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Joshua T. Dearborn · SciRah

Researcher profile · Semantic Scholar

Joshua T. Dearborn

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Joshua T. Dearborn — researcher profile on SciRah

h-index: 16
Works: 43
Citations: 1,339

Most-cited papers

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.
E. Musiek, M. Lim, Guangrui Yang, Adam Q. Bauer +14 more
2013Journal of Clinical Investigation477 citations Open access
Semantic Scholar
Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis
F. Liao, Y. Hori, E. Hudry, Adam Q. Bauer +11 more
2014Journal of Neuroscience134 citations Open access
Semantic Scholar
Core features of frontotemporal dementia recapitulated in progranulin knockout mice
N. Ghoshal, Joshua T. Dearborn, D. F. Wozniak, N. Cairns
2011Neurobiology of Disease124 citations Open access
Semantic Scholar
Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target
Yedda Li, Yue Xu, B. Benitez, Murtaza S. Nagree +15 more
2019Proceedings of the National Academy of Sciences of the United States of America86 citations Open access
Semantic Scholar
Synergistic effects of treating the spinal cord and brain in CLN1 disease
Charles Shyng, H. Nelvagal, Joshua T. Dearborn, J. Tyynelä +3 more
2017Proceedings of the National Academy of Sciences of the United States of America65 citations Open access
Semantic Scholar
An Anti-Neuroinflammatory That Targets Dysregulated Glia Enhances the Efficacy of CNS-Directed Gene Therapy in Murine Infantile Neuronal Ceroid Lipofuscinosis
S. Macauley, Andrew M. S. Wong, Charles Shyng, David P Augner +7 more
2014Journal of Neuroscience64 citations Open access
Semantic Scholar
A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation
Jia-Yang Chen, Mary E. Lambo, Xia Ge, Joshua T. Dearborn +12 more
2020bioRxiv56 citations Open access
Semantic Scholar
Expression of Nampt in Hippocampal and Cortical Excitatory Neurons Is Critical for Cognitive Function
L. R. Stein, D. F. Wozniak, Joshua T. Dearborn, S. Kubota +4 more
2014Journal of Neuroscience55 citations Open access
Semantic Scholar
Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers
Joshua T. Dearborn, S. Harmon, S. C. Fowler, K. O'Malley +3 more
2015Scientific Reports30 citations Open access
Semantic Scholar
Motivational Disturbances and Effects of L-dopa Administration in Neurofibromatosis-1 Model Mice
D. F. Wozniak, Kelly A. Diggs-Andrews, Sara B. Conyers, C. Yuede +6 more
2013PLoS ONE29 citations Open access
Semantic Scholar
Spinal manifestations of CLN1 disease start during the early postnatal period
H. Nelvagal, Joshua T. Dearborn, J. Ostergaard, M. Sands +1 more
2020Neuropathology and Applied Neurobiology27 citations Open access
Semantic Scholar
Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures
Joshua T. Dearborn, H. Nelvagal, N. Rensing, Keigo Takahashi +5 more
2022Scientific Reports25 citations Open access
Semantic Scholar
Loss of RBPj in Postnatal Excitatory Neurons Does Not Cause Neurodegeneration or Memory Impairments in Aged Mice
C. Sato, Mustafa Turkoz, Joshua T. Dearborn, D. F. Wozniak +2 more
2012PLoS ONE25 citations Open access
Semantic Scholar
Hormones in the mentally disturbed brain: steroids and peptides in the development and treatment of psychopathology.
G. Taylor, S. Maloney, Joshua T. Dearborn, Juergen Weiss
2009Central Nervous System Agents in Medicinal Chemistry25 citations
Semantic Scholar
Bone Marrow Transplantation Alters the Tremor Phenotype in the Murine Model of Globoid-Cell Leukodystrophy
Adarsh Reddy, D. F. Wozniak, N. B. Farber, Joshua T. Dearborn +2 more
2012Journal of Clinical Medicine22 citations Open access
Semantic Scholar
Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse model
Keigo Takahashi, Elizabeth M. Eultgen, Sophie H. Wang, N. Rensing +7 more
2023Journal of Clinical Investigation16 citations Open access
Semantic Scholar
Cell-autonomous expression of the acid hydrolase galactocerebrosidase
Christina R. Mikulka, Joshua T. Dearborn, B. Benitez, Amy Strickland +3 more
2020Proceedings of the National Academy of Sciences of the United States of America15 citations Open access
Semantic Scholar
Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep
H. Nelvagal, S. Eaton, Sophie H. Wang, Elizabeth M. Eultgen +26 more
2022Journal of Clinical Investigation13 citations Open access
Semantic Scholar
Histochemical Localization of Palmitoyl Protein Thioesterase-1 Activity
Joshua T. Dearborn, S. Ramachandran, Charles Shyng, Jui-Yun Lu +3 more
2015Molecular Genetics and Metabolism12 citations Open access
Semantic Scholar
Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice
D. F. Wozniak, Pamela Valnegri, Joshua T. Dearborn, S. C. Fowler +1 more
2019Scientific Reports11 citations Open access
Semantic Scholar
Impact of hepatitis C coinfection on cognitive outcomes in HIV-infected individuals
R. Paul, S. Letendre, Joshua T. Dearborn
200710 citations
Semantic Scholar
Widespread Expression of a Membrane-Tethered Version of the Soluble Lysosomal Enzyme Palmitoyl Protein Thioesterase-1.
Charles Shyng, S. Macauley, Joshua T. Dearborn, M. Sands
2017JIMD Reports6 citations Open access
Semantic Scholar
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
E. Musiek, Miranda M. Lim, Guangrui Yang, Adam Q. Bauer +14 more
20163 citations
Semantic Scholar
Adrenal Steroids Uniquely Influence Sexual Motivation Behavior in Male Rats
G. Taylor, Joshua T. Dearborn, S. Maloney
2012Behavioral Science3 citations Open access
Semantic Scholar
Recombinant NAGLU-IGF2 prevents physical and neurological disease and improves survival in Sanfilippo B syndrome
S. Le, Shih-Hsin Kan, Marie S. Roberts, Joshua T. Dearborn +16 more
2021bioRxiv2 citations Open access
Semantic Scholar
Progressive neuropathology in the spinal cord of a mouse model of CLN1 disease and assessing the efficacy of intrathecal enzyme replacement therapy (ERT)
J. Cooper, J. Dmytrus, Sarmi Sri, Joshua T. Dearborn +5 more
20162 citations
Semantic Scholar
Cortical interneuron loss and seizure generation as novel clinically relevant disease phenotypes in Cln2R207X mice
Keigo Takahashi, Elizabeth M. Eultgen, Sophie H. Wang, N. Rensing +5 more
2022bioRxiv1 citations Open access
Semantic Scholar
Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors
S. Sankar, Ethan S. Patterson, E. Lewis, Laura E. Waller +5 more
2017Genes & cancer1 citations Open access
Semantic Scholar
Adjunctive Therapy for Long-Term Support of Cognitive Impairment
Joshua T. Dearborn, S. Maloney, N. Hicklin, Elizabeth M. Lane +1 more
20091 citations
Semantic Scholar
Chronic oral cannabidiol delays seizure onset and reduces seizure burden in a mouse model of CLN2 disease
Joshua T. Dearborn, Keigo Takahashi, N. Rensing, Michael Wong +2 more
2026PLoS ONE0 citations Open access
Semantic Scholar
Intrastriatal injection of amplified Lewy body dementia (LBD) fibrils in mice results in accumulation of fibrils with LBD structure and neurodegeneration
Aditi V. Bagade, Rebecca L. Miller, Joshua T. Dearborn, Katherine Basore +7 more
2026bioRxiv0 citations Open access
Semantic Scholar
Leveraging Preclinical Models to Understand Human Neurobiology and Behavior.
Joshua T. Dearborn, D. Selmanovic, S. Chaturvedi, S. Sarafinovska +1 more
2026Current topics in behavioral neurosciences0 citations
Semantic Scholar
In vivo optical clearing of the mouse brain
