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I. Ayappa · SciRah

Researcher profile · Semantic Scholar

I. Ayappa

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I. Ayappa — researcher profile on SciRah

h-index: 41
Works: 262
Citations: 7,577

Most-cited papers

Ventilatory Burden as a Measure of Obstructive Sleep Apnea Severity Is Predictive of Cardiovascular and All-Cause Mortality.
A. Parekh, K. Kam, S. Wickramaratne, T. Tolbert +8 more
2023American Journal of Respiratory and Critical Care Medicine47 citations
Semantic Scholar
Night-to-night reliability and agreement of obstructive sleep apnea pathophysiologic mechanisms estimated with phenotyping using polysomnography in cognitively normal elderly subjects.
T. Tolbert, R. Schoenholz, A. Parekh, A. Berkalieva +3 more
2023Sleep21 citations Open access
Semantic Scholar
Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk
Zanetta Kovbasyuk, J. Ramos-Cejudo, A. Parekh, O. Bubu +7 more
2024Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease12 citations Open access
Semantic Scholar
Sleep-wake variation in body temperature regulates tau secretion and correlates with CSF and plasma tau
Geoffrey Canet, Felipe Da Gama Monteiro, Emma Rocaboy, Sofia Diego-Diàz +30 more
2025Journal of Clinical Investigation10 citations Open access
Semantic Scholar
OSA pathophysiology: a contemporary update.
T. Tolbert, I. Ayappa, D. Rapoport
2025Australian dental journal10 citations
Semantic Scholar
Combination of Ventilatory, Hypoxic, and Arousal Burden Predicts Short- and Long-term Consequences of OSA Better Than the Apnea-hypopnea Index
S. Wickramaratne, K. Kam, T. Tolbert, A. Varga +3 more
2023C98. RISKY BUSINESS: PREDICTING CONSEQUENCES OF OSA7 citations
Semantic Scholar
Nasal resistance and inflammation: mechanisms for obstructive sleep apnea from chronic rhinosinusitis
I. Ayappa, Robert Laumbach, Kathleen Black, M. Weintraub +13 more
2024Journal of Clinical Sleep Medicine (JCSM)6 citations Open access
Semantic Scholar
The stability of slow wave sleep and EEG oscillations across two consecutive nights of laboratory polysomnography in cognitively normal older adults
A. Mullins, Shayna Pehel, A. Parekh, K. Kam +6 more
2024Journal of Sleep Research6 citations
Semantic Scholar
COUNTERPOINT:: Are OSA Phenotypes Clinically Useful? No.
T. Tolbert, A. Parekh, D. Rapoport, I. Ayappa
2023Chest6 citations
Semantic Scholar
Enhancing sleep, wakefulness, and cognition with transcranial photobiomodulation: a systematic review
Naomi L. Gaggi, Z. Parincu, Anna Peterson, Courtney O'Brien +6 more
2025Frontiers in Behavioral Neuroscience5 citations Open access
Semantic Scholar
EEG slow oscillations and overnight spatial navigational memory performance in CPAP-treated obstructive sleep apnea
A. Mullins, A. Parekh, K. Kam, D. Valencia +13 more
2025Sleep5 citations Open access
Semantic Scholar
Phenotyping Using Polysomnography Attributes Reduced Respiratory Events after CPAP Therapy to Improved Upper Airway Collapsibility.
T. Tolbert, A. Parekh, David M. Rapoport, I. Ayappa
2024Annals of the American Thoracic Society3 citations
Semantic Scholar
Racial, ethnic and sex‐specific mechanisms of obstructive sleep apnea and Alzheimer's disease risk
K. Murali, J. Gills, Arlener D. Turner, Anthony Briggs +16 more
2026Alzheimer's & Dementia2 citations Open access
Semantic Scholar
Automating detection of inspiratory flow limitation: the next frontier in assessing sleep disordered breathing in pregnancy and risk for adverse pregnancy outcomes?
S. Pamidi, I. Ayappa
2024European Respiratory Journal2 citations
Semantic Scholar
Machine Learning Model Combining Ventilatory, Hypoxic, Arousal Domains Across Sleep Better Predicts Adverse Consequences of Obstructive Sleep Apnea
S. Wickramaratne, K. Korey, T. Tolbert, A. Varga +3 more
2024Annual International Conference of the IEEE Engineering in Medicine and Biology Society2 citations Open access
Semantic Scholar
0723 Slow wave activity surrounding K-complexes is associated with long-term all-cause mortality in a large community-dwelling cohort
D. Valencia, R. Schoenholz, Giles Bischoff, A. Berkalieva +7 more
