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Guan-Lei Wang · SciRah

Researcher profile · Semantic Scholar

Guan-Lei Wang

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Guan-Lei Wang — researcher profile on SciRah

h-index: 26
Works: 84
Citations: 2,085

Most-cited papers

Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation
Mi Wang, Hui Yang, Ling-Yun Zheng, Zheng Zhang +7 more
2012Circulation150 citations Open access
Semantic Scholar
Deficiency in ClC-3 Chloride Channels Prevents Rat Aortic Smooth Muscle Cell Proliferation
Guan-Lei Wang, Xueron Wang, Mo-Jun Lin, Hua He +2 more
2002Circulation Research108 citations Open access
Semantic Scholar
The ClC-3 Cl- channel in cell volume regulation, proliferation and apoptosis in vascular smooth muscle cells.
Y. Guan, Guan-Lei Wang, Jia-Guo Zhou
2006TIPS - Trends in Pharmacological Sciences104 citations
Semantic Scholar
TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase–Derived Reactive Oxygen Species Generation in Hypertension
Ming-Ming Ma, Min Gao, Kai-Min Guo, Mi Wang +8 more
2017HYPERTENSION94 citations
Semantic Scholar
Functional role of anion channels in cardiac diseases
D. Duan, Luis L. Liu, Nathan D. Bozeat, Z. M. Huang +4 more
2005Acta Pharmacologica Sinica88 citations
Semantic Scholar
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.
Wen-Liang Chen, Y. Qian, Wei-Feng Meng, J. Pang +6 more
2009Biochemical Pharmacology82 citations
Semantic Scholar
Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells.
Y. Guan, Jia-Guo Zhou, Zheng Zhang, Guan-Lei Wang +4 more
2006European Journal of Pharmacology77 citations
Semantic Scholar
Silence of ClC‐3 chloride channel inhibits cell proliferation and the cell cycle via G1/S phase arrest in rat basilar arterial smooth muscle cells
Yong-Bo Tang, Ying Liu, Jia-Guo Zhou, Guan-Lei Wang +2 more
2008Cell Proliferation75 citations Open access
Semantic Scholar
Design and synthesis of novel xyloketal derivatives and their vasorelaxing activities in rat thoracic aorta and angiogenic activities in zebrafish angiogenesis screen.
Zhongliang Xu, Yi-Ying Li, Qi Xiang, Z. Pei +6 more
2010Journal of Medicinal Chemistry72 citations
Semantic Scholar
Xyloketal B Suppresses Glioblastoma Cell Proliferation and Migration in Vitro through Inhibiting TRPM7-Regulated PI3K/Akt and MEK/ERK Signaling Pathways
Wen-Liang Chen, Ekaterina Turlova, Christopher L. F. Sun, Ji-sun Kim +7 more
2015Marine Drugs68 citations Open access
Semantic Scholar
Ginsenoside-Rd, a new voltage-independent Ca2+ entry blocker, reverses basilar hypertrophic remodeling in stroke-prone renovascular hypertensive rats.
Bing-Xiang Cai, Xiao-Yan Li, Jing-Hui Chen, Yong-Bo Tang +4 more
2009European Journal of Pharmacology61 citations Open access
Semantic Scholar
Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage.
Jia Zhao, Ling Li, C. Ling, Jie Li +7 more
2009Brain Research58 citations
Semantic Scholar
Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway
Ni Pan, Liu-Yi Lu, Mei Li, Guo-hao Wang +11 more
2017Acta Pharmacologica Sinica56 citations Open access
Semantic Scholar
Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo
Raymond Wong, Ahmed Abussaud, Joseph W. Leung, Baofeng Xu +6 more
2018Acta Pharmacologica Sinica55 citations Open access
Semantic Scholar
Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury
Ai-Jiao Xiao, Wenliang Chen, Baofeng Xu, R. Liu +8 more
2014Marine Drugs55 citations Open access
Semantic Scholar
Alteration of Volume-Regulated Chloride Movement in Rat Cerebrovascular Smooth Muscle Cells During Hypertension
Xiao-Lian Shi, Guan-Lei Wang, Zheng Zhang, Yu-Jie Liu +4 more
2007HYPERTENSION54 citations Open access
Semantic Scholar
Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells.