Maiko Kume, Ning-Dong Kang, Alejandro Akrouh, Dae Woo Kim +4 more
2026bioRxiv0 citations Open access
Semantic Scholar
Chronic oral cannabidiol delays or prevents seizures in a mouse model of CLN2 disease
Joshua T. Dearborn, Keigo Takahashi, N. Rensing, Michael Wong +2 more
2025bioRxiv0 citations Open access
Semantic Scholar
Limited therapeutic efficacy of N-acetyl-L-leucine in a mouse model of CLN1 disease
Ewa A. Ziółkowska, Nicole A. Pagán Torres, Hsintsung Chen, Letitia L. Williams +7 more
2025Scientific Reports0 citations Open access
Semantic Scholar
A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation
Jiayang Chen, Mary E. Lambo, Xia Ge, Joshua T. Dearborn +12 more
2024Neuron0 citations Open access
Semantic Scholar
Spontaneous seizures associated with cortical interneuron loss in mice are ameliorated via gene therapy
Keigo Takahashi, Elizabeth M. Eultgen, Sophie H. Wang, N. Rensing +7 more
2023Molecular Genetics and Metabolism0 citations
Semantic Scholar
Efficacy of recombinant human PPT1 enzyme replacement therapy in mouse and sheep models of CLN1 disease
H. Nelvagal, S. Eaton, Sophie H. Wang, Elizabeth M. Eultgen +13 more
2022Molecular Genetics and Metabolism0 citations
Semantic Scholar
In Utero Gene Therapy Treatment of Neuronal Ceroid Lipofuscinosis Type 1 Disease Improves Lifespan and Neurologic Function
Matthew T. Grant, Joshua T. Dearborn, M. Sands, Jesse D. Vrecenak
2021Journal of the American College of Surgeons0 citations
Semantic Scholar
27. Therapeutic Efficacy of Intracranial and Intrathecal AAV2/9-PPT1 in Infantile Batten Disease
Charles Shyng, H. Nelvagal, Joshua T. Dearborn, J. Cooper +1 more
2016Molecular Therapy0 citations Open access
Semantic Scholar
Novel Behavioral Markers in the Ppt1-/- Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis
Joshua T. Dearborn
20130 citations
Semantic Scholar
P1‐153: Core features of human frontotemporal dementia recapitulated in progranulin knockout mice
N. Ghoshal, Joshua T. Dearborn, D. F. Wozniak, N. Cairns
20100 citations
Semantic Scholar
Circadian clock proteins regulate neuronal redox homeostasis Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration and neurodegeneration
E. Musiek, Miranda M. Lim, Guangrui Yang, Adam Q. Bauer +15 more
0 citations
Semantic Scholar

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M. Sands×18
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M. Sands — researcher profile on SciRah
D. F. Wozniak×12
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D. F. Wozniak — researcher profile on SciRah
H. Nelvagal×12
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H. Nelvagal — researcher profile on SciRah
J. Cooper×12
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J. Cooper — researcher profile on SciRah

Keigo Takahashi

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Keigo Takahashi — researcher profile on SciRah

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S. Maloney — researcher profile on SciRah

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N. Rensing — researcher profile on SciRah

Elizabeth M. Eultgen×6

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Elizabeth M. Eultgen — researcher profile on SciRah

S. C. Fowler×5

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S. C. Fowler — researcher profile on SciRah

Charles Shyng×5

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Charles Shyng — researcher profile on SciRah

Sophie H. Wang×5

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Sophie H. Wang — researcher profile on SciRah

Adam Q. Bauer×4

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Adam Q. Bauer — researcher profile on SciRah