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D. Worthylake · SciRah

Researcher profile · Semantic Scholar

D. Worthylake

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D. Worthylake — researcher profile on SciRah

h-index: 21
Works: 58
Citations: 3,470

Most-cited papers

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
T. R. Gamble, S. Yoo, F. Vajdos, U. V. von Schwedler +5 more
1997Science610 citations
Semantic Scholar
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.
C. Hill, D. Worthylake, D. Bancroft, Allyson M. Christensen +1 more
1996Proceedings of the National Academy of Sciences of the United States of America497 citations Open access
Semantic Scholar
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
D. Worthylake, K. Rossman, J. Sondek
2000Nature378 citations
Semantic Scholar
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.
D. Worthylake, Hui Wang, S. Yoo, W. Sundquist +1 more
1999Acta Crystallographica Section D: Biological Crystallography249 citations
Semantic Scholar
Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase
J. H. Hurley, H. R. Faber, D. Worthylake, N. Meadow +3 more
1993Science239 citations
Semantic Scholar
A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange
K. Rossman, D. Worthylake, J. T. Snyder, D. Siderovski +2 more
2002EMBO Journal235 citations Open access
Semantic Scholar
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
J. T. Snyder, D. Worthylake, K. Rossman, L. Betts +4 more
2002Nature Structural Biology235 citations
Semantic Scholar
ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism*♦
C. Parke, E. Wojcik, Sunyoung Kim, D. Worthylake
2009Journal of Biological Chemistry154 citations Open access
Semantic Scholar
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors
A. E. Karnoub, D. Worthylake, K. Rossman, W. M. Pruitt +3 more
2001Nature Structural Biology98 citations
Semantic Scholar
The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.
Mariya Chhatriwala, L. Betts, D. Worthylake, J. Sondek
2007Journal of Molecular Biology92 citations Open access
Semantic Scholar
Three-dimensional structure of the Escherichia coli phosphocarrier protein IIIglc.
D. Worthylake, N. Meadow, S. Roseman, Der-Ing Liao +2 more
1991Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
Semantic Scholar
Crystal Structure of the Saccharomyces cerevisiae Ubiquitin-conjugating Enzyme Rad6 at 2.6 Å Resolution*
D. Worthylake, S. Prakash, L. Prakash, C. Hill
1998Journal of Biological Chemistry78 citations Open access
Semantic Scholar
Comparison of the NMR and X‐ray structures of the HIV‐1 matrix protein: Evidence for conformational changes during viral assembly
Michael A. Massiah, D. Worthylake, Allyson M. Christensen, W. Sundquist +2 more
1996Protein Science74 citations Open access
Semantic Scholar
Crystal Structure of the GTPase-activating Protein-related Domain from IQGAP1
V. Kurella, Jessica M. Richard, C. Parke, Louis F. LeCour +2 more
2009Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Allosteric Drug Discrimination Is Coupled to Mechanochemical Changes in the Kinesin-5 Motor Core*
Elizabeth D. Kim, Rebecca S Buckley, Sarah Learman, Jessica M. Richard +5 more
2010Journal of Biological Chemistry51 citations Open access
Semantic Scholar
The Structural Basis for Cdc42-induced Dimerization of IQGAPs
Louis F. LeCour, V. Boyapati, Jing Liu, Zhi-Gang Li +2 more
2016Structure45 citations Open access
Semantic Scholar
Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
D. Worthylake, K. Rossman, J. Sondek
2004Structure39 citations Open access
Semantic Scholar
Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange*
K. Rossman, D. Worthylake, J. T. Snyder, Li Cheng +2 more
2002Journal of Biological Chemistry37 citations Open access
Semantic Scholar
RhoGEF Specificity Mutants Implicate RhoA as a Target for Dbs Transforming Activity
Li Cheng, K. Rossman, G. Mahon, D. Worthylake +3 more
2002Molecular and Cellular Biology33 citations Open access
Semantic Scholar
The Conserved Sequence Repeats of IQGAP1 mediate binding to Ezrin
Jing Liu, J. Guidry, D. Worthylake
2013Journal of Proteome Research23 citations Open access
Semantic Scholar
Design and In Vivo Characterization of Immunoconjugates Targeting HIV gp160
S. Pincus, K. Song, Grace A. Maresh, A. Frank +13 more
2016Journal of Virology22 citations Open access
Semantic Scholar
Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42
L. Gorisse, Zhi-Gang Li, C. Wagner, D. Worthylake +4 more
2020Journal of Biological Chemistry20 citations Open access
Semantic Scholar
The IQGAP1 N-terminus Forms Dimers and the Dimer Interface is Required for Binding F-actin and Ca2+/calmodulin
Jing Liu, V. Kurella, Louis F. LeCour, Tomas D. Vanagunas +1 more
2016Biochemistry17 citations Open access
Semantic Scholar
Multipart Chaperone-Effector Recognition in the Type III Secretion System of Chlamydia trachomatis*
Li Shen, Megan A. Macnaughtan, Kyla M. Frohlich, Yan-Guang Cong +6 more
2015Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Hippo signaling pathway: A comprehensive gene expression profile analysis in breast cancer.
