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A. Lavecchia · SciRah

Researcher profile · Semantic Scholar

A. Lavecchia

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A. Lavecchia — researcher profile on SciRah

h-index: 45
Works: 217
Citations: 7,248

Most-cited papers

Machine-learning approaches in drug discovery: methods and applications.
A. Lavecchia
2015Drug Discovery Today716 citations
Semantic Scholar
Virtual screening strategies in drug discovery: a critical review.
A. Lavecchia, C. Di Giovanni
2013Current Medicinal Chemistry613 citations
Semantic Scholar
Deep learning in drug discovery: opportunities, challenges and future prospects.
A. Lavecchia
2019Drug Discovery Today273 citations
Semantic Scholar
In silico methods to address polypharmacology: current status, applications and future perspectives.
A. Lavecchia, Carmen Cerchia
2016Drug Discovery Today205 citations
Semantic Scholar
New avenues in artificial-intelligence-assisted drug discovery.
Carmen Cerchia, A. Lavecchia
2023Drug Discovery Today92 citations Open access
Semantic Scholar
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode
D. Capelli, Carmen Cerchia, R. Montanari, F. Loiodice +5 more
2016Scientific Reports89 citations Open access
Semantic Scholar
Therapeutic Targeting the Cell Division Cycle 25 (CDC25) Phosphatases in Human Acute Myeloid Leukemia — The Possibility to Target Several Kinases through Inhibition of the Various CDC25 Isoforms
A. Brenner, H. Reikvam, A. Lavecchia, Ø. Bruserud
2014Molecules86 citations Open access
Semantic Scholar
Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.
P. Vitale, S. Tacconelli, M. Perrone, Paola Malerba +7 more
2013Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors
C. Di Mauro, A. Pesapane, L. Formisano, R. Rosa +19 more
2017Scientific Reports80 citations Open access
Semantic Scholar
CDC25 phosphatase inhibitors: an update.
A. Lavecchia, C. Di Giovanni, E. Novellino
2012Mini-Reviews in Medical Chemistry72 citations
Semantic Scholar
TOPIC HIGHLIGHT
L. Sabatino, M. Pancione, C. Votino, T. Colangelo +4 more
201457 citations
Semantic Scholar
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes
Sabina Yasmin, F. Capone, A. Laghezza, F. Dal Piaz +9 more
2017Scientific Reports49 citations Open access
Semantic Scholar
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.
P. Vitale, M. Perrone, Paola Malerba, A. Lavecchia +1 more
2014European journal of medicinal chemistry42 citations Open access
Semantic Scholar
Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages.
F. De Falco, C. Di Giovanni, Carmen Cerchia, D. De Stefano +6 more
2016Biochemical Pharmacology40 citations
Semantic Scholar
Current status and future prospects of molecular hybrids with thiazolidinedione (TZD) scaffold in anticancer drug discovery.
Kalpana Tilekar, Onkar Shelke, N. Upadhyay, A. Lavecchia +1 more
2021Journal of Molecular Structure39 citations
Semantic Scholar
Development of peptidomimetic boronates as proteasome inhibitors.
N. Micale, R. Ettari, A. Lavecchia, C. Di Giovanni +6 more
2013European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion
A. Pesapane, C. Di Giovanni, F. Rossi, Daniela Alfano +5 more
2015OncoTarget37 citations Open access
Semantic Scholar
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation.
A. Laghezza, L. Piemontese, Carmen Cerchia, R. Montanari +8 more
2018Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Discovery of New Small Molecules Targeting the Vitronectin-Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion
V. E. Rea, A. Lavecchia, C. Di Giovanni, F. Rossi +5 more
2013Molecular Cancer Therapeutics35 citations
Semantic Scholar
Structural development studies of PPARs ligands based on tyrosine scaffold.
B. De Filippis, P. Linciano, Alessandra Ammazzalorso, C. Di Giovanni +8 more
2015European journal of medicinal chemistry34 citations Open access
Semantic Scholar
Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects
Kalpana Tilekar, Jessica D. Hess, N. Upadhyay, A. Bianco +7 more
2021Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
LT175 Is a Novel PPARα/γ Ligand with Potent Insulin-sensitizing Effects and Reduced Adipogenic Properties*
F. Gilardi, M. Giudici, N. Mitro, O. Maschi +12 more
2014Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays.
A. Lavecchia, C. Di Giovanni, Carmen Cerchia, Annapina Russo +2 more
2013Journal of Medicinal Chemistry32 citations
Semantic Scholar
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
A. Laghezza, G. Pochetti, A. Lavecchia, G. Fracchiolla +9 more
2013Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.
Valeria Troiano, Kety Scarbaci, R. Ettari, N. Micale +7 more
2014European journal of medicinal chemistry30 citations Open access
Semantic Scholar
