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K. Thrailkill · SciRah

Researcher profile · Semantic Scholar

K. Thrailkill

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K. Thrailkill — researcher profile on SciRah

h-index: 35
Works: 78
Citations: 3,916

Most-cited papers

Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues.
K. Thrailkill, C. K. Lumpkin, R. C. Bunn, S. F. Kemp +1 more
2005American Journal of Physiology. Endocrinology and Metabolism498 citations Open access
Semantic Scholar
Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy
K. Thrailkill, R. C. Bunn, J. Fowlkes
2008Endocrine181 citations Open access
Semantic Scholar
Bone formation is impaired in a model of type 1 diabetes.
K. Thrailkill, Li-Chu Liu, Elizabeth C. Wahl, R. C. Bunn +8 more
2005Diabetes177 citations Open access
Semantic Scholar
Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.
K. Thrailkill, L. Quarles, H. Nagase, K. Suzuki +2 more
1995Endocrinology155 citations
Semantic Scholar
Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases.
J. Fowlkes, K. Thrailkill, D. Serra, Ko Suzuki +1 more
1995Progress in Growth Factor Research147 citations
Semantic Scholar
Enhanced excretion of vitamin D binding protein in type 1 diabetes: a role in vitamin D deficiency?
K. Thrailkill, Chanhee Jo, G. Cockrell, C. Moreau +1 more
2011Journal of Clinical Endocrinology and Metabolism146 citations Open access
Semantic Scholar
Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial.
M. Davenport, B. Crowe, S. Travers, K. Rubin +9 more
2007Journal of Clinical Endocrinology and Metabolism126 citations
Semantic Scholar
Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.
J. Fowlkes, K. Suzuki, H. Nagase, K. Thrailkill
1994Endocrinology118 citations
Semantic Scholar
Microalbuminuria in Type 1 Diabetes Is Associated With Enhanced Excretion of the Endocytic Multiligand Receptors Megalin and Cubilin
K. Thrailkill, Teresa Nimmo, R. C. Bunn, G. Cockrell +4 more
2009Diabetes Care110 citations Open access
Semantic Scholar
INCREASING DURATION OF TYPE 1 DIABETES PERTURBS THE STRENGTH-STRUCTURE RELATIONSHIP AND INCREASES BRITTLENESS OF BONE
Jeffry S. Nyman, Jesse L. Even, Chanhee Jo, Erik G. Herbert +7 more
2010Bone106 citations Open access
Semantic Scholar
Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus.
J. Fowlkes, R. C. Bunn, Li-Chu Liu, Elizabeth C. Wahl +5 more
2008Endocrinology106 citations Open access
Semantic Scholar
Effects of Type 1 Diabetes on osteoblasts, osteocytes and osteoclasts
Evangelia Kalaitzoglou, I. Popescu, R. C. Bunn, J. Fowlkes +1 more
2016Current Osteoporosis Reports102 citations Open access
Semantic Scholar
Insulin-Like Growth Factor-I in Diabetes Mellitus: Its Physiology, Metabolic Effects, and Potential Clinical Utility
K. Thrailkill
2000Diabetes Technology & Therapeutics97 citations
Semantic Scholar
DIABETES PHARMACOTHERAPY AND EFFECTS ON THE MUSCULOSKELETAL SYSTEM
Evangelia Kalaitzoglou, J. Fowlkes, I. Popescu, K. Thrailkill
2018Diabetes/Metabolism Research Reviews93 citations Open access
Semantic Scholar
Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group.
K. Thrailkill, T. Quattrin, L. Baker, J. Kuntze +2 more
1999Diabetes Care91 citations
Semantic Scholar
Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation.
J. Fowlkes, K. Thrailkill, Carlos George-Nascimento, Carlyn K. Rosenberg +1 more
1997Endocrinology91 citations Open access
Semantic Scholar
Palmitate and insulin synergistically induce IL-6 expression in human monocytes
R. C. Bunn, G. Cockrell, Yang Ou, K. Thrailkill +2 more
2010Cardiovascular Diabetology90 citations Open access
Semantic Scholar
