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J. Broderick · SciRah

Researcher profile · Semantic Scholar

J. Broderick

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J. Broderick — researcher profile on SciRah

h-index: 47
Works: 170
Citations: 6,844

Most-cited papers

Radical S-Adenosylmethionine Enzymes
J. Broderick, Benjamin R. Duffus, Kaitlin S. Duschene, E. Shepard
2014Chemical Reviews702 citations Open access
Semantic Scholar
[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation.
J. Peters, G. Schut, E. Boyd, David W. Mulder +4 more
2015Biochimica et Biophysica Acta445 citations Open access
Semantic Scholar
Insights into [FeFe]-hydrogenase structure, mechanism, and maturation.
David W. Mulder, E. Shepard, J. Meuser, Neelambari Joshi +4 more
2011Structure242 citations Open access
Semantic Scholar
[FeFe]-hydrogenase oxygen inactivation is initiated at the H cluster 2Fe subcluster.
K. D. Swanson, Michael W. Ratzloff, David W. Mulder, J. Artz +8 more
2015Journal of the American Chemical Society138 citations
Semantic Scholar
Radical SAM Catalysis via an Organometallic Intermediate with an Fe–[5′-C]-Deoxyadenosyl Bond
M. Horitani, Krista A. Shisler, W. Broderick, Rachel U. Hutcheson +4 more
2016Science120 citations Open access
Semantic Scholar
Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction
Sang-Hoon Kim, C. Harzman, John k. Davis, Rachel U. Hutcheson +3 more
2012BMC Microbiology102 citations Open access
Semantic Scholar
Glycyl radical activating enzymes: Structure, mechanism, and substrate interactions
Krista A. Shisler, J. Broderick
2014Archives of Biochemistry and Biophysics99 citations Open access
Semantic Scholar
Mechanism of Radical Initiation in the Radical S-Adenosyl-L-methionine Superfamily
W. Broderick, B. Hoffman, J. Broderick
2018Accounts of Chemical Research90 citations Open access
Semantic Scholar
Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis
A. Byer, Hao Yang, Elizabeth C McDaniel, V. Kathiresan +15 more
2018Journal of the American Chemical Society86 citations Open access
Semantic Scholar
EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii.
David W. Mulder, Michael W. Ratzloff, E. Shepard, A. Byer +4 more
2013Journal of the American Chemical Society86 citations
Semantic Scholar
[FeFe]-hydrogenase maturation.
E. Shepard, Florence Mus, Jeremiah N. Betz, A. Byer +3 more
2014Biochemistry82 citations Open access
Semantic Scholar
Emerging paradigms for complex iron-sulfur cofactor assembly and insertion.
J. Peters, J. Broderick
2012Annual Review of Biochemistry81 citations
Semantic Scholar
Biosynthesis of complex iron-sulfur enzymes.
E. Shepard, E. Boyd, J. Broderick, J. Peters
2011Current Opinion in Chemical Biology74 citations
Semantic Scholar
The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by EPR and ENDOR Spectroscopies
Hao Yang, Elizabeth C McDaniel, Stella Impano, A. Byer +5 more
201963 citations Open access
Semantic Scholar
Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free
M. Horitani, A. Byer, Krista A. Shisler, T. Chandra +2 more
2015Journal of the American Chemical Society56 citations Open access
Semantic Scholar
[FeFe]-Hydrogenase Maturation: Insights into the role HydE plays in dithiomethylamine biosynthesis
Jeremiah N. Betz, Nicholas Boswell, Corey J. Fugate, G. Holliday +6 more
2015Biochemistry55 citations Open access
Semantic Scholar
Pyruvate Formate-lyase and Its Activation by Pyruvate Formate-lyase Activating Enzyme*
Adam V Crain, J. Broderick
2013Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG.
