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T. Uematsu · SciRah

Researcher profile · Semantic Scholar

T. Uematsu

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T. Uematsu — researcher profile on SciRah

h-index: 31
Works: 181
Citations: 2,803

Most-cited papers

Single- and multiple-dose pharmacokinetics of AM-1155, a new 6-fluoro-8-methoxy quinolone, in humans
M. Nakashima, T. Uematsu, K. Kosuge, H. Kusajima +4 more
1995Antimicrobial Agents and Chemotherapy169 citations Open access
Semantic Scholar
Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia.
A. Hara, T. Iwai, M. Niwa, T. Uematsu +3 more
1996Brain Research107 citations
Semantic Scholar
Pilot study of the uricosuric effect of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects
M. Nakashima, T. Uematsu, K. Kosuge, M. Kanamaru
2004European Journal of Clinical Pharmacology94 citations
Semantic Scholar
Interleukin-6 synthesis induced by prostaglandin E2: cross-talk regulation by protein kinase C.
O. Kozawa, A. Suzuki, H. Tokuda, T. Kaida +1 more
1998Bone76 citations
Semantic Scholar
Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein‐4‐stimulated osteocalcin synthesis in osteoblasts
O. Kozawa, D. Hatakeyama, T. Uematsu
2002Journal of Cellular Biochemistry64 citations
Semantic Scholar
Basic Fibroblast Growth Factor Stimulates Vascular Endothelial Growth Factor Release in Osteoblasts: Divergent Regulation by p42/p44 Mitogen‐Activated Protein Kinase and p38 Mitogen‐Activated Protein Kinase
H. Tokuda, O. Kozawa, T. Uematsu
2000Journal of Bone and Mineral Research63 citations Open access
Semantic Scholar
Dihydropyrimidine Dehydrogenase Activity in 150 Healthy Japanese Volunteers and Identification of Novel Mutations
K. Ogura, Tomokazu Ohnuma, Y. Minamide, A. Mizuno +6 more
2005Clinical Cancer Research60 citations Open access
Semantic Scholar
1,25-dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase.
Takuji Yamamoto, O. Kozawa, Kumiko Tanabe, Shigeru Akamatsu +4 more
2002Archives of Biochemistry and Biophysics59 citations
Semantic Scholar
The pharmacokinetics of the β2-adrenoceptor agonist, tulobuterol, given transdermally and by inhalation
T. Uematsu, M. Nakano, K. Kosuge, M. Kanamaru +1 more
2004European Journal of Clinical Pharmacology55 citations
Semantic Scholar
Involvement of p38 mitogen‐activated protein kinase in basic fibroblast growth factor‐induced interleukin‐6 synthesis in osteoblasts
O. Kozawa, H. Tokuda, H. Matsuno, T. Uematsu
1999Journal of Cellular Biochemistry50 citations
Semantic Scholar
Tumor Necrosis Factor-α Autoregulates Interleukin-6 Synthesis via Activation of Protein Kinase C
O. Kozawa, A. Suzuki, T. Kaida, H. Tokuda +1 more
1997Journal of Biological Chemistry50 citations Open access
Semantic Scholar
Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.
Toshikazu Yamaguchi, T. Hashizume, M. Matsuda, M. Sakashita +4 more
1994Arzneimittel-Forschung46 citations
Semantic Scholar
Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases.
D. Hatakeyama, O. Kozawa, M. Niwa, H. Matsuno +5 more
2002Biochimica et Biophysica Acta45 citations Open access
Semantic Scholar
HSP20, low-molecular-weight heat shock-related protein, acts extracellularly as a regulator of platelet functions: a novel defense mechanism.
O. Kozawa, H. Matsuno, M. Niwa, D. Hatakeyama +3 more
2002Life Science43 citations
Semantic Scholar
Caspase activation as an apoptotic evidence in the gerbil hippocampal CA1 pyramidal cells following transient forebrain ischemia.
M. Niwa, A. Hara, T. Iwai, Shao-Tan Wang +3 more
2001Neuroscience Letters43 citations
Semantic Scholar
Prostaglandin F2alpha stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells.
O. Kozawa, A. Suzuki, H. Tokuda, T. Uematsu
1997American Journal of Physiology42 citations
Semantic Scholar
Correlation of angiographic circulation time and cerebrovascular reserve by acetazolamide-challenged single photon emission CT.
Shiro Yamamoto, Manabu Watanabe, T. Uematsu, Ken-ichiro Takasawa +2 more