2023Sleep2 citations Open access
Semantic Scholar
Obstructive sleep apnea severity, Alzheimer's disease plasma markers, and CSF brain amyloidosis and tau pathology
O. Bubu, A. Mullins, Shreshtha Shah, J. Gills +22 more
2026Alzheimer's & Dementia1 citations Open access
Semantic Scholar
Establishing a physiological normative value of area-based hypoxic burden in obstructive sleep apnea
Li Zhou, Si Yang, S. Wickramaratne, P. Boulgakov +15 more
2026medRxiv1 citations Open access
Semantic Scholar
0348 Utility of Large Language Models for Extracting Sleep Apnea Specific Symptoms and Major Adverse Cardiovascular Events from Electronic Health Records
N. M. Mariappan, S. Wickramaratne, Z. Roberts, Li Zhou +7 more
2026SLEEPJ1 citations
Semantic Scholar
"Hypoxic burden" is a concept, not a single variable.
A. Varga, K. Kam, A. Parekh, T. Tolbert +2 more
2026Sleep1 citations
Semantic Scholar
Arousal threshold and the effect of CPAP on neurocognitive function: a new step towards a precision medicine approach for treating obstructive sleep apnoea
N. Marchi, S. Bailly, I. Ayappa, R. Heinzer
2024European Respiratory Journal1 citations
Semantic Scholar
0485 Can Hypoxic Burden Predict Improvement in Sleepiness and Cognition in Response to CPAP Treatment in OSA Patients?
Kaveh Gaynor-Sodeifi, Dylan Greenberg, A. Varga, I. Ayappa +2 more
2024Sleep1 citations
Semantic Scholar
Rebuttal From Dr Tolbert et al.
T. Tolbert, A. Parekh, D. Rapoport, I. Ayappa
2023Chest1 citations
Semantic Scholar
0308 The stability of slow wave sleep and EEG microstructure measures across two consecutive nights of laboratory polysomnography in cognitively normal older adults
A. Mullins, A. Parekh, K. Kam, O. Bubu +9 more
2022Sleep1 citations Open access
Semantic Scholar
0275 Effect of acutely induced severe OSA on AD plasma biomarkers
K. Kam, J. Jun, O. Bubu, A. Mullins +7 more
2022Sleep1 citations Open access
Semantic Scholar
The blob algorithm: a network approach to residual sleepiness in treated obstructive sleep apnea
Masrai K Williams, A. Varga, I. Ayappa
2026Sleep0 citations Open access
Semantic Scholar
0504 Neural Basis of Improved Sustained Attention Following Sleep Apnea Treatment
D. Azad, D. Valencia, S. Hishinuma, S. Wickramaratne +6 more
2026SLEEPJ0 citations
Semantic Scholar
Obstructive sleep apnea physiological burdens and cognitive performance in older community dwelling American adults
P. Pahari, J. Gills, E. Valkanova, A. Dharmapuri +10 more
2026Sleep Medicine0 citations
Semantic Scholar
Longitudinal associations of rapid eye movement (REM) sleep and slow‐wave sleep with plasma Alzheimer's disease biomarkers
Jeongyeon Hwang, L. Figueredo, D. Valencia, T. Tolbert +16 more
2026Alzheimer's & Dementia0 citations Open access
Semantic Scholar
0851 Longitudinal Effect of Rapid-Eye-Movement Sleep on Plasma Alzheimer’s Disease Biomarkers in Cognitively Normal Older Adults
Jeongyeon Hwang, L. Figueredo, D. Valencia, Masrai K Williams +8 more
2026SLEEPJ0 citations
Semantic Scholar
0493 Obstructive Sleep Apnea in Idiopathic Pulmonary Fibrosis is Associated with Reduced Arousal Threshold and Preserved Upper Airway Collapsibility
T. Tolbert, P. Boulgakov, B. Morgan, Claudia Loppnow +8 more
2026SLEEPJ0 citations
Semantic Scholar
Associations between REM OSA, White Matter Microstructure, and Cognition in Community-Dwelling Cognitively Unimpaired Older Adults
J. Gills, P. Pahari, E. Valkanova, J. McBride +9 more
2026Sleep Medicine0 citations
Semantic Scholar
The impact of ambient temperature on sleep duration: findings from GRAPHS cohort
H. R. Castillo, S. Kaali, R. Shah, M. Mujtaba +9 more
2026Sleep Medicine0 citations
Semantic Scholar
0519 Association of Ventilatory and Hypoxic Burden with AI-Derived Obstructive Sleep Apnea Symptoms and Risk Factors
Li Zhou, N. M. Mariappan, S. Wickramaratne, Z. Roberts +11 more
2026SLEEPJ0 citations
Semantic Scholar
White matter microstructure differences in obstructive sleep apnea severity groups assessed by diffusion tensor metrics and biophysical modeling
L. Figueredo, Jenny Chen, Naomi L. Gaggi, Xiao-Tong Song +20 more
2026Scientific Reports0 citations Open access
Semantic Scholar
