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G. Couchy · SciRah

Researcher profile · Semantic Scholar

G. Couchy

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G. Couchy — researcher profile on SciRah

h-index: 40
Works: 117
Citations: 11K

Most-cited papers

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
K. Schulze, S. Imbeaud, E. Letouzé, L. Alexandrov +20 more
2015Nature Genetics1,658 citations Open access
Semantic Scholar
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
Cécile Guichard, G. Amaddeo, S. Imbeaud, Y. Ladeiro +14 more
2012Nature Genetics1,404 citations Open access
Semantic Scholar
Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification.
J. Calderaro, G. Couchy, S. Imbeaud, G. Amaddeo +8 more
2017Journal of Hepatology681 citations
Semantic Scholar
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
J. Nault, S. Datta, S. Imbeaud, A. Franconi +13 more
2015Nature Genetics449 citations
Semantic Scholar
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
J. Nault, G. Couchy, C. Balabaud, G. Morcrette +52 more
2017Gastroenterology361 citations Open access
Semantic Scholar
A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection.
J. Nault, A. de Reyniès, A. Villanueva, J. Calderaro +15 more
2013Gastroenterology313 citations Open access
Semantic Scholar
Genotype‐phenotype correlation of CTNNB1 mutations reveals different ß‐catenin activity associated with liver tumor progression
S. Rebouissou, A. Franconi, J. Calderaro, E. Letouzé +8 more
2016Hepatology300 citations Open access
Semantic Scholar
Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting
B. Beuselinck, S. Job, E. Becht, A. Karadimou +15 more
2015Clinical Cancer Research282 citations Open access
Semantic Scholar
Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
C. Pilati, E. Letouzé, J. Nault, S. Imbeaud +19 more
2014Cancer Cell261 citations Open access
Semantic Scholar
Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
E. Letouzé, Jayendra Shinde, V. Renault, G. Couchy +13 more
2017Nature Communications248 citations Open access
Semantic Scholar
Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma
J. Nault, Yoann Martin, S. Caruso, T. Hirsch +22 more
2020Hepatology174 citations
Semantic Scholar
Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.
S. Caruso, Anna-Line Calatayud, Jill Pilet, T. La Bella +16 more
2019Gastroenterology167 citations Open access
Semantic Scholar
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
Q. Bayard, Léa Meunier, C. Péneau, V. Renault +18 more
2018Nature Communications141 citations Open access
Semantic Scholar
GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation.
J. Nault, M. Fabre, G. Couchy, C. Pilati +14 more
2012Journal of Hepatology135 citations
Semantic Scholar
Molecular Classification of Malignant Pleural Mesothelioma: Identification of a Poor Prognosis Subgroup Linked to the Epithelial-to-Mesenchymal Transition
A. de Reyniès, M. Jaurand, A. Renier, G. Couchy +13 more
2014Clinical Cancer Research124 citations Open access
Semantic Scholar
MODELING A HUMAN HCC SUBSET IN MICE THROUGH CO-EXPRESSION OF MET AND POINT-MUTANT β-CATENIN
Junyan Tao, Emily Xu, Yifei Zhao, Sucha Singh +6 more
2016Hepatology112 citations Open access
Semantic Scholar
Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib
B. Beuselinck, A. Karadimou, D. Lambrechts, B. Claes +17 more
2013British Journal of Cancer98 citations Open access
Semantic Scholar
Polyploidy spectrum: a new marker in HCC classification
Myriam Bou-Nader, S. Caruso, Romain Donné, Séverine Celton-Morizur +12 more
2019Gut91 citations Open access
Semantic Scholar
KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis.
Isabelle Gasnereau, M. Boissan, Germain Margall-Ducos, G. Couchy +6 more
2012American Journal of Pathology74 citations Open access
Semantic Scholar
Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study.
E. Trépo, S. Caruso, Jie Yang, S. Imbeaud +26 more
2021The Lancet Oncology71 citations Open access
Semantic Scholar
BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
T. Hirsch, A. Negulescu, Barkha Gupta, S. Caruso +16 more
2019Journal of Hepatology66 citations Open access
Semantic Scholar
Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity In Vitro
S. Rebouissou, T. La Bella, Samia Rekik, S. Imbeaud +11 more
2017Clinical Cancer Research61 citations
Semantic Scholar
Circulating tumour DNA in patients with hepatocellular carcinoma across tumour stages and treatments
C. Campani, S. Imbeaud, G. Couchy, M. Ziol +12 more
2024Gut58 citations
Semantic Scholar
Inflammatory hepatocellular adenomas developed in the setting of chronic liver disease and cirrhosis
J. Calderaro, J. Nault, C. Balabaud, G. Couchy +7 more
2016Modern Pathology56 citations Open access
Semantic Scholar
Molecular Subtypes of Clear-cell Renal Cell Carcinoma are Prognostic for Outcome After Complete Metastasectomy.
A. Verbiest, G. Couchy, S. Job, L. Caruana +11 more
2018European Urology55 citations
Semantic Scholar
Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma
B. Beuselinck, A. Verbiest, G. Couchy, S. Job +12 more