Rebecca C. Driesener, Benjamin R. Duffus, E. Shepard, Ian Bruzas +8 more
2013Biochemistry47 citations Open access
Semantic Scholar
Emerging themes in radical SAM chemistry
Krista A. Shisler, J. Broderick
2012Current Opinion in Structural Biology47 citations Open access
Semantic Scholar
S K-edge XAS and DFT Calculations on SAM Dependent Pyruvate Formate-Lyase Activating Enzyme: Nature of Interaction between the Fe4S4 Cluster and SAM and its Role in Reactivity
A. Dey, Yi Peng, W. Broderick, B. Hedman +3 more
2011Journal of the American Chemical Society47 citations Open access
Semantic Scholar
Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily
B. Hoffman, W. Broderick, J. Broderick
2023Annual Review of Biochemistry46 citations Open access
Semantic Scholar
Radical SAM Enzymes: Nature’s choice for radical reactions
J. Broderick, W. Broderick, B. Hoffman
2022FEBS Letters45 citations Open access
Semantic Scholar
H-Cluster assembly during maturation of the [FeFe]-hydrogenase
J. Broderick, A. Byer, Kaitlin S. Duschene, Benjamin R. Duffus +3 more
2014JBIC Journal of Biological Inorganic Chemistry38 citations
Semantic Scholar
Radical SAM Enzymes: Surprises along the Path to Understanding Mechanism
W. Broderick, J. Broderick
2019JBIC Journal of Biological Inorganic Chemistry36 citations Open access
Semantic Scholar
Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical
Hao Yang, Stella Impano, E. Shepard, Christopher D. James +3 more
2019Journal of the American Chemical Society34 citations Open access
Semantic Scholar
Reversible H Atom Abstraction Catalyzed by the Radical S-Adenosylmethionine Enzyme HydG
Benjamin R. Duffus, Shourjo Ghose, J. Peters, J. Broderick
2014Journal of the American Chemical Society34 citations Open access
Semantic Scholar
Viperin: a radical response to viral infection
Kaitlin S. Duschene, J. Broderick
2012Biomolecular Concepts28 citations Open access
Semantic Scholar
Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme
Krista A. Shisler, Rachel U. Hutcheson, M. Horitani, Kaitlin S. Duschene +10 more
2017Journal of the American Chemical Society27 citations Open access
Semantic Scholar
Radical AdoMet enzymes in complex metal cluster biosynthesis.
Benjamin R. Duffus, T. Hamilton, E. Shepard, E. Boyd +2 more
2012Biochimica et Biophysica Acta26 citations
Semantic Scholar
Mechanism of Radical S-Adenosyl-l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5′-Deoxyadenosyl Radical
Maike N. Lundahl, Raymond Sarksian, Hao Yang, Richard J. Jodts +7 more
2022Journal of the American Chemical Society24 citations Open access
Semantic Scholar
Examining Pathways of Iron and Sulfur Acquisition, Trafficking, Deployment, and Storage in Mineral-Grown Methanogen Cells
Devon Payne, E. Shepard, Rachel L. Spietz, Katherine F. Steward +6 more
2021Journal of Bacteriology23 citations Open access
Semantic Scholar
[FeFe]-Hydrogenase In Vitro Maturation.
Adrien Pagnier, Batuhan Balci, E. Shepard, W. Broderick +1 more
2022Angewandte Chemie22 citations Open access
Semantic Scholar
A Redox Active [2Fe-2S] Cluster on the Hydrogenase Maturase HydF
E. Shepard, A. Byer, Jeremiah N. Betz, J. Peters +1 more
2016Biochemistry22 citations Open access
Semantic Scholar
Special issue on iron–sulfur proteins: Structure, function, biogenesis and diseases
R. Lill, J. Broderick, D. Dean
2015Biochimica et Biophysica Acta22 citations Open access
Semantic Scholar
Radical S-Adenosyl-l-methionine Chemistry in the Synthesis of Hydrogenase and Nitrogenase Metal Cofactors*
A. Byer, E. Shepard, J. Peters, J. Broderick
