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T. Edgington · SciRah

Researcher profile · Semantic Scholar

T. Edgington

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T. Edgington — researcher profile on SciRah

h-index: 80
Works: 365
Citations: 24K

Most-cited papers

Role of tissue factor in embryonic blood vessel development
P. Carmeliet, N. Mackman, L. Moons, T. Luther +10 more
1996Nature750 citations
Semantic Scholar
A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas
R. Lin, Shingo Maeda, Cheng Liu, M. Karin +1 more
2007Oncogene555 citations Open access
Semantic Scholar
Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature
Xianming Huang, G. Molema, S. King, L. Watkins +2 more
1997Science502 citations
Semantic Scholar
Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells
Jin Yao, N. Mackman, T. Edgington, S. Fan
1997Journal of Biological Chemistry474 citations Open access
Semantic Scholar
Defense.
T. Edgington
1994The FASEB Journal474 citations
Semantic Scholar
Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.
Marcel Levi, H. ten Cate, K. Bauer, T. van der Poll +6 more
1994Journal of Clinical Investigation467 citations Open access
Semantic Scholar
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.
Cheng Liu, Cheng-Zao Sun, Haining Huang, K. Janda +1 more
2003Cancer Research332 citations
Semantic Scholar
Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.
M. Shoji, W. Hancock, K. Abe, C. Micko +13 more
1998American Journal of Pathology293 citations
Semantic Scholar
A recombinant human enzyme for enhanced interstitial transport of therapeutics.
L. H. Bookbinder, A. Hofer, M. Haller, M. Zepeda +6 more
2006Journal of Controlled Release291 citations
Semantic Scholar
Structural biology of tissue factor, the initiator of thrombogenesis in vivo 1
W. Ruf, T. Edgington
1994The FASEB Journal249 citations
Semantic Scholar
The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor.
H. ten Cate, Kenneth A. Bauer, Marcel Levi, T. Edgington +4 more
1993Journal of Clinical Investigation228 citations Open access
Semantic Scholar
Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
J. Yao, N. Mackman, T. Edgington, S. Fan
1997Journal of Biological Chemistry209 citations
Semantic Scholar
Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis.
Michael Eddleston, J. C. de la Torre, M. Oldstone, D. Loskutoff +2 more
1993Journal of Clinical Investigation171 citations Open access
Semantic Scholar
Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes.
S. Fan, T. Edgington
1993Journal of Immunology164 citations Open access
Semantic Scholar
Insights in Vessel Development and Vascular Disorders Using Targeted Inactivation and Transfer of Vascular Endothelial Growth Factor, the Tissue Factor Receptor, and the Plasminogen System
P. Carmeliet, L. Moons, M. Dewerchin, N. Mackman +10 more
1997Annals of the New York Academy of Sciences138 citations
Semantic Scholar
Tissue factor is expressed on monocytes during simulated extracorporeal circulation.
J. Kappelmayer, A. Bernabei, L. Edmunds, T. Edgington +1 more
1993Circulation Research120 citations Open access
Semantic Scholar
The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex.
Mingdong Huang, R. Syed, Enrico A. Stura, Martin J. Stone +4 more
1998Journal of Molecular Biology119 citations
Semantic Scholar
Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.
Wen-Yuan Wu, Yun-Ping Luo, Cheng-Zao Sun, Yuan Liu +7 more
2006Cancer Research118 citations Open access
Semantic Scholar
Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression
Yingchun Wang, J. Kelber, H. T. Tran Cao, Greg T. Cantin +9 more
2010Proceedings of the National Academy of Sciences of the United States of America115 citations Open access
Semantic Scholar
High molecular weight kininogen binds to Mac-1 on neutrophils by its heavy chain (domain 3) and its light chain (domain 5).
Y. Wachtfogel, R. D. de la Cadena, S. Kunapuli, L. Rick +5 more
1994Journal of Biological Chemistry102 citations
Semantic Scholar
Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis.
Ying-Ying Lin, Yongming Qiu, Cheng Xu, Qiao-Ling Liu +12 more
2014Journal of the National Cancer Institute101 citations
Semantic Scholar
Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits.
Christopher M. Speidel, P. Eisenberg, W. Ruf, T. Edgington +1 more
1995Circulation100 citations
Semantic Scholar
Control of RNA Processing by A Large Noncoding RNA Over-expressed in Carcinomas
R. Lin, Manami Roychowdhury-Saha, Chris Black, Andrew T. Watt +3 more
2011FEBS Letters90 citations Open access
Semantic Scholar
Prostate-specific membrane antigen directed selective thrombotic infarction of tumors.
Cheng Liu, Haining Huang, F. Doñate, C. Dickinson +4 more
2002Cancer Research89 citations
Semantic Scholar
Effector Cell Protease Receptor-1 Is a Vascular Receptor for Coagulation Factor Xa*
A. C. Nicholson, R. Nachman, D. Altieri, B. Summers +3 more
1996Journal of Biological Chemistry86 citations Open access
Semantic Scholar
Recombinant soluble human tissue factor secreted by Saccharomyces cerevisiae and refolded from Escherichia coli inclusion bodies: glycosylation of mutants, activity and physical characterization.
Martin J. Stone, W. Ruf, D. J. Miles, T. Edgington +1 more
1995Biochemical Journal86 citations Open access
Semantic Scholar
Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain.
W. Ruf, J. Schullek, M. J. Stone, T. Edgington
1994Biochemistry79 citations
Semantic Scholar
Integrin regulation of an inflammatory effector gene. Direct induction of the tissue factor promoter by engagement of beta 1 or alpha 4 integrin chains.
S. Fan, N. Mackman, Mei-Zhen Cui, T. Edgington
1995Journal of Immunology78 citations
Semantic Scholar