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand-macromolecule interaction.
E. Calleri, G. Fracchiolla, R. Montanari, G. Pochetti +6 more
2012Journal of Chromatography A30 citations
Semantic Scholar
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme
Rosario Rullo, Carmen Cerchia, R. Nasso, Virgilio Romanelli +3 more
2023Antioxidants29 citations Open access
Semantic Scholar
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine‐2,5‐dione Hybrids as Potential Antitumor Agents
Kalpana Tilekar, N. Upadhyay, F. Meyer-Almes, F. Loiodice +8 more
2020ChemMedChem29 citations
Semantic Scholar
The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein
D. Sarnataro, A. Pepe, G. Altamura, Imma De Simone +5 more
2016Scientific Reports29 citations Open access
Semantic Scholar
Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy.
N. Upadhyay, Kalpana Tilekar, F. Loiodice, N. Anisimova +8 more
2020Bioorganic chemistry (Print)28 citations
Semantic Scholar
On the Metabolically Active Form of Metaglidasen: Improved Synthesis and Investigation of Its Peculiar Activity on Peroxisome Proliferator‐Activated Receptors and Skeletal Muscles
A. Laghezza, R. Montanari, A. Lavecchia, L. Piemontese +10 more
2015ChemMedChem27 citations Open access
Semantic Scholar
Identification of a new series of amides as non-covalent proteasome inhibitors.
Kety Scarbaci, Valeria Troiano, N. Micale, R. Ettari +8 more
2014European journal of medicinal chemistry27 citations Open access
Semantic Scholar
N-Formyl Peptide Receptors Induce Radical Oxygen Production in Fibroblasts Derived From Systemic Sclerosis by Interacting With a Cleaved Form of Urokinase Receptor
F. Napolitano, F. Rossi, A. Pesapane, S. Varricchio +10 more
2018Frontiers in Immunology26 citations Open access
Semantic Scholar
Small Molecule Drugs and Targeted Therapy for Melanoma: Current Strategies and Future Directions.
Carmen Cerchia, A. Lavecchia
2017Current Medicinal Chemistry26 citations
Semantic Scholar
Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016)
C. Di Giovanni, E. Novellino, A. Chilin, A. Lavecchia +1 more
2016Expert Opinion on Investigational Drugs26 citations
Semantic Scholar
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.
Letizia Giampietro, A. Laghezza, Carmen Cerchia, Rosalba Florio +15 more
2019ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
E. Caiazzo, F. Maione, S. Morello, A. Lapucci +8 more
2016Biochemical Pharmacology25 citations
Semantic Scholar
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists
L. Sabatino, P. Ziccardi, Carmen Cerchia, L. Muccillo +5 more
2019Scientific Reports23 citations Open access
Semantic Scholar
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands.
Diana Zurlo, P. Ziccardi, C. Votino, T. Colangelo +8 more
2016Biochemical Pharmacology23 citations Open access
Semantic Scholar
Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening.
C. Di Giovanni, R. Ettari, Serena Sarno, Archimede Rotondo +8 more
2016European journal of medicinal chemistry23 citations Open access
Semantic Scholar
Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy.
A. Lavecchia, Carmen Cerchia
2019Future Medicinal Chemistry22 citations
Semantic Scholar
Isoxazole‐Based‐Scaffold Inhibitors Targeting Cyclooxygenases (COXs)
M. Perrone, P. Vitale, A. Panella, S. Ferorelli +3 more
2016ChemMedChem22 citations Open access
Semantic Scholar
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells
A. Capasso, Carmen Cerchia, C. Di Giovanni, G. Granato +5 more
2015OncoTarget22 citations Open access
Semantic Scholar
Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature
A. Lavecchia, C. Di Giovanni, Carmen Cerchia
2014Expert Opinion on Therapeutic Patents22 citations
Semantic Scholar
5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.
R. Petrelli, Ilaria Torquati, Sonja Kachler, L. Luongo +7 more
2015Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.
L. Piemontese, G. Fracchiolla, Antonio Carrieri, M. Parente +10 more
2015European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.
Antonio Carrieri, M. Giudici, M. Parente, M. De Rosas +9 more
2013European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents
Kety Scarbaci, Valeria Troiano, R. Ettari, Andrea Pinto +8 more
2014ChemMedChem20 citations
Semantic Scholar
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism and in Vitro Efficacy against Melanoma Cell Lines.
Carmen Cerchia, R. Nasso, M. Mori, S. Villa +9 more
2019Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
Alessandra Ammazzalorso, Isabella Bruno, Rosalba Florio, L. De Lellis +12 more
2020ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar

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F. Loiodice×16
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A. Laghezza×13
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