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W. Laver · SciRah

Researcher profile · Semantic Scholar

W. Laver

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W. Laver — researcher profile on SciRah

h-index: 66
Works: 229
Citations: 13K

Most-cited papers

Epitopes on protein antigens: misconceptions and realities.
W. Laver, G. Air, Robert G. Webster, Sandra J. Smith-Gill
1990Cell525 citations
Semantic Scholar
The neuraminidase of influenza virus
G. Air, W. Laver
1989Proteins: Structure, Function, and Bioinformatics299 citations
Semantic Scholar
Crystal structure of a bacterial sialidase (from Salmonella typhimurium LT2) shows the same fold as an influenza virus neuraminidase.
S. Crennell, E. Garman, W. Laver, E. Vimr +1 more
1993Proceedings of the National Academy of Sciences of the United States of America216 citations Open access
Semantic Scholar
Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
W. R. Tulip, J. Varghese, W. Laver, R. Webster +1 more
1992Journal of Molecular Biology196 citations
Semantic Scholar
Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en.
K. Staschke, J. Colacino, A. J. Baxter, G. Air +4 more
1995Virology144 citations Open access
Semantic Scholar
The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody.
R. Malby, W. R. Tulip, Vincent R. Harley, Jennifer L. Mckimm-Breschkin +3 more
1994Structure137 citations Open access
Semantic Scholar
Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid.
P. Bossart-Whitaker, M. Carson, Y. Babu, Craig D. Smith +2 more
1994Journal of Molecular Biology131 citations
Semantic Scholar
Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
W. R. Tulip, J. Varghese, A. T. Baker, A. van Donkelaar +3 more
1992Journal of Molecular Biology96 citations
Semantic Scholar
Antibody Epitopes on the Neuraminidase of a Recent H3N2 Influenza Virus (A/Memphis/31/98)
Upma Gulati, C. Hwang, L. Venkatramani, Shelly Gulati +6 more
2002Journal of Virology94 citations Open access
Semantic Scholar
Disarming flu viruses.
W. Laver, N. Bischofberger, R. G. Webster
1999Scientific American91 citations
Semantic Scholar
Structures of aromatic inhibitors of influenza virus neuraminidase.
M. J. Jedrzejas, Sangeeta Singh, Wayne J. Brouillette, W. Laver +2 more
1995Biochemistry90 citations
Semantic Scholar
Evolutionary changes in influenza B are not primarily governed by antibody selection.
G. Air, A. Gibbs, W. Laver, R. Webster
1990Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-A resolution: implications for the catalytic mechanism.
Musiri N. Janakiraman, C. White, W. Laver, G. Air +1 more
1994Biochemistry89 citations
Semantic Scholar
Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.
Pooran Chand, Yarlagadda S. Babu, Shanta Bantia, N. Chu +9 more
1997Journal of Medicinal Chemistry84 citations Open access
Semantic Scholar
Three-dimensional structures of influenza virus neuraminidase-antibody complexes.
P. Colman, W. R. Tulip, J. Varghese, P. Tulloch +4 more
1989Philosophical transactions of the Royal Society of London. Series B, Biological sciences81 citations
Semantic Scholar
The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
S. Crennell, E. Garman, C. Philippon, Andrea Vasella +3 more
1996Journal of Molecular Biology80 citations
Semantic Scholar
Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Antiinfluenza Activity.
C. Kim, W. Lew, Matthew A. Williams, H. Liu +8 more
199773 citations
Semantic Scholar
Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
W. R. Tulip, J. Varghese, R. G. Webster, W. Laver +1 more
1992Journal of Molecular Biology71 citations
Semantic Scholar
A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
C. White, M. N. Janakiraman, W. Laver, C. Philippon +3 more
1995Journal of Molecular Biology67 citations
Semantic Scholar
Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction.
Sangeeta Singh, M. J. Jedrzejas, G. Air, Ming Luo +2 more
1995Journal of Medicinal Chemistry64 citations
Semantic Scholar
An epidemiologically significant epitope of a 1998 human influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex.
L. Venkatramani, E. Bochkareva, Janis T Lee, Upma Gulati +3 more
2005Journal of Molecular Biology59 citations
Semantic Scholar
The Origin and Control of Pandemic Influenza
W. Laver, N. Bischofberger, R. Webster
2000Perspectives in biology and medicine58 citations Open access
Semantic Scholar
Detection and isolation of H5N1 influenza virus from large volumes of natural water.
A. Khalenkov, W. Laver, R. Webster
2008Journal of Virological Methods54 citations Open access
Semantic Scholar
Purification, thioredoxin renaturation, and reconstituted activity of the three subunits of the influenza A virus RNA polymerase.
Boguslaw Szewczyk, W. Laver, Donald F. Summers
1988Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase
G. Air, W. Laver, R. G. Webster
