomyces cerevisiae exhibits growth arrest and genetic instability at the MAT locus.
B. Schwartz, A. Hittelman, L. Daneshvar, Hirak S. Basu +2 more
1995Biochemical Journal33 citations Open access
Semantic Scholar
Radiation brain injury is reduced by the polyamine inhibitor alpha-difluoromethylornithine.
John R. Fike, G. T. Gobbel, L. Marton, Theresa M. Seilhan
1994Radiation Research33 citations
Semantic Scholar
Antizyme induction mediates feedback limitation of the incorporation of specific polyamine analogues in tissue culture.
John L. A. Mitchell, Carrie Simkus, T. Thane, Phil Tokarz +5 more
2004Biochemical Journal32 citations Open access
Semantic Scholar
Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes
Yu Wu, Nora Steinbergs, Tracy Murray-Stewart, L. Marton +1 more
2011Biochemical Journal31 citations Open access
Semantic Scholar
Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo
G. Zagaja, Maneesh Shrivastav, L. Marton, C. Rinker-Schaeffer +2 more
1998Cancer Chemotherapy and Pharmacology31 citations
Semantic Scholar
The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer
K. Dredge, J. Kink, Randolph M. Johnson, Ian Bytheway +1 more
2009Cancer Chemotherapy and Pharmacology27 citations
Semantic Scholar
Differential polyamine analogue effects in four human breast cancer cell lines.
C. Holst, B. Frydman, L. Marton, S. Oredsson
2006Toxicology26 citations
Semantic Scholar
Suppression and regression of choroidal neovascularization by polyamine analogues.
R. L. Silva, Y. Saishin, Y. Saishin, Hideo Akiyama +11 more
2005Investigative Ophthalmology and Visual Science26 citations Open access
Semantic Scholar
Scanning the Topography of Polyamine Blocker Binding in an Inwardly Rectifying Potassium Channel*
H. Kurata, Alejandro Akrouh, Jenny B. W. Li, L. Marton +1 more
2013Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel.
H. Kurata, Karthikeyan Diraviyam, L. Marton, C. Nichols
2008Biophysical Journal25 citations Open access
Semantic Scholar
Cyclopropane-containing polyamine analogues are efficient growth inhibitors of a human prostate tumor xenograft in nude mice.
B. Frydman, A. Blokhin, S. Brummel, G. Wilding +9 more
2003Journal of Medicinal Chemistry25 citations
Semantic Scholar
Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047
Tracy Murray-Stewart, E. Ferrari, Ying Xie, Fei Yu +3 more
2017PLoS ONE24 citations Open access
Semantic Scholar
Role of ornithine decarboxylase suppression and polyamine depletion in the antiproliferative activity of polyamine analogs.
L. Ghoda, H. Basu, C. Porter, L. Marton +1 more
1992Molecular Pharmacology24 citations
Semantic Scholar
Attachment of A172 human glioblastoma cells affects calcium signalling: a comparison of image cytometry, flow cytometry, and spectrofluorometry.
J. Szöllösi, B. Feuerstein, W. Hyun, M. Das +1 more
1991Cytometry24 citations Open access
Semantic Scholar
Recognition of Z-RNA and Z-DNA determinants by polyamines in solution: experimental and theoretical studies.
H. Basu, B. Feuerstein, D. Zarling, R. Shafer +1 more
1988Journal of Biomolecular Structure and Dynamics24 citations
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Reduction of the putative CD44+CD24− breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047
Helena Cirenajwis, S. Smiljanic, Gabriella Honeth, C. Hegardt +2 more
2010Anti-Cancer Drugs23 citations
Semantic Scholar
Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism
Tracy Murray-Stewart, Christin L. Hanigan, P. Woster, L. Marton +1 more
2013Molecular Cancer Therapeutics22 citations Open access
Semantic Scholar
Gene Expression Analysis of HCT116 Colon Tumor-derived Cells Treated with the Polyamine Analog PG-11047
N. Ignatenko, H. Yerushalmi, Ritu Pandey, Karen L. Kachel +3 more
2009Cancer Genomics & Proteomics20 citations
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Renal ornithine decarboxylase activity, polyamines, and compensatory renal hypertrophy in the rat.
M. Humphreys, S. Etheredge, Shan-Yan Lin, J. Ribstein +1 more
1988American Journal of Physiology20 citations
Semantic Scholar
Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme.
N. Yarlett, Gang Wu, W. Waters, J. Harp +7 more
2007Molecular and biochemical parasitology (Print)18 citations
Semantic Scholar
Trans-scleral delivery of polyamine analogs for ocular neovascularization.
R. L. Silva, S. Kachi, Hideo Akiyama, Ji-Kui Shen +8 more
2006Experimental Eye Research18 citations
Semantic Scholar
Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells
Yi Huang, Allison Pledgie, Ethel Rubin, L. Marton +4 more
200518 citations Open access
Semantic Scholar
Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines
L. Jeffers, D. Church, H. Basu, L. Marton +1 more
1997Cancer Chemotherapy and Pharmacology17 citations
Semantic Scholar
A Phase I dose-escalation study of the polyamine analogue PG-11047 in patients with advanced solid tumors
T. M. Stewart, A. Desai, Michael L. Fitzgerald, L. Marton +1 more
2020Cancer Chemotherapy and Pharmacology16 citations Open access
Semantic Scholar
A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma.
Tracy Murray-Stewart, D. V. Von Hoff, Michael L. Fitzgerald, L. Marton +11 more
2020Cancer Chemotherapy and Pharmacology16 citations Open access
Semantic Scholar
Modification of Radiation-Induced Brain Injury by α-Difluoromethylornithine
G. Gobbel, L. Marton, K. Lamborn, T. M. Seilhan +1 more
199116 citations
Semantic Scholar
Effect of α-Difluoromethylornithine on 1,3-Bis(2-chloroethyl)-1-nitrosourea and cis-Diamminedichloroplatinum(II) Cytotoxicity, DNA Interstrand Cross-Linking, and Growth in Human Brain Tumor Cell Lines in Vitro
K. Hunter, D. Deen, M. Pellarin, L. Marton
199016 citations
Semantic Scholar
Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells.
Yi Huang, J. Keen, Allison Pledgie, L. Marton +7 more
2006Journal of Biological Chemistry14 citations
Semantic Scholar
Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues.
C. Bacchi, D. Rattendi, Evangeline Faciane, N. Yarlett +6 more
2004Microbiology14 citations Open access
Semantic Scholar

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R. A. Casero×15
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R. A. Casero — researcher profile on SciRah
B. Frydman×15
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Aldonia L. Valasinas×10
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P. Woster — researcher profile on SciRah

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Yi Huang — researcher profile on SciRah

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H. Basu — researcher profile on SciRah

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A. Sarkar — researcher profile on SciRah