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W. Nes · SciRah

Researcher profile · Semantic Scholar

W. Nes

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W. Nes — researcher profile on SciRah

h-index: 40
Works: 173
Citations: 4,840

Most-cited papers

Insect Sterol Nutrition and Physiology: A Global Overview
S. Behmer, W. Nes
2003258 citations
Semantic Scholar
Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells
F. R. Santori, Pengxiang Huang*, S. A. van de Pavert, Eugene Douglass +13 more
2015Cell Metabolism229 citations Open access
Semantic Scholar
Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis.
A. Bellamine, A. T. Mangla, W. Nes, Michael R. Waterman
1999Proceedings of the National Academy of Sciences of the United States of America223 citations Open access
Semantic Scholar
CYP51: A Major Drug Target in the Cytochrome P450 Superfamily
G. Lepesheva, Tatyana Y. Hargrove, Yuliya Y. Kleshchenko, W. Nes +2 more
2008Lipids107 citations Open access
Semantic Scholar
The structural requirements of sterols for membrane function in Saccharomyces cerevisiae.
W. Nes, G. Janssen, F. G. Crumley, M. Kalinowska +1 more
1993Archives of Biochemistry and Biophysics99 citations
Semantic Scholar
Both methylerythritol phosphate and mevalonate pathways contribute to biosynthesis of each of the major isoprenoid classes in young cotton seedlings.
S. Opitz, W. Nes, J. Gershenzon
2014Phytochemistry96 citations
Semantic Scholar
Carbon-13 nmr studies on sitosterol biosynthesized from [13C]mevalonates
W. Nes, R. Norton, M. Benson
199295 citations
Semantic Scholar
Developmental regulation of sterol biosynthesis inZea mays
D. Guo, M. Venkatramesh, W. Nes
1995Lipids91 citations
Semantic Scholar
Identification of the Lipophilic Factor Produced by Macrophages That Stimulates Steroidogenesis.
W. Nes, Y. Lukyanenko, Z. Jia, S. Quideau +4 more
2000Endocrinology73 citations
Semantic Scholar
Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae.
Mylavarapu Venkatramesh, D. Guo, Z. Jia, W. Nes
1996Biochimica et Biophysica Acta64 citations
Semantic Scholar
Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase.
W. Nes, G. Janssen, A. Bergenstråhle
1991Journal of Biological Chemistry64 citations Open access
Semantic Scholar
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme
A. Warrilow, Josie E. Parker, C. L. Price, W. Nes +5 more
2016Antimicrobial Agents and Chemotherapy60 citations Open access
Semantic Scholar
9β,19-Cyclosterol Analysis by 1H and 13C NMR, Crystallographic Observations, and Molecular Mechanics Calculations
W. Nes, K. Koike, Z. Jia, Y. Sakamoto +3 more
199858 citations
Semantic Scholar
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)
A. Debnath, C. M. Calvet, Gareth Jennings, Wen-Xu Zhou +6 more
2017PLoS Neglected Tropical Diseases57 citations Open access
Semantic Scholar
Sterol Biosynthesis Inhibitors: Potential for Transition State Analogs and Mechanism-Based Inactivators Targeted at Sterol Methyltransferase
Zhihong Song, W. Nes
2007Lipids57 citations
Semantic Scholar
Enzyme mechanisms for sterol C-methylations.
W. Nes
2003Phytochemistry56 citations
Semantic Scholar
BIOCHEMISTRY and FUNCTION of STEROLS
E. Parish, W. Nes
199756 citations
Semantic Scholar
Sterol methyl transferase: enzymology and inhibition.
W. Nes
2000Biochimica et Biophysica Acta50 citations
Semantic Scholar
Overexpression, Purification, and Stereochemical Studies of the Recombinant (S)-Adenosyl-l-methionine: Δ24(25)- to Δ24(28)-Sterol Methyl Transferase Enzyme fromSaccharomyces cerevisiae
W. Nes, Brian S. McCourt, Wen-Xu Zhou, J. Ma +3 more
199847 citations
Semantic Scholar
Pollen sterols are associated with phylogeny and environment but not with pollinator guilds
Peng-Juan Zu, H. Koch, Orlando Schwery, S. Pironon +8 more
2021New Phytologist46 citations Open access
Semantic Scholar
Soybean sterol composition and utilization by Phytophthora sojae.
J. A. Marshall, A. L. Dennis, Toshihiro Kumazawa, Ann M. Haynes +1 more
2001Phytochemistry42 citations
Semantic Scholar
Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis.
W. Nes, Y. Lukyanenko, Hua-Jia Zhong, S. Quideau +4 more
2000Endocrinology42 citations Open access
Semantic Scholar
Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
Wen-Xu Zhou, A. Debnath, Gareth Jennings, Hye Jee Hahn +4 more
2018PLoS Pathogens41 citations Open access
Semantic Scholar
Structural requirements for transformation of substrates by the S-adenosyl-L-methionine:delta 24(25)-sterol methyltransferase. Inhibition by analogs of the transition state coordinate.
G. Janssen, W. Nes
1992Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Isopentenoids and other natural products : evolution and function
W. Nes
199439 citations
Semantic Scholar
Steroidal Triterpenes: Design of Substrate-Based Inhibitors of Ergosterol and Sitosterol Synthesis
