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A. Gruzman · SciRah

Researcher profile · Semantic Scholar

A. Gruzman

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A. Gruzman — researcher profile on SciRah

h-index: 22
Works: 78
Citations: 1,724

Most-cited papers

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis
A. Gruzman, William l. Wood, E. Alpert, M. D. Prasad +8 more
2007Proceedings of the National Academy of Sciences of the United States of America205 citations Open access
Semantic Scholar
Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction*
Danya Ben-Hail, Racheli Begas-Shvartz, M. Shalev, A. Shteinfer-Kuzmine +4 more
2016Journal of Biological Chemistry142 citations Open access
Semantic Scholar
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.
A. Gruzman, Gali Babai, S. Sasson
2009The review of diabetic studies : RDS121 citations Open access
Semantic Scholar
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
E. Meltzer-Mats, G. Babai-Shani, L. Pasternak, Neta Uritsky +7 more
2013Journal of Medicinal Chemistry79 citations Open access
Semantic Scholar
The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes
G. Cohen, Y. Riahi, E. Alpert, A. Gruzman +1 more
2007Archives of Physiology and Biochemistry72 citations
Semantic Scholar
A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid.
E. Alpert, A. Gruzman, H. Totary, N. Kaiser +2 more
2002Biochemical Journal72 citations Open access
Semantic Scholar
The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells
Y. Riahi, Yoav Sin-Malia, G. Cohen, E. Alpert +5 more
2010Diabetes68 citations Open access
Semantic Scholar
Synthesis and characterization of new and potent alpha-lipoic acid derivatives.
A. Gruzman, Adel Hidmi, J. Katzhendler, Abdalla Haj-Yehie +1 more
2004Bioorganic & Medicinal Chemistry55 citations
Semantic Scholar
A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2
N. Lev, Y. Barhum, T. Ben-Zur, I. Aharony +5 more
2015PLoS ONE54 citations Open access
Semantic Scholar
Delayed autoregulation of glucose transport in vascular endothelial cells
E. Alpert, A. Gruzman, Y. Riahi, R. Blejter +5 more
2005Diabetologia50 citations Open access
Semantic Scholar
NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
S. Kahremany, Lukas Hofmann, A. Gruzman, A. Dinkova-Kostova +1 more
2022Free Radical Biology & Medicine46 citations Open access
Semantic Scholar
Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor.
M. Krimsky, S. Yedgar, L. Aptekar, Ouri Schwob +4 more
2003American Journal of Physiology - Gastrointestinal and Liver Physiology43 citations
Semantic Scholar
Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha.
A. Gruzman, Ofer Shamni, Moriya Ben Yakir, Daphna Sandovski +7 more
2008Journal of Medicinal Chemistry37 citations
Semantic Scholar
Pruritus in psoriasis and atopic dermatitis: current treatments and new perspectives
S. Kahremany, Lukas Hofmann, M. Harari, A. Gruzman +1 more
2021Pharmacological Reports33 citations
Semantic Scholar
Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
S. Kahremany, Lukas Hofmann, A. Gruzman, G. Cohen
2020International Journal of Molecular Sciences33 citations Open access
Semantic Scholar
Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation
Bareket Daniel, Omer Green, O. Viskind, A. Gruzman
2013Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration29 citations
Semantic Scholar
Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements.
O. Dransfeld, I. Rakatzi, S. Sasson, A. Gruzman +3 more
2001Biochemical Journal28 citations Open access
Semantic Scholar
4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells.
E. Alpert, H. Altman, H. Totary, A. Gruzman +3 more
2004Biochemical Pharmacology26 citations
Semantic Scholar
Investigation of the Membrane Fluidity Regulation of Fatty Acid Intracellular Distribution by Fluorescence Lifetime Imaging of Novel Polarity Sensitive Fluorescent Derivatives
G. Bianchetti, Salome Azoulay-Ginsburg, Nimrod Y. Keshet-Levy, A. Malka +6 more
2021International Journal of Molecular Sciences25 citations Open access
Semantic Scholar
Novel inhibitors of leukocyte transendothelial migration.
Tamar Getter, R. Margalit, S. Kahremany, Laura Levy +12 more
2019Bioorganic chemistry (Print)25 citations
Semantic Scholar
Erratum to: Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations by Gruzman et al., Rev Diabet Stud 2009, 6(1):13-36.
A. Gruzman, Gali Babai, S. Sasson
200925 citations Open access
Semantic Scholar
Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells.
E. Bloch-Shilderman, Saleh Abu‐Raya, V. Trembovler, H. Boschwitz +3 more
2002Journal of Pharmacology and Experimental Therapeutics25 citations
Semantic Scholar
A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
Tamar Getter, I. Zaks, Y. Barhum, T. Ben-Zur +13 more
2015ChemMedChem21 citations
Semantic Scholar
Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site
Ido Rippin, N. Khazanov, Shirley Ben Joseph, Tania Kudinov +7 more
2020International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Activation of PPARδ: from computer modelling to biological effects
