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R. Novosyadlyy · SciRah

Researcher profile · Semantic Scholar

R. Novosyadlyy

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R. Novosyadlyy — researcher profile on SciRah

h-index: 20
Works: 38
Citations: 1,995

Most-cited papers

Biological Effects of Growth Hormone on Carbohydrate and Lipid Metabolism
A. Vijayakumar, R. Novosyadlyy, Yingjie Wu, S. Yakar +1 more
2009Growth Hormone & IGF Research318 citations Open access
Semantic Scholar
Insulin-mediated acceleration of breast cancer development and progression in a non-obese model of type 2 diabetes
R. Novosyadlyy, D. Lann, A. Vijayakumar, A. Rowzee +12 more
2010Cancer Research288 citations Open access
Semantic Scholar
Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.
S. Yakar, N. Núñez, P. Pennisi, P. Brodt +14 more
2006Endocrinology150 citations
Semantic Scholar
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model
N. Alikhani, Rosalyn D. Ferguson, R. Novosyadlyy, E. Gallagher +3 more
2012Oncogene141 citations Open access
Semantic Scholar
Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence.
D. LeRoith, R. Novosyadlyy, E. Gallagher, D. Lann +2 more
2008Experimental and clinical endocrinology & diabetes131 citations
Semantic Scholar
Insulin-Like Growth Factor-I Regulates the Liver Microenvironment in Obese Mice and Promotes Liver Metastasis
Yingjie Wu, P. Brodt, Hui B. Sun, Wilson Mejía +7 more
2010Cancer Research97 citations Open access
Semantic Scholar
Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes
Rosalyn D. Ferguson, R. Novosyadlyy, Y. Fierz, N. Alikhani +3 more
2012Breast Cancer Research96 citations Open access
Semantic Scholar
Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes–Mediated Mammary Tumor Progression
Y. Fierz, R. Novosyadlyy, A. Vijayakumar, S. Yakar +1 more
2009Diabetes96 citations Open access
Semantic Scholar
Insulin and IGFs in Obesity-Related Breast Cancer
Valentina Belardi, E. Gallagher, R. Novosyadlyy, D. LeRoith
2013Journal of mammary gland biology and neoplasia88 citations
Semantic Scholar
Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum
R. Novosyadlyy, N. Kurshan, D. Lann, A. Vijayakumar +2 more
2008Cell Death and Differentiation75 citations
Semantic Scholar
Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance—Implications for IGF-II and IGF-IR–Targeted Therapy
Bin Li, Sai-Wah Tsao, Kwok W. Chan, D. Ludwig +4 more
2014Clinical Cancer Research70 citations Open access
Semantic Scholar
Upregulation of heme oxygenase-1 gene by turpentine oil-induced localized inflammation: involvement of interleukin-6
K. Tron, R. Novosyadlyy, J. Dudás, A. Samoylenko +2 more
2005Laboratory Investigation58 citations Open access
Semantic Scholar
Hyperinsulinemia Promotes Metastasis to the Lung in a Mouse Model of Her2-mediated Breast Cancer
Rosalyn D. Ferguson, E. Gallagher, D. Cohen, Aviva Tobin-Hess +5 more
2013Endocrine-Related Cancer48 citations Open access
Semantic Scholar
Hyperinsulinemia and type 2 diabetes: Impact on cancer
R. Novosyadlyy, D. LeRoith
2010Cell Cycle39 citations Open access
Semantic Scholar
Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.
R. Novosyadlyy, D. LeRoith
2012The journals of gerontology. Series A, Biological sciences and medical sciences38 citations
Semantic Scholar
mTOR Inhibition Abrogates Insulin-Mediated Mammary Tumor Progression in Type 2 Diabetes
Y. Fierz, R. Novosyadlyy, A. Vijayakumar, S. Yakar +1 more
2010Endocrine-Related Cancer36 citations Open access
Semantic Scholar
Crosstalk between PDGF and IGF-I receptors in rat liver myofibroblasts: implication for liver fibrogenesis
R. Novosyadlyy, J. Dudás, R. Pannem, G. Ramadori +1 more
2005Laboratory Investigation35 citations Open access
Semantic Scholar
Insulin-like growth factor (IGF)-binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cells.
J. Scharf, F. Dombrowski, R. Novosyadlyy, C. Eisenbach +3 more
2004Endocrinology35 citations
Semantic Scholar
Expression and regulation of the insulin‐like growth factor axis components in rat liver myofibroblasts
R. Novosyadlyy, K. Tron, J. Dudás, G. Ramadori +1 more
2004Journal of Cellular Physiology29 citations Open access
Semantic Scholar