1990Journal of Virology52 citations Open access
Semantic Scholar
Crystal structures of neuraminidase-antibody complexes.
W. R. Tulip, J. Varghese, Robert G. Webster, G. Air +2 more
1989Cold Spring Harbor Symposia on Quantitative Biology51 citations
Semantic Scholar
Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
Matthew A. Williams, W. Lew, D. Mendel, Chun Y. Tai +4 more
199744 citations
Semantic Scholar
A single sequence change destabilizes the influenza virus neuraminidase tetramer.
J. Colacino, N. Chirgadze, Elspeth F. Garman, K. Murti +4 more
1997Virology43 citations Open access
Semantic Scholar
Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase
W. Kati, D. Montgomery, C. Maring, V. Stoll +5 more
2001Antimicrobial Agents and Chemotherapy39 citations Open access
Semantic Scholar
Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase
T. Saito, G. Taylor, W. Laver, Y. Kawaoka +1 more
1994Journal of Virology38 citations Open access
Semantic Scholar
Data for Drug Design. (Book Reviews: Use of X-Ray Crystallography in the Design of Antiviral Agents.)
W. Laver, G. Air
199036 citations
Semantic Scholar
Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture.
J. Colacino, W. Laver, G. Air
1997Journal of Infectious Diseases33 citations
Semantic Scholar
Guanidinobenzoic acid inhibitors of influenza virus neuraminidase.
E. Sudbeck, M. J. Jedrzejas, S. Singh, W. Brouillette +9 more
1997Journal of Molecular Biology33 citations
Semantic Scholar
Antigenic, sequence, and crystal variation in influenza B neuraminidase.
G. Air, W. Laver, Ming Luo, Stephen J. Stray +2 more
1990Virology33 citations
Semantic Scholar
Catalysis by Two Sialidases with the Same Protein Fold but Different Stereochemical Courses: A Mechanistic Comparison of the Enzymes from Influenza A Virus and Salmonella typhimurium
Xu-Ming Guo, W. Laver, E. Vimr, M. Sinnott
199432 citations
Semantic Scholar
Sialic acid is cleaved from glycoconjugates at the cell surface when influenza virus neuraminidases are expressed from recombinant vaccinia viruses.
M. Els, W. Laver, G. Air
1989Virology27 citations
Semantic Scholar
Red cells bound to influenza virus N9 neuraminidase are not released by the N9 neuraminidase activity.
G. Air, W. Laver
1995Virology25 citations Open access
Semantic Scholar
Approaches and Strategies for the Treatment of Influenza Virus Infections
J. Colacino, K. Staschke, W. Laver
1999Antiviral Chemistry & Chemotherapy21 citations Open access
Semantic Scholar
Crystallization of biologically active hemagglutinin-neuraminidase glycoprotein dimers proteolytically cleaved from human parainfluenza virus type 1
T. Takimoto, W. Laver, K. Murti, A. Portner
1992Journal of Virology13 citations Open access
Semantic Scholar
Crystallization of antibody-protein complexes
W. Laver
199013 citations
Semantic Scholar
Antibody recognition of the influenza virus neuraminidase.
G. Air, W. Laver, Robert G. Webster, M. Els +1 more
1989Cold Spring Harbor Symposia on Quantitative Biology13 citations
Semantic Scholar
Benzoic acid inhibitors of influenza virus neuraminidase.
Ming Luo, M. J. Jedrzejas, S. Singh, C. White +3 more
1995Acta Crystallographica Section D: Biological Crystallography11 citations
Semantic Scholar
Crystallization of Sendai virus HN protein complexed with monoclonal antibody Fab fragments.
W. Laver, Susan D. Thompson, K. Murti, A. Portner
1989Virology9 citations
Semantic Scholar
Three antibody molecules can bind simultaneously to each monomer of the tetramer of influenza virus neuraminidase and the trimer of influenza virus hemagglutinin
David C. Jackson, Brendan S. Crabb, Pantelis Poumbourios, W. R. Tulip +1 more
2005Archives of Virology8 citations
Semantic Scholar
Unusual diffraction of type B influenza virus neuraminidase crystals.
Ming Luo, W. Laver, G. Air
1992Acta Crystallographica Section A Foundations of Crystallography8 citations
Semantic Scholar
Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase.
W. Kati, D. Montgomery, C. Maring, V. Stoll +5 more
2001Antimicrobial Agents and Chemotherapy6 citations
Semantic Scholar
From the Great Barrier Reef to a "Cure" for the Flu: tall tales, but true
W. Laver
2004Perspectives in biology and medicine5 citations
Semantic Scholar
FIRST CRYSTAL STRUCTURE OF A BACTERIAL SIALIDASE SHOWS SAME FOLD AS INFLUENZA VIRUS NEURAMINIDASE
S. Crennell, E. Garman, W. Laver, E. Vimr +1 more
19935 citations
Semantic Scholar
New crystalline forms of neuraminidase of type B human influenza virus.
Yu-Juan Lin, Ming Luo, W. Laver, G. Air +2 more
1990Journal of Molecular Biology5 citations
Semantic Scholar
Book Review Hunting the 1918 Flu: One Scientist's Search for a Killer Virus By Kirsty Duncan. 297 pp., illustrated. Toronto, University of Toronto Press, 2003. $35. 0-8020-8748-5
W. Laver
20043 citations
Semantic Scholar

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