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K. Purushothaman · SciRah

Researcher profile · Semantic Scholar

K. Purushothaman

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K. Purushothaman — researcher profile on SciRah

h-index: 21
Works: 47
Citations: 3,440

Most-cited papers

Plaque Neovascularization Is Increased in Ruptured Atherosclerotic Lesions of Human Aorta: Implications for Plaque Vulnerability
Pedro R. Moreno, K. Purushothaman, V. Fuster, D. Echeverri +4 more
2004Circulation664 citations Open access
Semantic Scholar
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
S. Evrard, L. Lecce, K. Michelis, A. Nomura-Kitabayashi +17 more
2016Nature Communications589 citations Open access
Semantic Scholar
Neovascularization in human atherosclerosis.
P. Moreno, K. Purushothaman, E. Zias, Javier Sanz +1 more
2006Current molecular medicine407 citations Open access
Semantic Scholar
Detection of Lipid Pool, Thin Fibrous Cap, and Inflammatory Cells in Human Aortic Atherosclerotic Plaques by Near-Infrared Spectroscopy
Pedro R. Moreno, Robert A. Lodder, K. Purushothaman, William E. Charash +2 more
2002Circulation325 citations Open access
Semantic Scholar
Neovascularization in Human Atherosclerosis
P. Moreno, K. Purushothaman, M. Sirol, A. Levy +1 more
2006Circulation243 citations Open access
Semantic Scholar
Intimomedial Interface Damage and Adventitial Inflammation Is Increased Beneath Disrupted Atherosclerosis in the Aorta: Implications for Plaque Vulnerability
Pedro R. Moreno, K. Purushothaman, V. Fuster, William N. O'Connor
2002Circulation222 citations Open access
Semantic Scholar
Downregulation of the Hemoglobin Scavenger Receptor in Individuals With Diabetes and the Hp 2-2 Genotype: Implications for the Response to Intraplaque Hemorrhage and Plaque Vulnerability
A. Levy, K. Purushothaman, N. Levy, M. Purushothaman +10 more
2007Circulation Research150 citations Open access
Semantic Scholar
Corrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
S. Evrard, L. Lecce, K. Michelis, A. Nomura-Kitabayashi +17 more
2017Nature Communications84 citations Open access
Semantic Scholar
Plaque neovascularization: defense mechanisms, betrayal, or a war in progress
Pedro R. Moreno, Meeranani Purushothaman, K. Purushothaman
2012Annals of the New York Academy of Sciences80 citations
Semantic Scholar
Inflammation, neovascularization and intra-plaque hemorrhage are associated with increased reparative collagen content: Implication for plaque progression in diabetic atherosclerosis
K. Purushothaman, M. Purushothaman, P. Muntner, P. Lento +4 more
2011Vascular Medicine73 citations Open access
Semantic Scholar
Increased Neovascularization in Advanced Lipid-Rich Atherosclerotic Lesions Detected by Gadofluorine-M–Enhanced MRI
M. Sirol, P. Moreno, K. Purushothaman, E. Vucic +5 more
2009Circulation Cardiovascular Imaging67 citations Open access
Semantic Scholar
Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque.
Pedro R. Moreno, K. Purushothaman, M. Purushothaman, P. Muntner +6 more
2008Journal of the American College of Cardiology67 citations Open access
Semantic Scholar
Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis.
P. Moreno, Luis Astudillo, S. Elmariah, K. Purushothaman +5 more
2011Journal of Thoracic and Cardiovascular Surgery51 citations Open access
Semantic Scholar
Histopathological Evidence of Adventitial or Medial Injury Is a Strong Predictor of Restenosis During Directional Atherectomy for Peripheral Artery Disease
Arthur Tarricone, Z. Ali, Anitha Rajamanickam, K. Gujja +9 more
2015Journal of Endovascular Therapy50 citations
Semantic Scholar
Coronary atherosclerosis in sudden cardiac death: an autopsy study.
M. Sudha, S. Sundaram, K. Purushothaman, P. Kumar +1 more
2009Indian Journal of Pathology and Microbiology43 citations Open access
Semantic Scholar
Differential patterns of replacement and reactive fibrosis in pressure and volume overload are related to the propensity for ischaemia and involve resistin
