Researcher profile · Semantic Scholar

M. Semache

h-index: 14
Works: 29
Citations: 1,472

Most-cited papers

Glucolipotoxicity of the Pancreatic Beta Cell
V. Poitout, Julie Amyot, M. Semache, B. Zarrouki +2 more
2009Biochimica et Biophysica Acta382 citations Open access
Semantic Scholar
The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding
M. Kebede, T. Alquier, M. Latour, M. Semache +2 more
2008Diabetes175 citations Open access
Semantic Scholar
Lipolysis and the integrated physiology of lipid energy metabolism.
Shu-Pei Wang, Krishnakant G. Soni, M. Semache, Stéphanie Casavant +3 more
2008Molecular Genetics and Metabolism171 citations
Semantic Scholar
Carboxylesterase 3 (EC 3.1.1.1) Is a Major Adipocyte Lipase*
Krishnakant G. Soni, R. Lehner, P. Metalnikov, Paul O'donnell +5 more
2004Journal of Biological Chemistry158 citations Open access
Semantic Scholar
Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling
Julie Amyot, M. Semache, M. Ferdaoussi, G. Fontes +1 more
2012PLoS ONE129 citations Open access
Semantic Scholar
Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets
D. Hagman, M. Latour, S. Chakrabarti, G. Fontes +8 more
2008Diabetes80 citations Open access
Semantic Scholar
Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons
Aliza T. Ehrlich, M. Semache, Florence Gross, D. Da Fonte +9 more
2019iScience77 citations Open access
Semantic Scholar
Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells
G. Fontes, M. Semache, D. Hagman, C. Tremblay +4 more
2009Diabetes66 citations Open access
Semantic Scholar
Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading.
M. Fortier, Shu-Pei Wang, P. Mauriège, M. Semache +5 more
2004American Journal of Physiology. Endocrinology and Metabolism58 citations
Semantic Scholar
Mapping GPR88-Venus illuminates a novel role for GPR88 in Sensory Processing
Aliza T. Ehrlich, M. Semache, Julie Bailly, S. Wojcik +10 more
2017Brain Structure and Function37 citations Open access
Semantic Scholar
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects
Charlotte Avet, C. Sturino, S. Grastilleur, C. Le Gouill +7 more
2020Communications Biology29 citations Open access
Semantic Scholar
Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion
F. Semplici, M. Vaxillaire, S. Fogarty, M. Semache +10 more
2011Journal of Biological Chemistry27 citations Open access
Semantic Scholar
Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3β in Pancreatic β-Cells*
M. Semache, B. Zarrouki, G. Fontes, S. Fogarty +4 more
2013Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interactions with helices 5 and 6 drive the functional outcome
Tomek Stepniewski, A. Mancini, Richard Ågren, Mariona Torrens-Fontanals +5 more
2021Chemical Science17 citations Open access
Semantic Scholar
Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity
Stephen E. Flaherty, O. Bezy, Wei Zheng, Dong Yan +21 more
2023Nature Communications14 citations Open access
Semantic Scholar
Ackr3-Venus knock-in mouse lights up brain vasculature
Aliza T. Ehrlich, M. Semache, Pierre Couvineau, S. Wojcik +8 more
2021Molecular Brain10 citations Open access
Semantic Scholar
Lack of Preservation of Insulin Gene Expression by a Glucagon-Like Peptide 1 Agonist or a Dipeptidyl Peptidase 4 Inhibitor in an In Vivo Model of Glucolipotoxicity
G. Fontes, D. Hagman, M. Latour, M. Semache +1 more
2010Diabetes Research and Clinical Practice8 citations Open access
Semantic Scholar
Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines
M. Semache, J. Ghislain, B. Zarrouki, C. Tremblay +1 more
2014Islets7 citations Open access
Semantic Scholar
PAS Kinase Regulates PDX-1 Protein Stability Via Phosphorylation of GSK3β in Pancreatic Beta Cells
M. Semache, G. Fontes, S. Fogarty, Chintan K. Kikani +2 more
20132 citations Open access
Semantic Scholar
Large library docking for cannabinoid-1 receptor agonists with reduced side effects
Tia A. Tummino, Christos Iliopoulos-Tsoutsouvas, J. Bráz, E. O’Brien +24 more
2024bioRxiv1 citations Open access
Semantic Scholar
Signaling profile of a new PAR2 inhibitor with anti‐inflammatory effects
Charlotte Avet, M. Semache, Florence Gross, C. Le Gouill +4 more
20181 citations
Semantic Scholar
Abstract 4961: Novel biased PAR2 inhibitors with best-in-class properties reduce resistance to both chemotherapy and immunotherapy in oncology models
T. Brugat, Francesco Bergami, B. Rugeri, Aurélie Janvier +18 more
2023Cancer Research0 citations
Semantic Scholar
Large‐scale profiling of physiologically relevant naturally occurring rare GPCR variants using the bioSensAll® technology
F. Cao, Jenny Lau, Adeline Gadzinski, C. Normand +10 more
2022The FASEB Journal0 citations
Semantic Scholar
Ackr3-Venus knock-in mouse lights up brain vasculature
Aliza T. Ehrlich, M. Semache, Pierre Couvineau, S. Wojcik +8 more
2021Molecular Brain0 citations Open access
Semantic Scholar
OP0236 RELEVANCE OF BIASED PAR2 INHIBITORS IN REDUCING INFLAMMATION AND CARTILAGE DEGRADATION IN IN VITRO AND IN VIVO MODELS OF RHEUMATOID ARTHRITIS
T. Brugat, B. Rugeri, G. Hommet, A. Dumont +12 more
2020Annals of the Rheumatic Diseases0 citations Open access
Semantic Scholar
Monitoring Signalling and Trafficking of Neurotensin Type 1 Receptor in Animal Model using Fluorescent‐based Methods
Pierre Couvineau, Aliza T. Ehrlich, M. Semache, B. Kieffer +1 more
2019The FASEB Journal0 citations
Semantic Scholar
The Beta Cell in Metabolic Syndrome
B. Zarrouki, G. Fontes, M. Semache, Julie Amyot +1 more
20140 citations
Semantic Scholar
Glucose Regulation of Pdx-1 Does Not Involve Changes in Pcif1 Protein Expression
E. Nyam, M. Semache, V. Poitout
20140 citations
Semantic Scholar
PAS Kinase Mediates Palmitate Inhibition of Insulin Gene Expression in Pancreatic Beta-Cells
G. Fontes, M. Semache, D. Hagman, J. Rutter +1 more
20080 citations
Semantic Scholar

D. Hagman

×5

Aliza T. Ehrlich×5

C. Le Gouill×5

J. Rutter×5

Julie Amyot×4

B. Zarrouki×4

C. Tremblay×4

M. Hogue×4