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R. Hawtin · SciRah

Researcher profile · Semantic Scholar

R. Hawtin

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R. Hawtin — researcher profile on SciRah

h-index: 21
Works: 79
Citations: 2,528

Most-cited papers

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
A. Laird, P. Vajkoczy, L. Shawver, Andreas Thurnher +16 more
2000Cancer Research520 citations
Semantic Scholar
Red-Shifted Excitation Mutants of the Green Fluorescent Protein
S. Delagrave, R. Hawtin, Christopher M. Silva, Mary M. Yang +1 more
1995Bio/Technology312 citations
Semantic Scholar
Liquefaction of Autographa californica nucleopolyhedrovirus-infected insects is dependent on the integrity of virus-encoded chitinase and cathepsin genes.
R. Hawtin, T. Zarkowska, K. Arnold, Carole J. Thomas +4 more
1997Virology282 citations Open access
Semantic Scholar
Validation of biomarkers to predict response to immunotherapy in cancer: Volume I — pre-analytical and analytical validation
G. Masucci, A. Cesano, R. Hawtin, S. Janetzki +9 more
2016Journal of Immunotherapy for Cancer196 citations Open access
Semantic Scholar
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Rong Chen, W. Wierda, S. Chubb, R. Hawtin +4 more
2009Blood195 citations Open access
Semantic Scholar
Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
R. Hawtin, David E. Stockett, J. A. Byl, R. Mcdowell +6 more
2010PLoS ONE141 citations Open access
Semantic Scholar
Validation of biomarkers to predict response to immunotherapy in cancer: Volume II — clinical validation and regulatory considerations
K. Dobbin, A. Cesano, J. Alvarez, R. Hawtin +9 more
2016Journal of Immunotherapy for Cancer122 citations Open access
Semantic Scholar
SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples
Andrew Conroy, David E. Stockett, D. Walker, M. Arkin +3 more
2009Cancer Chemotherapy and Pharmacology121 citations Open access
Semantic Scholar
IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes
Leah Cushing, Aaron Winkler, S. Jelinsky, Katherine L. Lee +5 more
2017Journal of Biological Chemistry68 citations Open access
Semantic Scholar
AKT Signaling as a Novel Factor Associated with In Vitro Resistance of Human AML to Gemtuzumab Ozogamicin
D. Rosen, Kimberly H. Harrington, J. Cordeiro, Ling Y. Leung +8 more
2013PLoS ONE55 citations Open access
Semantic Scholar
Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients
S. Formenti, R. Hawtin, N. Dixit, E. Evensen +7 more
2019Journal of Immunotherapy for Cancer54 citations Open access
Semantic Scholar
Single-Cell Network Profiling of Peripheral Blood Mononuclear Cells from Healthy Donors Reveals Age- and Race-Associated Differences in Immune Signaling Pathway Activation
D. Longo, B. Louie, S. Putta, E. Evensen +7 more
2012Journal of Immunology46 citations Open access
Semantic Scholar
Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo
C. Scatena, J. Kumer, Jennifer P. Arbitrario, A. Howlett +3 more
2010Cancer Chemotherapy and Pharmacology45 citations Open access
Semantic Scholar
Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies
A. Cesano, O. Perbellini, E. Evensen, Charles C. Chu +16 more
2013Haematologica40 citations Open access
Semantic Scholar
Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks
R. Hawtin, David E. Stockett, O. Wong, Cecilia Lundin +2 more
2010OncoTarget37 citations Open access
Semantic Scholar
Filgotinib, a JAK1 Inhibitor, Modulates Disease-Related Biomarkers in Rheumatoid Arthritis: Results from Two Randomized, Controlled Phase 2b Trials
J. Tarrant, R. Galien, Wanying Li, L. Goyal +5 more
2020Rheumatology and Therapy32 citations Open access
Semantic Scholar
Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line
