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Mark D. Ericson · SciRah

Researcher profile · Semantic Scholar

Mark D. Ericson

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Mark D. Ericson — researcher profile on SciRah

h-index: 12
Works: 39
Citations: 742

Most-cited papers

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
G. Yeo, D. H. Chao, A. Siegert, Zoe M. Koerperich +11 more
2021Molecular Metabolism201 citations Open access
Semantic Scholar
Change in surface hardness of enamel by a cola drink and a CPP-ACP paste.
D. Tantbirojn, A. Huang, Mark D. Ericson, S. Poolthong
2008E -journal of dentistry153 citations
Semantic Scholar
Bench-Top to Clinical Therapies: A Review of Melanocortin Ligands from 1954 to 2016
Mark D. Ericson, Cody J Lensing, Katlyn A. Fleming, Katherine N Schlasner +2 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease71 citations Open access
Semantic Scholar
PEG Length and Chemical Linkage Controls Polyacridine Peptide DNA Polyplex Pharmacokinetics, Biodistribution, Metabolic Stability and In Vivo Gene Expression
S. Khargharia, Koby L Kizzire, Mark D. Ericson, Nicholas J. Baumhover +1 more
2013Journal of Controlled Release42 citations Open access
Semantic Scholar
Metabolically Stabilized Long-Circulating PEGylated Polyacridine Peptide Polyplexes Mediate Hydrodynamically Stimulated Gene Expression in Liver
C. Fernandez, Nicholas J. Baumhover, J. T. Duskey, S. Khargharia +3 more
2010Gene Therapy41 citations Open access
Semantic Scholar
A Fragment of the Escherichia coli ClpB Heat-Shock Protein is a Micromolar Melanocortin 1 Receptor Agonist
Mark D. Ericson, Sathya M. Schnell, K. Freeman, C. Haskell-Luevano
2015Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Discovery of a β-Hairpin Octapeptide c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro] Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology
Mark D. Ericson, Andrzej M. Wilczynski, Nicholas B. Sorensen, Zhi-Min Xiang +1 more
2015Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.
Katlyn A. Fleming, Mark D. Ericson, K. Freeman, Danielle N. Adank +3 more
2018ACS Chemical Neuroscience18 citations Open access
Semantic Scholar
Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.
Mark D. Ericson, K. Freeman, Sathya M. Schnell, Katlyn A. Fleming +1 more
2017Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Synergistic Multi-Residue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists
Katlyn A. Fleming, K. Freeman, Mark D. Ericson, C. Haskell-Luevano
2018Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
A Review of Single-Nucleotide Polymorphisms (SNPs) in Orexigenic Neuropeptides Targeting G-Protein Coupled Receptors (GPCRs)
Mark D. Ericson, C. Haskell-Luevano
2018ACS Chemical Neuroscience13 citations Open access
Semantic Scholar
A Macrocyclic Agouti-Related Protein/[Nle4, DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Sub-nanomolar Melanocortin Receptor Ligands
Mark D. Ericson, K. Freeman, Sathya M. Schnell, C. Haskell-Luevano
2017Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity
Tushar P. Patel, Yun Jun Joo, Arnold Y. Seo, Noah J Levi +14 more
2025Nature Communications8 citations
Semantic Scholar
Synthesis of homogenous disulfide cross‐linked polypeptides by iterative reducible ligation
Mark D. Ericson, K. Rice
2012Biopolymers8 citations
Semantic Scholar
Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
Brittany T Galuppo, Prabhath Mannam, J. Bonet, Bridget M. Pierpont +8 more
2024International Journal of Obesity7 citations Open access
Semantic Scholar
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R) Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput “Unbiased” Screening Campaign
Skye R. Doering, K. Freeman, Ginamarie Debevec, Phaedra Geer +8 more
2021Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
Comparative intracerebroventricular (ICV) and intrathecal (IT) administration of a nanomolar macrocyclic melanocortin receptor agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) decreases food intake in mice.
Danielle N. Adank, Mary M. Lunzer, Mark D. Ericson, Zoe M. Koeperich +3 more
2020ACS Chemical Neuroscience7 citations Open access
Semantic Scholar
Human β-Defensin-1 and β-Defensin-3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors
Mark D. Ericson, Anamika Singh, S. R. Tala, Erica M. Haslach +11 more
2018Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors
A. Todorovic, Mark D. Ericson, Ryan Palusak, Nicholas B. Sorensen +3 more
2016ACS Chemical Neuroscience7 citations Open access
Semantic Scholar
Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AGRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists
Zoe M. Koerperich, Mark D. Ericson, K. Freeman, Robert C. Speth +3 more
2019Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Arg-Phe-Phe D-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xaa-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles
Mark D. Ericson, Zoe M. Koerperich, K. Freeman, Katlyn A. Fleming +1 more
2018ACS Chemical Neuroscience6 citations Open access
Semantic Scholar
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86–132) Antagonist
Mark D. Ericson, Skye R. Doering, Courtney M. Larson, K. Freeman +9 more
2021Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP’s Inverse Agonist Pharmacology at the hMC4R
Mark D. Ericson, Erica M. Haslach, Sathya M. Schnell, K. Freeman +5 more
2021ACS Chemical Neuroscience5 citations Open access
Semantic Scholar
A Convergent Synthesis of Homogeneous Reducible Polypeptides
Mark D. Ericson, K. Rice
2013Tetrahedron Letters5 citations Open access
Semantic Scholar
Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands
Katherine N Schlasner, Mark D. Ericson, Skye R. Doering, K. Freeman +2 more
2019Molecules4 citations Open access
Semantic Scholar
Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy.
Marshall Winget, Mark D. Ericson, K. Freeman, C. Haskell-Luevano
2019ACS Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2’)-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2’)-Arg-NH2]
Mark D. Ericson, L. Trần, Sarah S. Mathre, K. Freeman +5 more
2023Journal of Medicinal Chemistry3 citations Open access
Semantic Scholar
Iterative Reducible Ligation to form Homogeneous Penicillamine Cross-linked Polypeptides
Mark D. Ericson, K. Rice
2013Tetrahedron Letters3 citations Open access
Semantic Scholar
The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands
Mark D. Ericson, K. Freeman, Travis M Lavoi, Haley M. Donow +5 more
2023International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Peptoid NPhe4 in AGRP-Based c[Pro1-Arg2-Phe3-Phe4-Xxx5-Ala6-Phe7-DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency.
Mark D. Ericson, K. Freeman, C. Haskell-Luevano
2020ACS Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist.
Mark D. Ericson, Romessa Shaikh, Courtney M. Larson, K. Freeman +1 more
2020ACS Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
N-branched tricyclic guanidines as novel melanocortin-3 receptor agonists and melanocortin-4 receptor antagonists
Nicholas A Weirath, Jonathan W. P. Zajac, Haley M. Donow, Travis M Lavoi +8 more
2025Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-Hi
Mark D. Ericson, K. Freeman, Courtney M. Larson, Jacob L Bouchard +4 more
2024ACS Pharmacology & Translational Science1 citations Open access
Semantic Scholar
Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide
Mark D. Ericson, Courtney M. Larson, K. Freeman, Lennart Nicke +2 more
2022ACS Omega1 citations Open access
Semantic Scholar
Synthesis and Pharmacological Characterization of Adrenocorticotropic Hormone (ACTH 1–24) and C-Terminal Truncated Analogues Identifies the Minimal ACTH N-Terminal Fragment Required for Melanocorton-2 Receptor Activation
A. Todorovic, Mark D. Ericson, K. Gridley, Nicholas B. Sorenson +1 more
2024International Journal of Peptide Research and Therapeutics0 citations Open access
Semantic Scholar
Correction to "Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign".
Skye R. Doering, K. Freeman, Ginamarie Debevec, Phaedra Geer +8 more
2023Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
Peptoid NPhe in AGRP-Based c[Pro‐Arg‐Phe‐Phe‐Xxx‐Ala‐Phe‐DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency
Mark D. Ericson, K. Freeman, C. Haskell-Luevano
20200 citations
Semantic Scholar
MACROMOLECULAR CONJUGATES FOR NON-VIRAL NUCLEIC ACID DELIVERY
Mark D. Ericson, K. Rice, G. Zuber
2014Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology0 citations
Semantic Scholar
A novel iterative reducible ligation strategy for the synthesis of homogeneous gene delivery polypeptides
Mark D. Ericson
20120 citations Open access
Semantic Scholar

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C. Haskell-Luevano×25
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Katlyn A. Fleming×6
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