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D. Shalinsky · SciRah

Researcher profile · Semantic Scholar

D. Shalinsky

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D. Shalinsky — researcher profile on SciRah

h-index: 30
Works: 77
Citations: 5,763

Most-cited papers

Rapid vascular regrowth in tumors after reversal of VEGF inhibition.
Michael R. Mancuso, Rachel B. Davis, S. Norberg, Shaun O’Brien +9 more
2006Journal of Clinical Investigation838 citations Open access
Semantic Scholar
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.
T. Inai, Michael R. Mancuso, H. Hashizume, F. Baffert +7 more
2004American Journal of Pathology761 citations Open access
Semantic Scholar
Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study.
E. Cohen, L. Rosen, E. Vokes, M. Kies +10 more
2008Journal of Clinical Oncology657 citations Open access
Semantic Scholar
Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3
D. Hu-Lowe, H. Zou, M. Grazzini, M. Hallin +12 more
2008Clinical Cancer Research593 citations Open access
Semantic Scholar
Broad Antitumor and Antiangiogenic Activities of AG3340, a Potent and Selective MMP Inhibitor Undergoing Advanced Oncology Clinical Trials
D. Shalinsky, John Brekken, H. Zou, Charles D. McDermott +8 more
1999Annals of the New York Academy of Sciences244 citations
Semantic Scholar
Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment
C. Chantrain, H. Shimada, S. Jodele, S. Groshen +5 more
2004Cancer Research232 citations Open access
Semantic Scholar
Blood-Based Biomarkers of SU11248 Activity and Clinical Outcome in Patients with Metastatic Imatinib-Resistant Gastrointestinal Stromal Tumor
A. Norden-Zfoni, J. Desai, J. Manola, P. Beaudry +9 more
2007Clinical Cancer Research203 citations Open access
Semantic Scholar
Validation of a Standardized Method for Enumerating Circulating Endothelial Cells and Progenitors: Flow Cytometry and Molecular and Ultrastructural Analyses
P. Mancuso, P. Antoniotti, J. Quarna, A. Calleri +10 more
2009Clinical Cancer Research173 citations
Semantic Scholar
AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging.
L. Wilmes, M. Pallavicini, L. M. Fleming, J. Gibbs +11 more
2007Magnetic Resonance Imaging147 citations
Semantic Scholar
Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340.
Angela V. Price, Qi-Wei Shi, Donald G. Morris, M. E. Wilcox +9 more
1999Clinical Cancer Research144 citations
Semantic Scholar
Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340).
H. Foda, E. Rollo, M. Drews, C. Conner +3 more
2001American Journal of Respiratory Cell and Molecular Biology137 citations
Semantic Scholar
HIV‐1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors
J. B. Johnston, Kun-Yan Zhang, Cláudia Silva, D. Shalinsky +5 more
2001Annals of Neurology131 citations
Semantic Scholar
Targeting Activin Receptor-Like Kinase 1 (ALK1) Inhibits Angiogenesis and Tumorigenesis Through a Mechanism of Action Complementary to Anti-VEGF Therapies
D. Hu-Lowe, E. Chen, Lianglin Zhang, K. D. Watson +21 more
2011Cancer Research128 citations Open access
Semantic Scholar
Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro.
Antti Jekunen, R. Christen, D. Shalinsky, S. B. Howell
1994British Journal of Cancer127 citations Open access
Semantic Scholar
Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, and 3, in Patients with Metastatic Melanoma
J. Fruehauf, J. Lutzky, D. McDermott, C. Brown +7 more
2011Clinical Cancer Research106 citations Open access
Semantic Scholar
Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors.
T. Nakahara, S. Norberg, D. Shalinsky, D. Hu-Lowe +1 more
2006Cancer Research104 citations Open access
Semantic Scholar
