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M. Hegi · SciRah

Researcher profile · Semantic Scholar

M. Hegi

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M. Hegi — researcher profile on SciRah

h-index: 77
Works: 247
Citations: 42K

Most-cited papers

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial
R. Stupp, S. Taillibert, A. Kanner, W. Read +25 more
2017Journal of the American Medical Association (JAMA)2,313 citations Open access
Semantic Scholar
EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
M. Weller, M. J. van den Bent, M. Preusser, É. Le Rhun +20 more
2020Nature Reviews Clinical Oncology1,765 citations Open access
Semantic Scholar
Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial.
R. Stupp, S. Taillibert, A. Kanner, S. Kesari +26 more
2015Journal of the American Medical Association (JAMA)1,213 citations Open access
Semantic Scholar
European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas.
M. Weller, M. J. van den Bent, J. Tonn, R. Stupp +21 more
2017The Lancet Oncology964 citations Open access
Semantic Scholar
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.
R. Stupp, M. Hegi, T. Gorlia, S. Erridge +33 more
2014The Lancet Oncology922 citations Open access
Semantic Scholar
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells
F. Klemm, Roeltje R. Maas, Robert L. Bowman, Mara Kornete +10 more
2020Cell911 citations Open access
Semantic Scholar
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma.
A. Berghoff, B. Kiesel, G. Widhalm, Orsolya Rajky +13 more
2015Neuro-Oncology533 citations Open access
Semantic Scholar
MGMT testing—the challenges for biomarker-based glioma treatment
W. Wick, M. Weller, M. J. van den Bent, M. Sanson +6 more
2014Nature Reviews Neurology530 citations Open access
Semantic Scholar
Glioma epigenetics: From subclassification to novel treatment options.
Olga Gusyatiner, M. Hegi
2017Seminars in Cancer Biology484 citations
Semantic Scholar
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma
B. Baumert, M. Hegi, M. J. van den Bent, A. von Deimling +33 more
2016The Lancet Oncology430 citations Open access
Semantic Scholar
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas
M. Shirahata, T. Ono, D. Stichel, D. Schrimpf +42 more
2018Acta Neuropathologica381 citations Open access
Semantic Scholar
Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma
R. Stupp, S. Taillibert, A. Kanner, W. Read +25 more
2017308 citations
Semantic Scholar
MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges.
A. Mansouri, Laureen D Hachem, S. Mansouri, F. Nassiri +10 more
2018Neuro-Oncology289 citations Open access
Semantic Scholar
Correlation of immune phenotype with IDH mutation in diffuse glioma
A. Berghoff, B. Kiesel, G. Widhalm, Dorothee Wilhelm +7 more
2017Neuro-Oncology239 citations Open access
Semantic Scholar
Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study.
L. B. Nabors, K. Fink, T. Mikkelsen, D. Grujicic +13 more
2015Neuro-Oncology227 citations Open access
Semantic Scholar
The local microenvironment drives activation of neutrophils in human brain tumors.
Roeltje R. Maas, Klara Soukup, Nadine Fournier, Matteo Massara +21 more
2023Cell179 citations Open access
Semantic Scholar
Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
C. Happold, T. Gorlia, O. Chinot, M. Gilbert +11 more
2016Journal of Clinical Oncology174 citations Open access
Semantic Scholar
Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082)
W. Wick, T. Gorlia, P. Bady, M. Plattén +22 more
2016Clinical Cancer Research146 citations Open access
Semantic Scholar
WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1
I. Vassallo, P. Zinn, Marta Lai, Premnath Rajakannu +2 more
2016Oncogene136 citations Open access
Semantic Scholar
Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG
D. Blumenthal, T. Gorlia, M. Gilbert, Michelle M. Kim +17 more
2015Neuro-Oncology130 citations Open access
Semantic Scholar
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
F. Klemm, Aylin Möckl, Anna Salamero-Boix, T. Alekseeva +15 more
2021Nature Cancer124 citations Open access
Semantic Scholar
Sensitivity Analysis of the MGMT-STP27 Model and Impact of Genetic and Epigenetic Context to Predict the MGMT Methylation Status in Gliomas and Other Tumors.
P. Bady, M. Delorenzi, M. Hegi
2016Journal of Molecular Diagnostics109 citations Open access
Semantic Scholar
EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection
D. Capper, G. Reifenberger, P. French, L. Schweizer +16 more
2023Neuro-Oncology101 citations Open access
Semantic Scholar
Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline
F. Sahm, S. Brandner, L. Bertero, D. Capper +13 more
2023Neuro-Oncology99 citations Open access
Semantic Scholar
Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma
Sebastian Kurscheid, P. Bady, Davide Sciuscio, Ivana Samaržija +12 more
2015Genome Biology89 citations Open access
Semantic Scholar
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms.
Leire Bejarano, Annamaria Kauzlaric, Eleni Lamprou, Joao Lourenço +13 more
