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Hanxin Lin · SciRah

Researcher profile · Semantic Scholar

Hanxin Lin

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Hanxin Lin — researcher profile on SciRah

h-index: 23
Works: 53
Citations: 2,104

Most-cited papers

Diagnostic Utility of Genome-wide DNA Methylation Testing in Genetically Unsolved Individuals with Suspected Hereditary Conditions.
E. Aref-Eshghi, E. Bend, S. Colaiacovo, Michelle Caudle +23 more
2019American Journal of Human Genetics176 citations Open access
Semantic Scholar
Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders.
E. Aref-Eshghi, J. Kerkhof, V. Pedro, Groupe di France +65 more
2021American Journal of Human Genetics172 citations Open access
Semantic Scholar
Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes.
E. Aref-Eshghi, D. Rodenhiser, L. Schenkel, Hanxin Lin +10 more
2018American Journal of Human Genetics167 citations Open access
Semantic Scholar
Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders.
E. Aref-Eshghi, J. Kerkhof, V. Pedro, M. Barat-Houari +64 more
2020American Journal of Human Genetics155 citations Open access
Semantic Scholar
Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2
Xuesen Zhao, Dan-Ying Chen, R. Szabla, Mei Zheng +10 more
2020Journal of Virology138 citations Open access
Semantic Scholar
BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin–Siris and Nicolaides–Baraitser syndromes
E. Aref-Eshghi, E. Bend, R. Hood, L. Schenkel +23 more
2018Nature Communications116 citations Open access
Semantic Scholar
Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels.
J. Kerkhof, L. Schenkel, Jack Reilly, Sheri McRobbie +10 more
2017Journal of Molecular Diagnostics114 citations Open access
Semantic Scholar
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses
Xuesen Zhao, M. Sehgal, Zhifei Hou, Jun-Jun Cheng +7 more
2017Journal of Virology108 citations Open access
Semantic Scholar
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2
Xuesen Zhao, Shuangli Zheng, Dan-Ying Chen, Mei Zheng +6 more
2020Journal of Virology95 citations Open access
Semantic Scholar
The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance
E. Aref-Eshghi, L. Schenkel, Hanxin Lin, C. Skinner +5 more
2017Epigenetics92 citations Open access
Semantic Scholar
Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction.
Hanxin Lin, Yan Feng, G. Wong, Li-Ping Wang +5 more
2008Journal of General Virology72 citations Open access
Semantic Scholar
Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C
L. Schenkel, E. Aref-Eshghi, C. Skinner, P. Ainsworth +5 more
2018Clinical Epigenetics66 citations Open access
Semantic Scholar
Inhibition of Endoplasmic Reticulum-Resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-Mediated Entry by Altering the Glycan Processing of Angiotensin I-Converting Enzyme 2
Xuesen Zhao, Fang Guo, M. Comunale, A. Mehta +7 more
2014Antimicrobial Agents and Chemotherapy62 citations Open access
Semantic Scholar
Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion
Mei Zheng, Xuesen Zhao, Shuangli Zheng, Dan-Ying Chen +6 more
2020Emerging Microbes and Infections57 citations Open access
Semantic Scholar
Gender and BCR‐ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia
Hanxin Lin, J. Sjaarda, J. Dyck, Randa L Stringer +7 more
2016European Journal of Haematology48 citations
Semantic Scholar
Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders.
E. Aref-Eshghi, L. Schenkel, Hanxin Lin, C. Skinner +6 more
2017Journal of Molecular Diagnostics45 citations Open access
Semantic Scholar
Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues
E. Aref-Eshghi, L. Schenkel, P. Ainsworth, Hanxin Lin +3 more
2018Frontiers in Oncology44 citations Open access
Semantic Scholar
