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Leyuan Xu · SciRah

Researcher profile · Semantic Scholar

Leyuan Xu

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Leyuan Xu — researcher profile on SciRah

h-index: 27
Works: 55
Citations: 1,736

Most-cited papers

Dendrimer advances for the central nervous system delivery of therapeutics.
Leyuan Xu, Hao Zhang, Yue Wu
2014ACS Chemical Neuroscience162 citations Open access
Semantic Scholar
Biomarkers of inflammation and repair in kidney disease progression.
Jeremy Puthumana, H. Thiessen-Philbrook, Leyuan Xu, S. Coca +13 more
2020Journal of Clinical Investigation149 citations Open access
Semantic Scholar
Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury.
Leyuan Xu, Diana Sharkey, L. Cantley
2019Journal of the American Society of Nephrology142 citations Open access
Semantic Scholar
Folate-mediated chemotherapy and diagnostics: an updated review and outlook
Leyuan Xu, Q. Bai, Xin Zhang, Hu Yang
2017Journal of Controlled Release110 citations Open access
Semantic Scholar
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition
Leyuan Xu, Jiankan Guo, D. Moledina, L. Cantley
2022Nature Communications89 citations Open access
Semantic Scholar
25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.
Yong-Jie Ma, Leyuan Xu, D. Rodriguez-Agudo, Xiao-Bo Li +4 more
2008American Journal of Physiology. Endocrinology and Metabolism80 citations Open access
Semantic Scholar
Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate
Leyuan Xu, Q. Bai, D. Rodriguez-Agudo, P. Hylemon +3 more
2010Lipids70 citations
Semantic Scholar
Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells
Q. Bai, Leyuan Xu, Genta Kakiyama, M. Runge‐Morris +4 more
2010Atherosclerosis69 citations Open access
Semantic Scholar
Folic Acid-Decorated Polyamidoamine Dendrimer Exhibits High Tumor Uptake and Sustained Highly Localized Retention in Solid Tumors: Its Utility for Local siRNA Delivery
Leyuan Xu, W. A. Yeudall, Hu Yang
2017Acta Biomaterialia63 citations Open access
Semantic Scholar
Longitudinal biomarkers and kidney disease progression after acute kidney injury
Yu-Meng Wen, Leyuan Xu, Isabel Melchinger, H. Thiessen-Philbrook +13 more
2023JCI Insight54 citations Open access
Semantic Scholar
Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation
Xiaojia Guo, Leyuan Xu, H. Velázquez, Tian-Min Chen +5 more
2021Journal of the American Society of Nephrology54 citations Open access
Semantic Scholar
Oxysterol Sulfation by SULT2B1b Suppresses LXR/SREBP-1c Signaling Pathway and Reduces Serum and Hepatic Lipids in Mouse Models of NAFLD
Q. Bai, Xin Zhang, Leyuan Xu, Genta Kakiyama +6 more
2012Metabolism: Clinical and Experimental48 citations Open access
Semantic Scholar
Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4α
Xiong-Jie Shi, Qiu-Qiong Cheng, Leyuan Xu, Jiong Yan +8 more
2013Molecular and Cellular Biology47 citations Open access
Semantic Scholar
The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application
Leyuan Xu, N. Sheybani, W. A. Yeudall, Hu Yang
2015Biomaterials Science46 citations Open access
Semantic Scholar
Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts.
T. A. Montgomery, Leyuan Xu, S. Mason, Amirtha V. Chinnadurai +3 more
2017Journal of the American Society of Nephrology45 citations Open access
Semantic Scholar
Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration
Naomi S Shin, A. Marlier, Leyuan Xu, N. Doilicho +3 more
