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J. Unsinger · SciRah

Researcher profile · Semantic Scholar

J. Unsinger

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J. Unsinger — researcher profile on SciRah

h-index: 27
Works: 57
Citations: 3,891

Most-cited papers

Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.
B. François, Robin Jeannet, T. Daix, A. Walton +12 more
2018JCI Insight408 citations Open access
Semantic Scholar
IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis
J. Unsinger, Margaret G. McGlynn, K. Kasten, Andrew S. Hoekzema +10 more
2010Journal of Immunology332 citations Open access
Semantic Scholar
Delayed administration of anti‐PD‐1 antibody reverses immune dysfunction and improves survival during sepsis
P. Brahmamdam, S. Inoue, J. Unsinger, Katherine C. Chang +2 more
2010Journal of Leukocyte Biology302 citations Open access
Semantic Scholar
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections
Kenneth E. Remy, M. Mazer, David A. Striker, A. Ellebedy +17 more
2020JCI Insight293 citations Open access
Semantic Scholar
Blockade ofthe negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis
Katherine C. Chang, C. Burnham, Stephanie M Compton, David Rasche +6 more
2013Critical Care273 citations Open access
Semantic Scholar
IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis
S. Inoue, J. Unsinger, C. Davis, J. Muenzer +7 more
2009Journal of Immunology250 citations Open access
Semantic Scholar
The new normal: immuno-modulatory agents against sepsis immune suppression
Noelle A. Hutchins, J. Unsinger, R. Hotchkiss, A. Ayala
2014Trends in Molecular Medicine239 citations Open access
Semantic Scholar
Multiple triggers of cell death in sepsis: death receptor and mitochondrial‐mediated apoptosis
Katherine C. Chang, J. Unsinger, Christopher G. Davis, Steven J. Schwulst +3 more
2007The FASEB Journal163 citations
Semantic Scholar
Dose Dependent Effect of Anti-CTLA-4 on Survival in Sepsis
S. Inoue, Lu-Long Bo, J. Bian, J. Unsinger +2 more
2011Shock147 citations Open access
Semantic Scholar
Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.
J. Unsinger, C. Burnham, Jacquelyn S. Mcdonough, M. Morre +4 more
2012Journal of Infectious Diseases135 citations Open access
Semantic Scholar
PNEUMONIA AFTER CECAL LIGATION AND PUNCTURE: A CLINICALLY RELEVANT "TWO-HIT" MODEL OF SEPSIS
J. Muenzer, C. Davis, Benjamin S. Dunne, J. Unsinger +2 more
2006Shock121 citations Open access
Semantic Scholar
Interleukin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through γδ T-Cell IL-17 Production in a Murine Model of Sepsis
K. Kasten, P. Prakash, J. Unsinger, Holly S. Goetzman +9 more
2010Infection and Immunity111 citations Open access
Semantic Scholar
Sepsis‐induced human lymphocyte apoptosis and cytokine production in “humanized” mice
J. Unsinger, Jacquelyn S. Mcdonough, Leonard D. Shultz, T. Ferguson +1 more
2009Journal of Leukocyte Biology108 citations Open access
Semantic Scholar
Differential lymphopenia‐induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury
J. Unsinger, H. Kazama, Jacquelyn S. Mcdonough, R. Hotchkiss +1 more
2009Journal of Leukocyte Biology87 citations Open access
Semantic Scholar
Deletion of MyD88 markedly attenuates sepsis‐induced T and B lymphocyte apoptosis but worsens survival
Octavia M. Peck-Palmer, J. Unsinger, Katherine C. Chang, Christopher G. Davis +2 more
2008Journal of Leukocyte Biology84 citations Open access
Semantic Scholar
Interleukin 7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression
Y. Shindo, J. Unsinger, Cary-Ann Burnham, Jonathan M. Green +1 more
