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I. Grants · SciRah

Researcher profile · Semantic Scholar

I. Grants

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I. Grants — researcher profile on SciRah

h-index: 19
Works: 56
Citations: 1,227

Most-cited papers

Sublethal levels of oxidant stress stimulate multiple serine/threonine kinases and suppress protein phosphatases in Jurkat T cells.
R. Whisler, M. Goyette, I. Grants, Y. Newhouse
1995Archives of Biochemistry and Biophysics186 citations
Semantic Scholar
Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation
Vladimir Grubišić, J. McClain, D. Fried, I. Grants +8 more
2020Cell Reports150 citations Open access
Semantic Scholar
Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI infection, IBD, POI, Neurological, Motility and GI Disorders
Andrómeda Liñán-Rico, Fabio Turco, F. Ochoa-Cortes, A. Harzman +8 more
2016Inflammatory Bowel Diseases96 citations Open access
Semantic Scholar
ADOA3R as a Therapeutic Target in Experimental Colitis: Proof by Validated High‐density Oligonucleotide Microarray Analysis
Jorge E. Guzman, Jun-Ge Yu, Z. Suntres, Andrey Bozarov +10 more
2006Inflammatory Bowel Diseases81 citations
Semantic Scholar
A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation
Reiner Schneider, P. Leven, T. Glowka, I. Kuzmanov +12 more
2020EMBO Molecular Medicine74 citations Open access
Semantic Scholar
Comparison of structural changes of cell surface carbohydrates in the eustachian tube epithelium of chinchillas infected with a Streptococcus pneumoniae neuraminidase-deficient mutant or its isogenic parent strain.
Hua H. Tong, M. James, I. Grants, Xia Liu +2 more
2001Microbial Pathogenesis58 citations
Semantic Scholar
A New Bioinformatics Approach to Analyze Gene Expressions and Signaling Pathways Reveals Unique Purine Gene Dysregulation Profiles that Distinguish between CD and UC
Leszek A Rybaczyk, Andrew J Rozmiarek, K. Circle, I. Grants +4 more
2009Inflammatory Bowel Diseases57 citations Open access
Semantic Scholar
Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells.
R. Whisler, I. Grants
1993Mechanisms of Ageing and Development53 citations
Semantic Scholar
Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model.
F. Christofi, Minsoo Kim, Jacqueline E. Wunderlich, Jian-Jing Xue +6 more
2004Gastroenterology50 citations Open access
Semantic Scholar
Impact of Disrupting Adenosine A3 Receptors (A3−/−AR) on Colonic Motility or Progression of Colitis in the Mouse
Tian-Hua Ren, I. Grants, Mazin A. Alhaj, M. McKiernan +5 more
2010Inflammatory Bowel Diseases49 citations Open access
Semantic Scholar
Dual purinergic synaptic transmission in the human enteric nervous system.
Jacqueline E. Wunderlich, B. Needleman, Zhixiong Chen, Jun-Ge Yu +6 more
2008American Journal of Physiology - Gastrointestinal and Liver Physiology43 citations
Semantic Scholar
Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model: ATP-gated P2X3 Channels in EC are Downregulated in Ulcerative Colitis
Andrómeda Liñán-Rico, Jacqueline E. Wunderlich, I. Grants, W. Frankel +6 more
2013Inflammatory Bowel Diseases34 citations Open access
Semantic Scholar
Differential expression of the α- and β-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults
R. Whisler, Y. Newhouse, I. Grants, K. Hackshaw
199533 citations
Semantic Scholar
Comparison of Alteration of Cell Surface Carbohydrates of the Chinchilla Tubotympanum and Colonial Opacity Phenotype of Streptococcus pneumoniae during Experimental Pneumococcal Otitis Media with or without an Antecedent Influenza A Virus Infection
Hua H. Tong, I. Grants, Xia Liu, T. Demaria
2002Infection and Immunity30 citations Open access
Semantic Scholar
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early life adversity in mice and humans.
J. McClain, E. Mazzotta, Nidia C Maradiaga, N. Duque-Wilckens +5 more
2020American Journal of Physiology - Gastrointestinal and Liver Physiology29 citations Open access
Semantic Scholar
