Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Yasuyuki Nagumo · SciRah

Researcher profile · Semantic Scholar

Yasuyuki Nagumo

Share profile

Yasuyuki Nagumo — researcher profile on SciRah

h-index: 16
Works: 56
Citations: 1,715

Most-cited papers

Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine
M. Narita, Yasuyuki Nagumo, Seiko Hashimoto, Michiko Narita +7 more
2006Journal of Neuroscience522 citations Open access
Semantic Scholar
Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala
M. Narita, C. Kaneko, Kan Miyoshi, Yasuyuki Nagumo +6 more
2006Neuropsychopharmacology284 citations
Semantic Scholar
Direct Evidence of Astrocytic Modulation in the Development of Rewarding Effects Induced by Drugs of Abuse
M. Narita, M. Miyatake, Michiko Narita, M. Shibasaki +5 more
2006Neuropsychopharmacology167 citations
Semantic Scholar
Chronic pain‐induced emotional dysfunction is associated with astrogliosis due to cortical δ‐opioid receptor dysfunction
M. Narita, Naoko Kuzumaki, Michiko Narita, C. Kaneko +10 more
2006Journal of Neurochemistry98 citations
Semantic Scholar
Protease-Activated Receptor-1 and Platelet-Derived Growth Factor in Spinal Cord Neurons Are Implicated in Neuropathic Pain after Nerve Injury
M. Narita, A. Usui, Michiko Narita, K. Niikura +5 more
2005Journal of Neuroscience73 citations Open access
Semantic Scholar
Implication of protein kinase C in the orexin‐induced elevation of extracellular dopamine levels and its rewarding effect
M. Narita, Yasuyuki Nagumo, M. Miyatake, D. Ikegami +2 more
2007European Journal of Neuroscience63 citations Open access
Semantic Scholar
Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats.
M. Narita, H. Akai, Yasuyuki Nagumo, N. Sunagawa +5 more
2004Neuroscience63 citations
Semantic Scholar
Chronic pain-induced astrocyte activation in the cingulate cortex with no change in neural or glial differentiation from neural stem cells in mice.
Naoko Kuzumaki, M. Narita, Michiko Narita, Nana Hareyama +5 more
2007Neuroscience Letters52 citations
Semantic Scholar
Implication of cyclin‐dependent kinase 5 in the development of psychological dependence on and behavioral sensitization to morphine
M. Narita, M. Shibasaki, Yasuyuki Nagumo, Michiko Narita +2 more
2005Journal of Neurochemistry32 citations
Semantic Scholar
Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.
H. Nagase, Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui +12 more
2017Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Rewiring of Afferent Fibers in the Somatosensory Thalamus of Mice Caused by Peripheral Sensory Nerve Transection
Yuichi Takeuchi, Miwako Yamasaki, Yasuyuki Nagumo, K. Imoto +2 more
2012Journal of Neuroscience30 citations Open access
Semantic Scholar
The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus.
M. Narushima, M. Uchigashima, Yuki Yagasaki, Takeshi Harada +7 more
2016Neuron29 citations Open access
Semantic Scholar
Involvement of mitogen-stimulated p70-S6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats.
M. Narita, H. Akai, T. Kita, Yasuyuki Nagumo +5 more
2005Neuroscience29 citations
Semantic Scholar
Age-related emotionality is associated with cortical δ-opioid receptor dysfunction-dependent astrogliosis
M. Narita, Naoko Kuzumaki, C. Kaneko, E. Tamai +6 more
200624 citations
Semantic Scholar
Role of spinal voltage-dependent calcium channel α2δ-1 subunit in the expression of a neuropathic pain-like state in mice
M. Narita, M. Nakajima, Kan Miyoshi, Michiko Narita +6 more
200720 citations
Semantic Scholar
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa +14 more
2023Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement
Kenichi Tanaka, Naoko Kuzumaki, Yusuke Hamada, Yukari Suda +3 more
