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R. Fletcher · SciRah

Researcher profile · Semantic Scholar

R. Fletcher

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R. Fletcher — researcher profile on SciRah

h-index: 12
Works: 44
Citations: 881

Most-cited papers

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Yasir S. Elhassan, K. Kľučková, R. Fletcher, M. Schmidt +18 more
2019Cell Reports407 citations Open access
Semantic Scholar
Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells
R. Fletcher, Joanna Ratajczak, C. Doig, Lucy A Oakey +10 more
2017Molecular Metabolism127 citations Open access
Semantic Scholar
Eosinophil-Derived Neurotoxin in Childhood Asthma: Correlation With Disease Severity
Chang-Keun Kim, Zak Callaway, R. Fletcher, Y. Koh
2010Journal of Asthma61 citations
Semantic Scholar
Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition
Abbi R. Hernandez, Cory Watson, Quinten P. Federico, R. Fletcher +4 more
2022Nutrients39 citations Open access
Semantic Scholar
The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism
R. Fletcher, G. Lavery
2018Journal of Molecular Endocrinology35 citations Open access
Semantic Scholar
Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-phase chronic myeloid leukaemia (MATCHPOINT): a single-arm, multicentre, phase 1/2 trial.
M. Copland, D. Slade, G. McIlroy, G. Horne +11 more
2021The Lancet Haematology33 citations Open access
Semantic Scholar
11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice
C. Doig, R. Fletcher, S. Morgan, E. McCabe +5 more
2017Endocrinology30 citations Open access
Semantic Scholar
The effect of lymphocytotoxic antibody reactivity on the results of single antigen mismatched platelet transfusions to alloimmunized patients.
MA Hussein, EJ Lee, R. Fletcher, Charles A. Schiffer
1996Blood28 citations
Semantic Scholar
Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD + depletion
Lucy A Oakey, R. Fletcher, Y. Elhassan, D. Cartwright +8 more
2018Wellcome Open Research20 citations Open access
Semantic Scholar
Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin
R. Watkins, W. Imruetaicharoenchoke, Martin L Read, N. Sharma +12 more
2016Journal of Clinical Endocrinology and Metabolism18 citations Open access
Semantic Scholar
Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity
D. Cartwright, Lucy A Oakey, R. Fletcher, C. Doig +9 more
2021Journal of Endocrinology16 citations Open access
Semantic Scholar
A quality improvement initiative on the management of osteoporosis in older people with Parkinsonism
I. Singh, R. Fletcher, L. Scanlon, M. Tyler +1 more
2016BMJ Quality Improvement Reports14 citations Open access
Semantic Scholar
Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction
C. Doig, A. Zielińska, R. Fletcher, Lucy A Oakey +10 more
2020Skeletal Muscle12 citations Open access
Semantic Scholar
Phazar: A Phase Ib Study to Assess the Safety and Tolerability of Ruxolitinib in Combination with Azacitidine in Advanced Phase Myeloproliferative Neoplasms (MPN), Including Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukaemia (AML) Arising from MPN [ISRCTN16783472]
M. Drummond, C. Gaskell, C. Harrison, A. Mead +12 more
20209 citations
Semantic Scholar
Nicotinamide riboside augments the human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures in aged subjects: a placebo-controlled, randomized trial
Yasir S. Elhassan, K. Kľučková, R. Fletcher, M. Schmidt +18 more
2019bioRxiv8 citations Open access
Semantic Scholar
Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis
Zijian Fang, Giuditta Corbizi Fattori, Thomas McKerrell, R. Boucher +32 more
2023Nature Communications7 citations Open access
Semantic Scholar
Effects of Tamoxifen on the Mutant Allele Burden and Disease Course in Patients with Myeloproliferative Neoplasms - Results of the Tamarin Study
C. Harrison, J. Baxter, R. Boucher, Thomas McKerrell +28 more
20205 citations Open access
Semantic Scholar
Cellular and genetic models of H6PDH and 11β‐HSD1 function in skeletal muscle
A. Zielińska, R. Fletcher, M. Sherlock, C. Doig +1 more
2017Cell Biochemistry and Function5 citations Open access
Semantic Scholar
Ponatinib in Combination with FLAG-IDA Chemotherapy for Blast-Phase Chronic Myeloid Leukemia: Final Results of the Seamless Phase I/II Dose-Finding UK Trials Acceleration Programme (TAP) Matchpoint Trial
M. Copland, D. Slade, G. McIlroy, G. Horne +11 more
2021Blood2 citations Open access
Semantic Scholar
Defective T‐cell response to COVID‐19 vaccination in acute myeloid leukaemia and myelodysplastic syndromes
J. Loke, V. Upasani, C. Gaskell, Sonia Fox +30 more
2023British Journal of Haematology1 citations Open access
Semantic Scholar
2204. Excess Antibiotic Therapy for 5 Common Conditions in Primary Care: Low-Hanging Fruit for Outpatient Antibiotic Stewardship
Payal K. Patel, Whitney R. Buckel, R. Fletcher, Nick Gangwer +5 more
2023Open Forum Infectious Diseases1 citations Open access
Semantic Scholar