Regulation of Tissue Factor—Mediated Initiation of the Coagulation Cascade by Cell Surface Grp78
G. Bhattacharjee, Jasimuddin Ahamed, B. Pedersen, Amr El-Sheikh +4 more
2005Arteriosclerosis, Thrombosis and Vascular Biology74 citations Open access
Semantic Scholar
In vivo interrogation of the molecular display of atherosclerotic lesion surfaces.
Cheng Liu, G. Bhattacharjee, W. Boisvert, R. B. Dilley +1 more
2003American Journal of Pathology70 citations Open access
Semantic Scholar
The Structural Basis of Function of the TF●VIIa Complex in the Cellular Initiation of Coagulation
T. Edgington, C. Dickinson, W. Ruf
1997Thrombosis and Haemostasis64 citations
Semantic Scholar
Correction for Seki et al., TIF1β regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner
Yingchun Wang, J. Kelber, H. T. Tran Cao, Greg T. Cantin +9 more
2010Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
Semantic Scholar
Upregulation of human immunodeficiency virus-1 in chronically infected monocytic cell line by both contact with endothelial cells and cytokines.
S. Fan, K. Hsia, T. Edgington
1994Blood46 citations Open access
Semantic Scholar
Key ligand interface residues in tissue factor contribute independently to factor VIIa binding.
J. Schullek, W. Ruf, T. Edgington
1994Journal of Biological Chemistry45 citations
Semantic Scholar
Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain.
W. Ruf, Justin Shobe, M. Rao, Craig D. Dickinson +2 more
1999Biochemistry43 citations
Semantic Scholar
Regulation of tissue factor gene expression in epithelial cells. Induction by serum and phorbol 12-myristate 13-acetate.
Mei-Zhen Cui, G. Parry, T. Edgington, N. Mackman
1994Arteriosclerosis and Thrombosis A Journal of Vascular Biology43 citations Open access
Semantic Scholar
Macromolecular Substrate Affinity for the Tissue Factor-Factor VIIa Complex Is Independent of Scissile Bond Docking*
Justin Shobe, C. Dickinson, T. Edgington, W. Ruf
1999Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Energetic contributions and topographical organization of ligand binding residues of tissue factor.
W. Ruf, C. Kelly, John R. Schullek, David M. A. Martin +4 more
1995Biochemistry41 citations
Semantic Scholar
Microfilament reorganization is associated with functional activation of alpha M beta 2 on monocytic cells.
G. Elemer, T. Edgington
1994Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Monoclonal antibody to an activation neoepitope of alpha M beta 2 inhibits multiple alpha M beta 2 functions.
G. Elemer, T. Edgington
1994Journal of Immunology36 citations Open access
Semantic Scholar
Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism.
V. Ollivier, S. Houssaye, C. Ternisien, A. Leon +5 more
1993Blood36 citations Open access
Semantic Scholar
Factor Xa Binding to Annexin 2 Mediates Signal Transduction via Protease-Activated Receptor 1
G. Bhattacharjee, Jasimuddin Ahamed, R. Pawlinski, Cheng Liu +3 more
2008Circulation Research33 citations Open access
Semantic Scholar
Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism
V. Ollivier, S. Houssaye, C. Ternisien, A. Leon +5 more
199333 citations
Semantic Scholar
The serine protease cofactor factor V is synthesized by lymphocytes.
N.-L.-L. Shen, S. Fan, J. Pyati, R. Graff +2 more
1993Journal of Immunology33 citations
Semantic Scholar
Dimerization of tissue factor supports solution-phase autoactivation of factor VII without influencing proteolytic activation of factor X.
F. Doñate, C. Kelly, W. Ruf, T. Edgington
2000Biochemistry30 citations
Semantic Scholar
Dose-dependent modulation of tissue factor protein and procoagulant activity in human monocyte-derived macrophages by oxidized low density lipoprotein.
S. Meisel, Xiao-Ping Xu, T. Edgington, B. Cercek +3 more
2011Journal of atherosclerosis and thrombosis28 citations Open access
Semantic Scholar
Procoagulant activity on injured arteries and associated thrombi is mediated primarily by the complex of tissue factor and factor VIIa
Christopher M. Speidel, John Daryl Thornton, Yuan-Meng Yuan, P. Eisenberg +2 more
1996Coronary Artery Disease22 citations
Semantic Scholar
The Train Has Left the Station
T. Edgington
1994The FASEB Journal22 citations
Semantic Scholar
Differentiation of adherent human monocytes into macrophages markedly enhances tissue factor protein expression and procoagulant activity.
S. Meisel, Xiao-Ping Xu, T. Edgington, P. Dimayuga +5 more
2002Atherosclerosis21 citations
Semantic Scholar
A novel vascular endothelial growth factor heparin-binding domain substructure binds to glycosaminoglycans in vivo and localizes to tumor microvascular endothelium.
Amr El-Sheikh, Cheng Liu, Haining Huang, T. Edgington
2002Cancer Research20 citations
Semantic Scholar

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N. Mackman×10
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N. Mackman — researcher profile on SciRah
W. Ruf×10
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Cheng Liu×8
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S. Fan×6
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W. Ruf — researcher profile on SciRah

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R. Lin — researcher profile on SciRah

Haining Huang×3

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C. Dickinson×3

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C. Dickinson — researcher profile on SciRah

Amr El-Sheikh×3

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Amr El-Sheikh — researcher profile on SciRah

G. Bhattacharjee×3

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G. Bhattacharjee — researcher profile on SciRah

P. Carmeliet×2

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P. Carmeliet — researcher profile on SciRah

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L. Moons — researcher profile on SciRah