S. Kahremany, A. Livne, A. Gruzman, H. Senderowitz +1 more
2015British Journal of Pharmacology20 citations Open access
Semantic Scholar
Direct production of glucose from glycogen under microwave irradiation
M. Klein, I. Pulidindi, N. Perkas, E. Meltzer-Mats +2 more
201219 citations
Semantic Scholar
Rational alteration of pharmacokinetics of chiral fluorinated and deuterated derivatives of emixustat for retina therapies
Eliav Blum, Jian-Ye Zhang, Jordan Zaluski, D. E. Einstein +6 more
2021Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage
S. Kahremany, Ilana Babaev, Raanan Gvirtz, Navit Ogen-Stern +4 more
2019Skin Pharmacology and Physiology16 citations
Semantic Scholar
Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.
L. Pasternak, Ella Meltzer-Mats, G. Babai-Shani, G. Cohen +5 more
2014Chemical Communications16 citations
Semantic Scholar
Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress.
Renana Shapira, S. Rudnick, Bareket Daniel, O. Viskind +7 more
2013Journal of Medicinal Chemistry16 citations
Semantic Scholar
Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose.
Ofer Shamni, G. Cohen, A. Gruzman, Hilal Zaid +3 more
2017Biochimica et Biophysica Acta - Biomembranes15 citations Open access
Semantic Scholar
SH-29 and SK-119 Attenuates Air-Pollution Induced Damage by Activating Nrf2 in HaCaT Cells
S. Kahremany, Lukas Hofmann, Noy Eretz-Kdosha, E. Silberstein +2 more
2021International Journal of Environmental Research and Public Health14 citations Open access
Semantic Scholar
Chemical chaperones targeted to the endoplasmic reticulum (ER) and lysosome prevented neurodegeneration in a C9orf72 repeat expansion drosophila amyotrophic lateral sclerosis (ALS) model
Salome Azoulay-Ginsburg, M. Di Salvio, M. Weitman, Michal Afri +4 more
2021Pharmacological Reports13 citations
Semantic Scholar
The lipophilic 4-phenylbutyric acid derivative prevents aggregation and retention of misfolded proteins.
Salome Azoulay-Ginsburg, Laura Trobiani, A. Setini, F. Favaloro +7 more
2019Chemistry13 citations
Semantic Scholar
Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKα-independent manner
E. Alpert, A. Gruzman, B. Lardi-Studler, G. Cohen +2 more
2006Diabetologia13 citations Open access
Semantic Scholar
Design and synthesis of novel protein kinase R (PKR) inhibitors
Sagiv Weintraub, Talia Yarnitzky, S. Kahremany, Iliana Barrera +4 more
2016Molecular diversity12 citations
Semantic Scholar
Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cδ-dependent manner
E. Alpert, A. Gruzman, T. Tennenbaum, S. Sasson
200712 citations
Semantic Scholar
Mimicking Neuroligin-2 Functions in β-cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy
Anna Munder, L. Israel, S. Kahremany, Rina Ben-Shabat-Binyamini +8 more
2017ACS Applied Materials and Interfaces11 citations Open access
Semantic Scholar
SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex
Sagiv Weintraub, Y. Moskovitz, Ohad Fleker, Ariel R. Levy +4 more
2015JBIC Journal of Biological Inorganic Chemistry11 citations
Semantic Scholar
Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics
Aviv Meir, Veronica Lepechkin-Zilbermintz, S. Kahremany, Fabian Schwerdtfeger +5 more
2019bioRxiv10 citations Open access
Semantic Scholar
Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model.
Lena Trifonov, V. Nudelman, Michael Zhenin, Erez Matsree +10 more
2018Journal of Medicinal Chemistry10 citations
Semantic Scholar
A versatile water-soluble chelating and radical scavenging platform.
Meital Eckshtain-Levi, R. Lavi, D. Yufit, Bareket Daniel +6 more
2016Chemical Communications10 citations
Semantic Scholar
Activators of AMPK: not just for type II diabetes.
I. Zaks, Tamar Getter, A. Gruzman
2014Future Medicinal Chemistry10 citations
Semantic Scholar
An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist
Lena Trifonov, Michal Afri, K. Palczewski, E. Korshin +1 more
2018Medicinal chemistry9 citations Open access
Semantic Scholar
4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice
Leenor Alfahel, Shirel Argueti-Ostrovsky, Shir Barel, Mahmood Ali Saleh +6 more
2022International Journal of Molecular Sciences8 citations Open access
Semantic Scholar
Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis
E. Alpert, Armin Akhavan, A. Gruzman, William J Hansen +7 more
2021Bioscience Reports8 citations Open access
Semantic Scholar
Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.
S. Kahremany, Ilana Babaev, Pinhas Hasin, Tigist Y. Tamir +9 more
2018ChemPlusChem8 citations
Semantic Scholar
A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK
Naomi Rozentul, Yosef Avrahami, M. Shubely, Laura Levy +5 more
2017Pharmaceutical Research8 citations
Semantic Scholar
A New Oxopiperazin‐Based Peptidomimetic Molecule Inhibits Prostatic Acid Phosphatase Secretion and Induces Prostate Cancer Cell Apoptosis
Pinchas Zer Aviv, M. Shubely, Yoni Moskovits, O. Viskind +5 more
20168 citations
Semantic Scholar
Antiproliferative Effect of Novel Aminoacridine-based Compounds.
Anna Munder, Y. Moskovitz, Boris Redko, Ariel R. Levy +3 more
2015Medicinal chemistry8 citations
Semantic Scholar

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