Comprehensive genetic sequence and copy number analysis for Charcot-Marie-Tooth disease in a Canadian cohort of 2517 patients
M. Volodarsky, J. Kerkhof, A. Stuart, M. Levy +5 more
2020Journal of Medical Genetics42 citations
Semantic Scholar
Broad and differential animal ACE2 receptor usage by SARS-CoV-2
Xuesen Zhao, Dan-Ying Chen, R. Szabla, Mei Zheng +10 more
2020bioRxiv37 citations Open access
Semantic Scholar
GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus
Dan-Ying Chen, Zhifei Hou, Dong Jiang, Mei Zheng +8 more
2019Emerging Microbes and Infections32 citations Open access
Semantic Scholar
Genome‐wide DNA methylation and RNA analyses enable reclassification of two variants of uncertain significance in a patient with clinical Kabuki syndrome
E. Aref-Eshghi, D. Bourque, J. Kerkhof, D. A. Carere +4 more
2019Human Mutation31 citations Open access
Semantic Scholar
Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry
Hanxin Lin, Yan Feng, X. Tu, Xuesen Zhao +4 more
2011Virus Research29 citations Open access
Semantic Scholar
Implementation of an NGS‐based sequencing and gene fusion panel for clinical screening of patients with suspected hematologic malignancies
M. Levy, Stephanie Santos, J. Kerkhof, A. Stuart +22 more
2019European Journal of Haematology24 citations
Semantic Scholar
Do discretion criteria for patent administrative law enforcement encourage innovation among firms?
Hanxin Lin, Cheryl X. Long
202123 citations Open access
Semantic Scholar
Cell Entry of Animal Coronaviruses
Yang Cheng, Xinglin Li, Xuesen Zhao, Hanxin Lin
2021Viruses19 citations Open access
Semantic Scholar
Incidental findings from cancer next generation sequencing panels
Nika Maani, K. Panabaker, J. McCuaig, K. Buckley +8 more
2021npj Genomic Medicine17 citations Open access
Semantic Scholar
Genetic and epigenetic profiling of BRCA1/2 in ovarian tumors reveals additive diagnostic yield and evidence of a genomic BRCA1/2 DNA methylation signature
E. Aref-Eshghi, J. McGee, V. Pedro, J. Kerkhof +6 more
2020Journal of Human Genetics17 citations Open access
Semantic Scholar
A Rational Approach to JAK2 Mutation Testing in Patients with Elevated Hemoglobin: Results from the JAK2 Prediction Cohort (JAKPOT) Study
B. Chin-Yee, P. Bhai, I. Cheong, M. Matyashin +10 more
2022Journal of general internal medicine16 citations Open access
Semantic Scholar
Secondary causes of elevated hemoglobin in patients undergoing molecular testing for suspected polycythemia vera in southwestern Ontario: a chart review
B. Chin-Yee, M. Matyashin, I. Cheong, P. Bhai +9 more
2022CMAJ Open15 citations Open access
Semantic Scholar
Clinical value of next‐generation sequencing compared to cytogenetics in patients with suspected myelodysplastic syndrome
E. Kawata, A. Lazo-Langner, A. Xenocostas, C. Hsia +13 more
2020British Journal of Haematology14 citations Open access
Semantic Scholar
Serum erythropoietin levels in 696 patients investigated for erythrocytosis with JAK2 mutation analysis
B. Chin-Yee, I. Cheong, M. Matyashin, A. Lazo-Langner +6 more
2022American journal of hematology/oncology13 citations
Semantic Scholar
Clinical Utility of Implementing a Frontline NGS-Based DNA and RNA Fusion Panel Test for Patients with Suspected Myeloid Malignancies
P. Bhai, C. Hsia, L. Schenkel, B. Hedley +11 more
2022Molecular Diagnosis & Therapy12 citations
Semantic Scholar
Analysis of Sequence and Copy Number Variants in Canadian Patient Cohort With Familial Cancer Syndromes Using a Unique Next Generation Sequencing Based Approach
P. Bhai, M. Levy, Kathleen Rooney, D. A. Carere +10 more
2021Frontiers in Genetics7 citations Open access
Semantic Scholar
Molecular profiling of solid tumors by next-generation sequencing: an experience from a clinical laboratory