OR03-06 NAD+ Availability Modulates 11β-HSD1-Mediated Glucocorticoid Regeneration in Mouse Skeletal Muscle
Yasir S. Elhassan, Ali Kabli, T. Nielsen, R. Fletcher +7 more
2020Journal of the Endocrine Society1 citations Open access
Semantic Scholar
Dance Movement Therapy for the Treatment of Depression
R. Fletcher, Heidi Gerschwitz
20191 citations
Semantic Scholar
Increasing NAD+ availability in skeletal muscle to augment energy metabolism
R. Fletcher, C. Doig, A. Zielińska, A. Griffin +2 more
20151 citations Open access
Semantic Scholar
Eosinophil-derived Neurotoxin and Eosinophil Cationic Protein Levels Correlate with Bronchial Wall Thickness in Children with Asthma Exacerbation
효빈 김, R. Fletcher, 준길 최, 운기 윤 +4 more
20071 citations
Semantic Scholar
3031 – CHROMOTHRIPSIS AND LEUKEMIC TRANSFORMATION IN MPN
C. Brierley, B. Yip, G. Orlando, H. Goyal +25 more
2023Experimental Hematology0 citations Open access
Semantic Scholar
University of Birmingham Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-phase chronic myeloid leukaemia (MATCHPOINT)
M. Copland, Daniel Slade, G. McIlroy, Gillian Horne +12 more
20220 citations
Semantic Scholar
Low Incidence of COVID-19 Infection in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity/Venetoclax Based Treatment: Initial Results of the PACE Prospective Clinical Study from the UK Trials Acceleration Program
Ting-Lo-Ke Ching, C. Gaskell, Sonia Fox, R. Fletcher +34 more
2021Blood0 citations Open access
Semantic Scholar
Molecular Characterisation of Participants in the Phazar Trial Reveals Prognostic Impact of Mutations in Advanced-Phase-MPN
C. Brierley, A. Rodriguez-Meira, M. Bashton, A. Hamblin +13 more
20200 citations Open access
Semantic Scholar
SUN-103 A Direct Comparison Of Metabolic Responses To Nad Repletion In C57bl/6j And C57bl/6n Diet-induced Obesity Mouse Models
Andreas Garten, D. Cartwright, Lucy A Oakey, R. Fletcher +8 more
2019Journal of the Endocrine Society0 citations Open access
Semantic Scholar
Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice
C. Doig, A. Zielińska, R. Fletcher, Lucy A Oakey +9 more
2019bioRxiv0 citations Open access
Semantic Scholar
A Direct Comparison of Metabolic Responses to NAD repletion in C57BL/6J and C57BL/6N diet-induced obesity mouse models
A. Garten, D. Cartwright, Lucy A Oakey, R. Fletcher +7 more
2018Endocrine Abstracts0 citations
Semantic Scholar
NAD+ availability modulates 11[beta]-HSD1 mediated glucocorticoid regeneration in mouse skeletal muscle
Yasir S. Elhassan, R. Fletcher, D. Cartwright, Lucy A Oakey +3 more
20170 citations
Semantic Scholar
Vitamin B3 salvage and NAD\(^+\) metabolism in skeletal muscle
R. Fletcher
20170 citations
Semantic Scholar
Nicotinamide riboside and cellular NAD+ redox state influence 11[beta]-HSD1 mediated glucocorticoid regeneration in skeletal muscle cells
Yasir S. Elhassan, R. Fletcher, Lucy Oldacre-Bartley, C. Doig +1 more
20160 citations
Semantic Scholar
NAD+ supplementation normalises central carbon metabolism in skeletal muscle: a mechanistic insight into the energetic consequences of age-related NAD+ decline
Lucy Oldacre-Bartley, R. Fletcher, Kate E. R. Hollinshead, Yasir S. Elhassan +4 more
20160 citations
Semantic Scholar
Mechanisms of ageing metabolic decline revealed by targeted metabolomics and energy metabolism in NAD+ depleted skeletal muscle
R. Fletcher, Lucy Oldacre-Bartley, C. Doig, C. Brenner +1 more
20160 citations
Semantic Scholar
A novel modulator of cellular invasion and metastasis in endocrine cancer
R. Watkins, W. Imruetaicharoenchoke, N. Sharma, E. Gentillin +8 more
20150 citations
Semantic Scholar
26. A novel modulator of cellular invasion and metastasis
N. Sharma, W. Imruetaicharoenchoke, R. Watkins, E. Gentillin +9 more
20150 citations
Semantic Scholar
Breaking NAD+: investigating NMRK2 as a regulator of muscle adaptation through NAD+ salvage
C. Doig, A. Zielińska, R. Fletcher, E. McCabe +2 more
20140 citations
Semantic Scholar
A novel modulator of cell invasion and metastasis
R. Watkins, V. Smith, N. Sharna, Martin L Read +5 more
20140 citations
Semantic Scholar
Depletion of glucose-6-phosphate transporter impacts SR calcium homeostasis in muscle
C. Doig, A. Zielińska, R. Fletcher, E. McCabe +1 more
20140 citations
Semantic Scholar
The metabolic consequences of glucose-6-phosphate transporter (G6PT) depletion in mice and Investigating the role of transcriptional intermediary factor 1-γ (TIF1γ) in mitosis
R. Fletcher
20130 citations
Semantic Scholar
University of Birmingham 11β-HSD1 modulates the set-point of brown adipose tissue response to glucocorticoids in male mice
C. Doig, R. Fletcher, S. Morgan, E. McCabe +5 more
0 citations
Semantic Scholar

Frequent co-authors

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C. Doig×20
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C. Doig — researcher profile on SciRah
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Lucy A Oakey×11
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Yasir S. Elhassan×10
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