2023Neurobiology of Pain16 citations Open access
Semantic Scholar
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
Hikari Yamamoto, Yasuyuki Nagumo, Y. Ishikawa, Y. Irukayama-Tomobe +9 more
2022PLoS ONE13 citations Open access
Semantic Scholar
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.
R. Nakajima, Naoshi Yamamoto, Shigeto Hirayama, Takashi Iwai +4 more
2015Bioorganic & Medicinal Chemistry13 citations Open access
Semantic Scholar
Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations.
Yasuyuki Nagumo, Yoshifumi Ueta, H. Nakayama, H. Osaki +4 more
2020Cell Reports11 citations Open access
Semantic Scholar
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.
Naoshi Yamamoto, Sayaka Ohrui, T. Okada, Masahiro Yata +11 more
2017Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.
Sayaka Ohrui, Naoshi Yamamoto, Tsuyoshi Saitoh, N. Kutsumura +9 more
2017Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Discovery of Orexin 2 Receptor Selective and Dual Orexin Receptor Agonists based on the Tetralin Structure: Switching of Receptor Selectivity by Chirality on the Tetralin Ring.
Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, T. Hino +10 more
2022Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.
T. Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto +6 more
2021Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.
Naoshi Yamamoto, Sayaka Ohrui, T. Okada, Tsuyoshi Saitoh +10 more
2019Bioorganic & Medicinal Chemistry8 citations Open access
Semantic Scholar
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.
Tsuyoshi Saitoh, Kazunori Seki, R. Nakajima, Naoshi Yamamoto +8 more
2019Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.
Yasuyuki Nagumo, Koki Katoh, Keita Iio, Tsuyoshi Saitoh +9 more
2020Bioorganic & Medicinal Chemistry Letters7 citations
Semantic Scholar
Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon
N. Kutsumura, Ryuichiro Ohshita, Jumpei Horiuchi, Kotaro Tateno +5 more
20177 citations Open access
Semantic Scholar
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.
N. Kutsumura, Yasuaki Koyama, Yasuyuki Nagumo, R. Nakajima +6 more
2017Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar
Synapse- and subtype-specific modulation of synaptic transmission by nicotinic acetylcholine receptors in the ventrobasal thalamus.
Yasuyuki Nagumo, Yuichi Takeuchi, K. Imoto, M. Miyata
2011Neurosciences research7 citations
Semantic Scholar
Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice.
M. Narita, M. Nakajima, Kan Miyoshi, Michiko Narita +6 more
2007Life Science6 citations
Semantic Scholar
Synthesis of Unnatural Morphinan Compounds to Induce Itch-like Behaviors in Mice: Towards the Development of MRGPRX2 Selective Ligands.
Keita Iio, N. Kutsumura, Yasuyuki Nagumo, Tsuyoshi Saitoh +7 more
2021Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities
N. Kutsumura, Yasuaki Koyama, Tsuyoshi Saitoh, Naoshi Yamamoto +8 more
2020Molecules5 citations Open access
Semantic Scholar
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.
Tsuyoshi Saitoh, Kazunori Seki, R. Nakajima, Naoshi Yamamoto +7 more
2019Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.
Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo +15 more
2021European journal of medicinal chemistry4 citations Open access
Semantic Scholar
Structure-Signal Relationships of the δ-Opioid-Receptor (DOR)-Selective Agonist KNT-127-Part II: Quinoline Ring Modifications for Enhanced G-Protein Signaling and Reduced β-Arrestin Recruitment.
Keita Kajino, T. Sugai, Tomoya Kakumoto, Ryoji Kise +9 more
2025Chemical and pharmaceutical bulletin3 citations Open access
Semantic Scholar
