M. Alexeyev

Most-cited papers

The maintenance of mitochondrial DNA integrity--critical analysis and update.
M. Alexeyev, I. Shokolenko, G. Wilson, S. Ledoux
2013Cold Spring Harbor Perspectives in Biology455 citations Open access
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Escherichia coli in Europe: An Overview
N. Allocati, M. Masulli, M. Alexeyev, C. di Ilio
2013International Journal of Environmental Research and Public Health438 citations Open access
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Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription
A. Al-Mehdi, V. Pastukh, B. Swiger, Darla J. Reed +5 more
2012Science Signaling385 citations Open access
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Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation.
Glenda Parra-Bonilla, D. Alvarez, A. Al-Mehdi, M. Alexeyev +1 more
2010American Journal of Physiology - Lung cellular and Molecular Physiology153 citations Open access
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Pseudomonas aeruginosa Exotoxin Y Is a Promiscuous Cyclase That Increases Endothelial Tau Phosphorylation and Permeability*
C. D. Ochoa, M. Alexeyev, V. Pastukh, R. Balczon +1 more
2012Journal of Biological Chemistry90 citations Open access
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Aging: A mitochondrial DNA perspective, critical analysis and an update.
I. Shokolenko, G. Wilson, M. Alexeyev
2014World Journal of Experimental Medicine87 citations Open access
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Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel
Donna L. Cioffi, Song-Wei Wu, Hairu Chen, M. Alexeyev +4 more
2012Circulation Research78 citations Open access
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Mitochondrial DNA: A disposable genome?
I. Shokolenko, M. Alexeyev
2015Biochimica et Biophysica Acta77 citations Open access
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Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury.
Ming-Yuan Jian, M. Alexeyev, P. Wolkowicz, J. Zmijewski +1 more
2013American Journal of Physiology - Lung cellular and Molecular Physiology74 citations Open access
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Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion
Xi-Ming Yang, L. Cui, James A. White, Jamie L. Kuck +6 more
2015Basic Research in Cardiology66 citations Open access
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Persistent damage induces mitochondrial DNA degradation
I. Shokolenko, G. Wilson, M. Alexeyev
2013DNA Repair64 citations Open access
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Mitochondrial defects associated with β-alanine toxicity: relevance to hyper-beta-alaninemia
A. Shetewy, K. Shimada-Takaura, Danielle Warner, C. Jong +4 more
2016Molecular and Cellular Biochemistry62 citations Open access
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Mitochondrial transcription in mammalian cells
I. Shokolenko, M. Alexeyev
2017Frontiers in Bioscience49 citations Open access
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Pseudomonas aeruginosa Exotoxin Y-Mediated Tau Hyperphosphorylation Impairs Microtubule Assembly in Pulmonary Microvascular Endothelial Cells
R. Balczon, Nutan Prasain, C. D. Ochoa, Jason Prater +5 more
2013PLoS ONE47 citations Open access
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TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension.
Abdallah Alzoubi, P. Almalouf, M. Toba, Kealan D O'Neill +7 more
2013American Journal of Pathology44 citations Open access
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Limited predictive value of TFAM in mitochondrial biogenesis
N. Kozhukhar, M. Alexeyev
2019Mitochondrion (Amsterdam. Print)42 citations Open access
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Lactate Dehydrogenase A Expression Is Necessary to Sustain Rapid Angiogenesis of Pulmonary Microvascular Endothelium
Glenda Parra-Bonilla, D. Alvarez, M. Alexeyev, A. Vasauskas +1 more
2013PLoS ONE41 citations Open access
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Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells
D. Spadafora, Nataliya Kozhukhar, Vladimir N. Chouljenko, K. Kousoulas +1 more
2016PLoS ONE39 citations Open access
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Mitochondrial DNA Ligase Is Dispensable for the Viability of Cultured Cells but Essential for mtDNA Maintenance*
I. Shokolenko, Rafik Z. Fayzulin, S. Katyal, P. Mckinnon +2 more
2013Journal of Biological Chemistry39 citations Open access
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35 Years of TFAM Research: Old Protein, New Puzzles
N. Kozhukhar, M. Alexeyev
2023Biology37 citations Open access
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Adenosine monophosphate‐activated kinase α1 promotes endothelial barrier repair
J. Creighton, Ming-Yuan Jian, Sarah L. Sayner, M. Alexeyev +1 more
2011The FASEB Journal37 citations Open access
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Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier.
Bing Zhu, Li Zhang, J. Creighton, M. Alexeyev +2 more
2010American Journal of Physiology - Lung cellular and Molecular Physiology34 citations Open access
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Endothelial hyperpermeability in severe pulmonary arterial hypertension: role of store-operated calcium entry.
Chun Zhou, M. Townsley, M. Alexeyev, N. Voelkel +1 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology33 citations Open access
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Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions
S. Voth, M. Gwin, C. Francis, R. Balczon +12 more
2020The FASEB Journal32 citations Open access
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Pseudomonas aeruginosa exoenzymes U and Y induce a transmissible endothelial proteinopathy.