2015Shock82 citations Open access
Semantic Scholar
Interleukin 7 immunotherapy improves host immunity and survival in a two‐hit model of Pseudomonas aeruginosa pneumonia
Y. Shindo, A. Fuchs, Christopher G. Davis, Timothy K Eitas +6 more
2017Journal of Leukocyte Biology81 citations Open access
Semantic Scholar
Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial
T. Daix, A. Mathonnet, Scott C. Brakenridge, P. Dequin +11 more
2023Annals of Intensive Care76 citations Open access
Semantic Scholar
Sepsis-Induced Apoptosis Leads to Active Suppression of Delayed-Type Hypersensitivity by CD8+ Regulatory T Cells through a TRAIL-Dependent Mechanism
J. Unsinger, H. Kazama, J. S. McDonough, Thomas S. Griffith +2 more
2010Journal of Immunology76 citations Open access
Semantic Scholar
BIM siRNA DECREASES LYMPHOCYTE APOPTOSIS AND IMPROVES SURVIVAL IN SEPSIS
Steven J. Schwulst, J. Muenzer, Octavia M. Peck-Palmer, Katherine C. Chang +7 more
2008Shock68 citations Open access
Semantic Scholar
Targeted delivery of siRNA to cell death proteins in sepsis
P. Brahmamdam, Eizo Watanabe, J. Unsinger, Katherine C. Chang +9 more
2009Shock60 citations Open access
Semantic Scholar
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement.
D. Spitzer, J. Unsinger, M. Bessler, J. Atkinson
2004Molecular Immunology58 citations
Semantic Scholar
MODULATION OF THE BCL-2 FAMILY BLOCKS SEPSIS-INDUCED DEPLETION OF DENDRITIC CELLS AND MACROPHAGES
Octavia M. Peck-Palmer, J. Unsinger, Katherine C. Chang, Jacquelyn S. Mcdonough +3 more
2009Shock52 citations Open access
Semantic Scholar
The Role of TCR Engagement and Activation-Induced Cell Death in Sepsis-Induced T Cell Apoptosis1
J. Unsinger, J. Herndon, C. Davis, J. Muenzer +2 more
2006Journal of Immunology48 citations Open access
Semantic Scholar
Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes.
J. Unsinger, Andrea Kröger, Hansjörg Hauser, D. Wirth
2001Molecular Therapy36 citations Open access
Semantic Scholar
Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders
Jin-Tao Zhang, Katherine Czerpaniak, Liang Huang, Xuemei Liu +5 more
2020Pain31 citations Open access
Semantic Scholar
Polyvalent DNA vaccines with bidirectional promoters
M. Kwissa, J. Unsinger, R. Schirmbeck, H. Hauser +1 more
2000Journal of molecular medicine28 citations
Semantic Scholar
A PEPTIDE-BASED CHECKPOINT IMMUNOMODULATOR ALLEVIATES IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS
T. Phares, V. Kotraiah, C. Chung, J. Unsinger +9 more
2020Shock22 citations Open access
Semantic Scholar
In Vivo Correction of Complement Regulatory Protein Deficiency with an Inhibitor Targeting the Red Blood Cell Membrane1
D. Spitzer, J. Unsinger, D. Mao, Xiaobo Wu +2 more
2005Journal of Immunology22 citations
Semantic Scholar
Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling
Zhaohua Guo, Jin-Tao Zhang, Xuemei Liu, J. Unsinger +2 more
2022Neurobiology of Pain17 citations Open access
Semantic Scholar
Viral Delivery of IL-7 Is a Potent Immunotherapy Stimulating Innate and Adaptive Immunity and Confers Survival in Sepsis Models
K. Lélu, C. Dubois, A. Evlachev, Morgane Crausaz +11 more
2022Journal of Immunology15 citations
Semantic Scholar
Stable and strictly controlled expression of LTR-flanked autoregulated expression cassettes upon adenoviral transfer.
J. Unsinger, W. Lindenmaier, T. May, H. Hauser +1 more
2004Biochemical and Biophysical Research Communications - BBRC15 citations
Semantic Scholar
Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis
J. Unsinger, A. Walton, Teresa M. Blood, D. Tenney +3 more