Greater hypoxic burden predicts weaker coordination between brain pulsation and CSF flow on 7T MRI independent of non-hypoxic arousals: Implications for glymphatic activity
Gawon Cho, K. Kam, Anne Chen, Yu-Tong Mao +12 more
2026bioRxiv0 citations Open access
Semantic Scholar
Elevated level of pro-Brain Natriuretic peptide (pro-BNP) is associated with History of Major Adverse Cardiovascular Events (MACE) in subjects with Obstructive Sleep Apnea
J. Sunderram, F. R. Castillo, H. R. Castillo, S. Ravi +11 more
2026Sleep Medicine0 citations
Semantic Scholar
A80-1-02 Longitudinal Effect of Sleep Apnea Burdens on Plasma Alzheimer’s Disease Biomarker in Cognitively Normal Older Adults
J. Hwang, L. Figueredo Atilano, P. Boulgakov, S. Chu +9 more
2026American Journal of Respiratory and Critical Care Medicine0 citations
Semantic Scholar
D97-06 Reevaluating the Centers for Medicare and Medicaid Services 90-Day Cpap Adherence Requirement: Persistent Use Among Early Nonadherent Patients
D. Hwang, M. Billings, R. Yan, I. Ayappa +7 more
2026American Journal of Respiratory and Critical Care Medicine0 citations
Semantic Scholar
B80-3-04 The Utility and Challenges of Extracting Symptom Data From Electronic Health Records Using Natural Language Processing for Cardiovascular Diseases and Obstructive Sleep Apnea
Y. Dong, A. Parekh, N. M. Mariappan, S. Wickramaratne +6 more
2026American Journal of Respiratory and Critical Care Medicine0 citations
Semantic Scholar
Characterizing older patients with Obstructive Sleep Apnea at heightened risk of prospective cognitive decline and/or Alzheimer's Disease stage transition
O. Bubu, J. Gills, P. Pahari, A. Parekh +6 more
2026Sleep Medicine0 citations
Semantic Scholar
REM sleep promotes overnight emotional memory in a picture recognition task
A. Mullins, K. Kam, K. Martillo, S. Ravi +6 more
2026Sleep Medicine0 citations
Semantic Scholar
1169 Sleep Apnea Related Hypoxic and Ventilatory Burdens and Their Impact on Global Cognitive Performance in Older Community Dwelling American Adults
Purbanka Pahari, J. Gills, E. Valkanova, A. Dharmapuri +7 more
2026SLEEPJ0 citations
Semantic Scholar
Medicare Coverage Requirements and Real-world CPAP Utilization: Early Non-adherence Does not Exclude Long-term Use.
M. E. Billings, D. Hwang, R. Yan, I. Ayappa +7 more
2026American Journal of Respiratory and Critical Care Medicine0 citations
Semantic Scholar
0501 Worse Left Ventricular Diastolic Dysfunction is not Associated with Greater Ventilatory Control Instability in Obstructive Sleep Apnea
T. Tolbert, D. Valencia, Eriko Hamada, Wenli Zhao +6 more
2026SLEEPJ0 citations
Semantic Scholar
0857 OSA Treatment with PAP Reduces Locus Coeruleus-Hippocampal Resting-State Functional Connectivity on 7T MRI in Cognitively Normal Older Adults
K. Kam, Naomi L. Gaggi, Laurel Morris, D. Valencia +5 more
2026SLEEPJ0 citations
Semantic Scholar
1157 The Impact of Chronic Rhinosinusitis on Insomnia Symptoms and Sleep Duration in World Trade Center Rescue and Recovery Workers
H. R. Castillo, S. Ravi, K. Martillo, Adriana De Resende +11 more
2025Sleep0 citations
Semantic Scholar
Effects of Air Pollution on Sleep in Postpartum Women in Rural Ghana
R. Shah, H. Romero Castillo, S. Kaali, I. Ayappa +8 more
2025American Journal of Respiratory and Critical Care Medicine0 citations
Semantic Scholar
Characterizing Imaging-based Cardiometabolic Markers Using Hybrid 18F-FDG Positron Emission Tomography/Magnetic Resonance Imaging in Patients With Actigraphy-derived Sleep Patterns
B. Xu, K. Gaynor-Sodeifi, H. Patel, P. Robson +4 more
2025American Journal of Respiratory and Critical Care Medicine0 citations
Semantic Scholar
1127 Actigraphy-Based Sleep Irregularity Measures and Cardiometabolic Imaging Biomarkers Using PET/MRI: A Descriptive Analysis
K. Gaynor-Sodeifi, Bolong Xu, Heli J. Patel, Philip M. Robson +4 more
2025Sleep0 citations
Semantic Scholar

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A. Varga×23
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A. Parekh×19
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T. Tolbert×17
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