A multicomponent motivational intervention to improve adherence among adolescents with poorly controlled type 1 diabetes: a pilot study.
C. Stanger, Stacy R. Ryan, L. Delhey, K. Thrailkill +3 more
2013Journal of Pediatric Psychology85 citations Open access
Semantic Scholar
Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus
K. Thrailkill, C. Moreau, G. Cockrell, Chanhee Jo +4 more
2010Endocrine75 citations Open access
Semantic Scholar
Effects of Systemic and Local Administration of Recombinant Human IGF‐I (rhIGF‐I) on De Novo Bone Formation in an Aged Mouse Model
J. Fowlkes, K. Thrailkill, Li-Chu Liu, Elizabeth C. Wahl +5 more
2006Journal of Bone and Mineral Research72 citations Open access
Semantic Scholar
SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice
K. Thrailkill, R. C. Bunn, J. Nyman, M. Rettiganti +5 more
2015Bone71 citations Open access
Semantic Scholar
Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes.
J. Fowlkes, D. Serra, R. C. Bunn, K. Thrailkill +2 more
2004Endocrinology69 citations Open access
Semantic Scholar
Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) Functions as an IGF-reversible Inhibitor of IGFBP-4 Proteolysis (*)
J. Fowlkes, D. Serra, Carlyn K. Rosenberg, K. Thrailkill
1995Journal of Biological Chemistry65 citations Open access
Semantic Scholar
The impact of SGLT2 Inhibitors, compared with Insulin, on Diabetic Bone Disease in a mouse model of Type 1 Diabetes
K. Thrailkill, Jeffry S. Nyman, R. C. Bunn, Sasidhar Uppuganti +4 more
2016Bone62 citations Open access
Semantic Scholar
Restoration of Regenerative Osteoblastogenesis in Aged Mice: Modulation of TNF
Elizabeth C. Wahl, J. Aronson, Li-Chu Liu, J. Fowlkes +12 more
2009Journal of Bone and Mineral Research61 citations Open access
Semantic Scholar
Role of serum in the developmental expression of alkaline phosphatase in MC3T3‐E1 osteoblasts
D. Yohay, Jian Zhang, K. Thrailkill, John M. Arthur +1 more
1994Journal of Cellular Physiology54 citations
Semantic Scholar
MMPs Are IGFBP‐Degrading Proteinases: Implications for Cell Proliferation and Tissue Growth
J. Fowlkes, Delial M. Serra, H. Nagase, K. Thrailkill
1999Annals of the New York Academy of Sciences53 citations
Semantic Scholar
Dual Hormonal Replacement With Insulin and Recombinant Human Insulin-Like Growth Factor I in IDDM: Effects on glycemic control, IGF-I levels, and safety profile
T. Quattrin, K. Thrailkill, L. Baker, Jean C. Litton +7 more
1997Diabetes Care52 citations
Semantic Scholar
Contributions of the Insulin/Insulin-Like Growth Factor-1 Axis to Diabetic Osteopathy
J. Fowlkes, Clay Bunn R, K. Thrailkill
2011Journal of Diabetes & Metabolism49 citations Open access
Semantic Scholar
Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes
K. Thrailkill, Chanhee Jo, G. Cockrell, C. Moreau +2 more
2011Osteoporosis International48 citations Open access
Semantic Scholar
A novel rat model for the study of deficits in bone formation in type-2 diabetes
Zhendong Liu, J. Aronson, Elizabeth C. Wahl, Li-Chu Liu +8 more
2007Acta Orthopaedica48 citations Open access
Semantic Scholar
Physiological matrix metalloproteinase concentrations in serum during childhood and adolescence, using Luminex® Multiplex technology
K. Thrailkill, C. Moreau, G. Cockrell, Pippa Simpson +4 more
2005Clinical Chemistry and Laboratory Medicine46 citations Open access
Semantic Scholar
Differentiation of MC3T3-E1 osteoblasts is associated with temporal changes in the expression of IGF-I and IGFBPs.
K. Thrailkill, S. Siddhanti, J. Fowlkes, L. Quarles
1995Bone46 citations
Semantic Scholar
Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone
K. Thrailkill, R. C. Bunn, C. K. Lumpkin, Elizabeth C. Wahl +5 more
2014Journal of Diabetes Research44 citations Open access
