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I. Santolini · SciRah

Researcher profile · Semantic Scholar

I. Santolini

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I. Santolini — researcher profile on SciRah

h-index: 10
Works: 16
Citations: 423

Most-cited papers

WAG/Rij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212‐2, with a reduced incidence of spike‐wave discharges
C. V. van Rijn, S. Gaetani, I. Santolini, A. Badura +7 more
2010Epilepsia62 citations Open access
Semantic Scholar
Metabotropic glutamate receptors in the thalamocortical network: Strategic targets for the treatment of absence epilepsy
R. Ngomba, I. Santolini, T. E. Salt, F. Ferraguti +3 more
2011Epilepsia58 citations Open access
Semantic Scholar
Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.
R. Ngomba, F. Ferraguti, A. Badura, R. Citraro +7 more
2008Neuropharmacology58 citations Open access
Semantic Scholar
Targeting metabotropic glutamate receptors in the treatment of epilepsy: rationale and current status
R. Celli, I. Santolini, G. van Luijtelaar, R. Ngomba +2 more
2019Expert opinion on therapeutic targets47 citations Open access
Semantic Scholar
Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.
R. Ngomba, I. Santolini, F. Biagioni, G. Molinaro +12 more
2011Neuropharmacology40 citations Open access
Semantic Scholar
Protective Role for Type 4 Metabotropic Glutamate Receptors against Ischemic Brain Damage
S. Moyanova, F. Mastroiacovo, L. Kortenska, Rumiana G Mitreva +7 more
2011Journal of Cerebral Blood Flow and Metabolism38 citations Open access
Semantic Scholar
Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats
V. D'Amore, I. Santolini, C. V. van Rijn, F. Biagioni +12 more
2012Neuropharmacology33 citations Open access
Semantic Scholar
Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats
V. D'Amore, I. Santolini, R. Celli, L. Lionetto +10 more
2014Neuropharmacology28 citations Open access
Semantic Scholar
The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?
R. Celli, I. Santolini, Michela Guiducci, G. van Luijtelaar +6 more
2017Current Neuropharmacology16 citations Open access
Semantic Scholar
Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?
S. Moyanova, A. De Fusco, I. Santolini, R. Celli +5 more
2018International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Pharmacological activation of mGlu5 receptors with the positive allosteric modulator, VU0360172 modulates thalamic GABAergic transmission.
R. Celli, Mark J. Wall, I. Santolini, M. Vergassola +9 more
2020Neuropharmacology10 citations Open access
Semantic Scholar
The anti-absence effect of mGlu5 receptor amplification with VU0360172 is maintained during and after antiepileptogenesis.
V. D'Amore, R. Raaijmakers, I. Santolini, C. V. van Rijn +3 more
2016Pharmacology, Biochemistry and Behavior10 citations
Semantic Scholar
Alterations in the α2δ ligand, thrombospondin‐1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies
I. Santolini, R. Celli, M. Cannella, Tiziana Imbriglio +55 more
2017Epilepsia7 citations Open access
Semantic Scholar
Is There a Future for mGlu5-Positive Allosteric Modulators in Absence Epilepsy? A Comparison with Ethosuximide
E. V. van Luijtelaar, V. D'Amore, I. Santolini, R. Ngomba
20171 citations Open access
Semantic Scholar
VU 0360172 , a mGlu 5 positive allosteric modulator , diminishes its anti-absence action after chronic ethosuximide
V. D'Amore, R. Raaijmakers, I. Santolini, C. V. van Rijn +3 more
20170 citations
Semantic Scholar
Single nucleotide polymorphisms (SNPs) of metabotropic glutamate receptor type 3 gene (GRM3) in children with absence epilepsy: a pathogenic link?
M. Mastrangelo, R. Gradini, F. Nicoletti, I. Santolini +4 more
20100 citations
Semantic Scholar

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