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P. J. Sapienza · SciRah

Researcher profile · Semantic Scholar

P. J. Sapienza

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P. J. Sapienza — researcher profile on SciRah

h-index: 17
Works: 41
Citations: 1,017

Most-cited papers

Hidden dynamic allostery in a PDZ domain
C. Petit, Jun Zhang, P. J. Sapienza, E. Fuentes +1 more
2009Proceedings of the National Academy of Sciences of the United States of America345 citations Open access
Semantic Scholar
Using NMR to study fast dynamics in proteins: methods and applications
P. J. Sapienza, Andrew L. Lee
2010Current opinion in pharmacology (Print)90 citations Open access
Semantic Scholar
The energetics of the interaction of BamHI endonuclease with its recognition site GGATCC.
L. E. Engler, P. J. Sapienza, Lydia F. Dorner, Rebecca B. Kucera +2 more
2001Journal of Molecular Biology78 citations
Semantic Scholar
Crystallographic and NMR evaluation of the impact of peptide binding to the second PDZ domain of PTP1E
Jun Zhang, P. J. Sapienza, H. Ke, A. Chang +4 more
2010Biochemistry70 citations Open access
Semantic Scholar
Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate.
P. J. Sapienza, Randall V. Mauldin, Andrew L. Lee
2011Journal of Molecular Biology32 citations
Semantic Scholar
Electron spin resonance shows common structural features for different classes of EcoRI-DNA complexes.
Katherine M. Stone, Jacqueline E. Townsend, J. Sarver, P. J. Sapienza +2 more
2008Angewandte Chemie31 citations Open access
Semantic Scholar
Native State Volume Fluctuations in Proteins as a Mechanism for Dynamic Allostery.
A. B. Law, P. J. Sapienza, Jun Zhang, X. Zuo +1 more
2017Journal of the American Chemical Society30 citations Open access
Semantic Scholar
The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase
Kevin Francis, P. J. Sapienza, Andrew L. Lee, A. Kohen
2016Biochemistry30 citations Open access
Semantic Scholar
Structure and Dynamics of the G121V Dihydrofolate Reductase Mutant: Lessons from a Transition-State Inhibitor Complex
Randall V. Mauldin, P. J. Sapienza, C. Petit, Andrew L. Lee
2012PLoS ONE28 citations Open access
Semantic Scholar
Protein Mass Effects on Formate Dehydrogenase
Chethya Ranasinghe, Qi Guo, P. J. Sapienza, Andrew L. Lee +3 more
2017Journal of the American Chemical Society24 citations Open access
Semantic Scholar
Thermodynamic and kinetic basis for the relaxed DNA sequence specificity of "promiscuous" mutant EcoRI endonucleases.
P. J. Sapienza, Crystal A. Dela Torre, W. McCoy, Samyukta V Jana +1 more
2005Journal of Molecular Biology23 citations
Semantic Scholar
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site
Zhen Wang, P. J. Sapienza, T. Abeysinghe, Calvin Luzum +4 more
2013Journal of the American Chemical Society22 citations Open access
Semantic Scholar
Chemical shift imprint of intersubunit communication in a symmetric homodimer
Bradley Falk, P. J. Sapienza, Andrew L. Lee
2016Proceedings of the National Academy of Sciences of the United States of America21 citations Open access
Semantic Scholar
Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity
P. J. Sapienza, Bradley Falk, Andrew L. Lee
2015Journal of the American Chemical Society21 citations Open access
Semantic Scholar
Dynamic allostery in substrate binding by human thymidylate synthase
Jeffrey P. Bonin, P. J. Sapienza, Andrew L. Lee
2022bioRxiv19 citations Open access
Semantic Scholar
Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.
Jeffrey P. Bonin, P. J. Sapienza, Emily M. Wilkerson, D. Goldfarb +5 more
2019Biophysical Journal17 citations Open access
Semantic Scholar
An Ancestral Tryptophanyl-tRNA Synthetase Precursor Achieves High Catalytic Rate Enhancement Without Ordered Ground-State Tertiary Structures
P. J. Sapienza, Li Li, T. Williams, Andrew L. Lee +1 more
2016ACS Chemical Biology17 citations Open access
Semantic Scholar
Structural and thermodynamic basis for enhanced DNA binding by a promiscuous mutant EcoRI endonuclease.
P. J. Sapienza, J. Rosenberg, L. Jen-Jacobson
2007Structure16 citations Open access
Semantic Scholar
Isotopic Labeling of Formate Dehydrogenase Perturbs the Protein Dynamics.
Chethya Ranasinghe, Philip Pagano, P. J. Sapienza, Andrew L. Lee +2 more
2019Journal of Physical Chemistry B15 citations
Semantic Scholar
Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase
Andrew L. Lee, P. J. Sapienza
2018Frontiers in Molecular Biosciences13 citations Open access
Semantic Scholar
Visualizing an allosteric intermediate using CuAAC stabilization of an NMR mixed labeled dimer
P. J. Sapienza, Michelle M. Currie, Noah M. Lancaster, Ke-Lin Li +5 more
2021ACS Chemical Biology11 citations Open access
Semantic Scholar
Widespread perturbation of function, structure, and dynamics by a conservative single atom substitution in thymidylate synthase
P. J. Sapienza, Andrew L. Lee
2016Biochemistry11 citations Open access
Semantic Scholar
Thermodynamic and Structural Basis for Relaxation of Specificity in Protein-DNA Recognition
P. J. Sapienza, Tian-Qi Niu, M. Kurpiewski, A. Grigorescu +1 more
2013Journal of Molecular Biology11 citations Open access
Semantic Scholar
Inter-Active Site Communication Mediated by the Dimer Interface Beta-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase.
P. J. Sapienza, K. Popov, D. Mowrey, Bradley Falk +2 more
2019Biochemistry10 citations Open access
Semantic Scholar
Backbone and ILV methyl resonance assignments of E. coli thymidylate synthase bound to cofactor and a nucleotide analogue
P. J. Sapienza, Andrew L. Lee
2013Biomolecular NMR Assignments9 citations Open access
Semantic Scholar
Mixed, nonclassical behavior in a classic allosteric protein
P. J. Sapienza, Jeffrey P. Bonin, H. P. Dinusha Jinasena, Ke-Lin Li +4 more
2023Proceedings of the National Academy of Sciences of the United States of America8 citations Open access
Semantic Scholar
Faculty of 1000 evaluation for Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor.
Andrew L. Lee, P. J. Sapienza
20188 citations
Semantic Scholar
A flexible, allosteric loop regulates protein activity and rewires electrostatics
Darex J. Vera-Rodriguez, P. J. Sapienza, Konstantin I. Popov, Andrew L. Lee
2025Protein Science4 citations Open access
Semantic Scholar
The Power of Protein Dynamics in Binding and Allostery
Andrew L. Lee, P. J. Sapienza
2026Biochemistry3 citations Open access
Semantic Scholar
Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.
Jeffrey P. Bonin, P. J. Sapienza, Emily Wilkerson, D. Goldfarb +5 more
2021Biophysical Journal2 citations Open access
Semantic Scholar
Thermodynamic, Kinetic, and Structural Basis for the Relaxed DNA Sequence Specificity of "Promiscuous" Mutant EcoRI Endonucleases
P. J. Sapienza
20051 citations
Semantic Scholar
Disordered N‑Terminal Tail “Wags the Dog” in Human Thymidylate Synthase
Meghan Ricciardi, P. J. Sapienza, Andrew L. Lee
2026Biochemistry0 citations Open access
Semantic Scholar
Incidental conformational switching in an allosteric enzyme
P. J. Sapienza, Darex J. Vera-Rodriguez, T. Mileur, Andrew L. Lee
2026bioRxiv0 citations Open access
Semantic Scholar
Dynamic view of an allosteric intermediate in a positively cooperative dimer
P. J. Sapienza, T. Mileur, M. S. Khan, Ke-Lin Li +2 more
2026bioRxiv0 citations Open access
Semantic Scholar
CuAAC stabilization of an NMR mixed labeled dimer
P. J. Sapienza, Michelle M. Currie, Ke-Lin Li, J. Aubé +1 more
2021bioRxiv0 citations Open access
Semantic Scholar
Drugging Protein-Protein Interfaces of a Supramolecular Assembly as a Means to Overcome Resistance to Active Site Thymidylate Synthase Inhibitors
Tigran M. Abramyan, A. Tropsha, Andrew L. Lee, P. J. Sapienza
20200 citations Open access
Semantic Scholar
Crystallographic and NMR evaluation of the impact of peptide binding to the second PDZ domain of PTP1E
Jun Zhang, P. J. Sapienza, H. Ke, A. Chang +5 more
20110 citations
Semantic Scholar
In the Arms of EcoRI - probing the Binding Specificity of the Restriction Endonuclease Using Electron Spin Resonance
J. Sarver, Katherine M. Stone, Jacqueline E. Townsend, P. J. Sapienza +2 more
20110 citations Open access
Semantic Scholar
Ligand Induced Changes in FKBP12 ps-ns Dynamics: The Free Enzyme
P. J. Sapienza, Andrew L. Lee
20100 citations
Semantic Scholar
Ligand Induced Changes in FKBP12 ps-ns Dynamics: The Rapamycin-Bound Enzyme
P. J. Sapienza, Andrew L. Lee
20100 citations
Semantic Scholar
Structure of the A138T promiscuous mutant of the EcoRI restriction endonuclease bound to its cognate recognition site.
P. J. Sapienza, J. Rosenberg, L. Jen-Jacobson
20070 citations
Semantic Scholar

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