Rong Chen, S. Chubb, T. Cheng, R. Hawtin +2 more
2010Cancer Research32 citations Open access
Semantic Scholar
Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity
J. Ptacek, R. Hawtin, Dongmei Sun, B. Louie +29 more
2021PLoS ONE29 citations Open access
Semantic Scholar
A phase 1b/2 study of vosaroxin in combination with cytarabine in patients with relapsed or refractory acute myeloid leukemia
J. Lancet, G. Roboz, L. Cripe, G. Michelson +9 more
2015Haematologica28 citations Open access
Semantic Scholar
Racial differences in B cell receptor signaling pathway activation
D. Longo, B. Louie, K. Mathi, Z. Pós +4 more
2012Journal of Translational Medicine21 citations Open access
Semantic Scholar
Engineered baculoviruses for pest control
R. Possee, A. Barnett, R. Hawtin, L. King
199721 citations
Semantic Scholar
Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes
B. Sherry, P. Jain, P. Chiu, Ling Y. Leung +7 more
2015Immunologic research13 citations Open access
Semantic Scholar
Immune monitoring technology primer: Single Cell Network Profiling (SCNP)
R. Hawtin, A. Cesano
2015Journal of Immunotherapy for Cancer13 citations Open access
Semantic Scholar
Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML.
D. Rosen, J. Cordeiro, A. Cohen, N. Lacayo +3 more
2012Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis13 citations
Semantic Scholar
Inter-donor variation in cell subset specific immune signaling responses in healthy individuals.
D. Longo, B. Louie, E. Wang, Z. Pós +3 more
2012American Journal of Clinical and Experimental Immunology13 citations
Semantic Scholar
Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for clinical response biomarker identification
D. Hotson, Ryan Alvarado, Andrew Conroy, S. Putta +10 more
2013Journal of Immunotherapy for Cancer10 citations Open access
Semantic Scholar
SU 6668 Is a Potent Antiangiogenic and Antitumor Agent That Induces Regression of Established Tumors 1
A. Laird, P. Vajkoczy, L. Shawver, Andreas Thurnher +16 more
200010 citations
Semantic Scholar
Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP)
D. Rosen, Ling Y. Leung, B. Louie, J. Cordeiro +5 more
2014Journal of Translational Medicine9 citations Open access
Semantic Scholar
Prospects for the development of a genetically engineered baculovirus insecticide
R. Hawtin, L. King, R. Possee
19928 citations
Semantic Scholar
Functional Pathway Analysis Using SCNP of FLT3 Receptor Pathway Deregulation in AML Provides Prognostic Information Independent from Mutational Status
A. Cesano, S. Putta, D. Rosen, A. Cohen +8 more
2013PLoS ONE7 citations Open access
Semantic Scholar
High-dimensional analysis of the aging immune system: Verification of age-associated differences in immune signaling responses in healthy donors
D. Longo, B. Louie, J. Ptacek, G. Friedland +14 more
2014Journal of Translational Medicine5 citations Open access
Semantic Scholar
Single cell network profiling assay in bladder cancer
T. Covey, M. Vira, M. Westfall, Michael Gulrajani +7 more
2013Cytometry Part A4 citations Open access
Semantic Scholar
Mechanism of Action of SNS-032, a Novel Cyclin Dependent Kinase Inhibitor, in Chronic Lymphocytic Leukemia: Comparison with Flavopiridol.
Rong Chen, W. Wierda, Sherri Benaissa, U. Hoch +5 more
20074 citations
Semantic Scholar
Voreloxin (formerly known as SNS-595) in Combination with Cytarabine Demonstrates Preliminary Clinical Responses in a Phase 1 Study in Relapsed/Refractory Acute Myeloid Leukemia.
J. Lancet, J. Karp, L. Cripe, G. Roboz +6 more
20083 citations
Semantic Scholar
SAT0155 WHOLE BLOOD TRANSCRIPTIONAL CHANGES FOLLOWING SELECTIVE INHIBITION OF JANUS KINASE 1 (JAK1) BY FILGOTINIB IN MTX-NAÏVE ADULTS WITH MODERATELY-TO-SEVERELY ACTIVE RHEUMATOID ARTHRITIS (RA) (FINCH3)