Elie R. Chemaly, Soojeong Kang, Shi-Hong Zhang, Latronya Mccollum +5 more
2013Journal of Physiology41 citations Open access
Semantic Scholar
An Algorithm for the Use of Embolic Protection During Atherectomy for Femoral Popliteal Lesions.
P. Krishnan, Arthur Tarricone, K. Purushothaman, M. Purushothaman +7 more
2017JACC: Cardiovascular Interventions37 citations Open access
Semantic Scholar
Atherosclerosis neovascularization and imaging.
K. Purushothaman, J. Sanz, E. Zias, Valentin Fuster +1 more
2006Current molecular medicine37 citations
Semantic Scholar
Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis.
K. Purushothaman, M. Purushothaman, A. Levy, P. Lento +11 more
2012Journal of the American College of Cardiology36 citations Open access
Semantic Scholar
Genotype-Dependent Impairment of Hemoglobin Clearance Increases Oxidative and Inflammatory Response in Human Diabetic Atherosclerosis
M. Purushothaman, P. Krishnan, K. Purushothaman, U. Baber +7 more
2012Arteriosclerosis, Thrombosis and Vascular Biology29 citations Open access
Semantic Scholar
Inflammation and neovascularization in diabetic atherosclerosis.
K. Purushothaman, P. Meerarani, P. Moreno
2007Indian journal of experimental biology29 citations
Semantic Scholar
Enhanced neointimal fibroblast, myofibroblast content and altered extracellular matrix composition: Implications in the progression of human peripheral artery restenosis
P. Krishnan, K. Purushothaman, M. Purushothaman, I. Turnbull +8 more
2016Atherosclerosis20 citations Open access
Semantic Scholar
Neovascularization is the most powerful independent predictor for progression to disruption in high-risk atherosclerotic plaques
K. Purushothaman, V. Fuster, W. O'Connor, P. Moreno
200315 citations Open access
Semantic Scholar
Association of Altered Collagen Content and Lysyl Oxidase Expression in Degenerative Mitral Valve Disease
K. Purushothaman, M. Purushothaman, I. Turnbull, D. Adams +6 more
2017Cardiovascular pathology13 citations Open access
Semantic Scholar
Expression of angiotensin-converting enzyme 2 and its end product angiotensin 1-7 is increased in diabetic atheroma: implications for inflammation and neovascularization.
K. Purushothaman, P. Krishnan, M. Purushothaman, Jose M. Wiley +7 more
2013Cardiovascular pathology13 citations
Semantic Scholar
RESISTIN AGGRAVATES ATHEROSCLEROSIS IN APOE-/- MICE AND IS ELEVATED IN HUMAN ATHEROSCLEROTIC LESIONS
Xin-Jiang Cai, Rihab Bouchareb, Soojeong Kang, Y. Sassi +5 more
2019Journal of the American College of Cardiology12 citations Open access
Semantic Scholar
Histological features of restenosis associated with paclitaxel drug-coated balloon: implications for therapy.
P. Krishnan, K. Purushothaman, M. Purushothaman, Arthur Tarricone +6 more
2019Cardiovascular pathology12 citations
Semantic Scholar
Relation of Internal Elastic Lamellar Layer Disruption to Neointimal Cellular Proliferation and Type III Collagen Deposition in Human Peripheral Artery Restenosis.
P. Krishnan, K. Purushothaman, M. Purushothaman, U. Baber +7 more
2016American Journal of Cardiology8 citations
Semantic Scholar
Intravascular Ultrasound Is an Effective Tool for Predicting Histopathology-Confirmed Evidence of Adventitial Injury Following Directional Atherectomy for the Treatment of Peripheral Artery Disease
P. Krishnan, Arthur Tarricone, Z. Ali, K. Purushothaman +9 more
2016Journal of Endovascular Therapy8 citations
Semantic Scholar
831-1 Ruptured diabetic atherosclerotic plaques have more inflammation and neovascularization than ruptured plaques from patients without diabetes
K. Purushothaman, W. O'Connor, D. Echeverri, C. Amadi +3 more
20043 citations Open access
Semantic Scholar
Increased incidence of internal elastic lamina rupture and intimal medial changes in complex atherosclerotic lesions: understanding the remodeling paradox and plaque disruption