P. Bhai, Jacob P. Turowec, Stephanie Santos, J. Kerkhof +10 more
2023Frontiers in Oncology6 citations Open access
Semantic Scholar
Reducing cytogenetic testing in the era of next generation sequencing: Are we choosing wisely?
E. Kawata, B. Hedley, B. Chin-Yee, A. Xenocostas +12 more
2021International Journal of Laboratory Hematology5 citations
Semantic Scholar
A Prediction Rule to Guide JAK2 Testing in Patients with Suspected Polycythemia Vera
B. Chin-Yee, P. Bhai, I. Cheong, M. Matyashin +8 more
2021Blood5 citations
Semantic Scholar
Lynch syndrome screening of women with endometrial cancer: feasibility and outcomes in a community program.
G. Turashvili, C. M. McLachlin, Hanxin Lin, Robert Gharbharan +1 more
2021Journal of Obstetrics and Gynaecology Canada4 citations
Semantic Scholar
LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2
Xuesen Zhao, Shuangli Zheng, Dan-Ying Chen, Mei Zheng +6 more
2020bioRxiv4 citations Open access
Semantic Scholar
Mutational Landscape of Patients Referred for Elevated Hemoglobin Level
P. Bhai, B. Chin-Yee, V. Pope, Ian-Seng Cheong +8 more
2022Current Oncology3 citations Open access
Semantic Scholar
Investigating Erythrocytosis: Changing Practice Patterns in the Era of Molecular Diagnostics
B. Chin-Yee, M. Matyashin, P. Bhai, I. Cheong +9 more
2021Blood2 citations
Semantic Scholar
Clinical and technical assessment of MedExome vs. NGS panels in patients with suspected genetic disorders in Southwestern Ontario
E. Aref-Eshghi, J. Kerkhof, Deana Alexis Carere, M. Volodarsky +11 more
2020Journal of Human Genetics2 citations
Semantic Scholar
Clinical validation of a single NGS targeted panel pipeline using the KAPA HyperChoice system for detection of germline, somatic and mitochondrial sequence and copy number variants
J. Kerkhof, Cassandra Rastin, L. Schenkel, Hanxin Lin +1 more
2023Expert Review of Molecular Diagnostics1 citations Open access
Semantic Scholar
Reevaluating the Role of Cytogenetic Testing in Patients with Suspected Myelodysplastic Syndrome in the Era of Next Generation Sequencing
E. Kawata, A. Xenocostas, C. Hsia, A. Lazo-Langner +9 more
2019Blood1 citations Open access
Semantic Scholar
P1019: A PREDICTION RULE TO GUIDE JAK2 MUTATION TESTING IN PATIENTS WITH SUSPECTED POLYCYTHEMIA VERA: RESULTS FROM THE JAK2 PREDICTION COHORT (JAKPOT) STUDY
B. Chin-Yee, Pratibha Bhai, I. Cheong, Maxim Matyashin +10 more
2022HemaSphere0 citations Open access
Semantic Scholar
Clinical Features and Mutational Landscape of Patients Referred for Suspected Essential Thrombocytosis: A Descriptive Study Using a 'Real-World’ Database
Ala Almanaseer, B. Chin-Yee, P. Bhai, I. Cheong +8 more
2022Blood0 citations
Semantic Scholar
Incidental findings from cancer next generation sequencing panels
Nika Maani, K. Panabaker, J. McCuaig, K. Buckley +8 more
2021npj Genomic Medicine0 citations Open access
Semantic Scholar
Spectrum of Myeloid Mutations in Patients with Elevated Hemoglobin
P. Bhai, B. Chin-Yee, I. Cheong, M. Matyashin +9 more
2021Blood0 citations Open access
Semantic Scholar
Genetic and epigenetic profiling of BRCA1/2 in ovarian tumors reveals additive diagnostic yield and evidence of a genomic BRCA1/2 DNA methylation signature
E. Aref-Eshghi, J. McGee, V. Pedro, J. Kerkhof +6 more
2020Journal of Human Genetics0 citations Open access
Semantic Scholar
Identifying Myeloid Mutations By NGS in Patients with Unexplained Erythrocytosis
E. Kawata, A. Xenocostas, C. Hsia, A. Lazo-Langner +6 more
20200 citations Open access
Semantic Scholar
Reducing Cytogenetic Testing in the Era of Next Generation Sequencing (NGS); Are We Choosing Wisely?
E. Kawata, B. Hedley, B. Chin-Yee, A. Xenocostas +10 more
20200 citations
Semantic Scholar

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