Semantic Scholar
Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes
J. Fowlkes, R. C. Bunn, G. Cockrell, Lindsey M. Clark +3 more
2011International Journal of Experimental Diabetes Research39 citations Open access
Semantic Scholar
Physiological matrix metalloproteinase (MMP) concentrations: comparison of serum and plasma specimens
K. Thrailkill, G. Cockrell, Pippa Simpson, C. Moreau +2 more
2006Clinical Chemistry and Laboratory Medicine34 citations Open access
Semantic Scholar
Dual hormonal replacement therapy with insulin and recombinant human insulin-like growth factor (IGF)-I in insulin-dependent diabetes mellitus: effects on the growth hormone/IGF/IGF-binding protein system.
K. Thrailkill, T. Quattrin, L. Baker, Jean C. Litton +7 more
1997Journal of Clinical Endocrinology and Metabolism33 citations Open access
Semantic Scholar
Preserving and restoring bone with continuous insulin infusion therapy in a mouse model of type 1 diabetes
J. Nyman, Evangelia Kalaitzoglou, R. C. Bunn, Sasidhar Uppuganti +2 more
2017Bone Reports31 citations Open access
Semantic Scholar
Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes
J. Fowlkes, Jeffry S. Nyman, R. C. Bunn, Chanhee Jo +6 more
2013Bone30 citations Open access
Semantic Scholar
Characterization of matrix metalloproteinases in human urine: alterations during adolescence
K. Thrailkill, Sudha Kumar, Carlyn K. Rosenberg, Kathy J. Auten +1 more
1999Pediatric nephrology (Berlin, West)26 citations
Semantic Scholar
RASopathies: the Musculoskeletal Consequences and their Etiology and Pathogenesis
J. Fowlkes, K. Thrailkill, R. C. Bunn
2021Bone24 citations Open access
Semantic Scholar
Insulin Pump Therapy Started at the Time of Diagnosis: Effects on Glycemic Control and Pancreatic β-Cell Function in Type 1 Diabetes
K. Thrailkill, C. Moreau, C. Swearingen, M. Rettiganti +5 more
2011Diabetes Technology & Therapeutics23 citations
Semantic Scholar
Improvement of HbA1c Without Increased Hypoglycemia in Adolescents and Young Adults with Type 1 Diabetes Mellitus Treated with Recombinant Human Insulin-like Growth Factor-I and Insulin
T. Quattrin, K. Thrailkill, L. Baker, J. Kuntze +3 more
2001Journal of Pediatric Endocrinology & Metabolism (JPEM)23 citations
Semantic Scholar
Efficacy and safety of mecasermin rinfabate
S. F. Kemp, J. Fowlkes, K. Thrailkill
2006Expert Opinion on Biological Therapy20 citations
Semantic Scholar
Canagliflozin, an SGLT2 inhibitor, corrects glycemic dysregulation in TallyHO model of T2D but only partially prevents bone deficits
K. Thrailkill, R. C. Bunn, Sasidhar Uppuganti, Philip D. Ray +4 more
2020Bone18 citations Open access
Semantic Scholar
Direct Bone Formation during Distraction Osteogenesis does not require TNFα Receptors and Elevated Serum TNFα Fails to Inhibit Bone Formation in TNFR1 Deficient Mice
Elizabeth C. Wahl, J. Aronson, Li-Chu Liu, R. A. Skinner +7 more
2009Bone18 citations Open access
Semantic Scholar
Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone
K. Thrailkill, R. C. Bunn, Sasidhar Uppuganti, Philip D. Ray +5 more
2020Bone16 citations Open access
Semantic Scholar
GAD-alum immunotherapy in Type 1 diabetes mellitus.
Alba E. Morales, K. Thrailkill
2011Immunotherapy16 citations
Semantic Scholar
The role of vitamin D in the metabolic homeostasis of diabetic bone
K. Thrailkill, J. Fowlkes
2013Clinical Reviews in Bone and Mineral Metabolism13 citations Open access
Semantic Scholar
Stimulant Medication Use and Response to Growth Hormone Therapy: An NCGS Database Analysis
J. Frindik, Alba E. Morales, J. Fowlkes, S. F. Kemp +3 more
2009Hormone Research in Paediatrics13 citations
Semantic Scholar

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