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R. Moaddel · SciRah

Researcher profile · Semantic Scholar

R. Moaddel

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R. Moaddel — researcher profile on SciRah

h-index: 59
Works: 274
Citations: 15K

Most-cited papers

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
P. Zanos, R. Moaddel, Patrick J. Morris, Lace M. Riggs +7 more
2018Pharmacological Reviews1,107 citations Open access
Semantic Scholar
Plasma proteomic signature of age in healthy humans
Toshiko Tanaka, A. Biancotto, R. Moaddel, A. Moore +8 more
2018Aging Cell509 citations Open access
Semantic Scholar
Ketamine Has Distinct Electrophysiological and Behavioral Effects in Depressed and Healthy Subjects
A. Nugent, E. Ballard, T. Gould, Lawrence T. Park +3 more
2018Molecular Psychiatry236 citations Open access
Semantic Scholar
Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
C. Ubaida-Mohien, A. Lyashkov, M. Gonzalez-Freire, Ravi Tharakan +7 more
2019eLife188 citations Open access
Semantic Scholar
High-potency ligands for DREADD imaging and activation in rodents and monkeys
J. Bonaventura, M. Eldridge, Feng Hu, Juan L. Gomez +21 more
2019Nature Communications170 citations Open access
Semantic Scholar
Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function
E. Lumsden, Timothy A. Troppoli, S. J. Myers, P. Zanos +17 more
2019Proceedings of the National Academy of Sciences of the United States of America155 citations Open access
Semantic Scholar
(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions
P. Zanos, Jaclyn N. Highland, Brent W. Stewart, P. Georgiou +7 more
2019Proceedings of the National Academy of Sciences of the United States of America144 citations Open access
Semantic Scholar
Natural polyphenols as sirtuin 6 modulators
M. Rahnasto-Rilla, Jonna Tyni, M. Huovinen, Elina M. Jarho +6 more
2018Scientific Reports135 citations Open access
Semantic Scholar
Proteomics in aging research: A roadmap to clinical, translational research
R. Moaddel, C. Ubaida-Mohien, Toshiko Tanaka, A. Lyashkov +6 more
2021Aging Cell122 citations Open access
Semantic Scholar
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
P. Georgiou, P. Zanos, Ta-Chung M. Mou, Xiao-jing An +18 more
2022Nature Neuroscience116 citations Open access
Semantic Scholar
Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging
C. Ubaida-Mohien, M. Gonzalez-Freire, A. Lyashkov, R. Moaddel +4 more
2019Frontiers in Physiology86 citations Open access
Semantic Scholar
Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring
M. Ghorasaini, Yassene Mohammed, J. Adamski, Lisa F Bettcher +28 more
2021Analytical Chemistry81 citations Open access
Semantic Scholar
Kynurenines link chronic inflammation to functional decline and physical frailty
Reyhan M. Westbrook, Tae Chung, Jacqueline Lovett, C. Ward +12 more
2020JCI Insight80 citations Open access
Semantic Scholar
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications
Jaclyn N. Highland, P. Zanos, Lace M. Riggs, P. Georgiou +7 more
2021Pharmacological Reviews78 citations Open access
Semantic Scholar
Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression
Cristan A. Farmer, Jessica R. Gilbert, R. Moaddel, J. George +8 more
2020Neuropsychopharmacology76 citations Open access
Semantic Scholar
Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects
R. Moaddel, M. Shardell, M. Khadeer, Jacqueline Lovett +8 more
2018Psychopharmacology76 citations Open access
Semantic Scholar
Elevated Plasma Growth and Differentiation Factor-15 is Associated with Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults.
R. Semba, M. Gonzalez-Freire, Toshiko Tanaka, A. Biancotto +4 more
2019The journals of gerontology. Series A, Biological sciences and medical sciences72 citations Open access
Semantic Scholar
The Kynurenine Pathway and Bipolar Disorder: Intersection of the Monoaminergic and Glutamatergic Systems and Immune Response
B. Kadriu, Cristan A. Farmer, P. Yuan, Lawrence T. Park +9 more
2019Molecular Psychiatry72 citations Open access
Semantic Scholar
(R)‐Ketamine exerts antidepressant actions partly via conversion to (2R,6R)‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses
P. Zanos, Jaclyn N. Highland, Xin Liu, Timothy A. Troppoli +8 more
2019British Journal of Pharmacology71 citations Open access
Semantic Scholar
Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging
R. Semba, Ping-Bo Zhang, Fatemeh Adelnia, K. Sun +9 more
2019Aging Cell71 citations Open access
Semantic Scholar
Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18: 2 Predicts Greater Decline of Gait Speed in Older Adults The Baltimore Longitudinal Study of Aging
M. Gonzalez-Freire, R. Moaddel, K. Sun, E. Fabbri +5 more
2019The journals of gerontology. Series A, Biological sciences and medical sciences69 citations Open access
Semantic Scholar
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Michael Vreones, M. Mustapić, R. Moaddel, Krishna A. Pucha +4 more
2022Aging Cell66 citations Open access
Semantic Scholar
Plasma metabolites associated with chronic kidney disease and renal function in adults from the Baltimore Longitudinal Study of Aging
Y. Yamaguchi, Marta Zampino, R. Moaddel, Teresa K. Chen +3 more
2021Metabolomics62 citations Open access
Semantic Scholar
Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction
Tyler G. Demarest, V. Varma, Darlene Estrada, M. Babbar +7 more
2020Acta Neuropathologica60 citations Open access
Semantic Scholar
Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine
Jaclyn N. Highland, Patrick J. Morris, P. Zanos, Jacqueline Lovett +6 more
2018Journal of Psychopharmacology58 citations Open access
Semantic Scholar
Plasma proteins related to inflammatory diet predict future cognitive impairment
Michael R. Duggan, Lauren Butler, Zhong-Sheng Peng, Gulzar N. Daya +15 more
2023Molecular Psychiatry46 citations Open access
Semantic Scholar
Searching for a mitochondrial root to the decline in muscle function with ageing
M. Gonzalez-Freire, Fatemeh Adelnia, R. Moaddel, L. Ferrucci
2018Journal of Cachexia, Sarcopenia and Muscle44 citations Open access
Semantic Scholar
A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets
Jackson A. Roberts, V. Varma, Y. An, Sudhir Varma +27 more
2021Science Advances43 citations Open access
Semantic Scholar
Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle
Tyler G. Demarest, G. Truong, Jacqueline Lovett, J. Mohanty +5 more
2019Analytical Biochemistry43 citations Open access
Semantic Scholar
Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults
R. Semba, M. Gonzalez-Freire, R. Moaddel, K. Sun +7 more
2018Journal of Clinical Endocrinology and Metabolism43 citations Open access
Semantic Scholar
Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search
J. Bonaventura, Juan L. Gomez, Meghan L. Carlton, Sherry Lam +10 more
2022Molecular Psychiatry40 citations Open access
Semantic Scholar
Rapid screening and identification of monoamine oxidase-A inhibitors from Corydalis Rhizome using enzyme-immobilized magnetic beads based method.
Yan-Yan Zhang, Qi-Qin Wang, Ruijie Liu, Hai-Bo Zhou +4 more
2019Journal of Chromatography A35 citations
Semantic Scholar
Tetra-linoleoyl cardiolipin depletion plays a major role in the pathogenesis of sarcopenia
R. Semba, R. Moaddel, Ping-Bo Zhang, C. Ramsden +1 more
2019Medical Hypotheses35 citations Open access
Semantic Scholar
Identification of gingerenone A as a novel senolytic compound
R. Moaddel, M. Rossi, S. Rodriguez, R. Munk +4 more
2022PLoS ONE34 citations Open access
Semantic Scholar
Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans
Jaclyn N. Highland, Cristan A. Farmer, P. Zanos, Jacqueline Lovett +3 more
2021Journal of Psychopharmacology33 citations Open access
Semantic Scholar
Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study
A. McGarry, J. Gaughan, Cory Hackmyer, Jacqueline Lovett +6 more
2020Scientific Reports33 citations Open access
Semantic Scholar
Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products
Yu-Mei Zhao, Lv-Hua Wang, Si-Fan Luo, Qi-Qin Wang +3 more
2018Journal of Chromatography A33 citations Open access
Semantic Scholar
A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)-Hydroxynorketamine in Healthy Volunteers
S. Raja, Jeffrey T. Guptill, M. Mack, M. Peterson +37 more
2024Clinical pharmacology and therapy30 citations Open access
Semantic Scholar
Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration
R. Moaddel, P. Zanos, Cristan A. Farmer, B. Kadriu +11 more
2022Translational Psychiatry29 citations Open access
Semantic Scholar
A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801
Patrick J. Morris, Richard D. Burke, Alok K. Sharma, Daniel C. Lynch +9 more
2021Neurotoxicology and Teratology28 citations Open access
Semantic Scholar
Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities
M. Rahnasto-Rilla, Joni P. Järvenpää, M. Huovinen, Anna-Mari Schroderus +5 more
2020Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie26 citations Open access
Semantic Scholar
Proteins in the pathway from high red blood cell width distribution to all-cause mortality
Y. Osawa, Toshiko Tanaka, R. Semba, G. Fantoni +5 more
2022EBioMedicine25 citations Open access
Semantic Scholar
Metabolomic Profile of Different Dietary Patterns and Their Association with Frailty Index in Community-Dwelling Older Men and Women
Toshiko Tanaka, S. Talegawkar, Yichen Jin, Julián Candia +4 more
2022Nutrients25 citations Open access
Semantic Scholar
Plasma metabolomic signatures of dual decline in memory and gait in older adults
Qu Tian, M. Shardell, Pei-lun Kuo, Toshiko Tanaka +4 more
2023GeroScience21 citations Open access
Semantic Scholar
Proteomic signatures of in vivo muscle oxidative capacity in healthy adults
Fatemeh Adelnia, C. Ubaida-Mohien, R. Moaddel, M. Shardell +5 more
2020Aging Cell21 citations Open access
Semantic Scholar
Serum lipids in adults with late age-related macular degeneration: a case-control study
R. Semba, R. Moaddel, M. Cotch, F. Jónasson +9 more
2019Lipids in Health and Disease21 citations Open access
Semantic Scholar
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells
Jonna Tenhunen, T. Kučera, M. Huovinen, J. Küblbeck +8 more
2021Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie20 citations Open access
Semantic Scholar
Proteomics and Epidemiological Models of Human Aging
C. Ubaida-Mohien, R. Moaddel, A. Moore, Pei-lun Kuo +5 more
2021Frontiers in Physiology20 citations Open access
Semantic Scholar
Targeted deletion of interleukin-6 in a mouse model of chronic inflammation demonstrates opposing roles in aging: benefit and harm.
Li-Na Ma, Lolita S Nidadavolu, Huan-Le Yang, J. Langdon +14 more
2020The journals of gerontology. Series A, Biological sciences and medical sciences20 citations Open access
Semantic Scholar
Linoleic acid in diets of mice increases total endocannabinoid levels in bowel and liver: modification by dietary glucose
S. Ghosh, J. O'Connell, O. Carlson, I. González-Mariscal +4 more
2019Obesity Science & Practice20 citations Open access
Semantic Scholar

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