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I. Hargreaves · SciRah

Researcher profile · Semantic Scholar

I. Hargreaves

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I. Hargreaves — researcher profile on SciRah

h-index: 54
Works: 193
Citations: 11K

Most-cited papers

Disorders of Human Coenzyme Q10 Metabolism: An Overview
I. Hargreaves, R. Heaton, D. Mantle
2020International Journal of Molecular Sciences165 citations Open access
Semantic Scholar
Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders
K. Stępień, R. Heaton, S. Rankin, A. Murphy +3 more
2017Journal of Clinical Medicine143 citations Open access
Semantic Scholar
Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis
Mona Sadeghian, Vincenzo Mastrolia, Ali Rezaei Haddad, A. Mosley +7 more
2016Scientific Reports138 citations Open access
Semantic Scholar
'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'
R. Abeti, Michael H. Parkinson, I. Hargreaves, Plamena R. Angelova +4 more
2016Cell Death and Disease121 citations Open access
Semantic Scholar
Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)
I. Cirilli, E. Damiani, P. Dludla, I. Hargreaves +5 more
2021Antioxidants104 citations Open access
Semantic Scholar
Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review
K. Stępień, F. Roncaroli, Nadia Turton, C. Hendriksz +3 more
2020Journal of Clinical Medicine102 citations Open access
Semantic Scholar
Clinical, pathological and functional characterization of riboflavin-responsive neuropathy
A. Manole, Z. Jaunmuktane, I. Hargreaves, M. H. Ludtmann +23 more
2017Brain : a journal of neurology81 citations Open access
Semantic Scholar
Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson’s Disease
Mesfer Al Shahrani, S. Heales, I. Hargreaves, M. Orford
2017Journal of Clinical Medicine77 citations Open access
Semantic Scholar
Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders.
D. Yubero, R. Montero, M. Martín, J. Montoya +50 more
2016Mitochondrion (Amsterdam. Print)73 citations Open access
Semantic Scholar
Coenzyme Q10 and Immune Function: An Overview
D. Mantle, R. Heaton, I. Hargreaves
2021Antioxidants71 citations Open access
Semantic Scholar
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s
C. Toomey, W. Heywood, James R. Evans, Joanne Lachica +16 more
2022Acta Neuropathologica Communications68 citations Open access
Semantic Scholar
Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models
A. Dyson, F. Dal-Pizzol, G. Sabbatini, A. Lach +10 more
2017PLoS Medicine61 citations Open access
Semantic Scholar
Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients
L. Schottlaender, C. Bettencourt, A. Kiely, A. Chalasani +4 more
2016PLoS ONE61 citations Open access
Semantic Scholar
Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: Effect of coenzyme Q10 supplementation on these parameters.
N. Cornelius, Jonathan H. Wardman, I. Hargreaves, V. Neergheen +4 more
2017Mitochondrion (Amsterdam. Print)60 citations Open access
Semantic Scholar
Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation
D. Mantle, I. Hargreaves
2022International Journal of Molecular Sciences59 citations Open access
Semantic Scholar
Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson’s disease
S. Foti, I. Hargreaves, Stephanie Carrington, A. Kiely +2 more
2019Scientific Reports57 citations Open access
Semantic Scholar
SPECIAL COLLECTION : TRANSLATIONAL IMPACT OF RAT Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats
J. Tarry-Adkins, Denise S. Fernandez-Twinn, Jian-Hua Chen, I. Hargreaves +3 more
201654 citations
Semantic Scholar
Primary Coenzyme Q10 Deficiency: An Update
D. Mantle, L. Millichap, J. Castro-Marrero, I. Hargreaves
2023Antioxidants53 citations Open access
Semantic Scholar
Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview
D. Mantle, I. Hargreaves
2019Antioxidants51 citations Open access
Semantic Scholar
Pontocerebellar hypoplasia type 2D and optic nerve atrophy further expand the spectrum associated with selenoprotein biosynthesis deficiency.
E. Pavlidou, V. Salpietro, R. Phadke, I. Hargreaves +10 more
2016European journal of paediatric neurology51 citations
Semantic Scholar
Coenzyme Q10 Metabolism: A Review of Unresolved Issues
D. Mantle, G. López-Lluch, I. Hargreaves
2023International Journal of Molecular Sciences49 citations Open access
Semantic Scholar
Drug-Induced Mitochondrial Toxicity
I. Hargreaves, Mesfer Al Shahrani, Luke H. Wainwright, S. Heales
2016Drug Safety49 citations
Semantic Scholar
Incidence of primary mitochondrial disease in children presenting with acute liver failure under 2 years of age
P. McKiernan, S. Ball, S. Santra, K. Foster +9 more
2016Journal of Pediatric Gastroenterology and Nutrition - JPGN45 citations Open access
Semantic Scholar
Targetable Pathways for Alleviating Mitochondrial Dysfunction in Neurodegeneration of Metabolic and Non-Metabolic Diseases
L. Millichap, E. Damiani, Luca Tiano, I. Hargreaves
2021International Journal of Molecular Sciences43 citations Open access
Semantic Scholar
Coenzyme Q10, Ageing and the Nervous System: An Overview
D. Mantle, R. Heaton, I. Hargreaves
2021Antioxidants40 citations Open access
Semantic Scholar
Plasma coenzyme Q10 status is impaired in selected genetic conditions