2020Journal of Leukocyte Biology13 citations Open access
Semantic Scholar
Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization
S. Ryu, Jin-Tao Zhang, Roli Simoes, Xuemei Liu +5 more
2024The Journal of Headache and Pain12 citations Open access
Semantic Scholar
New Approaches towards ex vivo and in vivo Gene Therapy
H. Hauser, Dirk Spitzer, Els Verhoeyen, J. Unsinger +1 more
2000Cells Tissues Organs8 citations
Semantic Scholar
Comment on “IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis” and Comment on “IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis”
Richard Hotchkiss, J. Unsinger, C. Caldwell, D. Hildeman
2010Journal of Immunology6 citations Open access
Semantic Scholar
G-CSF induced progenitor mobilization in mice with PIGA- blood cells.
Bing Han, J. Unsinger, Fulu Liu, D. Link +1 more
2004The Hematology Journal6 citations
Semantic Scholar
Autophagy Regulates Müller Glial Cell Inflammatory Activation
T. Doggett, Zhenqing Zhou, Sohini Rebba, J. Unsinger +2 more
2025Investigative Ophthalmology and Visual Science4 citations Open access
Semantic Scholar
Genetic Approaches to Recombinant Protein Production in Mammalian Cells
Peter P. Mueller, D. Wirth, J. Unsinger, H. Hauser
20033 citations
Semantic Scholar
Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot
J. Unsinger, D. Osborne, A. Walton, E. Han +12 more
2024Shock2 citations Open access
Semantic Scholar
Generation of mammalian cells with conditional expression of crerecombinase
D. Klehr-Wirth, F. Kuhnert, J. Unsinger, H. Hauser
19972 citations Open access
Semantic Scholar
Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot
J. Unsinger, D. Osborne, AH Walton, E. Han +12 more
2023bioRxiv1 citations Open access
Semantic Scholar
IL-7 Promotes T Cell Viability, Enhances Immunity, and Improves Survival in Sepsis
K. Kasten, A. Seitz, J. Unsinger, David A Hildeman +2 more
20101 citations
Semantic Scholar
Sepsis-Induced T Cell Apoptosis Activation-Induced Cell Death in The Role of TCR Engagement and
J. Unsinger, J. Herndon, C. Davis, J. Muenzer +2 more
20061 citations
Semantic Scholar
Entwicklung regulierbarer retro- und adenoviraler Vektoren für die Gentherapie
J. Unsinger
20011 citations
Semantic Scholar
Low-Dose Interleukin-2 Resolves Stress-Induced Chronic Sensitization Independent of Opioid Receptor Signaling
Roli Simoes, S. Kraus, Jin-Tao Zhang, L. F. do Nascimento +6 more
2026bioRxiv0 citations Open access
Semantic Scholar
Adaptive Immunity and Confers Survival in Immunotherapy Stimulating Innate and Viral Delivery of IL-7 Is a Potent
Inchauspé, Leung-Theung-Long, J. Unsinger, Perrine J. Martin +13 more
20220 citations
Semantic Scholar
SepsisProduction in a Murine Model of T-Cell δ γ Neutrophil Recruitment through Interleukin-7 (IL-7) Treatment Accelerates
R. Hotchkiss, David A Hildeman, Cristina Mazuski, Tony T. Zhou +7 more
20140 citations
Semantic Scholar
of Fungal Sepsis
J. Unsinger, C. Burnham, Jacquelyn S. Mcdonough, M. Morre +3 more
20120 citations
Semantic Scholar
Sepsis-induced immunosuppression is mediated by TRAIL-expressing CD8+ regulatory T cells (87.13)
Thomas S. Griffith, J. Unsinger, H. Kazama, J. S. McDonough +2 more
2010Journal of Immunology0 citations
Semantic Scholar

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T. Ferguson×9
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Katherine C. Chang×9
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Jacquelyn S. Mcdonough

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C. Caldwell — researcher profile on SciRah

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