2022Journal of the American Society of Nephrology43 citations Open access
Semantic Scholar
25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages.
Leyuan Xu, Shanwei Shen, Yong-Jie Ma, Jin Koung Kim +5 more
2012American Journal of Physiology. Endocrinology and Metabolism41 citations Open access
Semantic Scholar
Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells.
Leyuan Xu, S. Kittrell, W. A. Yeudall, Hu Yang
2016Nanomedicine40 citations Open access
Semantic Scholar
Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery
Leyuan Xu, Remy C. Cooper, Juan Wang, W. A. Yeudall +1 more
2017ACS Biomaterials Science & Engineering38 citations Open access
Semantic Scholar
Semi-Interpenetrating Network (sIPN) Co-Electrospun Gelatin/Insulin Fiber Formulation for Transbuccal Insulin Delivery
Leyuan Xu, N. Sheybani, S. Ren, G. Bowlin +2 more
2014Pharmaceutical Research34 citations
Semantic Scholar
The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events
Steven Menez, Yu-Meng Wen, Leyuan Xu, D. Moledina +16 more
2023Kidney International32 citations Open access
Semantic Scholar
Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Hannah Melchinger, F. Calderon-Gutierrez, Wassim Obeid, Leyuan Xu +8 more
2022American Society of Nephrology. Clinical Journal31 citations Open access
Semantic Scholar
Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug
O. Zolotarskaya, Leyuan Xu, K. Valerie, Hu Yang
2015RSC Advances29 citations Open access
Semantic Scholar
Click Hybridization of Immune Cells and Polyamidoamine Dendrimers
Leyuan Xu, Olga Yu. Zolotarskaya, W. A. Yeudall, Hu Yang
2014Advanced Healthcare Materials29 citations Open access
Semantic Scholar
StAR overexpression decreases serum and tissue lipids in apolipoprotein E-deficient mice
Yan-Xia Ning, Leyuan Xu, S. Ren, W. Pandak +2 more
2009Lipids29 citations Open access
Semantic Scholar
5-Cholesten-3β,25-Diol 3-Sulfate Decreases Lipid Accumulation in Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model
Leyuan Xu, Jin Koung Kim, Q. Bai, Xin Zhang +5 more
2013Molecular Pharmacology28 citations Open access
Semantic Scholar
Cholesterol metabolite, 5-cholesten-3beta, 25-diol 3-sulfate, promotes hepatic proliferation in mice
Xin Zhang, Q. Bai, Genta Kakiyama, Leyuan Xu +3 more
2012Journal of Steroid Biochemistry and Molecular Biology27 citations Open access
Semantic Scholar
Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro.
Xin Zhang, Q. Bai, Leyuan Xu, Genta Kakiyama +3 more
2012American Journal of Physiology - Gastrointestinal and Liver Physiology25 citations Open access
Semantic Scholar
Toxicological risks of SDHIs and QoIs to zebrafish (Danio rerio) and the corresponding poisoning mechanism.
Xue-Ping Huang, Ai-Ping Wang, Yueh-Shieh Chen, Qingping Sun +5 more
2022Aquatic Toxicology19 citations
Semantic Scholar
The Role of Myeloid Cells in Acute Kidney Injury and Kidney Repair.
Leyuan Xu
2021Kidney36019 citations Open access
Semantic Scholar
Characterization of Temporospatial Distribution of Renal Tubular Casts by Nephron Tracking after Ischemia Reperfusion Injury.
Naomi S Shin, A. Marlier, Leyuan Xu, Tukiet T. Lam +2 more
2022AJP - Renal Physiology13 citations Open access
Semantic Scholar
Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy.
Leyuan Xu, Hu Yang
2019Methods in molecular biology11 citations
Semantic Scholar
Dendrimer-based RNA interference delivery for cancer therapy
Leyuan Xu, W. A. Yeudall, Hu Yang
20139 citations
Semantic Scholar