Hassan Yousefi, M. R. Delavar, Fatemeh Piroozian, M. Baghi +5 more
2022Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie16 citations Open access
Semantic Scholar
Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope
Mohammad Sadraeian, F. Guimarães, A. P. D. de Araújo, D. Worthylake +2 more
2017Scientific Reports16 citations Open access
Semantic Scholar
Regulation of ROCKII by Localization to Membrane Compartments and binding to DynaminI
Sylvester Tumusiime, M. Rana, Swapnil S. Kher, V. Kurella +4 more
2009Biochemical and Biophysical Research Communications - BBRC13 citations Open access
Semantic Scholar
Crystal Structure and Computational Modeling of the Fab Fragment from a Protective Anti-Ricin Monoclonal Antibody
Zhi-Yu Zhao, D. Worthylake, L. LeCour, Grace A. Maresh +1 more
2012PLoS ONE12 citations Open access
Semantic Scholar
A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming
Hassan Yousefi, M. Khosla, L. Lauterboeck, S. Okpechi +10 more
2022Oncogene8 citations
Semantic Scholar
Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis
Partha K. Chandra, S. Braun, Sudipa Maity, Jorge A. Castorena-Gonzalez +10 more
2023Viruses6 citations Open access
Semantic Scholar
TRIMERIC HIV-1 MATRIX PROTEIN
C. Hill, D. Worthylake, D. Bancroft, Allyson M. Christensen +1 more
19966 citations
Semantic Scholar
CRYSTAL STRUCTURE OF THE SACCHAROMYCES CEREVISIAE UBIQUITIN-CONJUGATING ENZYME RAD6 (UBC2) AT 2.6A RESOLUTION
D. Worthylake, S. Prakash, L. Prakash, C. Hill
19984 citations
Semantic Scholar
ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-Water Mechanism
C. Parke, E. Wojcik, D. Worthylake, Sunyoung Kim
20102 citations Open access
Semantic Scholar
HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID
C. Hill, T. R. Gamble, F. Vajdos, D. Worthylake +1 more
19972 citations
Semantic Scholar
Three-dimensional structure of the Escherichia coli phosphocarrier protein
D. Worthylake, Norman D. MEADOWt, Saul ROSEMANt, O. Herzberg +1 more
2 citations
Semantic Scholar
Correction to: A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming
Hassan Yousefi, M. Khosla, L. Lauterboeck, S. Okpechi +10 more
2023Oncogene1 citations Open access
Semantic Scholar
Structural Basis for the Regulation of Microtubule-Binding Affinity by Cytoplasmic Dynein
Elizabeth D. Kim, Jessica M. Richard, D. Worthylake, K. Sutoh +1 more
20121 citations
Semantic Scholar
Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2
C. Parke, E. Wojcik, Sunyoung Kim, D. Worthylake
20091 citations
Semantic Scholar
Crystal structure of the GAP-related domain of IQGAP1
V. Kurella, Jessica M. Richard, C. Parke, H. Bellamy +1 more
20091 citations
Semantic Scholar
Abstract 1858: Active and allosteric site evolution directs ordered water use in kinesin catalysis
Micquel Downs, D. Worthylake, Jessica M. Richard, C. Parke +3 more
2023Journal of Biological Chemistry0 citations Open access
Semantic Scholar
IQGAP1 calponin homology domain fragment (CHDF) mutant K161C under oxidizing conditions
J. Liu, D. Worthylake
20160 citations
Semantic Scholar
N-Terminal Coiled-Coils in the Human Kinesin-5 and Kinesin-1 Stalk are Sufficient for Tetrameric Organization
Rebecca S Buckley, Victoria Dauphin, Tomas D. Vanagunas, D. Worthylake +3 more
20160 citations Open access
Semantic Scholar
Eg5 motor domain mutant E162S
M. Luo, C. Park, D. Worthylake, S. Kim
20160 citations
Semantic Scholar
Mapping the Processivity Determinants of the Kinesin-3 Motor Domain
Keith J. Mickolajczyk, W. Hancock, C. Berger, R. Kanada +13 more
20160 citations
Semantic Scholar
Eg5 motor domain mutant Y231F
M. Luo, C. Parke, D. Worthylake
20160 citations
Semantic Scholar
Proton Tunneling Accelerates ATP Hydrolysis in Kinesin‐5 Proteins
Sunyoung Kim, Jessica M. Richard, C. Parke, D. Worthylake +1 more
20150 citations
Semantic Scholar
Crystal structure and in vitro analysis of human IQGAP1 Calponin homology domain: implication for its interactions with Ca2+ bound Calmodulin and F‐actin
Jing Liu, V. Kurella, Louis F. LeCour, D. Worthylake
20130 citations
Semantic Scholar
Proton tunneling accelerates ATP hydrolysis in Eg5 kinesin
C. Parke, Elizabeth D. Kim, Jessica M. Richard, D. Worthylake +1 more
20120 citations Open access
Semantic Scholar
Human Eg5 in complex with S-trityl-L-cysteine
C. Parke, E. Wojcik, Sunyoung Kim, D. Worthylake
20100 citations
Semantic Scholar
Structural Features of RhoGEFs
J. T. Snyder, K. Rossman, D. Worthylake, J. Sondek
20100 citations
Semantic Scholar

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J. Sondek×9
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K. Rossman×8
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E. Wojcik — researcher profile on SciRah

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C. Hill — researcher profile on SciRah

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V. Kurella — researcher profile on SciRah

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J. T. Snyder — researcher profile on SciRah

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