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N. Puhakka · SciRah

Researcher profile · Semantic Scholar

N. Puhakka

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N. Puhakka — researcher profile on SciRah

h-index: 20
Works: 57
Citations: 1,495

Most-cited papers

Commonalities in epileptogenic processes from different acute brain insults. Does it translate?
P. Klein, R. Dingledine, E. Aronica, C. Bernard +22 more
2017Epilepsia255 citations Open access
Semantic Scholar
Epilepsy biomarkers - Toward etiology and pathology specificity
A. Pitkänen, Xavier Ekolle Ndode-Ekane, Niina Lapinlampi, N. Puhakka
2018Neurobiology of Disease160 citations Open access
Semantic Scholar
Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs
J. Karttunen, Mette Heiskanen, Vicente Navarro-Ferrandis, Shalini Das Gupta +5 more
2018Journal of Extracellular Vesicles105 citations Open access
Semantic Scholar
Etiology matters – Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy
K. J. Dębski, A. Pitkänen, N. Puhakka, A. Bot +7 more
2016Scientific Reports95 citations Open access
Semantic Scholar
Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury
M. Drexel, N. Puhakka, Elke Kirchmair, H. Hörtnagl +2 more
2015Neuropharmacology82 citations Open access
Semantic Scholar
Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets
A. Lipponen, J. Paananen, N. Puhakka, A. Pitkänen
2016Scientific Reports71 citations Open access
Semantic Scholar
Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs
E. V. van Vliet, N. Puhakka, James D. Mills, P. Srivastava +9 more
2017Epilepsia54 citations Open access
Semantic Scholar
Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation
A. Korotkov, N. Puhakka, Shalini Das Gupta, Niina Vuokila +10 more
2020Brain Pathology45 citations Open access
Semantic Scholar
miR-124-3p is a chronic regulator of gene expression after brain injury
Niina Vuokila, K. Lukasiuk, A. Bot, E. V. van Vliet +3 more
2018Cellular and Molecular Life Sciences43 citations Open access
Semantic Scholar
Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid‐percussion injury in rats
Niina Lapinlampi, P. Andrade, Tomi Paananen, Elina Hämäläinen +3 more
2020Epilepsia37 citations Open access
Semantic Scholar
Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury
Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi +4 more
2021International Journal of Molecular Sciences36 citations Open access
Semantic Scholar
Chronic Regulation of miR-124-3p in the Perilesional Cortex after Experimental and Human TBI
Niina Vuokila, E. Aronica, A. Korotkov, E. V. van Vliet +3 more
2020International Journal of Molecular Sciences36 citations Open access
Semantic Scholar
Harmonization of lateral fluid-percussion injury model production and postinjury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
X. Ndode-Ekane, C. Santana-Gomez, P. Casillas-Espinosa, Idrish Ali +11 more
2019Epilepsy Research36 citations Open access
Semantic Scholar
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
R. Immonen, Gregory D. Smith, R. Brady, David K. Wright +19 more
2019Epilepsy Research33 citations Open access
Semantic Scholar
Biomarkers for posttraumatic epilepsy.
A. Pitkänen, Tomi Paananen, Jenni Kyyriäinen, Shalini Das Gupta +10 more
2020Epilepsy & Behavior31 citations
Semantic Scholar
Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis
P. Casillas-Espinosa, P. Andrade, C. Santana-Gomez, Tomi Paananen +16 more
2019Epilepsy Research30 citations Open access
Semantic Scholar
Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury
A. Lipponen, A. El-Osta, Antony Kaspi, M. Ziemann +6 more
2018Acta Neuropathologica Communications29 citations Open access
Semantic Scholar
Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis
Alaa Kamnaksh, N. Puhakka, Idrish Ali, Gregory D. Smith +16 more
2018Epilepsy Research26 citations Open access
Semantic Scholar
Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis
C. Santana-Gomez, P. Andrade, Matthew R. Hudson, Tomi Paananen +15 more
2019Epilepsy Research24 citations Open access
Semantic Scholar
Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury.
Niina Vuokila, Shalini Das Gupta, R. Huusko, J. Tohka +2 more
2020Neuroscience20 citations Open access
Semantic Scholar
Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury
N. Puhakka, A. Bot, Niina Vuokila, K. J. Dębski +2 more
2017PLoS ONE19 citations Open access
Semantic Scholar
Epileptogenesis after traumatic brain injury in Plaur-deficient mice.
T. Bolkvadze, N. Puhakka, A. Pitkänen
2016Epilepsy & Behavior19 citations
Semantic Scholar
Epilepsy Phenotype and Its Reproducibility After Lateral Fluid-Percussion -Induced Traumatic Brain Injury In Rats – A Multicenter EpiBioS4Rx Study Project 1
X. Ndode-Ekane, Idrish Ali, Cesar Santana Gomez, P. Andrade +19 more
2023Epilepsia17 citations Open access
Semantic Scholar
Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI
Mette Heiskanen, Olli Jääskeläinen, Eppu Manninen, Shalini Das Gupta +6 more
2022International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury
Shalini Das Gupta, A. Lipponen, Kaisa M. A. Paldanius, N. Puhakka +1 more