2014Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Iron–sulfur cluster coordination in the [FeFe]‐hydrogenase H cluster biosynthetic factor HydF
Neelambari Joshi, E. Shepard, Amanda S. Byer, K. D. Swanson +2 more
2012FEBS Letters19 citations
Semantic Scholar
[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis
Adrien Pagnier, Batuhan Balci, E. Shepard, Hao Yang +6 more
2022Angewandte Chemie18 citations Open access
Semantic Scholar
Active-Site Controlled, Jahn–Teller Enabled Regioselectivity in Reductive S–C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes
Stella Impano, Hao Yang, Richard J. Jodts, Adrien Pagnier +6 more
2020Journal of the American Chemical Society17 citations Open access
Semantic Scholar
Flavodoxin Cofactor Binding Induces Structural Changes that are Required for Protein-Protein Interactions with NADP+ Oxidoreductase and Pyruvate Formate-Lyase Activating Enzyme
Adam V Crain, J. Broderick
2013Biochimica et Biophysica Acta17 citations Open access
Semantic Scholar
Cyanide and Carbon Monoxide Ligand Formation in Hydrogenase Biosynthesis
K. D. Swanson, Benjamin R. Duffus, T. Beard, J. Peters +1 more
201117 citations
Semantic Scholar
The B12-Independent Glycerol Dehydratase Activating Enzyme from Clostridium butyricum Cleaves SAM to Produce 5’-Deoxyadenosine and not 5’-Deoxy-5’-(methylthio)adenosine
W. Walls, J. Moody, Elizabeth C McDaniel, M. Villanueva +3 more
2021Journal of Inorganic Biochemistry16 citations Open access
Semantic Scholar
S-Adenosyl-l-ethionine is a Catalytically Competent Analog of S-Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG
Stella Impano, Hao Yang, E. Shepard, Ryan Swimley +4 more
2020Angewandte Chemie16 citations Open access
Semantic Scholar
Pyruvate formate-lyase activating enzyme: The catalytically active 5′-deoxyadenosyl radical caught in the act of H-atom abstraction
Maike N. Lundahl, Hao Yang, W. Broderick, Brian M. Hoffman +1 more
2023Proceedings of the National Academy of Sciences of the United States of America15 citations Open access
Semantic Scholar
Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies
A. Byer, Elizabeth C McDaniel, Stella Impano, W. Broderick +1 more
2018Methods in Enzymology15 citations Open access
Semantic Scholar
H-cluster assembly intermediates built on HydF by the radical SAM enzymes HydE and HydG
A. Byer, E. Shepard, Michael W. Ratzloff, Jeremiah N. Betz +3 more
2019JBIC Journal of Biological Inorganic Chemistry14 citations Open access
Semantic Scholar
Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation
E. Shepard, A. Byer, P. Aggarwal, Jeremiah N. Betz +6 more
2017Biochemistry14 citations Open access
Semantic Scholar
Radical SAM Enzymes in Methylation and Methylthiolation
Rachel U. Hutcheson, J. Broderick
2012Metallomics14 citations Open access
Semantic Scholar
Compositional and structural insights into the nature of the H-cluster precursor on HydF.
Anna G. Scott, R. Szilágyi, David W. Mulder, Michael W. Ratzloff +5 more
2018Dalton Transactions13 citations
Semantic Scholar
Radical SAM Enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed during Substrate-Free Turnover
Adrien Pagnier, Hao Yang, Richard J. Jodts, Christopher D. James +5 more
2020Journal of the American Chemical Society11 citations Open access
Semantic Scholar
Radical S-adenosylmethionine maquette chemistry: Cx3Cx2C peptide coordinated redox active [4Fe–4S] clusters
Amanda Galambas, Jacquelyn Miller, Morgan Jones, Elizabeth C McDaniel +6 more
2019JBIC Journal of Biological Inorganic Chemistry11 citations
Semantic Scholar

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