Xi-lin Lu, Xiao-li Yao, Zhi-yong Liu, Heng Zhang +9 more
2010Brain Research45 citations
Semantic Scholar
Neuroprotective effects of volume-regulated anion channel blocker DCPIB on neonatal hypoxic-ischemic injury
Ammar Alibrahim, Li-Yan Zhao, C. Y. Bae, A. Barszczyk +3 more
2012Acta Pharmacologica Sinica39 citations Open access
Semantic Scholar
Xyloketal B Exhibits Its Antioxidant Activity through Induction of HO-1 in Vascular Endothelial Cells and Zebrafish
Zhen-Xing Li, Jian-Wen Chen, Feng Yuan, Yun-Ying Huang +10 more
2013Marine Drugs37 citations Open access
Semantic Scholar
WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells
Ya-juan Zhang, Hua-qing Zheng, Bao-yi Chen, Lu Sun +3 more
2017Acta Pharmacologica Sinica34 citations Open access
Semantic Scholar
Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition.
Xue-Lin Zeng, Lu Sun, Hua-qing Zheng, Guan-Lei Wang +4 more
2019Journal of Molecular and Cellular Cardiology31 citations
Semantic Scholar
Role of Cl- channels in primary brain tumour.
Tayyebeh Saberbaghi, Raymond Wong, J. Rutka, Guan-Lei Wang +2 more
2019Cell Calcium31 citations
Semantic Scholar
Involvement of Kv1.5 Protein in Oxidative Vascular Endothelial Cell Injury
Wen-Liang Chen, Xiong-qing Huang, Li-Yan Zhao, J. Li +6 more
2012PLoS ONE28 citations Open access
Semantic Scholar
Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension.
Ling-Yun Zheng, Lei Li, Ming-Ming Ma, Yun Liu +6 more
2013Cardiovascular Research27 citations
Semantic Scholar
Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites
Xue Bai, Bin Zhang, Ping Wang, Guan-Lei Wang +7 more
2018Acta Pharmacologica Sinica26 citations Open access
Semantic Scholar
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells
Jia-Wei Zeng, Xue-Lin Zeng, Fei-ya Li, Ming-Ming Ma +5 more
2014Apoptosis26 citations
Semantic Scholar
Transmembrane member 16A participates in hydrogen peroxide‐induced apoptosis by facilitating mitochondria‐dependent pathway in vascular smooth muscle cells
Jia-Wei Zeng, Bao-yi Chen, Xiao-Fei Lv, Lu Sun +6 more
2018British Journal of Pharmacology24 citations Open access
Semantic Scholar
Xyloketal B Attenuates Atherosclerotic Plaque Formation and Endothelial Dysfunction in Apolipoprotein E Deficient Mice
Li-Yan Zhao, J. Li, Feng Yuan, Mei Li +13 more
2015Marine Drugs24 citations Open access
Semantic Scholar
Molecular mechanisms of regulation of fast‐inactivating voltage‐dependent transient outward K+ current in mouse heart by cell volume changes
Guan-Lei Wang, Ge-Xin Wang, Shintaro Yamamoto, L. Ye +3 more
2005Journal of Physiology24 citations
Semantic Scholar
LNK deficiency decreases obesity-induced insulin resistance by regulating GLUT4 through the PI3K-Akt-AS160 pathway in adipose tissue
Xiaozhu Zhong, Chuan-Feng Ke, Zhaoxi Cai, Hao Wu +9 more
2020Aging23 citations Open access
Semantic Scholar
Xyloketal B: A marine compound with medicinal potential.
Hai-fan Gong, Julia Bandura, Guan-Lei Wang, Zhong-Ping Feng +1 more
2021Pharmacology and Therapeutics22 citations
Semantic Scholar
Marine Compound Xyloketal B as a Potential Drug Development Target for Neuroprotection
Hai-fan Gong, Zheng-wei Luo, Wenliang Chen, Zhong-Ping Feng +2 more
2018Marine Drugs22 citations Open access
Semantic Scholar
Ca2+/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl- Channel Regulation in Cerebrovascular Cells.
Cai-xia Lin, Xiao-Fei Lv, Feng Yuan, Xiang-yu Li +5 more
2017Circulation Journal22 citations Open access
Semantic Scholar
Functional Characterization of Novel Alternatively Spliced ClC-2 Chloride Channel Variants in the Heart*
F. Britton, Guan-Lei Wang, Z. M. Huang, L. Ye +3 more
2005Journal of Biological Chemistry21 citations Open access