Jialin Liu, W. Nes
2009Molecules38 citations Open access
Semantic Scholar
Enzymology of phytosterol transformations.
W. Nes, Mylavarapu Venkatramesh
1999Critical reviews in biochemistry and molecular biology38 citations
Semantic Scholar
Novel sterol transformations promoted by Saccharomyces cerevisiae strain GL7: evidence for 9 beta, 19-cyclopropyl to 9(11)-isomerization and for 14-demethylation to 8(14)-sterols.
Mylavarapu Venkatramesh, W. Nes
1995Archives of Biochemistry and Biophysics33 citations
Semantic Scholar
Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases
D. Lamb, T. Y. Hargrove, Bin Zhao, Z. Wawrzak +6 more
2020Molecular biology and evolution32 citations Open access
Semantic Scholar
Sterol methyltransferase2: purification, properties, and inhibition.
Wen-Xu Zhou, W. Nes
2003Archives of Biochemistry and Biophysics32 citations
Semantic Scholar
Regulation of Isopentenoid Metabolism
W. Nes, E. Parish, J. Trzăskos
199227 citations Open access
Semantic Scholar
Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]
Brad A. Haubrich, U. Singha, M. B. Miller, C. Nes +8 more
2015Journal of Lipid Research26 citations Open access
Semantic Scholar
Molecular characterization and functional analysis of Glycine max sterol methyl transferase 2 genes involved in plant membrane sterol biosynthesis
A. Neelakandan, Hanh T. M. Nguyen, Rajesh Kumar, L. Tran +5 more
2010Plant Molecular Biology26 citations
Semantic Scholar
Developmental differences in the sterol composition of Solenopsis invicta
A. Ba, D. Guo, R. Norton, S. Phillips +1 more
199524 citations
Semantic Scholar
Structural requirements for substrate recognition of Mycobacterium tuberculosis 14 alpha-demethylase: implications for sterol biosynthesis.
A. Bellamine, A. T. Mangla, A. L. Dennis, W. Nes +1 more
2001Journal of Lipid Research23 citations
Semantic Scholar
Stereochemistry of Hydrogen Migration from C-24 to C-25 during Phytosterol Biomethylation
D. Guo, Z. Jia, W. Nes
199623 citations
Semantic Scholar
Regulation of Sterol Biosynthesis and Its Phylogenetic Implications
S. R. Parker, W. Nes
199223 citations
Semantic Scholar
Biodiversity of CYP51 in trypanosomes.
G. Lepesheva, T. Y. Hargrove, R. Ott, W. Nes +1 more
2006Biochemical Society Transactions22 citations
Semantic Scholar
Regulation of sterol biosynthesis in sunflower by 24(R,S),25-epiminolanosterol, a novel C-24 methyl transferase inhibitor.
W. Nes, G. Janssen, R. Norton, M. Kalinowska +4 more
1991Biochemical and Biophysical Research Communications - BBRC22 citations
Semantic Scholar
Structural complex of sterol 14alpha-demethylase (CYP51) with 14alpha-methylenecyclopropyl-delta7-24, 25-dihydrolanosterol
T. Y. Hargrove, Z. Wawrzak, Jialin Liu, M. Waterman +2 more
201120 citations
Semantic Scholar
Fluorinated Sterols are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei
D. Leaver, P. Patkar, U. K. Singha, M. B. Miller +3 more
2015Chemistry and Biology19 citations Open access
Semantic Scholar
Chapter nine Engineering pathway enzymes to understand the function and evolution of sterol structure and activity
P. Jayasimha, C. Bowman, J. M. Pedroza, W. Nes
200619 citations
Semantic Scholar
Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site.
W. Nes
2005Biochemical Society Transactions18 citations
Semantic Scholar
Sterol methyl transferase. Evidence for successive C-methyl transfer reactions generating Δ24(28)- and Δ25(27)-olefins by a single plant enzyme
A. L. Dennis, W. Nes
200218 citations
Semantic Scholar
Metabolic engineering of soybean affords improved phytosterol seed traits.
A. Neelakandan, S. Chamala, B. Valliyodan, W. Nes +1 more
2012Plant Biotechnology Journal17 citations Open access
Semantic Scholar
Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae.
W. Nes, B. McCourt, W.-X. Zhou, J. Ma +3 more
1998Archives of Biochemistry and Biophysics17 citations
Semantic Scholar
Stereochemical Features of C-methylations on the Path to Δ24(28)-Methylene and Δ24(28)-Ethylidene Sterols: Studies on the Recombinant Phytosterol Methyl Transferase from Arabidopsis thaliana
Yu-Sen Tong, B. McCourt, D. Guo, A. T. Mangla +5 more
199716 citations
Semantic Scholar
Mechanism-based enzyme inactivators of phytosterol biosynthesis.
Wen-Xu Zhou, Zhihong Song, Ragu Kanagasabai, Jialin Liu +5 more
2004Molecules15 citations Open access
Semantic Scholar
Antifungal sterol biosynthesis inhibitors.
D. Guo, A. T. Mangla, Wen-Liang Zhou, M. López +3 more
1997Sub-cellular biochemistry15 citations
Semantic Scholar
Sterol C24-methyltransferase: mechanistic studies of the C-methylation reaction with 24-fluorocycloartenol.
Jun-Qing Wang, Jialin Liu, Zhihong Song, W. Nes
2008Bioorganic & Medicinal Chemistry Letters14 citations
Semantic Scholar

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