R. Montero, D. Yubero, M. C. Salgado, M. González +14 more
2019Scientific Reports39 citations Open access
Semantic Scholar
Coenzyme Q10 in the Treatment of Mitochondrial Disease
V. Neergheen, A. Chalasani, Luke H. Wainwright, D. Yubero +3 more
201739 citations Open access
Semantic Scholar
Production of Mannosylerythritol Lipids (MELs) to be Used as Antimicrobial Agents Against S. aureus ATCC 6538
C. Ceresa, S. Hutton, Marta Lajarin-Cuesta, R. Heaton +3 more
2020Current Microbiology38 citations Open access
Semantic Scholar
The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification
R. Heaton, S. Heales, K. Rahman, D. Sexton +1 more
2020Journal of Clinical Medicine38 citations Open access
Semantic Scholar
A recurrent mitochondrial p.Trp22Arg NDUFB3 variant causes a distinctive facial appearance, short stature and a mild biochemical and clinical phenotype
C. Alston, Caoimhe Howard, M. Oláhová, S. Hardy +17 more
2016Journal of Medical Genetics38 citations Open access
Semantic Scholar
MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy
E. Bugiardini, A. Mitchell, I. D. Rosa, Hue-Tran Horning-Do +14 more
2019Human Molecular Genetics37 citations Open access
Semantic Scholar
Neuropathologic Characterization of Pontocerebellar Hypoplasia Type 6 Associated With Cardiomyopathy and Hydrops Fetalis and Severe Multisystem Respiratory Chain Deficiency due to Novel RARS2 Mutations
N. Lax, C. Alston, K. Schon, Soo‐Mi Park +11 more
2015Journal of Neuropathology and Experimental Neurology37 citations Open access
Semantic Scholar
Expanding the molecular and phenotypic spectrum of truncating MT-ATP6 mutations
E. Bugiardini, Emanuela Bottani, S. Marchet, O. Poole +16 more
2020Neurology: Genetics34 citations Open access
Semantic Scholar
Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex I deficiency
Syeda T. Ahmed, C. Alston, Sila Hopton, Lang-Ping He +7 more
2017Scientific Reports30 citations Open access
Semantic Scholar
Coenzyme Q10 Supplementation in Fibrosis and Aging.
I. Hargreaves, D. Mantle
2019Advances in Experimental Medicine and Biology28 citations
Semantic Scholar
Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction
R. Ghosh, A. Wood‐Kaczmar, L. Dobson, Edward J. Smith +12 more
2020The FASEB Journal27 citations Open access
Semantic Scholar
The Effect of Organophosphate Exposure on Neuronal Cell Coenzyme Q10 Status
Nadia Turton, R. Heaton, Fahima Ismail, S. Roberts +3 more
2020Neurochemical Research24 citations Open access
Semantic Scholar
Blood Mononuclear Cell Mitochondrial Respiratory Chain Complex IV Activity is Decreased in Multiple Sclerosis Patients: Effects of β-Interferon Treatment
I. Hargreaves, N. Mody, J. Land, S. Heales
2018Journal of Clinical Medicine24 citations Open access
Semantic Scholar
Clinicopathologic and molecular spectrum of RNASEH1-related mitochondrial disease
E. Bugiardini, O. Poole, A. Manole, A. Pittman +21 more
2017Neurology: Genetics24 citations Open access
Semantic Scholar
Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype
Neringa Jurkute, Francesca Cancellieri, Lisa Pohl, Catherina H. Z. Li +80 more
2022npj Genomic Medicine23 citations Open access
Semantic Scholar
Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance
Antonia Hufnagel, Denise S. Fernandez-Twinn, H. Blackmore, Thomas J. Ashmore +6 more
2021Journal of Physiology22 citations Open access
Semantic Scholar
The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q10 Status and Mitochondrial Function
Emma C Proctor, Nadia Turton, Elle Jo Boan, E. Bennett +3 more
2020International Journal of Molecular Sciences22 citations Open access
Semantic Scholar
Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
P. Lear, David Gonzalez-Touceda, Begoña Porteiro Couto, Patricia Viaño +11 more
2015Endocrinology21 citations Open access
Semantic Scholar
Biosynthesis, Deficiency, and Supplementation of Coenzyme Q
Carmine Staiano, L. García-Corzo, D. Mantle, Nadia Turton +3 more
2023Antioxidants20 citations Open access
Semantic Scholar
Assessment of Mitochondrial Dysfunction in Experimental Autoimmune Encephalomyelitis (EAE) Models of Multiple Sclerosis
Xiuling Ng, Mona Sadeghian, S. Heales, I. Hargreaves
2019International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis.
J. Morel, I. Hargreaves, D. Brealey, V. Neergheen +6 more
2017Clinical science19 citations
Semantic Scholar
Secondary Mitochondrial Dysfunction as a Cause of Neurodegenerative Dysfunction in Lysosomal Storage Diseases and an Overview of Potential Therapies
K. Stępień, Neve Cufflin, A. Donald, Simon Jones +2 more
2022International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
The Biochemical Assessment of Mitochondrial Respiratory Chain Disorders
Nadia Turton, Neve Cufflin, Mollie Dewsbury, Olivia M. Fitzpatrick +10 more
2022International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring
L. Mennitti, Asha A. M. Carpenter, E. Loche, L. Pantaleão +8 more
2021International Journal of Obesity17 citations Open access
Semantic Scholar
Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma
Kathleen Keatley, Samuel Stromei-Cleroux, T. Wiltshire, Nina K. M. Rajala +12 more
2019International Journal of Molecular Sciences17 citations Open access
Semantic Scholar

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