2004AJNR. American journal of neuroradiology40 citations
Semantic Scholar
Tumor necrosis factor-α-mediated signal transduction in human neutrophils: Involvement of sphingomyelin metabolites in the priming effect of tnf-α on the fMLP-stimulated superoxide production
M. Niwa, O. Kozawa, H. Matsuno, Y. Kanamori +2 more
199939 citations
Semantic Scholar
The calcimimetic agent KRN 1493 lowers plasma parathyroid hormone and ionized calcium concentrations in patients with chronic renal failure on haemodialysis both on the day of haemodialysis and on the day without haemodialysis.
Naro Ohashi, T. Uematsu, S. Nagashima, M. Kanamaru +5 more
2004British Journal of Clinical Pharmacology38 citations Open access
Semantic Scholar
Effects of MS-551, a New Class III Antiarrhythmic Drug, on Programmed Stimulation-Induced Ventricular Arrhythmias, Electrophysiology, and Hemodynamics in a Canine Myocardial Infarction Model
Kazunao Kondoh, H. Hashimoto, Hiroshi Nishiyama, K. Umemura +3 more
1994Journal of Cardiovascular Pharmacology38 citations Open access
Semantic Scholar
Nuclear factor-κB activates dual inhibition sites in the regulation of tumor necrosis factor-α-induced neutrophil apoptosis
M. Niwa, A. Hara, Y. Kanamori, D. Hatakeyama +5 more
200037 citations
Semantic Scholar
Therapeutic Drug Monitoring in Hair Samples
T. Uematsu
199336 citations
Semantic Scholar
Protective Effect of Apoptosis-Inhibitory Agent, N-Tosyl-l-Phenylalanyl Chloromethyl Ketone against Ischemia-Induced Hippocampal Neuronal Damage
A. Hara, M. Niwa, Masaya Nakashima, T. Iwai +3 more
1998Journal of Cerebral Blood Flow and Metabolism34 citations Open access
Semantic Scholar
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
H. Kawamura, T. Otsuka, H. Matsuno, M. Niwa +4 more
1999American Journal of Physiology. Endocrinology and Metabolism33 citations Open access
Semantic Scholar
Plasmin Generation Plays different Roles in the Formation and Removal of Arterial and Venous Thrombus in Mice
H. Matsuno, O. Kozawa, K. Okada, S. Ueshima +2 more
2002Thrombosis and Haemostasis31 citations
Semantic Scholar
A Novel Recombinant Soluble Human Thrombomodulin, ART‐123, Activates the Protein C Pathway in Healthy Male Volunteers
M. Nakashima, T. Uematsu, K. Umemura, I. Maruyama +1 more
1998Journal of clinical pharmacology31 citations
Semantic Scholar
Neuronal degradation in mouse retina after a transient ischemia and protective effect of hypothermia
Xiao-dan Wang, M. Niwa, A. Hara, H. Matsuno +4 more
2002Neurological Research29 citations
Semantic Scholar
Prostaglandin D2induces interleukin-6 synthesis via Ca2+mobilization in osteoblasts: regulation by protein kinase C
H. Tokuda, O. Kozawa, A. Harada, T. Uematsu
199929 citations
Semantic Scholar
Relationship between magnitude of hypothermia during ischemia and preventive effect against post-ischemic DNA fragmentation in the gerbil hippocampus.
M. Niwa, A. Hara, T. Iwai, Masaya Nakashima +4 more
1998Brain Research28 citations
Semantic Scholar
Zinc suppresses IL‐6 synthesis by prostaglandin F2α in osteoblasts: Inhibition of phospholipase C and phospholipase D
D. Hatakeyama, O. Kozawa, T. Otsuka, T. Shibata +1 more
2002Journal of Cellular Biochemistry26 citations
Semantic Scholar
Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells.
Kouseki Hirade, O. Kozawa, Kumiko Tanabe, M. Niwa +7 more
2002American Journal of Physiology. Heart and Circulatory Physiology26 citations
Semantic Scholar
Mitogen-Activated Protein (MAP) Kinases Are Involved in Interleukin-1 (IL-1)-Induced IL-6 Synthesis in Osteoblasts: Modulation Not of p38 MAP Kinase, But of p42/p44 MAP Kinase by IL-1-Activated Protein Kinase C1.
M. Miwa, O. Kozawa, H. Tokuda, T. Uematsu
1999Endocrinology26 citations
Semantic Scholar
Basic fibroblast growth factor induces interleukin-6 synthesis in osteoblasts: autoregulation by protein kinase C.
O. Kozawa, A. Suzuki, T. Uematsu
1997Cellular Signalling25 citations
Semantic Scholar
