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Sakae Ikeda · SciRah

Researcher profile · Semantic Scholar

Sakae Ikeda

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Sakae Ikeda — researcher profile on SciRah

h-index: 20
Works: 67
Citations: 1,977

Most-cited papers

Corneal avascularity is due to soluble VEGF receptor-1
B. Ambati, M. Nozaki, Nirbhai Singh, Atsunobu Takeda +33 more
2006Nature710 citations Open access
Semantic Scholar
Progress toward understanding the genetic and biochemical mechanisms of inherited photoreceptor degenerations.
Laura Pacione, M. Szego, Sakae Ikeda, P. Nishina +1 more
2003Annual Review of Neuroscience155 citations
Semantic Scholar
Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene.
Sakae Ikeda, Nima Shiva, Akihiro Ikeda, Richard S. Smith +9 more
2000Human Molecular Genetics107 citations
Semantic Scholar
Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament severing proteins
P. Narayanan, Paul D Chatterton, Akihiro Ikeda, Sakae Ikeda +3 more
2015Nature Communications99 citations Open access
Semantic Scholar
Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice.
Akihiro Ikeda, Sakae Ikeda, Thomas Gridley, P. Nishina +1 more
2001Human Molecular Genetics83 citations
Semantic Scholar
Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina.
Sakae Ikeda, Wei He, Akihiro Ikeda, J. Naggert +2 more
1999Investigative Ophthalmology and Visual Science81 citations
Semantic Scholar
Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor).
Sakae Ikeda, L. Cunningham, D. Boggess, N. Hawes +5 more
2003Human Molecular Genetics73 citations Open access
Semantic Scholar
Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice.
Sakae Ikeda, N. Hawes, Bo Chang, Cindy S. Avery +2 more
1999Investigative Ophthalmology and Visual Science67 citations
Semantic Scholar
Spontaneous corneal hem- and lymphangiogenesis in mice with destrin-mutation depend on VEGFR3 signaling.
C. Cursiefen, Sakae Ikeda, P. Nishina, Richard S. Smith +8 more
2005American Journal of Pathology62 citations Open access
Semantic Scholar
Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies
Wei-Hua Lee, Hitoshi Higuchi, Sakae Ikeda, E. Macke +13 more
2016eLife50 citations Open access
Semantic Scholar
GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members.
Wei He, Sakae Ikeda, R. Bronson, G. Yan +3 more
2000Brain Research. Molecular Brain Research50 citations
Semantic Scholar
Mutation in Archain 1, a Subunit of COPI Coatomer Complex, Causes Diluted Coat Color and Purkinje Cell Degeneration
Xin-Jie Xu, R. Kedlaya, Hitoshi Higuchi, Sakae Ikeda +3 more
2010PLoS Genetics47 citations Open access
Semantic Scholar
Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor)
Sakae Ikeda, L. Cunningham, D. Boggess, C. D. Hobson +4 more
200344 citations Open access
Semantic Scholar
Effect of destrin mutations on the gene expression profile in vivo.
A. Verdoni, N. Aoyama, Akihiro Ikeda, Sakae Ikeda
2008Physiological Genomics37 citations Open access
Semantic Scholar
Serum Response Factor is Essential for the Proper Development of Skin Epithelium
A. Verdoni, Sakae Ikeda, Akihiro Ikeda
2010Mammalian Genome31 citations Open access
Semantic Scholar
Reduced synaptic vesicle density and aberrant synaptic localization caused by a splice site mutation in the Rs1h gene
Britt A. Johnson, Sakae Ikeda, L. H. Pinto, Akihiro Ikeda
2006Visual Neuroscience24 citations
Semantic Scholar
A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.
D. Maddox, G. B. Collin, Akihiro Ikeda, C. H. Pratt +8 more
2015Investigative Ophthalmology and Visual Science23 citations Open access
Semantic Scholar
The effect of Tmem135 overexpression on the mouse heart
Sarah A Lewis, T. Takimoto, Shima Mehrvar, Hitoshi Higuchi +6 more
2018PLoS ONE22 citations Open access
Semantic Scholar
An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice.
D. Maddox, Sakae Ikeda, Akihiro Ikeda, Weidong Zhang +3 more
2012Investigative Ophthalmology and Visual Science22 citations Open access
Semantic Scholar
Genetic Modification of the Schisis Phenotype in a Mouse Model of X-Linked Retinoschisis
Britt A. Johnson, N. Aoyama, Nicole H Friedell, Sakae Ikeda +1 more
2008Genetics21 citations Open access
Semantic Scholar
Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice
E. Macke, Erika Henningsen, Erik Jessen, Nicholas A. Zumwalde +11 more
2019Genetics18 citations Open access
Semantic Scholar
Defects in Actin Dynamics Lead to an Autoinflammatory Condition through the Upregulation of CXCL5
A. Verdoni, Richard S. Smith, Akihiro Ikeda, Sakae Ikeda
2008PLoS ONE18 citations Open access
Semantic Scholar
A Pathogenic Relationship Between a Regulator of the Actin Cytoskeleton and Serum Response Factor
A. Verdoni, K. Schuster, B. S. Cole, Akihiro Ikeda +2 more
2010Genetics16 citations Open access
Semantic Scholar
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Michael Landowski, Vijesh J. Bhute, Samuel Grindel, Zachary Haugstad +10 more
2023Communications Biology13 citations Open access
Semantic Scholar
Tyrosinase Is the Modifier of Retinoschisis in Mice
Britt A. Johnson, B. S. Cole, E. Geisert, Sakae Ikeda +1 more
2010Genetics13 citations Open access
Semantic Scholar
A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
M. Landowski, Vijesh J. Bhute, T. Takimoto, Samuel Grindel +4 more