Neuropharmacology of Purinergic Receptors in Human Submucous Plexus: Involvement of P2X1, P2X2, P2X3 Channels, P2Y and A3 Metabotropic Receptors in Neurotransmission
Andrómeda Liñán-Rico, Jacqueline E. Wunderlich, Josh Enneking, Deryka D. Tso +8 more
2015Neuropharmacology28 citations Open access
Semantic Scholar
Signal transduction in human B cells during aging: alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness.
R. Whisler, B.-Q. Liu, Y. Newhouse, J. Walters +2 more
1991Lymphokine and cytokine research26 citations
Semantic Scholar
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Andrey Bozarov, Yu-Zhong Wang, Jun-Ge Yu, Jacqueline E. Wunderlich +6 more
2009American Journal of Physiology - Gastrointestinal and Liver Physiology23 citations Open access
Semantic Scholar
Cyclic AMP modulation of human B cell proliferative responses: role of cAMP-dependent protein kinases in enhancing B cell responses to phorbol diesters and ionomycin.
Ronald L. Whisler, Bei-Qing Liu, I. Grants, Y. Newhouse
1992Cellular Immunology23 citations
Semantic Scholar
UTP – Gated Signaling Pathways of 5-HT Release from BON Cells as a Model of Human Enterochromaffin Cells
Andrómeda Liñán-Rico, F. Ochoa-Cortes, A. Zuleta-Alarcón, Mazin A. Alhaj +6 more
2017Frontiers in Pharmacology19 citations Open access
Semantic Scholar
The Role of Excitatory Amino Acids in Hypothermic Injury to Mammalian Spinal Cord Neurons
Geert Craenen, S. Jeftinija, I. Grants, J. H. Lucas
1996Journal of Neurotrauma18 citations
Semantic Scholar
Serial Syngeneic Transplantation of Large Granular Lymphocyte Leukemia in F344 Rats
P. Stromberg, I. Grants, G. Kociba, G. S. Krakowka +1 more
1990Veterinary Pathology-Supplement12 citations Open access
Semantic Scholar
BQ788 Reveals Glial ETBR Modulation of Neuronal Cholinergic and Nitrergic Pathways to Inhibit Intestinal Motility: ETBR Signaling is Linked to POI
E. Mazzotta, I. Grants, E. Villalobos-Hernandez, S. Chaudhuri +12 more
2023British Journal of Pharmacology11 citations Open access
Semantic Scholar
Spleen Cell Population Changes and Hemolytic Anemia in F344 Rats with Large Granular Lymphocyte Leukemia
P. Stromberg, G. Kociba, I. Grants, G. S. Krakowka +2 more
1990Veterinary Pathology-Supplement9 citations
Semantic Scholar
63 Gliomodulation of Neuronal and Motor Behavior in the Human GI Tract
A. L. Rico, I. Grants, B. Needleman, K. Williams +9 more
20156 citations
Semantic Scholar
Increased Jun Immunoreactivity in an In Vitro Model of Mammalian Spinal Neuron Physical Injury
R. Raghupathi, I. Grants, Lisa J. Rosenberg, Tracy K. McIntosh +1 more
1998Journal of Neurotrauma6 citations
Semantic Scholar
Clopidogrel IBS Patients Have Higher Incidence of Gastrointestinal Symptoms Influenced by Age and Gender
S. Soghomonyan, Mahmoud Abdelrasoul, A. Zuleta-Alarcón, I. Grants +8 more
2017Digestive Diseases and Sciences4 citations Open access
Semantic Scholar
Differential expression of the alpha- and beta-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults.
R. Whisler, Y. Newhouse, I. Grants, K. Hackshaw
1995Mechanisms of Ageing and Development3 citations
Semantic Scholar
383 Modulation of Ca2+ Waves in Human Enteric Glial Cells
A. L. Rico, Fabio Turco, S. Soghomonyan, I. Grants +7 more
20152 citations
Semantic Scholar
27 Novel Purinergic P1, P2X and P2Y Receptor Signaling Targets in the Human Enteric Nervous System and Glia
Jacqueline E. Wunderlich, Tian-Hua Ren, B. Needleman, D. Mikami +2 more
20092 citations
Semantic Scholar
Transplantation of Large Granular Lymphocyte Leukemia in Congenitally Athymic Rats
P. Stromberg, T. J. Rosol, I. Grants, L. E. Mezza
1992Veterinary Pathology-Supplement2 citations
Semantic Scholar
Inhibition of in vitro plaque formation by large granular lymphocyte leukemia cells from F344 rats.
P. Stromberg, I. Grants, J. A. Reiter, G. S. Krakowka +3 more
1990Journal of clinical & laboratory immunology2 citations
Semantic Scholar
212: ROUTINE PATCH-CLAMP RECORDINGS IN ISOLATED INTACT NEURAL NETWORKS OF HUMAN MYENTERIC GANGLIA IS A SUITABLE AND RELIABLE IN VITRO TECHNIQUE TO STUDY THE “HUMAN LITTLE BRAIN IN THE GUT”
