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T. Rabbitts · SciRah

Researcher profile · Semantic Scholar

T. Rabbitts

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T. Rabbitts — researcher profile on SciRah

h-index: 89
Works: 425
Citations: 29K

Most-cited papers

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A Global Consortium study
K. Hastie, Hao-Yang Li, Daniel H. Bedinger, S. Schendel +69 more
2021Science303 citations Open access
Semantic Scholar
The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
M. McCormack, L. Young, S. Vasudevan, C. D. de Graaf +4 more
2010Science255 citations
Semantic Scholar
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia.
Sofie Peirs, F. Matthijssens, S. Goossens, I. Van de Walle +17 more
2014Blood242 citations
Semantic Scholar
Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.
F. McCaughan, J. Pole, A. Bankier, B. Konfortov +6 more
2010American Journal of Respiratory and Critical Care Medicine117 citations Open access
Semantic Scholar
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
C. E. Quevedo, A. Cruz-Migoni, N. Béry, A. Miller +12 more
2018Nature Communications115 citations Open access
Semantic Scholar
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
A. Cruz-Migoni, P. Canning, C. E. Quevedo, Carole J. R. Bataille +6 more
2019Proceedings of the National Academy of Sciences of the United States of America111 citations Open access
Semantic Scholar
A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
N. Béry, A. Miller, T. Rabbitts
2020Nature Communications102 citations Open access
Semantic Scholar
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
Sandrine Guillard, P. Kolasinska-Zwierz, J. Debreczeni, J. Breed +11 more
2017Nature Communications93 citations Open access
Semantic Scholar
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe
N. Béry, S. Legg, J. Debreczeni, J. Breed +12 more
2019Nature Communications86 citations Open access
Semantic Scholar
Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.
M. McCormack, Benjamin J Shields, J. Jackson, Chayanica Nasa +5 more
2013Blood75 citations Open access
Semantic Scholar
LMO2 at 25 years: a paradigm of chromosomal translocation proteins
J. Chambers, T. Rabbitts
2015Open Biology70 citations Open access
Semantic Scholar
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.
Bin E. Li, Tao Gan, M. Meyerson, T. Rabbitts +1 more
2013Blood66 citations Open access
Semantic Scholar
Interfering with RAS–effector protein interactions prevent RAS-dependent tumour initiation and causes stop–start control of cancer growth
Tomoyuki N. Tanaka, T. Rabbitts
2010Oncogene62 citations Open access
Semantic Scholar
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
N. Béry, A. Cruz-Migoni, Carole J. R. Bataille, C. E. Quevedo +6 more
2018eLife54 citations Open access
Semantic Scholar
Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target
J. Town, H. Pais, Sally M. Harrison, Lucy F. Stead +4 more
2016Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes.
J. El-Jawhari, Yasser M. El-Sherbiny, G. Scott, R. Morgan +7 more
2014Molecular Immunology46 citations
Semantic Scholar
Intracellular antibodies and cancer: New technologies offer therapeutic opportunities
David Pérez-Martínez, Tomoyuki N. Tanaka, T. Rabbitts
2010Bioessays44 citations
Semantic Scholar
Lipid-mRNA Nanoparticle Designed to Enhance Intracellular Delivery Mediated by Shock Waves
Jing Zhang, Shamit Shrivastava, R. Cleveland, T. Rabbitts
2019ACS Applied Materials and Interfaces43 citations Open access
Semantic Scholar
Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture
Tomoyuki N. Tanaka, T. Rabbitts
2010Nature Protocols42 citations
Semantic Scholar
Single Domain Intracellular Antibodies from Diverse Libraries
Tomoyuki N. Tanaka, H. Sewell, S. Waters, S. Phillips +1 more
2010Journal of Biological Chemistry38 citations Open access
Semantic Scholar
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection
A. Miller, A. Leach, Jemima C. Thomas, C. McAndrew +10 more
2021Scientific Reports34 citations Open access
Semantic Scholar
Functional inhibition of β-catenin-mediatedWnt signaling by intracellular VHHantibodies
Laura E Newnham, Michael J Wright, G. Holdsworth, Kostas Kostarelos +3 more
2014mAbs29 citations Open access
Semantic Scholar
Selection and Characterization of a Nanobody Biosensor of GTP-Bound RHO Activities
Laura Keller, N. Béry, Claudine Tardy, L. Ligat +3 more
2019Antibodies28 citations Open access
Semantic Scholar
Chromosomal Translocations and Genome Rearrangements in Cancer
J. Rowley, M. L. Le Beau, T. Rabbitts
2015Cambridge International Law Journal26 citations
Semantic Scholar
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol
Antoine Chabloz, J. Schaefer, I. Kozieradzki, Shane J.F. Cronin +7 more
2020Communications Biology25 citations Open access
Semantic Scholar
Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats
A. Miller, S. Carr, T. Rabbitts, Hanif Ali
2020mAbs24 citations Open access
Semantic Scholar
Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex
H. Sewell, T. Tanaka, K. el Omari, E. Mancini +4 more
2014Scientific Reports20 citations Open access
Semantic Scholar
Changing the Subcellular Location of the Oncoprotein Bcr-Abl Using Rationally Designed Capture Motifs
Andrew S. Dixon, J. E. Constance, Tomoyuki N. Tanaka, T. Rabbitts +1 more
2011Pharmaceutical Research17 citations Open access
Semantic Scholar
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency
A. Leach, F. T. Ilca, Zulaikha Akbar, M. Ferrari +6 more
2021Antiviral Research15 citations Open access
Semantic Scholar
Intracellular Antibodies for Drug Discovery and as Drugs of the Future
T. Rabbitts
2023Antibodies14 citations Open access
Semantic Scholar
LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
K. Ruggero, O. Al-Assar, J. Chambers, R. Codrington +2 more
2016Leukemia14 citations Open access
Semantic Scholar
Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model
H. Pais, K. Ruggero, Jing Zhang, O. Al-Assar +7 more
2019Scientific Reports13 citations Open access
Semantic Scholar
Selection of human single domain antibodies recognizing the CMYC protein using enhanced intracellular antibody capture.
J. Zeng, H.-C. Li, T. Tanaka, T. Rabbitts
2015JIM - Journal of Immunological Methods13 citations
Semantic Scholar
Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis
Shaheen S. Sikandar, G. Gulati, Jane Antony, Isobel J. Fetter +14 more
2022Science Advances12 citations Open access
Semantic Scholar
The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis
Yoshihiro Yamada, Yi Zhong, Shiho Miki, A. Taura +1 more
2021Scientific Reports12 citations Open access
Semantic Scholar
A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2
N. Béry, Carole J. R. Bataille, A. Russell, A. Hayes +6 more
2021Science Advances12 citations Open access
Semantic Scholar
Bioluminescence Resonance Energy Transfer 2 (BRET2)‐Based RAS Biosensors to Characterize RAS Inhibitors
N. Béry, T. Rabbitts
2019Current Protocols in Cell Biology11 citations
Semantic Scholar
Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription
Hanif Ali, A. Daser, P. Dear, H. Wood +2 more
2013Genes, Chromosomes and Cancer11 citations
Semantic Scholar
Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins
A. Leach, A. Miller, E. Bentley, G. Mattiuzzo +4 more
2021Scientific Reports10 citations Open access
Semantic Scholar
Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions.
Jing Zhang, T. Rabbitts
2014Biochimica et Biophysica Acta10 citations
Semantic Scholar
Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
D. Coleman, P. Keane, P. Chin, L. Ames +15 more
2024iScience9 citations Open access
Semantic Scholar
An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells
Jing Zhang, A. Jain, Sabine Milhas, D. Williamson +6 more
2021Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis9 citations Open access
Semantic Scholar
Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody
Tomoyuki N. Tanaka, Jemima C. Thomas, R. van Montfort, A. Miller +1 more
2021Scientific Reports9 citations Open access
Semantic Scholar
Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein
Le-Yuan Bao, Clare Hannon, Abimael Cruz-Mignoni, D. Ptchelkine +9 more
2017Scientific Reports9 citations Open access
Semantic Scholar
Intracellular antibody capture (IAC) methods for single domain antibodies.
Tomoyuki N. Tanaka, T. Rabbitts
2012Methods in molecular biology9 citations
Semantic Scholar
KRAS full length G12V GPPNHP
A. Cruz-Migoni, C. E. Quevedo, S. Carr, M. Ehebauer +2 more
20198 citations
Semantic Scholar
Immunopolymer Lipid Nanoparticles for Delivery of Macromolecules to Antigen-Expressing Cells.
A. Jain, Carole J. R. Bataille, Sabine Milhas, A. Miller +2 more
2020ACS Applied Bio Materials7 citations Open access
Semantic Scholar
Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3
J. Chambers, T. Brend, T. Rabbitts
2019Scientific Reports7 citations Open access
Semantic Scholar
Single Domain Antibody Fragments as Drug Surrogates Targeting Protein–Protein Interactions inside Cells
Jia Zeng, Jing Zhang, Tomoyuki N. Tanaka, T. Rabbitts
20137 citations Open access
Semantic Scholar
Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation
Cristiana Barone, R. Orsenigo, A. Cazzola, Elisabetta D’Errico +14 more
2023Cancers6 citations Open access
Semantic Scholar

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