2022Scientific Reports11 citations Open access
Semantic Scholar
Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice
M. Landowski, Samuel Grindel, Pawan K. Shahi, Abigail Johnson +10 more
2020Investigative Ophthalmology and Visual Science11 citations Open access
Semantic Scholar
Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background
Sharolyn V. Kawakami-Schulz, A. Verdoni, S. Sattler, Akihiro Ikeda +1 more
2012Molecular Vision10 citations
Semantic Scholar
Genetic basis of age-dependent synaptic abnormalities in the retina
Hitoshi Higuchi, E. Macke, Wei-Hua Lee, Samuel Miller +3 more
2014Mammalian Genome9 citations Open access
Semantic Scholar
Roles of transmembrane protein 135 in mitochondrial and peroxisomal functions - implications for age-related retinal disease
Michael Landowski, Purnima Gogoi, Sakae Ikeda, Akihiro Ikeda
2024Frontiers in Ophthalmology8 citations Open access
Semantic Scholar
Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene
Wei-Hua Lee, Vijesh J. Bhute, Hitoshi Higuchi, Sakae Ikeda +2 more
2020Experimental biology and medicine8 citations Open access
Semantic Scholar
Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.
Sharolyn V. Kawakami-Schulz, A. Verdoni, S. Sattler, Erik Jessen +3 more
2014Physiological Genomics7 citations Open access
Semantic Scholar
Towards understanding the function of the tubby gene family in the retina.
Sakae Ikeda, Akihiro Ikeda, J. Naggert, P. Nishina
2003Advances in Experimental Medicine and Biology6 citations
Semantic Scholar
Genetic modification of corneal neovascularization in Dstncorn1 mice
Sharolyn V. Kawakami-Schulz, S. Sattler, Anna-Lisa Doebley, Akihiro Ikeda +1 more
2013Mammalian Genome5 citations Open access
Semantic Scholar
Gene targeting in the mouse.
A. Griep, M. John, Sakae Ikeda, Akihiro Ikeda
2011Methods in molecular biology5 citations
Semantic Scholar
Expression of LH-alpha and -beta subunit mRNAs in the rat placenta.
M. Shinozaki, H. Uchida, Sakae Ikeda, Sik-Min Kwan +2 more
1997Endocrine journal4 citations Open access
Semantic Scholar
Mitochondrial fusion controls the development of specialized mitochondrial structure and metabolism in rod photoreceptor cells
Michael Landowski, Ryo Hagimori, Purnima Gogoi, Vijesh J. Bhute +3 more
2025bioRxiv3 citations
Semantic Scholar
Purification, Rheological Characterization, and Visualization of Viscous, Neutral, Hetero-exopolysaccharide Produced by Lactic Acid Bacteria.
Sakae Ikeda, D. Kondoh, Ni Putu Desy Aryantini, T. Urashima +1 more
2018Methods in molecular biology2 citations Open access
Semantic Scholar
Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells
Michael Landowski, Ryo Hagimori, Purnima Gogoi, Pawan K. Shahi +8 more
2026Frontiers in Cell and Developmental Biology1 citations Open access
Semantic Scholar
Association Between C22:5-Containing Lipids and RPE Pathologies in Mice with Tmem135 Overexpression
Michael Landowski, Sakae Ikeda, Akihiro Ikeda
2025Advances in Experimental Medicine and Biology1 citations
Semantic Scholar
A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
Michael Landowski, Samuel Grindel, Y. Hao, Sakae Ikeda +2 more
2023Journal of Visualized Experiments1 citations Open access
Semantic Scholar
Deletion of Serum Response Factor Rescues the Cornea Defects Caused by the Loss of Actin Depolymerizing Factor (ADF/Destrin) in Mouse
A. Verdoni, K. Schuster, B. S. Cole, Akihiro Ikeda +2 more
20101 citations
Semantic Scholar
DHA deficiency drives neural oxidized-lipid stress and microglial activation
Ryo Hagimori, Purnima Gogoi, Pawan K. Shahi, Ryoya Ueno +13 more
2026bioRxiv0 citations Open access
Semantic Scholar
TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism
Ryo Hagimori, Michael Landowski, Siyu Song, Purnima Gogoi +9 more
2026bioRxiv0 citations Open access
Semantic Scholar
A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
Michael Landowski, Vijesh J. Bhute, Tetsuya Takimoto, Samuel Grindel +4 more
2022Scientific Reports0 citations Open access
Semantic Scholar
Genomic analysis of cat lens and lens tumor
Akihiro Ikeda, T. Takimoto, Kazuya Oikawa, Sakae Ikeda +4 more
20200 citations
Semantic Scholar
Overexpression of TMEM135 Causes Progressive RPE Atrophy Dependent on Mouse Genetic Background
Samuel Grindel, M. Landowski, Adrienne Race, Abigail Johnson +9 more
20200 citations
Semantic Scholar
Altered fate of corneal epithelial cells in Dstncorn1 mice
Yu-Yu Zhu, Sharolyn V. Kawakami-Schulz, Wei-Hua Lee, Akihiro Ikeda +2 more
20170 citations
Semantic Scholar
Metabolic alterations caused by dysregulation of mitochondrial dynamics in RPE cells
Wei-Hua Lee, Vijesh J. Bhute, Sarah A Lewis, Hitoshi Higuchi +3 more
20170 citations
Semantic Scholar
Age-dependent retinal abnormalities and neurodegeneration in the small kinky tail mutant
E. Macke, Erika Henningsen, Erik Jessen, Hitoshi Higuchi +3 more
20170 citations
Semantic Scholar

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Akihiro Ikeda×35
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P. Nishina×12
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P. Nishina — researcher profile on SciRah
J. Naggert×9
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Michael Landowski×9
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