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives
Koki Katoh, N. Kutsumura, Naoshi Yamamoto, Yasuyuki Nagumo +6 more
2022Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.
Koki Katoh, Naoshi Yamamoto, Y. Ishikawa, Y. Irukayama-Tomobe +6 more
2022Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Rapid‐Onset Therapeutic Effects of Delta Opioid Receptor Agonists on Depression‐Like Behaviors Induced by Chronic Social Defeat Stress
A. Tokuda, Yasuyuki Nagumo, Keita Kajino, Keita Iio +5 more
2025Neuropsychopharmacology Reports2 citations Open access
Semantic Scholar
Structure-Signal Relationships of the δ-Opioid-Receptor (DOR)-Selective Agonist KNT-127-Part I: Impact of the Morphinan Skeleton on the G-Protein-Biased DOR Agonism.
Keita Kajino, T. Sugai, Ryoji Kise, Riko Suzuki +8 more
2025Chemical and pharmaceutical bulletin2 citations Open access
Semantic Scholar
Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.
Kenta Maeda, Sayaka Ohrui, A. Tokuda, Yasuyuki Nagumo +5 more
2023Organic Letters2 citations
Semantic Scholar
Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton.
Mao Amezawa, Naoshi Yamamoto, Yasuyuki Nagumo, N. Kutsumura +4 more
2023Bioorganic & Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord
T. Komatsu, S. Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi +21 more
2016Pharmacology, Biochemistry and Behavior2 citations
Semantic Scholar
[Effects of fasudil on neuropathic pain-like state in mice].
Mitsuru Shiokawa, Takanori Yamaguchi, M. Narita, Daiki Okutsu +5 more
2007Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology2 citations
Semantic Scholar
Novel Baeyer–Villiger-type oxidation of 4,5-epoxymorphinan derivatives
T. Hino, N. Kutsumura, Tsuyoshi Saitoh, Naoshi Yamamoto +4 more
20201 citations
Semantic Scholar
Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton.
N. Kutsumura, Yasuaki Koyama, Yuko Suzuki, K. Tominaga +4 more
2018Organic Letters1 citations
Semantic Scholar
Synthesis of Novel 1,3-Dioxa-5-thiazatriquinane and 1-Oxa-3,5-dithiazatriquinane Derivatives and Their Pharmacologies
H. Nagase, Ryuichiro Ohshita, N. Kutsumura, Yasuyuki Nagumo +3 more
20181 citations Open access
Semantic Scholar
A Novel Rearrangement Reaction of Morphinan to Arylmorphan Skeletons and the Pharmacologies of Arylmorphan Derivatives
H. Nagase, Masahiro Yata, N. Kutsumura, Yasuyuki Nagumo +4 more
2019Heterocycles0 citations Open access
Semantic Scholar
P3-b03 Robust regulation of excitatory input onto parvalbumin-positive cells in postnatal mouse visual cortex
N. Atapour, T. Hensch, Huijing Hu, S. Lai +12 more
20180 citations
Semantic Scholar
P3-k12 Relationship between the stimulus intensity and the spatio-temporal patterns of the evoked activity in the rat sensorimotor cortex using improved optical recording system
Noriyuki Hama, S. Ito, A. Hirota, Yasuyuki Nagumo +3 more
20180 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Naoshi Yamamoto×25
Invite
Naoshi Yamamoto — researcher profile on SciRah
N. Kutsumura×25
Invite
N. Kutsumura — researcher profile on SciRah
H. Nagase×24
Invite
H. Nagase — researcher profile on SciRah
Tsuyoshi Saitoh×22
Invite
Tsuyoshi Saitoh — researcher profile on SciRah

×16

Invite

Y. Ishikawa — researcher profile on SciRah

Y. Irukayama-Tomobe×14

Invite

Y. Irukayama-Tomobe — researcher profile on SciRah

M. Yanagisawa×13

Invite

M. Yanagisawa — researcher profile on SciRah

Tsutomu Suzuki×11

Invite

Tsutomu Suzuki — researcher profile on SciRah

Invite

M. Narita — researcher profile on SciRah

Invite

R. Tanimura — researcher profile on SciRah

Michiko Narita×8

Invite

Michiko Narita — researcher profile on SciRah

Yasuhiro Ogawa×8

Invite

Yasuhiro Ogawa — researcher profile on SciRah