Measurement of furancarboxylic acid, a candidate for uremic toxin, in human serum, hair, and sweat, and analysis of pharmacological actions in vitro
T. Sassa, H. Matsuno, M. Niwa, O. Kozawa +4 more
2000Archives of Toxicology24 citations
Semantic Scholar
Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts
O. Kozawa, M. Niwa, D. Hatakeyama, H. Tokuda +4 more
2002Journal of Cellular Biochemistry23 citations
Semantic Scholar
The Measurement of Caffeine Concentration in Scalp Hair as an Indicator of Liver Function
A. Mizuno, T. Uematsu, Seiichiro Gotoh, Eiichi Katoh +1 more
1996The Journal of pharmacy and pharmacology21 citations Open access
Semantic Scholar
Involvement of p42/p44 MAP kinase in endothelin-1-induced interleukin-6 synthesis in osteoblast-like cells.
H. Kawamura, T. Otsuka, H. Tokuda, H. Matsuno +4 more
1999Bone19 citations
Semantic Scholar
Pharmacokinetic and pharmacodynamic properties of a novel xanthine oxidase inhibitor, BOF-4272, in healthy volunteers.
T. Uematsu, M. Nakashima
1994Journal of Pharmacology and Experimental Therapeutics17 citations
Semantic Scholar
Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils.
M. Niwa, Koichi Hotta, Y. Kanamori, D. Hatakeyama +9 more
2003European Journal of Pharmacology16 citations
Semantic Scholar
Interleukin (IL)-17 enhances prostaglandin F(2 alpha)-stimulated IL-6 synthesis in osteoblasts.
H. Tokuda, O. Kozawa, T. Uematsu
2002Prostaglandins, Leukotrienes and Essential Fatty Acids16 citations
Semantic Scholar
Inhibitors of Fibrinolytic Components Play Different Roles in the Formation and Removal of Arterial Thrombus in Mice
H. Matsuno, O. Kozawa, K. Okada, S. Ueshima +2 more
2002Journal of Cardiovascular Pharmacology16 citations Open access
Semantic Scholar
The loss of recombinant human granulocyte colony-stimulating factor and recombinant human TNF-alpha priming effects on the superoxide-generating response in exudated neutrophils is associated with a decrease in their receptor affinities.
Masayuki Niwa, A. Yousif, K. Kohno, Y. Kanamori +3 more
1996Journal of Immunology16 citations Open access
Semantic Scholar
Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction.
H. Matsuno, O. Kozawa, N. Yoshimi, Shigeru Akamatsu +6 more
2002Blood15 citations
Semantic Scholar
Clinical outcome of smoking-cessation trial of nicotine chewing gum evaluated by analysis of nicotine in hair.
Atsuhiro Mizuno, T. Uematsu, Toshitsugu Ishikawa, Noboru Yoshimine +1 more
1997Therapeutic Drug Monitoring15 citations
Semantic Scholar
Involvement of phospholipase D activation in endothelin‐1‐induced release of arachidonic acid in osteoblast‐like cells
O. Kozawa, A. Suzuki, J. Shinoda, N. Ozaki +2 more
1997Journal of Cellular Biochemistry14 citations
Semantic Scholar
Hair analysis of flecainide for assessing the individual drug-taking behavior
Y. Takiguchi, R. Ishihara, Mayumi Torii, R. Kato +2 more
2002European Journal of Clinical Pharmacology13 citations
Semantic Scholar
Leukemia inhibitory factor enhances bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3.
O. Kozawa, T. Otsuka, T. Uematsu
2002Cellular Signalling13 citations
Semantic Scholar
Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production.
M. Niwa, O. Kozawa, H. Matsuno, Y. Kanamori +2 more
2000Life Science13 citations
Semantic Scholar
Protein kinase C activation by interleukin (IL)‐1 limits IL‐1‐induced IL‐6 synthesis in osteoblast‐like cells: Involvement of phosphatidylcholine‐specific phospholipase C
O. Kozawa, A. Suzuki, H. Tokuda, T. Kaida +1 more
1997Journal of Cellular Biochemistry13 citations
Semantic Scholar
Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide.
O. Kozawa, D. Hatakeyama, H. Tokuda, Y. Oiso +2 more
2002Cellular Signalling12 citations
Semantic Scholar

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H. Matsuno×18
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M. Niwa×16
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H. Tokuda×12
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D. Hatakeyama×8

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