E. Villalobos-Hernández, F. Ochoa-Cortes, E. Mazzotta, Samhita Chaudhuri +5 more
2022Gastroenterology1 citations
Semantic Scholar
Su1309 – Impact of Gut Surgical Manipulation on Enteric Glia, Ca2+ Waves, ADP Signaling, Neural-Glial Communication, ET-1 Siganling and Molecular Signaling in a Mouse Model of Postoperative Ileus
E. Mazzotta, E. Villalobos-Hernández, Reiner Schneider, P. Leven +10 more
2019Gastroenterology1 citations
Semantic Scholar
UTP is a Potential Physiological Regulator of Human Enteric Glial Cell Communication by Activating P2Y4 and P2Y6 Receptors
A. L. Rico, A. Zuleta-Alarcón, F. Ochoa-Cortes, I. Grants +3 more
20171 citations
Semantic Scholar
Sa1689 Hemichannels, GJICs and ATP Signaling in Human Enteric Glial Cells (hEGC)
F. Ochoa-Cortes, A. L. Rico, A. Zuleta-Alarcón, Min Zhou +6 more
20161 citations
Semantic Scholar
Sa1682 Mechanosensory Signaling in Human Enteric Glial Cells
F. Ochoa-Cortes, A. L. Rico, A. Zuleta-Alarcón, Min Zhou +9 more
20161 citations
Semantic Scholar
Su2021 UTP Evokes CA2+ Oscillations in Human Enterochromaffin Cells via Multiple Intracellular Signaling and Ionic Mechanisms
A. L. Rico, F. Ochoa-Cortes, Mazin A. Alhaj, Josh Enneking +5 more
20141 citations Open access
Semantic Scholar
Sa2057 CA2+ Waves Are Mediated by a Uridine Nucleotide Receptor in a Human Enterochromaffin (BON) Cell Model - A Potential Regulatory Mechanism Involved in 5-HT Release
A. L. Rico, I. Grants, Jacqueline E. Wunderlich, Josh Enneking +1 more
20131 citations
Semantic Scholar
Clinically-Relevant A3 Ar Agonists (IB-MECA and 2-Cl-IB-MECA) and A3−/−Ar KO Mice Display a Complex Profile of Clinical Activity in DSS Colitis
Tian-Hua Ren, I. Grants, W. Frankel, F. Christofi
20111 citations Open access
Semantic Scholar
253c GLIAL CONNEXIN-43 HEMICHANNELS ARE CRITICAL DETERMINANTS OF GUT INFLAMMATION IN MOUSE POSTOPERATIVE ILEUS AND REACTIVE HUMAN ENTERIC GLIA
lvio Mazzotta, I. Grants, Samhita Chaudhuri, Reiner Schneider +7 more
2023Gastroenterology0 citations
Semantic Scholar
472 HIGH-FAT DIET-INDUCED FERROPTOSIS PROMOTES ENTERIC NEURODEGENERATION: A MECHANISM FOR INTESTINAL MOTILITY DISORDERS
A. Balasubramaniam, Yun-Shan Liu, I. Grants, S. Chaudhuri +4 more
2023Gastroenterology0 citations
Semantic Scholar
Su1308 – “First in Man” Patch Clamp Recordings in Freshly Isolated Networks of Human Myenteric Ganglia
E. Villalobos-Hernández, F. Ochoa-Cortes, E. Mazzotta, Christopher J. Suozzi +5 more
2019Gastroenterology0 citations Open access
Semantic Scholar
Pilot Study in Human GUT Mucosal Biopsies: Severity of Disease is Predictive of Higher Levels of Acute Biologic Release of Glial S100Î' Protein in Ulcerative Colitis and Crohn's Disease
Fabio Turco, A. L. Rico, Mahmoud Abdelrasoul, A. Zuleta-Alarcón +8 more
20170 citations
Semantic Scholar
IL-1 β/IL-1R Signaling in Human Enteric Glial Cells - Induction of a Reactive Phenotype and Disruption of Mechanosensitivity, Purinergic Signaling and Ca2+ Waves
A. Zuleta-Alarcón, S. Wehner, Mahmoud Abdelrasoul, P. Fadda +5 more
20170 citations
Semantic Scholar
Mo1647 Retrospective Analysis in IBS Patients Reveals a Higher Incidence of GI Symptoms in Plavix Patients Influenced by Age and Gender
S. Soghomonyan, I. Grants, F. Ochoa-Cortes, Mahmoud Abdelrasoul +7 more
20160 citations
Semantic Scholar
Sa1683 Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for Intestinal Infections, Motility and IBD
A. L. Rico, Fabio Turco, F. Ochoa-Cortes, A. Harzman +6 more
20160 citations
Semantic Scholar
Gastrointestinal Motility Tracking the Moveable Feast: Sonomicrometry and
B. Coulie, J. Szurszewski, G. Farrugia, L. Xue +11 more
20150 citations
Semantic Scholar
183 Glial Transmission in Human Enteric Nervous System
Jacqueline E. Wunderlich, I. Grants, B. Needleman, A. Otey +4 more
20120 citations
Semantic Scholar
182 Neural Circuit Behavior in Enteric Neural Plexus Developed From Neural Crest-Derived Stem Cells (ENPCs)
Jacqueline E. Wunderlich, J. Gisser, C. Gariepy, I. Grants +2 more
20120 citations
Semantic Scholar

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