Macrophages-mediated delivery of protoporphyrin for sonodynamic therapy of rheumatoid arthritis
Lin Wu, Kaiyue Zhao, Leyuan Xu, Junming Cui +5 more
2024Ultrasonics sonochemistry5 citations Open access
Semantic Scholar
Inflammation-mediated Upregulation of VCAM-1 but not KIM-1 during Acute Kidney Injury to Chronic Kidney Disease Transition
Isabel Melchinger, Kailin Guo, Jiankan Guo, Leyuan Xu
2022bioRxiv3 citations Open access
Semantic Scholar
Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages-Too Many To Be True.
Naomi S Shin, A. Marlier, Leyuan Xu, N. Doilicho +3 more
2022Journal of the American Society of Nephrology1 citations Open access
Semantic Scholar
[Determination of 18 pesticide residues in environmental water by solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry].
Song Yang, Nan Zou, Yun Gao, Leyuan Xu +3 more
2020Se pu = Chinese journal of chromatography1 citations
Semantic Scholar
Semi-Interpenetrating Network Gelatin Fiber Sca old for Oral Mucosal Delivery of Insulin
Leyuan Xu
20131 citations
Semantic Scholar
Cytosolic sulfotransferase 2 B 1 b promotes hepatocyte proliferation gene expression in vivo and in vitro
Xin Zhang, Q. Bai, Leyuan Xu, Genta Kakiyama +3 more
20121 citations
Semantic Scholar
Engineering of Polyamidoamine Dendrimers for Cancer Therapy
Leyuan Xu
20150 citations
Semantic Scholar
Semi-Interpenetrating Network (sIPN) Co-Electrospun Gelatin/Insulin Fiber Formulation for Transbuccal Insulin Delivery
Leyuan Xu, N. Sheybani, S. Ren, G. Bowlin +2 more
2014Pharmaceutical Research0 citations
Semantic Scholar
Nanopreparations for Central Nervous System Diseases
Leyuan Xu, Hu Yang
20140 citations
Semantic Scholar
PVT Property Determination at Elevated Temperatures and Pressures by Floating-Piston Technique
Postdoc Journal, Yue Wu, Leyuan Xu, Hao Zhang
20140 citations
Semantic Scholar
Investigation of Poly(amidoamine) Dendrimer Based Simvastatin Oral Formulations: Pharmacokinetic and Pharmacodynamic Studies
Leyuan Xu, Hao Zhang, Yue Wu
20130 citations
Semantic Scholar
Application of Lattice‐Cluster Theory for Predicting High‐Pressure Phase Equilibrium of Hyperbranched Polymer Mixtures
Leyuan Xu, Hao Zhang, Yue Wu
20130 citations
Semantic Scholar
Pressure-Volume-Temperature Property Determination for Fluids at Extreme Pressures
Postdoc Journal, Yue Wu, Leyuan Xu, Hao Zhang +2 more
20130 citations
Semantic Scholar
25-Hydroxycholesterol-3-Sulfate Decreases Hepatic Steatosis and Inflammation in Mouse Models of Nonalcoholic Fatty Liver Disease by Down-Regulating Sterol Regulatory Element Binding Protein-1c
Leyuan Xu, Q. Bai, Genta Kakiyama, D. Heuman +2 more
20110 citations Open access
Semantic Scholar
Induction of IKBa Expression Mediates the Anti-Inflammatory Response to 25-Hydroxycholesterol-3-Sulfate (25HC3S) in Primary Rat Hepatocytes and THP-1 Macrophages
Leyuan Xu, Jin Koung Kim, Xu Wang, D. Heuman +2 more
20110 citations Open access
Semantic Scholar
25‐Hydroxycholesterol sulfation regulates lipid metabolism in vivo in mice
S. Ren, Q. Bai, Leyuan Xu, William M. Pandak
20110 citations
Semantic Scholar
In Vivo Overexpression of Hydroxysteroid Sulfotransferase SULT2B1b in Mice Reduces Hepatic Lipids and Suppresses SREBP Signaling: Further Evidence for Oxysterol Sulfates as Endogenous Regulators of Hepatic Lipid Metabolism
Q. Bai, Xin Zhang, Leyuan Xu, Genta Kakiyama +3 more
20110 citations Open access
Semantic Scholar

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