P. Moreno, K. Purushothaman, V. Fuster, W. O'Connor
20023 citations Open access
Semantic Scholar
Disrupted Atherosclerosis in the Aorta : Implications for Plaque Vulnerability Intimomedial Interface Damage and Adventitial Inflammation Is Increased Beneath
P. Moreno, K. Purushothaman, V. Fuster, W. O'Connor
20023 citations
Semantic Scholar
Abstract 18618: Endothelial to Mesenchymal Transition Contributes to Atherosclerotic Plaque Formation and Correlates With Plaque Instability
L. Lecce, S. Evrard, K. Michelis, A. Nomura-Kitabayashi +17 more
20162 citations
Semantic Scholar
831-6 Atherosclerotic plaque inflammation is associated with increased intima-medial neovascularization
K. Purushothaman, D. Echeverri, W. O'Connor, C. Amadi +3 more
20042 citations Open access
Semantic Scholar
ENHANCED LYSYL OXIDASE EXPRESSION IN PERIPHERAL ARTERY RESTENOSIS IS ASSOCIATED WITH ALTERED COLLAGENS: IMPLICATIONS IN RESTENOTIC PLAQUE PROGRESSION AND THERAPEUTIC INTERVENTION
P. Krishnan, P. Moreno, M. Purushothaman, M. Zafar +7 more
20181 citations Open access
Semantic Scholar
Abstract P014: Association Between Serum Resistin Levels and Coronary Artery Disease: A Meta-analysis
P. Agasthi, Sivakanth Aloor, V. Yarlagadda, Avantika Chenna +2 more
20161 citations
Semantic Scholar
Neovascularization and Intra-plaque Hemorrhage: Role of Haptoglobin, Macrophages, and Heme-Oxygenase-1 Pathway
K. Purushothaman, M. Purushothaman, A. Levy, Samin K. Sharma +2 more
20101 citations
Semantic Scholar
1082-186 Reduced inflammation and neovascularization and increased fibrous cap thickness in advanced aortic atherosclerotic plaques from cigarette smokers
K. Purushothaman, D. Echeverri, W. O'Connor, J. Badimón +3 more
20041 citations Open access
Semantic Scholar
Human Diabetic Atherosclerotic Plaques are Associated with Increased Intra-Plaque Hemorrhage, Iron Deposition and Altered Heme Oxygenase-1 and Ferritin Protein Expression
K. Purushothaman, Meerarani, Purushothaman, P. Krishnan +5 more
20160 citations
Semantic Scholar
Abstract 14325: Smoking and Plaque Composition in Human Peripheral Arterial Disease: Implications for Disease Progression and Thrombogenicity
K. Purushothaman, P. Krishnan, M. Purushothaman, Baber Usman +7 more
20130 citations
Semantic Scholar
SYNERGISTIC IMPACT OF CHRONIC KIDNEY DISEASE AND DIABETES MELLITUS ON PERIPHERAL VASCULAR ATHEROSCLEROTIC PLAQUE NEOVASCULARIZATION AND INFLAMMATION
U. Baber, K. Purushothaman, P. Krishnan, M. Purushothaman +6 more
20120 citations Open access
Semantic Scholar
Macrophage hemoglobin scavenger receptor CD163 is functionally linked to heme oxygenase‐1 and ferritin expression in human diabetic atherosclerotic plaques
M. Purushothaman, K. Purushothaman, A. Levy, Patrick A. Lento +4 more
20100 citations
Semantic Scholar
SIGNIFICANT DOWN-REGULATION OF THE ANTI-INFLAMMATORY CYTOKINE INTERLEUKIN-10 IS GENOTYPE DEPENDENT IN ATHEROSCLEROTIC PLAQUES WITH INTRA-PLAQUE HEMORRHAGE
P. Moreno, K. Purushothaman, M. Purushothaman, P. Krishnan +6 more
20100 citations Open access
Semantic Scholar
Detection des neovaisseaux en IRM facilitee par le gadofluorine determinant les plaques vulnerables
M. Sirol, K. Purushothaman, P. Moreno, P. Soyer +2 more
20090 citations
Semantic Scholar
Abstract 2309: Intra-Valve Hemorrhage is Associated with Increased Inflammation, Neovascularization and Calcification in Patients with Severe Aortic Stenosis
P. Moreno, Luis Astudillo, E. Zias, K. Purushothaman +5 more
20080 citations
Semantic Scholar
Abstract 297: Haptoglobin Genotype is a Determinant of Oxidation and Inflammation in the Atherosclerotic Plaque
A. Levy, Joanne E. Levy, Shiri Kalet-Litman, N. Levy +5 more
20060 citations
Semantic Scholar
The Shape and Size of the Murine Hp 2 Allele Protein Product Is Similar to the Human Hp 2 Allele Protein Product
A. Levy, Joanne E. Levy, Shiri Kalet-Litman, R. Miller‐Lotan +7 more
20060 citations
Semantic Scholar

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