2019Scientific Reports17 citations Open access
Semantic Scholar
Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort
Mette Heiskanen, Shalini Das Gupta, J. D. Mills, E. V. van Vliet +6 more
2023International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology
N. Puhakka, Shalini Das Gupta, Niina Vuokila, A. Pitkänen
2022Biomedicines14 citations Open access
Semantic Scholar
Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury
Jenni Kyyriäinen, Natallie Kajevu, Ivette Bañuelos, Leonardo Lara +10 more
2021International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury—EpiBioS4Rx Project 1 study
Mette Heiskanen, X. Ndode-Ekane, Idrish Ali, C. Santana-Gomez +20 more
2024Epilepsia13 citations Open access
Semantic Scholar
Epileptogenesis after traumatic brain injury in Plau-deficient mice.
T. Bolkvadze, Jukka Rantala, N. Puhakka, P. Andrade +1 more
2015Epilepsy & Behavior13 citations
Semantic Scholar
Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization
Shalini Das Gupta, X. Ndode-Ekane, N. Puhakka, A. Pitkänen
2020Scientific Reports12 citations Open access
Semantic Scholar
Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies
X. Ndode-Ekane, Idrish Ali, C. Santana-Gomez, P. Casillas-Espinosa +21 more
2023Epilepsy Research11 citations Open access
Semantic Scholar
Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury.
J. Hiltunen, X. Ndode-Ekane, A. Lipponen, M. Drexel +3 more
2021Neuroscience11 citations Open access
Semantic Scholar
Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study
E. V. van Vliet, Mirte Scheper, James D. Mills, N. Puhakka +12 more
2024Epilepsia7 citations Open access
Semantic Scholar
Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
Robert Ciszek, X. Ndode-Ekane, Cesar Santana Gomez, P. Casillas-Espinosa +15 more
2018Epilepsy Research7 citations Open access
Semantic Scholar
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury
Mette Heiskanen, Ivette Bañuelos, Eppu Manninen, P. Andrade +3 more
2024Epilepsia6 citations
Semantic Scholar
SRPX2 Expression and the uPAR Interactome.
Mehwish Anwer, T. Bolkvadze, N. Puhakka, X. Ndode-Ekane +1 more
2019Neuroscience5 citations
Semantic Scholar
Sushi repeat‐containing protein X‐linked 2: A novel phylogenetically conserved hypothalamo‐pituitary protein
Mehwish Anwer, T. Bolkvadze, X. Ndode-Ekane, N. Puhakka +11 more
2018The Journal of comparative neurology5 citations Open access
Semantic Scholar
Lateral fluid-percussion injury leads to pituitary atrophy in rats
Mehwish Anwer, R. Immonen, Nick M. E. A. Hayward, X. Ndode-Ekane +3 more
2019Scientific Reports4 citations Open access
Semantic Scholar
Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study
Akul Sharma, R. Cabeen, N. Harris, David K. Wright +27 more
2025Imaging Neuroscience3 citations Open access
Semantic Scholar
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
V. Vangoor, Giuliano Giuliani, M. D. de Wit, Carolina K. Rangel +8 more
2024Acta Neuropathologica3 citations Open access
Semantic Scholar
Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology
Natallie Kajevu, A. Lipponen, P. Andrade, Ivette Bañuelos +5 more
2023International Journal of Molecular Sciences3 citations Open access
Semantic Scholar
Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury
N. Puhakka, Shalini Das Gupta, Sara Leskinen, Mette Heiskanen +4 more
2023Neurotrauma Reports3 citations Open access
Semantic Scholar
Gene Expression Profile as a Predictor of Seizure Liability
A. Lipponen, Natallie Kajevu, T. Natunen, Robert Ciszek +3 more
2023International Journal of Molecular Sciences3 citations Open access
Semantic Scholar
Compartment-specific total RNA profile of Hippocampal and Cortical cells from Mesial Temporal Lobe Epilepsy tissue
V. Vangoor, Giuliano Giuliani, M. D. de Wit, M. Venø +8 more
2021medRxiv3 citations Open access
Semantic Scholar
Standardization of preclinical methodologies for discovery and validation of circulating microRNA biomarkers for post-traumatic epileptogenesis – Lessons learned from the EpiBioS4Rx Project 1
N. Puhakka, Mette Heiskanen, X. Ndode-Ekane, Idrish Ali +20 more
2025Epilepsy Research2 citations Open access
Semantic Scholar
Molecular and functional changes in GABAergic transmission during epileptogenesis in a rat model of post-traumatic epilepsy.
N. Puhakka, Pierangelo Cifelli, Gabriele Ruffolo, A. Gaeta +9 more
2025Experimental Neurology2 citations Open access
Semantic Scholar
Brain abscess - A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury.
Jenni Kyyriäinen, P. Andrade, Xavier Ekolle Ndode-Ekane, Eppu Manninen +6 more
2024Epilepsy Research2 citations Open access
Semantic Scholar
Image Data Harmonization Tools for the Analysis of Posttraumatic Epilepsy Development in Preclinical Multisite MRI Studies
Sweta Bhagavatula, Ryan P. Cabeen, N. Harris, O. Gröhn +29 more
2023Epilepsy Research2 citations Open access
Semantic Scholar
Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury
Mehwish Anwer, Leonardo Lara-Valderrábano, J. Karttunen, X. Ndode-Ekane +2 more
2020Journal of Neurotrauma2 citations
Semantic Scholar

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