The Matrix Metalloproteinase Inhibitor Prinomastat Enhances Photodynamic Therapy Responsiveness in a Mouse Tumor Model
A. Ferrario, C. Chantrain, K. V. von Tiehl, S. Buckley +5 more
2004Cancer Research97 citations
Semantic Scholar
Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies.
D. Shalinsky, John Brekken, Helen Y. Zou, L. A. Bloom +4 more
1999Clinical Cancer Research88 citations
Semantic Scholar
Heterogeneity in the angiogenic response of a BT474 human breast cancer to a novel vascular endothelial growth factor‐receptor tyrosine kinase inhibitor: Assessment by voxel analysis of dynamic contrast‐enhanced MRI
Ka-Loh Li, L. Wilmes, R. Henry, M. Pallavicini +7 more
2005Journal of Magnetic Resonance Imaging67 citations
Semantic Scholar
In vitro modulation of cisplatin accumulation in human ovarian carcinoma cells by pharmacologic alteration of microtubules.
R. Christen, Antti P. Jekunen, Jeffrey A. Jones, F. Thiebaut +2 more
1993Journal of Clinical Investigation61 citations Open access
Semantic Scholar
Axitinib (AG-013736) in patients with metastatic melanoma: A phase II study
J. Fruehauf, J. Lutzky, D. McDermott, C. Brown +6 more
200855 citations
Semantic Scholar
Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice.
D. Shalinsky, E. Bischoff, M. Gregory, M. Gottardis +7 more
1995Cancer Research55 citations
Semantic Scholar
Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro.
D. Shalinsky, M. Andreeff, Stephen B. Howell
1990Cancer Research53 citations
Semantic Scholar
Enhanced antitumor efficacy of cisplatin in combination with ALRT1057 (9-cis retinoic acid) in human oral squamous carcinoma xenografts in nude mice.
D. Shalinsky, E. Bischoff, M. Gregory, W. Lamph +4 more
1996Clinical Cancer Research51 citations
Semantic Scholar
The efficacy of 9-cis retinoic acid in experimental models of cancer
M. Gottardis, W. Lamph, D. Shalinsky, A. Wellstein +1 more
2005Breast Cancer Research and Treatment49 citations
Semantic Scholar
A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice.
D. Shalinsky, E. Bischoff, W. Lamph, Lin Zhang +4 more
1997Cancer Research45 citations
Semantic Scholar
Modulation of cisplatin cytotoxicity by permeabilization of the plasma membrane by digitonin in vitro.
Antti P. Jekunen, D. Shalinsky, D. Hom, K. Albright +2 more
1993Biochemical Pharmacology37 citations
Semantic Scholar
Phase I/pharmacokinetic study of high-dose progesterone and doxorubicin.
R. Christen, E. McClay, S. Plaxe, S. Yen +6 more
1993Journal of Clinical Oncology37 citations
Semantic Scholar
Regulation of initial vinblastine influx by P-glycoprotein.
D. Shalinsky, Antti Jekunen, J. Alcaraz, R. Christen +3 more
1993British Journal of Cancer37 citations Open access
Semantic Scholar
Early combined treatment with carboplatin and the MMP inhibitor, prinomastat, prolongs survival and reduces systemic metastasis in an aggressive orthotopic lung cancer model.
Jiang Liu, M. Tsao, M. Pagura, D. Shalinsky +3 more
2003Lung Cancer30 citations
Semantic Scholar
A phase II study of axitinib (AG-013736 [AG]) in patients (pts) with advanced thyroid cancers
E. Cohen, E. Vokes, L. Rosen, M. Kies +6 more
200727 citations
Semantic Scholar
Phase I trial of SU14813 in patients with advanced solid malignancies.
Walter Fiedler, G. Giaccone, P. Lasch, I. van der Horst +6 more
2011Annals of Oncology26 citations Open access
Semantic Scholar
Enhancement of the loss of multiple drug resistance by hydroxyurea.
R. Christen, D. Shalinsky, S. B. Howell
1992Seminars in Oncology23 citations
Semantic Scholar
Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations
D. Shalinsky, John Brekken, H. Zou, S. Kolis +3 more
1998Investigational new drugs19 citations
Semantic Scholar