Blockade of insulin-like growth factor type-1 receptor with cixutumumab (IMC-A12): a novel approach to treatment for multiple cancers.
E. Rowinsky, J. Schwartz, N. Zojwalla, H. Youssoufian +5 more
2011Current Drug Targets26 citations
Semantic Scholar
The Increased Risk of Cancer in Obesity and Type 2 Diabetes: Potential Mechanisms
E. Gallagher, R. Novosyadlyy, S. Yakar, D. LeRoith
201020 citations
Semantic Scholar
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation
R. Novosyadlyy, A. Vijayakumar, D. Lann, Y. Fierz +2 more
2009Oncogene20 citations Open access
Semantic Scholar
Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats.
R. Novosyadlyy, R. Dargel, J. Scharf
2005Growth Hormone & IGF Research19 citations Open access
Semantic Scholar
A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation
Yang Shen, Lin Zeng, R. Novosyadlyy, A. Forest +19 more
2015mAbs18 citations Open access
Semantic Scholar
Temporal and spatial expression of IGF-I and IGFBP-1 during acute-phase response induced by localized inflammation in rats.
R. Novosyadlyy, A. Lelbach, N. Sheikh, K. Tron +3 more
2009Growth Hormone & IGF Research10 citations
Semantic Scholar
Type 2 diabetes and cancer
E. Gallagher, R. Novosyadlyy, D. LeRoith
20156 citations
Semantic Scholar
Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer
R. Novosyadlyy, A. Vijayakumar, Y. Fierz, D. LeRoith
20114 citations
Semantic Scholar
Cancer Therapy : Preclinical Id 1-Induced IGF-II and Its Autocrine / Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance — Implications for IGF-II and IGF-IR – Targeted Therapy
Bin Li, Sai-Wah Tsao, Kwok W. Chan, D. Ludwig +4 more
20143 citations
Semantic Scholar
P35 Reduced serum IGF-1 levels do not affect insulin-mediated mammary tumor progression in type 2 diabetes
Y. Fierz, R. Novosyadlyy, A. Vijayakumar, S. Yakar +1 more
20101 citations
Semantic Scholar
OR12,3 Insulin-like growth factor I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum
R. Novosyadlyy, N. Kurshan, D. Lann, A. Vijayakumar +2 more
20081 citations
Semantic Scholar
P34 Increased mammary tumor lung metastases in an MKR mouse model of type 2 diabetes
Rosalyn D. Ferguson, R. Novosyadlyy, Y. Fierz, Hui B. Sun +2 more
20100 citations
Semantic Scholar
Growth Hormone, Insulin-like Growth Factor I and Insulin: their Relationship to Aging and Cancer
R. Novosyadlyy, E. Gallagher, D. LeRoith
20100 citations
Semantic Scholar
P59 Antitumor response of preclinical tumor models to IGF-IR targeted therapy is not dependent on PTEN or PIK3CA mutational status
D. Deevi, Douglas B. Burtrum, R. Novosyadlyy, J. Tonra +1 more
20100 citations
Semantic Scholar
Anti-diabetic therapy inhibits mammary tumor progression Insulin sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression Running Title: Anti-diabetic therapy inhibits mammary tumor progression
Y. Fierz, R. Novosyadlyy, A. Vijayakumar, S. Yakar +1 more
20090 citations
Semantic Scholar
IGF-I receptor-dependent mitogenic effect of platelet- derived growth factor in rat liver myofibroblasts
R. Novosyadlyy, G. Ramadori, J. Scharf
20040 citations
Semantic Scholar
Heme oxygenase-1 as intracellular positive acute phase protein in the rat liver: possible regulatory mechanisms
K. Tron, R. Novosyadlyy, B. Haralanova-Ilieva, G. Ramadori
20040 citations
Semantic Scholar
Differential effects of primary and immortalized hepatocytes on liver mesenchymal cells in co-cultures
J. Dudás, V. Bordoni, R. Novosyadlyy, J. Scharf +5 more
20040 citations
Semantic Scholar
Differential expression of the insulin-like growth factor axis components in rat hepatic stellate cells and liver myofibroblasts
R. Novosyadlyy, J. Dudás, K. Tron, G. Ramadori +1 more
20040 citations
Semantic Scholar

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D. LeRoith×22
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S. Yakar×16
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A. Vijayakumar×11
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Y. Fierz×9
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E. Gallagher×7

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D. Lann — researcher profile on SciRah

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