K. A. Morrow, C. D. Ochoa, R. Balczon, Chun Zhou +5 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology32 citations Open access
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Pseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloids
R. Balczon, K. A. Morrow, Chun Zhou, Bradley Edmonds +8 more
2017The FASEB Journal31 citations Open access
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Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pseudomonas aeruginosa Pneumonia in Critically Ill Patients: An Exploratory Study
B. Wagener, Naseem Anjum, Sarah C. Christiaans, Morgan E Banks +13 more
2020Toxins28 citations Open access
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Mitochondrial DNA: Consensuses and Controversies
I. Shokolenko, M. Alexeyev
2022DNA27 citations Open access
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Unit Title Elimination of mitochondrial DNA from mammalian cells
Natalya Khozhukhar, D. Spadafora, Yelitza A. R. Rodriguez, M. Alexeyev
2018Current Protocols in Cell Biology24 citations Open access
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The “fast” and the “slow” modes of mitochondrial DNA degradation
I. Shokolenko, G. Wilson, M. Alexeyev
2014Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis22 citations Open access
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ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection
Kierra S. Hardy, A. Tuckey, P. Renema, Mita R. Patel +11 more
2022Toxins21 citations Open access
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Carbonic anhydrase IX is a critical determinant of pulmonary microvascular endothelial cell pH regulation and angiogenesis during acidosis.
Ji-Young Lee, M. Alexeyev, N. Kozhukhar, V. Pastukh +2 more
2018American Journal of Physiology - Lung cellular and Molecular Physiology21 citations Open access
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Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1.
N. Xu, Donna L. Cioffi, M. Alexeyev, Thomas C. Rich +1 more
2015American Journal of Physiology - Cell Physiology21 citations Open access
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Quantification of mtDNA content in cultured cells by direct droplet digital PCR
N. Kozhukhar, Anthony Fant, M. Alexeyev
2021Mitochondrion (Amsterdam. Print)19 citations Open access
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A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions
Rafik Z. Fayzulin, M. Perez, N. Kozhukhar, D. Spadafora +2 more
2015Nucleic Acids Research16 citations Open access
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TFAM’s Contributions to mtDNA Replication and OXPHOS Biogenesis Are Genetically Separable
N. Kozhukhar, M. Alexeyev
2022Cells15 citations Open access
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Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: Modulation of transmissible cytotoxicity.
P. Renema, N. Kozhukhar, V. Pastukh, D. Spadafora +5 more
2020American Journal of Physiology - Lung cellular and Molecular Physiology15 citations Open access
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Effect of hypernatremia on injury caused by energy deficiency: role of T-type Ca2+ channel.
Viktor Pastukh, Hairu Chen, Song-Wei Wu, C. Jong +2 more
2010American Journal of Physiology - Cell Physiology15 citations Open access
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A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication
N. Kozhukhar, D. Spadafora, Yelitza A. R. Rodriguez, M. Alexeyev
2022Cells14 citations Open access
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N-cadherin coordinates AMP kinase-mediated lung vascular repair.
Ming-Yuan Jian, Yan-Ping Liu, Qian Li, P. Wolkowicz +3 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology14 citations Open access
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The efficiency of the translesion synthesis across abasic sites by mitochondrial DNA polymerase is low in mitochondria of 3T3 cells
N. Kozhukhar, D. Spadafora, Rafik Z. Fayzulin, I. Shokolenko +1 more
2015Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis14 citations Open access
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α1G T-type calcium channel determines the angiogenic potential of pulmonary microvascular endothelial cells.
Zhen Zheng, Hairu Chen, Peilin Xie, C. Dickerson +3 more
2019American Journal of Physiology - Cell Physiology13 citations Open access
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Extrinsic acidosis suppresses glycolysis and migration while increasing network formation in pulmonary microvascular endothelial cells.
Ji-Young Lee, M. Onanyan, I. Garrison, Roderica White +7 more
2019American Journal of Physiology - Lung cellular and Molecular Physiology13 citations Open access
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S100A6 is a positive regulator of PPP5C-FKBP51-dependent regulation of endothelial calcium signaling
Barnita Haldar, C. L. Hamilton, V. Solodushko, Kevin A. Abney +4 more
2020The FASEB Journal11 citations Open access
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Mitochondrial DNA: the common confusions
M. Alexeyev
2020Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis10 citations Open access
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Mitochondrial DNA Damage, Repair, Degradation and Experimental Approaches to Studying These Phenomena
I. Shokolenko, S. Ledoux, G. Wilson, M. Alexeyev
201110 citations Open access
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The C-Terminal Tail of Mitochondrial Transcription Factor A Is Dispensable for Mitochondrial DNA Replication and Transcription In Situ
N. Kozhukhar, M. Alexeyev
2023International Journal of Molecular Sciences8 citations Open access
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Serine/threonine phosphatase 5 (PP5C/PPP5C) regulates the ISOC channel through a PP5C-FKBP51 axis
C. L. Hamilton, Kevin A. Abney, A. Vasauskas, M. Alexeyev +4 more
2017Pulmonary Circulation8 citations Open access
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Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption
C. L. Hamilton, P. I. Kadeba, A. Vasauskas, V. Solodushko +4 more
2017Pulmonary Circulation8 citations Open access
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PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells.
Ji-Young Lee, R. Stevens, V. Pastukh, V. Pastukh +14 more
2023American Journal of Respiratory Cell and Molecular Biology7 citations Open access
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