2024Cancer Cell83 citations Open access
Semantic Scholar
Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter--still a dilemma?
M. Hegi, R. Stupp
2015Neuro-Oncology83 citations Open access
Semantic Scholar
Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence.
Spencer S. Watson, A. Zomer, Nadine Fournier, Joao Lourenço +16 more
2024Cancer Cell82 citations Open access
Semantic Scholar
The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033
P. Bady, Sebastian Kurscheid, M. Delorenzi, T. Gorlia +18 more
2018Acta Neuropathologica81 citations Open access
Semantic Scholar
Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome
M. Weller, L. Nabors, T. Gorlia, H. Leske +13 more
2016OncoTarget80 citations Open access
Semantic Scholar
Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders' Collaborative Consortium (EORTC 1419).
C. Hertler, J. Felsberg, D. Gramatzki, É. Le Rhun +46 more
2023European Journal of Cancer77 citations Open access
Semantic Scholar
Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation
Vladimir Wischnewski, Roeltje R. Maas, Paola Guerrero Aruffo, K. Soukup +17 more
2023Nature Cancer66 citations Open access
Semantic Scholar
Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.
Patrick Y. Wen, M. Weller, E. Lee, M. Touat +42 more
2025Neuro-Oncology65 citations Open access
Semantic Scholar
Mir-21–Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact
P. Sathyan, P. Zinn, Anantha L. Marisetty, Bin Liu +25 more
2015Journal of Neuroscience59 citations Open access
Semantic Scholar
Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells
Lea Beltzig, C. Schwarzenbach, P. Leukel, K. Frauenknecht +5 more
2022Cancers53 citations Open access
Semantic Scholar
Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors
Ángel F. Álvarez-Prado, Roeltje R. Maas, K. Soukup, F. Klemm +9 more
2023Cell Reports Medicine52 citations Open access
Semantic Scholar
The TICking clock of EGFR therapy resistance in glioblastoma: Target Independence or target Compensation.
Hamza Saleem, U. K. Abdul, Asli Küçükosmanoglu, M. Houweling +7 more
2019Drug resistance updates50 citations Open access
Semantic Scholar
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors.
Leire Bejarano, Joao Lourenço, Annamaria Kauzlaric, Eleni Lamprou +10 more
2025Immunity40 citations Open access
Semantic Scholar
Improving survival in molecularly selected glioblastoma.
R. Stupp, R. Lukas, M. Hegi
2019The Lancet39 citations
Semantic Scholar
BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma
Olga Gusyatiner, P. Bady, M. D. T. Pham, Yvonne Lei +4 more
2021Neuro-Oncology38 citations Open access
Semantic Scholar
Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity
M. Oikonomaki, P. Bady, M. Hegi
2017OncoTarget36 citations Open access
Semantic Scholar
No benefit from TMZ treatment in glioblastoma with truly unmethylated MGMT promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly glioblastoma patients
M. Hegi, Felix Boakye Oppong, James R. Perry, W. Wick +5 more
2024Neuro-Oncology35 citations Open access
Semantic Scholar
Tumor treating fields (TTFields): A novel treatment modality added to standard chemo- and radiotherapy in newly diagnosed glioblastoma—First report of the full dataset of the EF14 randomized phase III trial.
R. Stupp, S. Taillibert, A. Kanner, S. Kesari +16 more
201529 citations
Semantic Scholar
BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression
Alessandro Tancredi, Olga Gusyatiner, P. Bady, Michelle C. Buri +4 more
2022Cell Death and Disease28 citations Open access
Semantic Scholar
Survey on current practice within the European Low-Grade Glioma Network: where do we stand and what is the next step?
E. Mandonnet, M. Wager, F. Almairac, M. Baron +26 more
2017Neuro-Oncology Practice27 citations Open access
Semantic Scholar
Author Correction: EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
Michael Weller, M. J. van den Bent, M. Preusser, É. Le Rhun +20 more
2022Nature Reviews Clinical Oncology26 citations Open access
Semantic Scholar
Current management of low-grade gliomas.
A. Hottinger, M. Hegi, B. Baumert
2016Current Opinion in Neurology25 citations Open access
Semantic Scholar
LTBK-01: PROSPECTIVE, MULTI-CENTER PHASE III TRIAL OF TUMOR TREATING FIELDS TOGETHER WITH TEMOZOLOMIDE COMPARED TO TEMOZOLOMIDE ALONE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
R. Stupp, A. Idbaih, D. M. Steinberg, W. Read +16 more
201623 citations Open access
Semantic Scholar
In vivo characterization of brain metabolism by 1H MRS, 13C MRS and 18FDG PET reveals significant glucose oxidation of invasively growing glioma cells
Marta Lai, I. Vassallo, B. Lanz, C. Poitry-Yamate +4 more
2018International Journal of Cancer19 citations Open access
Semantic Scholar
Genome-wide DNA methylation detection by MethylCap-seq and Infinium HumanMethylation450 BeadChips: an independent large-scale comparison
T. de Meyer, P. Bady, G. Trooskens, S. Kurscheid +7 more
2015Scientific Reports19 citations Open access
Semantic Scholar

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