2017Acta oncologica52 citations Open access
Semantic Scholar
The liver‐specific microRNA‐122*, the complementary strand of microRNA‐122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry
A. Simerzin, Elina Zorde-Khvalevsky, M. Rivkin, Revital Adar +7 more
2016Hepatology52 citations Open access
Semantic Scholar
Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated With Outcome During Pazopanib Therapy in the Metastatic Setting
A. Verbiest, G. Couchy, S. Job, J. Zucman-Rossi +11 more
2017Clinical Genitourinary Cancer51 citations
Semantic Scholar
Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease.
N. Guldiken, G. Kobazi Ensari, P. Lahiri, G. Couchy +8 more
2016Journal of Hepatology50 citations
Semantic Scholar
TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.
Zakaria Ezzoukhry, E. Henriet, L. Piquet, K. Boyé +6 more
2016European Journal of Cell Biology49 citations
Semantic Scholar
VEGFR1 single nucleotide polymorphisms associated with outcome in patients with metastatic renal cell carcinoma treated with sunitinib – a multicentric retrospective analysis
B. Beuselinck, A. Karadimou, D. Lambrechts, B. Claes +21 more
2014Acta oncologica49 citations Open access
Semantic Scholar
Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas
J. Nault, G. Couchy, S. Caruso, Léa Meunier +6 more
2018Hepatology46 citations
Semantic Scholar
Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma
Antoine L’Hermitte, Sandrine Pham, Mathilde Cadoux, G. Couchy +8 more
2018Hepatology44 citations Open access
Semantic Scholar
Clear-cell Renal Cell Carcinoma: Molecular Characterization of IMDC Risk Groups and Sarcomatoid Tumors.
A. Verbiest, Inne Renders, S. Caruso, G. Couchy +16 more
2019Clinical Genitourinary Cancer41 citations Open access
Semantic Scholar
Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma
K. Poussin, C. Pilati, G. Couchy, J. Calderaro +14 more
2013Oncoimmunology40 citations Open access
Semantic Scholar
Germline and somatic DICER1 mutations in familial and sporadic liver tumors.
S. Caruso, J. Calderaro, E. Letouzé, J. Nault +8 more
2017Journal of Hepatology37 citations
Semantic Scholar
Hepatocyte nuclear factor 1&agr; suppresses steatosis-associated liver cancer by inhibiting PPAR&ggr; transcription
Cecilia Patitucci, G. Couchy, A. Bagattin, T. Cañeque +7 more
2017Journal of Clinical Investigation34 citations Open access
Semantic Scholar
Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.
J. Nault, I. Mami, T. La Bella, S. Datta +15 more
2016Molecular Therapy34 citations Open access
Semantic Scholar
DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes
Léa Meunier, T. Hirsch, S. Caruso, S. Imbeaud +9 more
2021Hepatology33 citations Open access
Semantic Scholar
Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib
B. Beuselinck, D. Lambrechts, T. van Brussel, P. Wolter +16 more
2014Acta oncologica31 citations Open access
Semantic Scholar
MicroRNAs Targeting HIF-2α, VEGFR1 and/or VEGFR2 as Potential Predictive Biomarkers for VEGFR Tyrosine Kinase and HIF-2α Inhibitors in Metastatic Clear-Cell Renal Cell Carcinoma
L. Kinget, E. Roussel, A. Verbiest, M. Albersen +10 more
2021Cancers29 citations Open access
Semantic Scholar
PTEN expression and mutations in TSC1, TSC2 and MTOR are associated with response to rapalogs in patients with renal cell carcinoma
J. M. Roldan-Romero, B. Beuselinck, María Santos, J. Rodríguez-Moreno +19 more
2020International Journal of Cancer29 citations Open access
Semantic Scholar
RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs
B. Beuselinck, J. Jean-Baptiste, G. Couchy, S. Job +15 more
2015British Journal of Cancer28 citations Open access
Semantic Scholar
Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas
Q. Bayard, S. Caruso, G. Couchy, S. Rebouissou +13 more
2020Gut26 citations Open access
Semantic Scholar
Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear‐cell renal cell carcinoma patients treated with sunitinib
B. Beuselinck, J. Jean-Baptiste, P. Schöffski, G. Couchy +13 more
2016BJU International26 citations
Semantic Scholar
Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin
O. Breig, Maïlyn Yates, V. Neaud, G. Couchy +6 more
2016OncoTarget20 citations Open access
Semantic Scholar
Characterization of a novel PXR isoform with potential dominant-negative properties.
C. Breuker, C. Planque, F. Rajabi, J. Nault +12 more
2014Journal of Hepatology17 citations
Semantic Scholar
Focal β‐catenin mutation identified on formalin‐fixed and paraffin‐embedded inflammatory hepatocellular adenomas
Joan Saldarriaga, B. Bisig, G. Couchy, C. Castain +4 more
2017Histopathology16 citations
Semantic Scholar
Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before.
C. Sempoux, B. Bisig, G. Couchy, C. Balabaud +2 more
2017Human Pathology16 citations
Semantic Scholar
Borderline Hepatocellular Adenomas: a Practical Diagnostic Approach Based on Pathological and Molecular Features.
N. Poté, S. Caruso, Julien Caderaro, F. Cauchy +10 more
2023Modern Pathology14 citations Open access
Semantic Scholar

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