Semantic Scholar
SGK1 mediates the hypotonic protective effect against H2O2-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway
Bao-yi Chen, Cheng-cui Huang, Xiao-Fei Lv, Hua-qing Zheng +5 more
2020Acta Pharmacologica Sinica20 citations Open access
Semantic Scholar
Threonine532 phosphorylation in ClC‐3 channels is required for angiotensin II‐induced Cl− current and migration in cultured vascular smooth muscle cells
Ming-Ming Ma, Cai-xia Lin, Can-Zhao Liu, Min Gao +5 more
2016British Journal of Pharmacology20 citations Open access
Semantic Scholar
TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner
Hua-qing Zheng, Xiaolong Li, Xin Zeng, Cheng-cui Huang +7 more
2021Acta Pharmaceutica Sinica B19 citations Open access
Semantic Scholar
Endophilin A2 Influences Volume-Regulated Chloride Current by Mediating ClC-3 Trafficking in Vascular Smooth Muscle Cells.
Can-Zhao Liu, Xiang-yu Li, Ren-Hong Du, Min Gao +6 more
2016Circulation Journal18 citations Open access
Semantic Scholar
Overexpression of Lnk in the Ovaries Is Involved in Insulin Resistance in Women With Polycystic Ovary Syndrome.
Meihua Hao, FENG-NING F. Yuan, Chen-chen Jin, Ze-Hong Zhou +7 more
2016Endocrinology18 citations Open access
Semantic Scholar
Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells.
Yun Liu, Min Gao, Ming-Ming Ma, Yong-Bo Tang +4 more
2016Journal of Molecular and Cellular Cardiology18 citations
Semantic Scholar
ClC-3 deficiency prevents atherosclerotic lesion development in ApoE-/- mice.
Jing Tao, Can-Zhao Liu, Jing Yang, Zhi-Zhong Xie +7 more
2015Journal of Molecular and Cellular Cardiology18 citations
Semantic Scholar
ClC-3 deficiency protects preadipocytes against apoptosis induced by palmitate in vitro and in type 2 diabetes mice
Yun-Ying Huang, Xiong-qing Huang, Li-Yan Zhao, Fang-Yun Sun +10 more
2014Apoptosis18 citations
Semantic Scholar
Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation
Can-Zhao Liu, Fei-ya Li, Xiao-Fei Lv, Ming-Ming Ma +4 more
2019Acta Pharmacologica Sinica17 citations Open access
Semantic Scholar
Xyloketal B exerts antihypertensive effect in renovascular hypertensive rats via the NO-sGC-cGMP pathway and calcium signaling
Li-Yan Zhao, J. Li, Xiong-qing Huang, Guo-hao Wang +8 more
2018Acta Pharmacologica Sinica17 citations Open access
Semantic Scholar
Suppression of Kv1.5 protects against endothelial apoptosis induced by palmitate and in type 2 diabetes mice
Jie Du, Feng Yuan, Li-Yan Zhao, Jie Zhu +12 more
2017Life Science17 citations
Semantic Scholar
Increased intracellular Cl− concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases
Hui-Jing Han, Chang Liu, Mei Li, Jin Wang +9 more
2022Acta Pharmacologica Sinica16 citations Open access
Semantic Scholar
CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca2+ influx and RhoA/Rock pathway in VSMCs.
Li-Yan Zhao, Feng Yuan, Ni Pan, Yun Yu +5 more
2021Frontiers in Bioscience14 citations Open access
Semantic Scholar
Clcn3 deficiency ameliorates high-fat diet-induced obesity and adipose tissue macrophage inflammation in mice
Ming-Ming Ma, Chen-chen Jin, Xue-Lian Huang, Lu Sun +10 more
2019Acta Pharmacologica Sinica14 citations Open access
Semantic Scholar
Antiplatelet and Antithrombotic Effects of Isaridin E Isolated from the Marine-Derived Fungus via Downregulating the PI3K/Akt Signaling Pathway
Ni Pan, Zi-Cheng Li, Zhi-Hong Li, Sen-Hua Chen +8 more
2021Marine Drugs13 citations Open access
Semantic Scholar
Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl− concentration and activation of SGK1 signaling pathway
Han Yang, Chao Zhang, Liang Hu, Chang Liu +19 more
2022Acta Pharmacologica Sinica10 citations Open access
Semantic Scholar

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