P. Taylor, B. Downie, E. Elboudwarej, S. Kim +5 more
20202 citations Open access
Semantic Scholar
BCR Responsiveness is associated with Time to First Treatment (TTFT) in B-Cell Chronic Lymphocytic Leukemia (B-CLL): results from a Single Cell Network Profiling (SCNP) verification study
A. Cesano, E. Evensen, J. Ptacek, J. Cordeiro +4 more
20112 citations
Semantic Scholar
Abstract C222: Voreloxin is synergistic in in vitro combination with cytarabine and additive in combination with azacitidine, decitabine, and clofarabine
David E. Stockett, J. Kumer, C. Scatena, J. Silverman +2 more
20092 citations
Semantic Scholar
Proteomic Profiling of Angelman Syndrome for Disease-associated Biomarker Discovery (P8-8.001)
R. Hawtin, Julien Couthouis, Showkhin Khan, Grace Wang +6 more
2024Neurology1 citations
Semantic Scholar
THU0194 SELECTIVE INHIBITION OF JANUS KINASE 1 (JAK1) BY FILGOTINIB MODULATES THE DISEASE-ASSOCIATED WHOLE BLOOD TRANSCRIPTIONAL PROFILE OF PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS
P. Taylor, B. Downie, L. Zhuo, R. Hawtin +2 more
2019Poster Presentations1 citations Open access
Semantic Scholar
FRI0133 FILGOTINIB, A SELECTIVE JANUS KINASE 1 (JAK1) INHIBITOR, MODULATES DISEASE-ASSOCIATED CYTOKINES IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS
P. Taylor, E. Elboudwarej, Wanying Li, R. Hawtin +2 more
2019Poster Presentations1 citations
Semantic Scholar
Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for response biomarker identification
D. Hotson, Ryan Alvarado, Andrew Conroy, S. Putta +11 more
2014Journal of Translational Medicine1 citations Open access
Semantic Scholar
109 Functional activity, but not PD-1 expression level, differentiates primary CLL from healthy PD1+ T cells using SCNP
Spencer C. Liang, Ling Y. Leung, S. Putta, D. Hotson +2 more
20141 citations
Semantic Scholar
High-dimensional analysis of the aging immune system: Verification of age-associated differences in immune signaling responses in healthy donors
D. Longo, B. Louie, J. Ptacek, G. Friedland +14 more
2014Journal of Translational Medicine1 citations Open access
Semantic Scholar
PUBLICATION
R. Hawtin, J. Ptacek, E. Evensen, J. Cordeiro +29 more
20131 citations Open access
Semantic Scholar
Single Cell Network Profiling (SCNP) Identifies Altered Signaling Between Patient Risk Groups in B-Cell Chronic Lymphocytic Leukemia (B-CLL).
J. Ptacek, E. Evensen, G. Friedland, J. Cordeiro +7 more
20121 citations
Semantic Scholar
Single Cell Network Profiling (SCNP) Functionally Characterizes FLT3 Pathway Deregulation in Non-M3 Acute Myeloid Leukemia (AML) and Provides Prognostic Value Independent From Mutational Status
A. Cesano, S. Putta, K. Mathi, D. Rosen +6 more
20111 citations
Semantic Scholar
Impact of Time From Blood Draw to Peripheral Blood Mononuclear Cell (PBMC) Processing and Cryopreservation on Functional Pathway Activity As Measured by Single Cell Network Profiling (SCNP) Assays
D. Longo, B. Louie, E. Evensen, R. Hawtin +1 more
20111 citations
Semantic Scholar
Single Cell Network Profiling (SCNP) Reveals Race-Associated Differences in B Cell Receptor Signaling Pathway Activation
D. Longo, B. Louie, K. Mathi, Z. Pós +4 more
20111 citations
Semantic Scholar
Abstract #1708: Voreloxin is active in breast cancer biopsies and potency is enhanced in a BRCA2 mutant background
R. Hawtin, David E. Stockett, Cecilia Lundin, T. Helleday +1 more
20091 citations
Semantic Scholar
Abstract C226: Clinical evidence of mechanism‐based activity in voreloxin‐treated AML patients
Andrew Conroy, Tan Nguyen, O. Wong, J. Fox +1 more
20091 citations
Semantic Scholar

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