Regional lymphatic drug exposure following intraperitoneal administration of 5-fluorouracil, carboplatin, and etoposide.
P. Lindnér, D. Heath, D. Shalinsky, Stephen B. Howell +2 more
1993Surgical oncology17 citations
Semantic Scholar
Levels of circulating endothelial cells (CECs) and monocytes as pharmacodynamic markers of SU11248 activity in patients (pts) with metastatic imatinib-resistant GIST
A. Norden-Zfoni, J. Manola, J. Desai, J. Morgan +6 more
200514 citations
Semantic Scholar
Magnetic Resonance Imaging Detects Early Changes in Microvascular Permeability in Xenograft Tumors after Treatment with the Matrix Metalloprotease Inhibitor Prinomastat
M. Wiart, L. Fournier, Viktor Novikov, D. Shames +4 more
2004Technology in Cancer Research and Treatment11 citations Open access
Semantic Scholar
Modulation of vinblastine sensitivity by dipyridamole in multidrug resistant fibrosarcoma cells lacking mdr1 expression.
D. Shalinsky, M. Slovak, S. B. Howell
1991British Journal of Cancer11 citations Open access
Semantic Scholar
Inhibition of GSH-dependent PGH2 isomerase in mammary adenocarcinoma cells by allicin.
D. Shalinsky, D. B. McNamara, Krishna C. Agrawal
1989Prostaglandins11 citations
Semantic Scholar
Novel Ultrasound and DCE-MRI Analyses after Antiangiogenic Treatment with a Selective VEGF Receptor Inhibitor
K. D. Watson, Xiaowen Hu, Chun-Yen Lai, H. Lindfors +4 more
2011Ultrasound in Medicine and Biology10 citations Open access
Semantic Scholar
Evaluation of ALK-1 expression in circulating endothelial cells (CECs) as an exploratory biomarker for PF-03446962 undergoing phase I trial in cancer patients.
P. Mancuso, D. Shalinsky, A. Calleri, Jessica Quarna +6 more
2009Journal of Clinical Oncology9 citations
Semantic Scholar
Quantification of Circulating Endothelial Cells by Flow Cytometry
P. Mancuso, A. Calleri, Francesco Bertolini, C. Tacchetti +2 more
2009Clinical Cancer Research8 citations Open access
Semantic Scholar
Pharmacodynamic analysis of target receptor tyrosine kinase activity and apoptosis in GIST tumors responding to therapy with SU11248
D. Davis, D. McConkey, J. Heymach, J. Desai +6 more
20058 citations
Semantic Scholar
AG-028262, a novel selective VEGFR tyrosine kinase antagonist that potently inhibits KDR signaling and angiogenesis in vitro and in vivo
H. Zou, Qiuhua Li, M. Grazzini, Roslyn Dillon +16 more
20048 citations
Semantic Scholar
Prinomastat: A Potent and Selective Matrix Metalloprotease Inhibitor–Preclinical and Clinical Development for Oncology
D. Shalinsky, B. Shetty, Y. Pithavala, S. Bender +4 more
20008 citations
Semantic Scholar
AG-013736, a novel VEGF receptor and PDGF receptor inhibitor with potent activity against human bladder carcinoma in vitro and in vivo.
K. Zhu, M. Pino, A. Siefker-Radtke, D. Shalinsky +2 more
2006Journal of Clinical Oncology7 citations
Semantic Scholar
A pharmacodynamically guided dose selection of PF-00337210 in a phase I study in patients with advanced solid tumors
J. Bruce, P. LoRusso, P. Goncalves, E. Heath +8 more
2016Cancer Chemotherapy and Pharmacology6 citations Open access
Semantic Scholar
Pharmacokinetics of cisplatin in an isolated liver perfusion system in humans
P. Naredi, S. Holmberg, L. Hafström, D. Heath +2 more
19926 citations
Semantic Scholar
The synthesis of tritium‐labelled azidothymidine
S. Aggarwal, D. Shalinsky, K. Agrawal
19886 citations
Semantic Scholar
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues – A population pharmacokinetic/pharmacodynamic analysis of rucaparib
D. Wang, Chunze Li, Wan Sun, Shu-Zhong Zhang +6 more
2015Clinical pharmacology in drug development5 citations Open access
Semantic Scholar

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